scholarly journals On the issue of tangential necrectomy in burn surgery (literature review)

2020 ◽  
pp. 24-35
Author(s):  
E. V. Zinoviev ◽  
V. V. Soloshenko ◽  
A. S. Kourov ◽  
S. G. Shapovalov
Keyword(s):  
Literature Survey ◽  
Burn Injuries ◽  
Evidence Based ◽  
Electronic Library ◽  
Postoperative Wound ◽  
Burn Victims ◽  
Pubmed Database ◽  
Burn Surgery ◽  
Excised Tissues ◽  
Convincing Data

Relevance. Treatment of choice for patients with deep burns is early surgery, i.e. necrectomy with simultaneous plastic closure of the postoperative defect. However, technical implementation of necrectomy is still under debate.Intention. To assess current scientific views on the use of tangential necrectomy in the surgical treatment of burn victims.Methodology. A literature survey was carried out using PubMed database, the Google Academy search engine, and also resources of the Scientific electronic library (eLIBRARY.ru).Results and Discussion. The analysis allows us to conclude that at present tangential necrectomy for burn injuries is not generally approved. There is no convincing data on its indications, acceptable areas of simultaneously excised tissues and ex cision depth are not determined, the technique for performing tangential necrectomy using an electrodermatome has not been developed. There is no information on effective methods for closing postoperative defects using tangential excision of a scab.Conclusion. Thus, tangential necrectomy indications as well as acceptable areas of simultaneously dissected tissues and the depth of excision, tangential necrectomy technique via electrodermatome for closing postoperative wound defects need evidence-based justification.

Cola Beverages: Clinical Uses versus Adverse Effects

2019 ◽  
Vol 15 (2) ◽  
pp. 130-139
Author(s):  
Ehsan T. Moghaddam ◽  
Ali Tafazoli
Keyword(s):  
Adverse Effects ◽  
Health Risks ◽  
Feeding Tube ◽  
Evidence Based ◽  
Journal Articles ◽  
Healthcare Settings ◽  
Pubmed Database ◽  
Excessive Consumption ◽  
Points Of View ◽  
Medical Articles

Background: Excessive consumption of cola beverages is accompanied by numerous public health risks. But besides these well-known adverse effects, recently, several medical articles have been published that show some indications for cola beverages in clinical practice like resolution of gastrointestinal or feeding tube obstructions, increasing bioavailability and palatability of other medications, rehydration and other uses in healthcare settings. These approaches are not without shortcomings and complications. Methods: In this systematic review we tried to explore these new uses for practitioners and also reemphasize on the most evidence-based complications of cola consumption like bone loss and metabolic and cardiovascular adverse effects in cases of misuse and overuse from both clinical and nutritional points of view via searching the PubMed database. Results: We chose 145 journal articles from the most relevant ones plus 30 extra references and categorized their topics in two classes of medical uses and adverse effects. Conclusion: It could be stated that cola beverages have demonstrated interesting uses and benefits in medicine but their use should be regulated as strict as possible.

scholarly journals The hospital telemedicine TELEMED database: Providing information on evidence-based telemedicine services to hospital managers and healthcare professionals

2021 ◽  
pp. 1357633X2110155
Author(s):  
Kristian Kidholm ◽  
Ida W Svendsen ◽  
Knud Yderstræde ◽  
Anne M Ølholm ◽  
Kathrine Rayce ◽  
...  
Keyword(s):  
Literature Search ◽  
Healthcare Professionals ◽  
Economic Effects ◽  
Control Group ◽  
Evidence Based ◽  
Implementation Challenges ◽  
Hospital Managers ◽  
Pubmed Database ◽  
Significant Difference ◽  
Hospital Patients

Background Increased use of telemedicine in the healthcare system is a political goal in Denmark. Although the number of hospital patients using interventions such as the video consultation has increased in recent years only a small proportion of the outpatient and inpatient visits involve telemedicine. The TELEMED database ( https://telemedicine.cimt.dk/ ) has been launched at the Center for Innovative Medical Technologies in Denmark to ensure that hospital managers and healthcare professionals have access to information about telemedicine services and their effectiveness. This article describes the development and the content of the TELEMED database. Methods A structured literature search was made in the PubMed Database for randomised controlled trials or observational studies with a control group that investigated the effect of telemedicine interventions for hospital patients. Data were extracted from each article on the clinical effectiveness, patient perceptions, economic effects and implementation challenges. As the database should only provide inspiration to healthcare professionals regarding possibilities for use of telemedicine, the risk of bias in the studies was not assessed. Results The literature search resulted in 2825 hits. Based on full text assessment, 331 articles were included for data extraction and assessment. These articles present telemedicine services used in 22 different medical specialities. Forty-eight percent of the studies found a positive, statistically significant clinical effect, while 47% showed no statistically significant difference. In 48% of the studies, patients’ experiences were examined and of these 68% found positive patient experiences. Fifty-four percent of the articles included information on the economic effects and, of these, 51% found reduction in healthcare utilization. In the majority of studies between two and four types of implementation challenges were found. Conclusions and recommendations: The TELEMED database provides an easily accessible overview of existing evidence-based telemedicine services for use by hospital managers and health professionals, who whish to to implement telemedicine. The database is freely available and expected to be continuously improved and broadened over time.

scholarly journals A SYSTEMATIC REVIEW OF THERMAL MONITORING TECHNIQUES IN A PEDIATRIC RESUSCITATION AND INTENSIVE CARE UNIT

2020 ◽  
Vol 24 (1) ◽  
pp. 35-39
Author(s):  
Maria A. Berezhnaya ◽  
V. G. Amcheslavskiy
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Relevant Literature ◽  
Evidence Based ◽  
Clinical Knowledge ◽  
Thermal Monitoring ◽  
Intensive Care Unit Staff ◽  
Pediatric Resuscitation ◽  
Pubmed Database ◽  
Based Medicine

This article includes studies which meet the requirements of evidence-based medicine and is written for resuscitation and intensive care unit staff. Articles from PubMed database were used in it. The review of the relevant literature is aimed at practitioners and nurses. These recommendations reflect the current scientific and clinical knowledge base. In everyday practice, the differences and limitations of thermal monitoring and the application of thermoregulatory effects in each individual patient should be taken into account. These recommendations should not be construed as a mandatory protocol of action, and the use of these recommendations does not guarantee a specific clinical outcome. There is no conflict of interest.

scholarly journals Genesis of research on burn injury (analysis of domestic articles in 2005–2017)

2019 ◽  
pp. 108-120 ◽  
Author(s):  
V. I. Evdokimov ◽  
A. S. Kourov
Keyword(s):  
Burn Injury ◽  
Scientific Journal ◽  
Experimental Studies ◽  
Weighted Average ◽  
Burn Injuries ◽  
Annual Number ◽  
Journal Articles ◽  
Russian Science ◽  
Electronic Library ◽  
Russian Science Citation Index

Relevance.According to the Federal Statistics Service (Rosstat), (315.8 ± 8.5) thousand thermal and chemical burns or (220.6 ± 6.5) burns per 100 thousand people of the country’s population were recorded annually in Russia in 2005–2015. These injuries account for 2.4 % of the structure of all injuries in Russia.Intention.Analysis of the content of scientific journal articles of domestic authors on burn injuriesMethodology.We conducted a search in the electronic database of the Scientific Electronic Library, which made it possible to identify in 2005–2017 1649 scientific journal articles of domestic authors. The average annual number of articles on burn injury indexed in the Russian Science Citation Index was (127 ± 13). There is an increase in the interest of researchers to the problems of burns. The content of the articles correlated with the developed classifier for burn injury.Results and Discussion.General questions of burn injuries were described in 1.6 %, problems of organization of medical care for burn victims – in 4.9 %, characteristics of burn injuries – in 42.9 %, information on diagnostics, treatment, probable complications and rehabilitation of victims – in 41.3 %, experimental studies of burn injury in animals – in 9.3 % of publications. The presented indicators reflected the content of the articles, and, to some extent, objective data. For example, superficial and limited burns were studied to a lesser extent, although they actually prevail. As a rule, the object of research was complex cases that could be of increased interest among readers. The weighted average impact factor of the journals in which the articles were published was 0.304, the average number of citations per article was 1.42, 42.6 % of the articles were cited at least once, Hirsch index was 15. Some authors used inadequate study design. When preparing publications, the groups of authors were often redundant, which resulted in a significant decrease in the number of articles and citations per 1 coauthor.Conclusion. The study helps optimize research in the field of burn injuries. Among the created array of articles, 74.2 % of publications had a full text, 69.4 % of articles were provided free of charge to registered readers of the Scientific Electronic Library.

scholarly journals Evidence-Based Management of Gout - A Systematic Search and Review

2020 ◽  
Author(s):  
Md Abu Bakar Siddiq
Keyword(s):  
Risk Factors ◽  
Treatment Options ◽  
Evidence Based ◽  
Level Of Evidence ◽  
Pharmacological Agents ◽  
New Synthesis ◽  
Pubmed Database ◽  
Anti Inflammatory ◽  
Clinical Conditions

Gout is the most common form of inflammatory arthritis. Hyperuricaemia is the pre-requisite for gout and is influenced by variable modifiable and non-modifiable risk factors. Clinical features unique for gout are due to deposition of monosodium urate (MSU) crystal in articular and extra articular tissues. Among various treating agents, anti-inflammatory drugs and urate lowering therapies (ULT) are used widely and successfully, however, non-medicinal means are also effective in the disorder. In their updated guidelines, ACR (2012) and EULAR (2016) recommended both medicinal and non-medicinal approaches that could be used in treating gout, though some of the recommendations are based on lower level of evidence. Moreover, researchers’ continued effort in finding new gout managing agents appear promising, for example, role of Lesinurad in gout management (CLEAR1, CLEAR2). In this new synthesis the author is aimed to provide updated information on gout management based on a systematic review including published work within last ten years between 2008 and 2018 and for this purpose, using ‘clinical trials in gout management’ string, published worked searched in PubMed database from 1st September 2018 to 30 October 2018. Besides the recent ACR and EULAR evidence based management guidelines, the author reviewed another 91 (total 93) articles to make this new draft – 39 articles describe role of pharmacological agents and 54 describe different gout risks, pharmacokinetics/pharmacodynamics of ULT, association between raised sUA level and renal impairment, efficacy of non-pharmacological agents in reducing sUA. According to published work, anti-inflammatory agent is the most appropriate drug group in mitigating inflammatory symptoms of gout, though they often adversely affect over other vital 2 organs with impaired function. Besides ULT, uricase analogues are also found useful in non refractory gout. Since anti-inflammatory agents and ULT contraindicate in some clinical conditions, intra-articular steroid and or adrenocorticotropic hormone (ACTH) are appropriate alternatives instead. However, head-to-head comparison between different NSAIDs, NSAID and prednisolone, NSAID and colchicine are yet to perform. Use of combined anti-inflammatory preparations in gout is also based on lower level of evidence. Regarding effective maximum dose and long-standing impact of ULT on vital organs we are yet to reach a conclusion. Likewise, non-medicinal approaches are widely using in achieving target sUA level, though some of them are based on biased study outcomes and or study with inadequate power, requiring further analysis. Among non-pharmacological approaches, life-style modification, restriction of purine rich diets, avoidance of gout inciting agents are important, but inconclusive. Educating patients’ about diseases, risk factors, available treatment options and side effects from them are also important in terms of achieving sUA level, nevertheless too much counseling sometimes could be worthless.

scholarly journals Computer analysis of the emotional modality of 20 million publications in PUBMED database indicates ways to increase the effectiveness of pharmacotherapy by identifying pseudoscientific publications aimed at negative emotional "pumping" of doctors

2021 ◽  
pp. 19-40
Author(s):  
V. A. Maximov ◽  
I. Yu. Torshin ◽  
O. A. Gromova ◽  
A. N. Galustyan ◽  
I. V. Gogoleva ◽  
...  
Keyword(s):  
Evidence Based Medicine ◽  
Clinical Medicine ◽  
International Standards ◽  
Scientific Quality ◽  
Evidence Based ◽  
Treatment Standards ◽  
Pronounced Increase ◽  
Pubmed Database ◽  
Based Medicine

The search for original publications on fundamental and clinical medicine that would produce results of the highest scientific quality represents an urgent need for every medical researcher. Such publications are essential, in particular, for the development of reliable treatment standards. The Englishlanguage resources PUBMED and EMBASE are essential to help in solving this problem. However, there is an obvious problem in assessing the quality of the studies found. The paper formulates a method for analyzing the texts of biomedical publications, which is based on an algorithmic assessment of the emotional modality of medical texts (so-called sentiment analysis). The use of the topological theory of data analysis made it possible to develop a set of high-precision algorithms for identifying 16 types of sentiments (manipulative turns of speech, research without positive results, propaganda, falsification of results, negative personal attitude, aggressiveness of the text, negative emotional background, etc.). On the basis of the developed algorithms, a point scale for assessing the sentiment quality of research was obtained, which we called the "β-score": the higher the β-score, the less the evaluated text contains manipulative language constructions. As a result, the ANTIFAKE system (http://antifake-news.ru) was developed to analyze the sentiment-quality of Englishlanguage scientific texts. An analysis of ~ 20 million abstracts from PUBMED showed that publications with low sentiment quality (β-score <0, that is, that the prevalence of manipulative constructions over meaningful ones) is only 19 %. In the overwhelming majority of thematic headings (27,090 out of 27,840 headings of the MESH system PUBMED), a positive dynamics of sentiment quality of the texts of publications is shown by years). At the same time, as a result of the study, 249 headings were identified with sharply negative dynamics of sentiment quality and with a pronounced increase in manipulative sentiments characteristic of the "yellow" English-language press. These headings include tens of thousands of publications in peer-reviewed journals, which are aimed at (1) legalizing ethically unacceptable practices (euthanasia, perversions, so-called "population control", etc.), (2) discrediting psychiatry as a science, (3) media the war against micronutrients and (4) discrediting evidence-based medicine under the guise of developing the so-called "international standards of evidence-based medicine". In general, the developed system of artificial intelligence allows researchers to filter out pseudoscientific publications, the text of which is overloaded with emotional manipulation and which are published under the guise of "evidence-based standards".

scholarly journals Exercise Interventions for Adults with Burn Injuries

2021 ◽  
Author(s):  
Liz Burton ◽  
Carolyn Knight ◽  
Brittney Malone ◽  
Lexie Rivers ◽  
Rachel Walker ◽  
...  
Keyword(s):  
Burn Injuries ◽  
Bottom Line ◽  
Exercise Interventions ◽  
Early Exercise ◽  
Burn Victims ◽  
Mobility Training ◽  
Meta Analyses ◽  
Study Designs ◽  
Motion Quality

The purpose of this critically appraised topic (CAT) is to provide the highest quality of evidence available on the implementation of exercise interventions in the early burn rehabilitation phase in adult burn victims. This portfolio contains four peer-reviewed research articles from national and international journals. The study designs include one systematic review and meta analyses, one retrospective cohort study and two randomized control trials. These articles covered three types of exercise interventions including resistance training, mobility training, and physiotherapy. Overall, the clinical bottom line of this CAT is that exercise interventions in early burn rehabilitation may be effective in improving upper extremity function, muscle strength, range of motion, quality of life, and decreasing length of stay and inf lammation. Further research is needed to determine the effects of early exercise interventions in adults in the burn ICU.

scholarly journals A systematic review and meta-analysis of the efficacy and safety of remdesivir in COVID-19 patients

2021 ◽  
Vol 4 (1) ◽  
pp. 298-303
Author(s):  
Sumanta Saha ◽  
Sujata Saha
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Random Effect ◽  
Fixed Effect Model ◽  
Evidence Based ◽  
Efficacy And Safety ◽  
Randomized Controlled ◽  
Effect Model ◽  
Pubmed Database ◽  
The Us

Background: This systematic review compares the efficacy and safety of remdesivir between its recipient and non-recipient COVID-19 patients from the recently published randomized controlled trials (RCT).  Methods: For eligible trials comparing the above outcomes, a literature search took place in the PubMed database. The reviewed trials data were abstracted and critically appraised using the Cochrane tool. Then, a random-effect meta-analysis followed to compare the risk between the compared interventions in risk ratio (RR). By plying the I2 and Chi2 statistics, the heterogeneity estimation happened. A sensitivity analysis iterated the preliminary meta-analysis using a fixed-effect model. Results: Two eligible RCTs included in this review sourced data from about 833 COVID-19 patients from 115 hospitals in Asia, Europe, and the US. The risk of bias was primarily low. Random-effect meta-analysis suggested a clinical improvement (RR: 1.09; 95% CI: 1.02, 1.16; P=0.02; I2: 0%) and decrease in the risk of any serious side effects (RR: 0.64; 95% CI: 0.43, 0.94; P<0.001; I2: 0%) in the remdesivir treated COVID-19 patients. The rest of the outcomes did not vary between the juxtaposed interventions. Conclusion: Evidence-based on early RCTs suggest that remdesivir is a clinically useful and safe drug to treat COVID-19 patients.

scholarly journals Analysis of psychiatric problems in burn patients in a tertiary burn unit: a prospective study

2017 ◽  
Vol 4 (12) ◽  
pp. 4015 ◽  
Author(s):  
Manimaran Ramachandran ◽  
Alagar Raja Durairaj ◽  
Surya Rao Rao Venkata Mahipathy ◽  
Narayanamurthy Sundaramurthy
Keyword(s):  
Psychiatric Disorders ◽  
Psychosocial Problems ◽  
Burn Injuries ◽  
Wound Management ◽  
Predisposing Factor ◽  
Medical College ◽  
Burn Surgery ◽  
A Prospective Study ◽  
And Coping

Background: Burn injuries in our part of the world generally occurs in the lower socio-economic groups. A large part of these patients suffers from underlying psychiatric disorders. This study is to see the prevalence rates and clinical diagnosis of psychiatric disorders and psychosocial problems as a predisposing factor to burns and squeal to burns in our population, hence necessitate the consultation with the psychiatric team management to improve the outcome from the time of critical phase recovery to the rehabilitation phase.Methods: 114 patients admitted with suicidal burns above the age of 15 years were included in the study at Dept. of Plastic, Reconstructive and Burn Surgery, Govt. Kilpauk Medical College and Hospital for a period of 2 years and evaluated.Results: The patients were mostly married females in the 2nd to 3rd decade of life. Most of them had some form of pre-morbid psychopathology. 60% of patients had >50% burns and only 17% were survivors. After 1 year of psychotherapy, most patients had returned to normalcy.Conclusions: In our study deformity related depression were more after recovery hence prevention of deformity with usage of appropriate splintage, wound management, early grafting and intense physiotherapy will produce a drastic change in their wellbeing and coping ability and help long term rehabilitation and return to normalcy.

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