scholarly journals Physical Evaluation of Transfersome that Contains Pandan Leaves Extract (Pandanus amaryllifolius R.)

2021 ◽  
Vol 5 (4) ◽  
pp. 369-374
Author(s):  
Rini Ambarwati ◽  
Yulianita Yulianita
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Average Particle Size ◽  
Particle Morphology ◽  
Entrapment Efficiency ◽  
Average Particle ◽  
Hard Tissue ◽  
Long Time ◽  
Original Size ◽  
Active Substances

Pandan leaves have been researched and have effectiveness in the treatment of burns. The process of healing burns takes a long time and cause a hard tissue because it loses its elasticity, making it difficult to penetrate. In this study, pandanus leaves were formulated into the nanovesicle carrier system, namely trasfersom. Transfersomes have the ability to deform, namely the ability to reduce the particle size 5-10 times from the original size when passing through the gaps between cells so that transfersom can increase the penetration of active substances. The three formulas used are based on the ratio of concentrations of trasfersome vesicles, namely phospholipids and span 80. Formula 1 is (90:10), Formula 2 (85:15) and Formula 3 (80:20). The best formula is determined based on transfersom characterization, including particle size and PDI (solidispersity index), zeta potential, entrapment efficiency, deformability, and TEM particle morphology. The results showed that Formula 3 (80:20) is the most stable formula with an average particle size of 730.1 ± 4.9 nm, PDI value <0.7, zeta potential - 9.94 ± 1.02 mV, efficiency absorption 80.23%, and the deformability value 6.225.  

scholarly journals Karakterisasi Nanopartikel Ekstrak Bunga Kecombrang dengan Penambahan Poloksamer

2018 ◽  
Vol 1 (3) ◽  
pp. 121-124
Author(s):  
Tresna Lestari ◽  
Tita Nofianti ◽  
Lilis Tuslinah ◽  
Ruswanto Ruswanto ◽  
Firda Adityas
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Average Particle Size ◽  
Particle Morphology ◽  
Entrapment Efficiency ◽  
Polydispersity Index ◽  
Average Particle ◽  
Flower Extract ◽  
Round Form ◽  
Nanoparticle Formulation

Bunga kecombrang diketahui memiliki aktivitas sebagai antioksidan. Teknologi formulasi nanopartikel diharapkan dapat meningkatkan aktivitas biologis dari ekstrak.Penelitian ini dilakukan untuk memperoleh nanopartikel dari ekstrak bunga kecombrang dengan karakteristik yang baik.Pembuatan nanopartikel dilakukan dengan penambahan poloksamer dengan variasi konsentrasi 1, 3 dan 5%. Formulasi selanjutnya dianalisis meliputi ukuran partikel rata-rata, indeks polidispersitas, potensial zeta, efisiensi penjeratan dan morfologi partikel menggunakan SEM.Hasil karakterisasi diperoleh ukuran partikel rata-rata ketiga formula berada dalam rentang 134,7-193,1 nm, indeks polidispersitas <0,5 untuk semua formula, nilai potensial zeta antara -41,0 - (-24,3) mV dan efisiensi penjeratan terhadap senyawa flavonoid 89,93-97,99 %. Berdasarkan hasil SEM nanopartikel diketahui berbentuk bulat dengan permukaan yang halus.Berdasarkan hasil penelitian disimpulkan bahwa nanopartikel ekstrak bunga kecombrang dengan penambahan poloksamer 1, 3 dan 5% memiliki karakteristik yang baik dan memenuhi syarat sebagai sediaan nanopartikel.   Kecombrang flowers are known to have antioxidant activity. Nanoparticle formulation technology is expected to increase the biological activity of the extract. This study was conducted to obtain the nanoparticles from kecombrang flower extract with good characteristics. The preparation of nanoparticles was carried out by adding poloxamer with various concentrations of 1, 3 and 5%.Furthermore, the formula were analyzed, including the average particle size, polydispersity index, zeta potential, entrapment efficiency and particle morphology using SEM. The results of the characterization obtained an average particle size of the three formulas in the range of 134.7-193.1 nm, polydispersity index <0 , 5 for all formulas, zeta potential values ​​in range of -41.0 - (-24.3) mV and entrapment efficiency of flavonoid compounds of 89.93-97.99%The results of SEM examination showed that nanoparticles  was in round form with a smooth surface. Based on the results of the study,  itcan be concluded that kecombrang flower extract nanoparticles with the addition of poloxamer 1, 3 and 5% had good characteristics and met the criteria of  nanoparticle

Formulation and Evaluation of Polymeric Nanoparticles of an Antiviral Drug for Gastroretention

2012 ◽  
Vol 4 (4) ◽  
pp. 1557-1562 ◽  
Author(s):  
Ankit Anand Kharia ◽  
A K Singhai ◽  
R Verma
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Average Particle Size ◽  
Chlorinated Solvents ◽  
Entrapment Efficiency ◽  
The Body ◽  
Hydrophilic Polymers ◽  
Polydispersity Index ◽  
Average Particle ◽  
Loading Efficiency

The aim of present study was to formulate and evaluate nanoparticles of acyclovir by using different hydrophilic polymers. Acyclovir was selected as a suitable drug for gastro-retentive nanoparticles due to its short half life, low bioavailability, high frequency of administration, and narrow absorption window in stomach and upper part of GIT. The nano-precipitation method was used to prepare nanoparticles so as to avoid both chlorinated solvents and surfactants to prevent their toxic effect on the body. Nanoparticles of acyclovir were prepared by using hydrophilic polymers such as bovine serum albumin, chitosan, and gelatin. The prepared formulations were then characterized for particle size, polydispersity index, zeta potential, loading efficiency, encapsulation efficiency and drug-excipient compatibility. The prepared nanoparticulate formulations of acyclovir with different polymers in 1:1 ratio have shown particle size in the range of 250.12-743.07 nm, polydispersity index (PDI) in the range of 0.681-1.0, zeta potential in the range of -14.2 to +33.2 mV, loading efficiency in the range of 8.74-17.54%, and entrapment efficiency in the range of 55.7%-74.2%. Nanoparticulate formulation prepared with chitosan in 1:1 ratio showed satisfactory results i.e. average particle size 312.04 nm, polydispersity index 0.681, zeta potential 33.2 mV, loading efficiency 17.54%, and entrapment efficiency 73.4%. FTIR study concluded that no major interaction occurred between the drug and polymers used in the present study.  

scholarly journals Preparation and Characterization of Chitosan Coated PLGA Nanoparticles of Resveratrol: Improved Stability, Antioxidant and Apoptotic Activities in H1299 Lung Cancer Cells

Coatings ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 439 ◽  
Author(s):  
Hibah M. Aldawsari ◽  
Nabil A. Alhakamy ◽  
Rayees Padder ◽  
Mohammad Husain ◽  
Shadab Md
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Average Particle Size ◽  
Spherical Shape ◽  
Entrapment Efficiency ◽  
Aqueous Solubility ◽  
Plga Nanoparticles ◽  
Steady Increase ◽  
Average Particle

Resveratrol (RES) is a polyphenolic compound which has shown beneficial pharmacological effects such as anti-inflammatory, antioxidant, and anti-cancer effects. However, poor aqueous solubility, bioavailability, and low stability are the major limitations to the clinical application of RES. Therefore, in the present study, chitosan (CS) coated PLGA nanoparticles of RES (CS-RES-PLGA NPs) was developed, characterized and its anticancer activity was evaluated in the H1299 lung carcinoma cell line. The effects of the increase in CS coating and cryoprotectant concentration on particle size, polydispersity index (PDI) and zeta potential (ZP) were determined. The particle size, PDI, ZP and entrapment efficiency of the optimized CS-RES-PLGA NPs were found to be 341.56 ± 7.90 nm, 0.117 ± 0.01, 26.88 ± 2.69 mV and 75.13% ± 1.02% respectively. The average particle size and ZP showed a steady increase with an increase in CS concentration. The increase in positive zeta potential is evident for higher CS concentrations. The effect of trehalose as cryoprotectant on average particle size was decreased significantly (p < 0.05) when it was increased from 1%−5% w/v. TEM and SEM showed uniform particle distribution with a smooth surface and spherical shape. The CS coating provides modulation of in vitro drug release and showed a sustained release pattern. The stability of RES loaded PLGA NPs was improved by CS coating. CS-coated NPs showed greater cytotoxicity and apoptotic activities compared to free RES. The CS coated NPs had a higher antioxidant effect than the free RES. Therefore, CS coated PLGA NPs could be a potential nanocarrier of RES to improve drug solubility, entrapment, sustain release, stability and therapeutic application.

scholarly journals DERMAL DELIVERY OF DOCETAXEL LOADED NANO LIQUID CRYSTALS FOR THE TREATMENT OF SKIN CANCER

2019 ◽  
pp. 188-193 ◽  
Author(s):  
ARTI MAJUMDAR ◽  
NIDHI DUBEY ◽  
NITIN DUBEY
Keyword(s):  
Liquid Crystals ◽  
Skin Cancer ◽  
Zeta Potential ◽  
Average Particle Size ◽  
Entrapment Efficiency ◽  
Cell Uptake ◽  
Diffusion Method ◽  
Average Particle ◽  
Uptake Study

Objective: The aim of the present study is to develop docetaxel-loaded nano liquid crystals (NLCs) to enhanced and effective delivery of the drug to the skin cancer. Methods: NLCs bearing docetaxel were prepared by an emulsification solvent diffusion method. The formulated NLCs were characterized for average particle size, polydispersity index (PDI) Zeta potential, entrapment efficiency and in vitro drug release study. The prepared formulations were studied for it's in vitro cell line and cell uptake study. Results: It was revealed that the average size of NLCs was found 178.3±5.07, PDI was 0.189, percent entrapment efficiency was found 71.3±2.49 and Zeta potential was found-17.3±2.4. In vitro release determined by Franz diffusion cell was found 61.6±3.2% after 72 hr. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay shows that Docetaxel loaded NLCs were giving more cytotoxicity as compared to the plain drug. The cell uptake study was found enhanced uptake of fluorescein isothiocyanate (FITC) loaded NLCs in comparison to plain FITC. Docetaxel and docetaxel-loaded NLCs showed 28.3±0.3 and 39.3±1.3 growth inhibition respectively after 48h upon incubation at 0.5 µg/ml concentration (p<0.05). Conclusion: The result of the studies was concluded that NLCs can be used as impending drug delivery system which may enhance the drug uptake and maintain the drug level for longer period of time and it is potential carrier system which can be used for the treatment of skin diseases like cancer.

Molten Salt Synthesis of CaCu3Ti4O12

2008 ◽  
Vol 368-372 ◽  
pp. 115-117 ◽  
Author(s):  
Ke Pi Chen ◽  
Yong He ◽  
Dong Yu Liu ◽  
Zong De Liu
Keyword(s):  
Particle Size ◽  
Molten Salt ◽  
Average Particle Size ◽  
Particle Morphology ◽  
Holding Time ◽  
Molten Salt Synthesis ◽  
Average Particle ◽  
Molten Salt Method ◽  
Particle Size Analyzer ◽  
Size And Morphology

CCTO powders were prepared by using molten salt method in the NaCl-KCl system. The effects of temperature and holding time on phase compositions, particle morphology and size have been investigated by X-ray diffraction, scanning electron microscope and laser particle size analyzer. Using CaCO3, CuO and TiO2 as starting materials, CCTO compound could be synthesized at any temperature from 800oC to 1000oC in the NaCl-KCl system. The average particle size increased obviously with the increasing of temperature above 850 oC. Holding time had great effect on grain size and morphology.

Rheological, Structural and Mechanical Characterization of Monolithic Zircon-Alumina Bodies

2014 ◽  
Vol 793 ◽  
pp. 151-158 ◽  
Author(s):  
M. León-Carriedo ◽  
C.A. Gutiérrez Chavarría ◽  
J.L. Rodríguez Galicia ◽  
Jorge López-Cuevas ◽  
M.I. Pech Canul
Keyword(s):  
Particle Size ◽  
Raw Materials ◽  
Mechanical Test ◽  
Average Particle Size ◽  
Young Modulus ◽  
Particle Morphology ◽  
Ceramic Materials ◽  
Transgranular Fracture ◽  
Average Particle

In the present work, the characterization of monolithic materials formulated at different weight concentrations was conducted; employing two of the ceramic materials most used in the refractory industry, zircon and alumina. These monolithic materials were fabricated using colloidal techniques, specifically plaster casting mold, in order to obtain pieces with a higher particle consolidation and density, reducing porosity to lower values than the obtained using traditional shaping process of these materials. The monoliths were obtained employing two ceramic powders with different average particle size and morphology to achieve better packing in the green body. This characterization was carried out, firstly, determining the particle size of the raw materials by laser diffraction and the evaluation of particle morphology by scanning electron microscopy. Aqueous suspensions were formulated by containing both ceramic materials, which were dispersed with Tamol 963, and analyzed by rheometric techniques. Subsequently, bars were manufactured having the following dimensions; 4 mm wide, 3 mm thick and 45 mm in length, according to ASTM C1161-02cc, to be characterized microstructural and mechanically, also was observed the fracture habit after the mechanical test. As a final result, the materials formulated at higher alumina content showed higher density values, reaching 94.95% of the theoretical density, also showed a higher thermal expansion coefficient and high rupture modulus, reaching up to 600 MPa and Young modulus of 230 GPa. From the microstructure characterization it was observed that alumina matrix shows a transgranular fracture across the grains and zircon particles exhibited intergranular fracture among the grain boundaries.

scholarly journals Development and Evaluation of Floating Microspheres of Sumatriptan Succinate using Ethyl Cellulose and Mucilage Extracted from Vigna Mungo

2021 ◽  
pp. 24-36
Author(s):  
Nilesh S. Kulkarni ◽  
Mukta A. Kulkarni ◽  
Rahul H. Khiste ◽  
Mohini C. Upadhye ◽  
Shashikant N. Dhole
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Ethyl Cellulose ◽  
Polymer Concentration ◽  
Average Particle Size ◽  
Entrapment Efficiency ◽  
Vigna Mungo ◽  
Average Particle ◽  
Sumatriptan Succinate

Aim: The present investigation is to formulate and evaluate gastroretentive floating microspheres for sumatriptan succinate. Gastric retention is widely used approach to retain dosage form in stomach and to enhance absorption of drugs. Methods: The gastroretentive floating microspheres was prepared by two different techniques as solvent evaporation and W/O/W multiple emulsion technique. Ethyl cellulose, HPMC K4M polymer and mucilage extracted from Vigna Mungo in various proportions were used for formulation of microspheres. Combination of ethyl acetate and acetone in different proportion was used as organic phase and the microspheres were characterized for particle size, shape, morphology, percentage yield, entrapment efficiency, drug loading, In-Vitro Floating/Buoyancy study, In-vitro Floating/Buoyancy study and release kinetics. Results: The average particle size of all batches was found in the range 100 to 210 μm and the entrapment efficiency of all formulations was found in the range of 17.46 % to 59.28 %.Total floating time for Sumatriptan succinate floating microspheres was observed more than 12 h. The In-Vitro drug release study was performed for all formulations showed drug release in controlled manner. Conclusion: The particle size was increased with increased polymer concentration and it showed that polymer concentration has an impact on the entrapment efficiency. Ethyl cellulose microspheres showed more entrapment and sustained delivery of sumatriptan Succinate than microspheres prepared by combination of Ethyl cellulose: HPMC K4M and Ethyl cellulose: Vigna mungo mucilage.

scholarly journals Formulation and evaluation of polymeric nanoparticles of an antihypetensive drug for gastroretention

2018 ◽  
Vol 8 (6) ◽  
pp. 82-86 ◽  
Author(s):  
Surendranath Betala ◽  
M Mohan Varma ◽  
K Abbulu
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Chlorinated Solvents ◽  
Entrapment Efficiency ◽  
The Body ◽  
Hydrophilic Polymers ◽  
Polydispersity Index ◽  
Average Particle ◽  
Loading Efficiency ◽  
Gastro Retentive

The aim of present study was to formulate and evaluate nanoparticles of carvedilol by using different hydrophilic polymers. Carvedilol was selected as a suitable drug for gastro- retentive nanoparticles due to its short half life, low bioavailability, high frequency of administration, and narrow absorption window in stomach and upper part of GIT. The nano-precipitation method was used to prepare nanoparticles so as to avoid both chlorinated solvents and surfactants to prevent their toxic effect on the body. Nanoparticles of  carvedilol were prepared by using hydrophilic polymers such as HPMC K100M, chitosan, and gelatin. The prepared formulations were then characterized for particle size, polydispersity index, zeta potential, loading efficiency, encapsulation efficiency and drug-excipient compatibility. The prepared nanoparticulate formulations of carvedilol  with different polymers in 1:1 ratio have shown particle size in the range of 250.12-743.07 nm, polydispersity index (PDI) in the range of 0.681-1.0, zeta potential in the range of -14.2 to +33.2 mV, loading efficiency in the range of 8.74-17.54%, and entrapment efficiency in the range of 55.7%-74.2%. Nanoparticulate formulation prepared with chitosan in 1:1 ratio showed satisfactory results i.e. average particle size 312.04 nm, polydispersity index 0.681, zeta potential 33.2 mV, loading efficiency 17.54%, and entrapment efficiency 73.4%. FTIR study concluded that no major interaction occurred between  the drug and polymers used in the present study. Keywords: Nanoparticles; gastro-retentive; nano-precipitation, polydispersity index, zeta potential; entrapment efficiency.

Investigation on the Preparation, Characteristics, and Controlled Release Model of Paeonol-Loaded Liposome in Carbomer Hydrogel

2020 ◽  
Vol 17 (2) ◽  
pp. 159-173
Author(s):  
Qinqin Liu ◽  
Hongmei Xia ◽  
Yinxiang Xu ◽  
Yongfeng Cheng ◽  
Zhiqing Cheng
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Average Particle Size ◽  
Entrapment Efficiency ◽  
Average Particle ◽  
Filtration Method ◽  
Ethanol Injection ◽  
Soybean Phospholipid ◽  
Release Model

Objective: Paeonol is a phenolic compounce that is volatile. In order to decrease its volatility and achieve controlled release, paeonol-loaded liposome in carbomer hydrogel was prepared by coating with soybean phospholipid via ethanol injection method and then added into the carbomer hydrogel. Methods: The quality of paeonol-loaded liposome in carbomer hydrogel was evaluated by the degree of roundness, particle size distribution, zeta potential, entrapment efficiency (filtration method and chitosan neutralization method), viscosity, infrared spectrum, etc. Furthermore, the diffusion from paeonolloaded liposome in hydrogel was studied in vitro. Results: The results showed that the average particle size of paeonol-loaded liposome was about 401 nm, the potential was -17.8 mV, and the entrapment efficiency was above 45%. The viscosity of paeonol- loaded liposome in hydrogel was 23.972×10-3 Pa*s, and the diffusion rate from paeonol-loaded liposome in hydrogel in vitro was obviously slower than that from the other paeonol preparations. Conclusion: The conclusions could be drawn that paeonol-loaded liposome in hydrogel was a kind of novel preparation, and its diffusion in vitro had obvious controlled-release characteristics, which further proved that it might improve the bioavailability of paeonol.

Preparation and characterization of natural quercetin-based Mongolia Medicine SenDeng-4 nanoemulsion (N-QUE-NE) and its antibacterial activity..

2020 ◽  
Vol 18 ◽  
Author(s):  
Yanfang Zhang ◽  
Rina Du ◽  
Pengwei Zhao ◽  
Sha Lu ◽  
Rina Wu ◽  
...  
Keyword(s):  
Particle Size ◽  
Antibacterial Activity ◽  
Zeta Potential ◽  
High Speed ◽  
Antibacterial Effect ◽  
Average Particle Size ◽  
Antagonistic Effect ◽  
Dilution Method ◽  
Average Particle

Background: Quercetin is the main active ingredient of Xanthoceras sorbifolia Bunge. Traditional compatibility theory of traditional Chinese medicine has typically reported a synergistic interaction among multiple components, while the synergistic effects of nanoemulsion have not been fully clarified. Objective: To study preparation and characterization of quercetin-based Mongolia Medicine Sendeng-4 nanoemulsion (NQUE-NE) and its antibacterial activity and mechanisms. Methods: The morphology of the nanoemulsion was observed by transmission electron microscopy (TEM), and the zeta potential, polydispersity index (PDI), and particle size distribution were determined by the nanometer particle size analyze. The stability of nanoemulsion was investigated by light test, high speed centrifugal test and storage experiment at different temperature. The combined bacteriostatic effect of N-QUE-NE was studied in vitro by double-dilution method and checkerboard dilution method. Results: The appearance of N-QUE-NE was pale yellow, clear and transparent. The nanoemulsion particles were spherical and uniformly distributed under TEM. The PDI was 0.052, the average particle size was 19.6nm, and the Zeta potential was -0.2mV. When quercetin nanoemulsion (QUE-NE) was used in combination with tannin nanoemulsion (TAN-NE) and toosendanin nanoemulsion (TOO-NE), it exhibited a synergistic antibacterial effect. However, the combination of QUE-NE and geniposide nanoemulsion (GEN-NE) exhibited an antagonistic effect. It was revealed that the antibacterial effect was in order of quercetin-tannin-toosendanin nanoemulsion (QUE-TAN-TOO-NE) ＞ quercetin-tannin nanoemulsion (QUE-TANNE) ＞ QUE-NE ＞ quercetin-tannin-toosendanin-geniposide nanoemulsion (QUE-TAN-TOO-GEN-NE). Conclusion: This study explored the preparation and efficacy of N-QUE-NE, and the results showed that quercetin, tannin and toosendanin had satisfactory synergistic antibacterial effects. The antagonistic effect of quercetin and geniposide in nanoemulsion indicated that it is not beneficial to the antibacterial effect of Sendeng-4, and further research needs to be conducted to clarify its antibacterial effect.

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