scholarly journals Analysis of the Indigenous and Pathogenic Microbiota in Bone Sequestration due to Osteonecrosis of the jaws by Bisphosphonates (MRONJ)

2020 ◽  
Vol 5 (1) ◽  
pp. 1-5
Author(s):  
Picardo Silvana N ◽  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Bone Mineral ◽  
Chronic Treatment ◽  
Bone Area ◽  
Necrotic Bone ◽  
Mineral Research ◽  
Osteonecrosis Of The Jaws ◽  
Oral Environment

The American Surgery of Bone Mineral Research (ASBMR) defined MRONJ as “necrotic bone area exposed to the oral environment with more than eight weeks of permanence, in the presence of chronic treatment with BPs, in the absence of radiation therapy to the head and neck in 2007.

scholarly journals “Medication Related Osteonecrosis of the Jaw (MRONJ): Dental Atraumatic Treatment: Antiseptic Mouthwashes”.

2020 ◽  
pp. 1-5
Keyword(s):  
Povidone Iodine ◽  
Rapid Onset ◽  
Osteonecrosis Of The Jaw ◽  
Antiangiogenic Agents ◽  
Bone Area ◽  
Necrotic Bone ◽  
Onset Of Action ◽  
Mineral Research ◽  
Oral Environment ◽  
Cetyl Pyridinium

The American Surgery of Bone Mineral Research (ASBMR) in 2007 defined MRONJ as “necrotic bone area exposed to the oral environment with more than eight weeks of permanence, in the presence of chronic treatment with Bisphosphonates (BP), in the absence of radiation therapy to the head and neck”. Historically, the first drugs associated with the condition were BP, which led to coining of the term MRONJ. However, scientist need to include other drugs in the etiopathogenesis of osteonecrosis, such as other antiresorptive: Denosumab (DS) and antiangiogenic agents. MRONJ treatment is controversial nowadays and depend on Stages of the illness. Some authors recommend high toilettes and resection bone so other, prefer atraumatic therapies focused in antiseptic agents and interdisciplinary (dentist-physician) control. The most common antiseptic agents used are Povidone Iodine, Rifamycin, Cetyl pyridinium chlorid and Chlorhexidine. Alcohol preparations have the fastest onset of action, followed by chlorhexidine and then povidone iodine. However, residual antimicrobial activity is greatest with chlorhexidine. Formulations that contain both chlorhexidine and alcohol combine the rapid onset of alcohol with the persisting effects of chlorhexidine.

scholarly journals Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaws with the Use of Buccal Fat Pad: Case Report

2015 ◽  
Vol 26 (3) ◽  
pp. 317-320 ◽  
Author(s):  
Luiz Fernando Mathias Duarte ◽  
Kleber Alonso ◽  
Elaine Cristina Basso ◽  
Luciano Lauria Dib
Keyword(s):  
Surgical Treatment ◽  
Metastatic Breast ◽  
Bone Area ◽  
Fat Pad ◽  
Buccal Fat Pad ◽  
Necrotic Bone ◽  
Osteonecrosis Of The Jaws ◽  
Oral Communications ◽  
Oral Deformities ◽  
Bone Exposure

Bisphosphonate-related osteonecrosis of the jaws (BROJ) has been described since 2003 as an adverse effect of bisphosphonate medications. These drugs act on the vasculature and bone remodeling, mainly on osteoclastic activity and can cause areas of necrotic bone exposure. Treatment for the BROJ is not yet defined, but surgical treatment is one of the forms proposed, which may cause oral deformities like sinus communication in some cases. In situations like this the buccal fat pad is an important alternative for coating nasal-oral communications, due its large blood supply, elasticity, absence of restriction by age and safety. This paper presents the case of a 58-year-old woman with BROJ in the left maxilla caused by the use of zoledronic acid for metastatic breast cancer. The extensive necrotic bone area was surgically removed resulting in oral sinus communication. A buccal fat pad was used to cover the defect. More studies should be performed regarding the treatment of BROJ but, if necessary, a buccal fat pad flap could be an alternative to solve nasal-oral communications related to BROJ.

scholarly journals Analysis of the critical dose of radiation therapy in the incidence of Osteoradionecrosis in head and neck cancer patients: a case series

BDJ Open ◽  
2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Zain Iqbal ◽  
Panayiotis Kyzas
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Pathological Fracture ◽  
Case Series ◽  
Electronic Patient Records ◽  
Head And Neck Tumours ◽  
Necrotic Bone ◽  
The Mean ◽  
Associated Risk Factors ◽  
Mandibular Surgery

Abstract Introduction Osteoradionecrosis (ORN) is a dramatic complication following radiation therapy (RT) for head and neck tumours. Symptoms include pain, trismus, and malodour. ORN can present with exposed necrotic bone, an orocutaneous fistula, and/ or a pathological fracture. Aims To analyse the RT dose responsible for the pathogenesis of ORN and its associated risk factors. Methods The data of 17 patients from 2005 to 2017 were retrospectively reviewed from the Pinnacle(3), WebPublication, and Electronic patient records (EPR) provided by Christie Hospital and Pennine Acute NHS Trust. Results The mean RT dose that ORN sites received was 57.3 Gy. The mean onset duration for ORN after RT was 640.6 days. six patients (35.2%) developed ORN following post-RT dental extractions. Conclusion RT dosages of >57.3 Gy significantly increase the likelihood of developing ORN. Mandibular surgery, post-RT dental extraction, concurrent smoking, and alcohol abuse all amplify the risk of developing ORN.

Effect of Designed Nursing Education on Awareness of Patients Receiving Head and Neck Radiation Therapy

2020 ◽  
Vol 5 (1) ◽  
pp. 1-15
Author(s):  
Doha Abdel Gawad ◽  
Manal Fareed ◽  
Naser Abd El- Bary ◽  
Hanan Attallah
Keyword(s):  
Radiation Therapy ◽  
Nursing Education ◽  
Head And Neck ◽  
Head And Neck Radiation

scholarly journals Acute Toxicity and Preliminary Clinical Outcomes of Concurrent Radiation Therapy and Weekly Docetaxel and Daily Cisplatin for Head and Neck Cancer

2005 ◽  
Vol 35 (11) ◽  
pp. 639-644 ◽  
Author(s):  
Yoshizumi Kitamoto ◽  
Tetsuo Akimoto ◽  
Hitoshi Ishikawa ◽  
Tetsuo Nonaka ◽  
Hiroyuki Katoh ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Acute Toxicity ◽  
Head And Neck ◽  
Clinical Outcomes ◽  
Neck Cancer ◽  
Weekly Docetaxel

Systemic Therapy for Head and Neck Skin Cancers

FACE ◽  
2021 ◽  
pp. 273250162110138
Author(s):  
Rebecca Knackstedt ◽  
Peter Taub ◽  
Gary Rogers ◽  
Brian Gastman
Keyword(s):  
Radiation Therapy ◽  
High Risk ◽  
Head And Neck ◽  
Systemic Therapy ◽  
Malignant Tumors ◽  
Curative Therapy ◽  
Recurrent Tumors ◽  
Skin Cancers ◽  
Systemic Therapies ◽  
Melanoma Skin

The mainstay of curative therapy for head and neck skin cancers relies upon surgery and/or radiation therapy. However, for some aggressive, non-resectable or recurrent tumors, systemic therapy is necessary. Recent emerging classes of drugs have shown to improve survival for high-risk, recurrent, and unresectable variants of these tumors. The goal of this paper is to review options for systemic therapies for head and neck skin cancers including melanoma, non-melanoma skin cancers and other rare and non-malignant tumors.

Hyperfractionated Radiation Therapy With or Without Concurrent Low-Dose Daily Cisplatin in Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Prospective Randomized Trial

2000 ◽  
Vol 18 (7) ◽  
pp. 1458-1464 ◽  
Author(s):  
Branislav Jeremic ◽  
Yuta Shibamoto ◽  
Biljana Milicic ◽  
Nebojsa Nikolic ◽  
Aleksandar Dagovic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Low Dose ◽  
Locally Advanced ◽  
Progression Free Survival ◽  
High Grade ◽  
Free Survival

PURPOSE: To investigate whether the addition of cisplatin (CDDP) to hyperfractionation (Hfx) radiation therapy (RT) offers an advantage over the same Hfx RT given alone in locally advanced (stages III and IV) squamous cell carcinoma of the head and neck. PATIENTS AND METHODS: One hundred thirty patients were randomized to receive either Hfx RT alone to a tumor dose of 77 Gy in 70 fractions in 35 treatment days over 7 weeks (group I, n = 65) or the same Hfx RT and concurrent low-dose (6 mg/m2) daily CDDP (group II, n = 65). RESULTS: Hfx RT/chemotherapy offered significantly higher survival rates than Hfx RT alone (68% v 49% at 2 years and 46% v 25% at 5 years; P = .0075). It also offered higher progression-free survival (46% v 25% at 5 years; P = .0068), higher locoregional progression-free survival (LRPFS) (50% v 36% at 5 years; P = .041), and higher distant metastasis-free survival (DMFS) (86% v 57% at 5 years; P = .0013). However, there was no difference between the two treatment groups in the incidence of either acute or late high-grade RT-induced toxicity. Hematologic high-grade toxicity was more frequent in group II patients. CONCLUSION: As compared with Hfx RT alone, Hfx RT and concurrent low-dose daily CDDP offered a survival advantage, as well as improved LRPFS and DMFS.

Randomized Preoperative and Postoperative Radiation Therapy for Patients with Carcinoma of the Head and Neck: Preliminary Report

1980 ◽  
Vol 90 (6) ◽  
pp. 930-945 ◽  
Author(s):  
James B. Snow ◽  
Richard D. Gelber ◽  
Simon Kramer ◽  
Lawrence W. Davis ◽  
Victor A. Marcial ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Preliminary Report ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy
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