scholarly journals The impact of M. O. Menshikov's childhood upon the formation of his publicistic interests

2021 ◽  
pp. 133-150
Author(s):  
Nikolay Igorevich Krizhanovsky ◽  
Svetlana Mikhailovna San'kova
Keyword(s):  
Early Life ◽  
Life Experience ◽  
Family Relations ◽  
Elementary And Secondary Education ◽  
Stage Of Development ◽  
The Rich ◽  
Poor Peasant ◽  
Peasant Family ◽  
Naval Engineering ◽  
The Impact

The subject of this research is the early life of M. O. Menshikov – one of the ideologists of the Russian nationalism of the early XX century and leading publicist of the largest all-Russian newspaper “Novoe Vremya”. The goal consists in full reconstruction of the conditions of his childhood and early youth. The methods of deduction, induction, comparative and prospective analysis were used for reconstructing separate circumstances of the initial stage of development of Menshikov’s personality and holistic biographical picture. The synthesis of objective analysis of the facts with subjective assessments of the events described by Menshikov himself in his diaries and articles allowed depicting the external circumstances of his youth, as well as reconstruct the peculiarities of development of his inner world and social reflection. The conclusion is made that a range of the core themes of Menshikov's publicistic writing, which were covered in the newspaper “Nedelya” and later in “Novoe Vremya”, and ultimately brought him popularity, take roots in his childhood and early youth: “family relations”, “upbringing and education”, “pursuit of belonging”, “finding  happiness through harmony with the world”. These topics were covered by Menshikov based on the rich life experience, a long path from the poor peasant family to the cadet of Naval Engineering School in Kronstadt. The fact that he was able to understand the problems  of the commoners made him closer to the reader. The provided biography is currently the most detailed study of the early life of M. O. Menshikov's; many facts are introduced for the first time. The article also presents additional empirical material on the history of childhood, elementary and secondary education in Russia of the late XIX century.

scholarly journals Intra-individual methylomics detects the impact of early-life adversity

2019 ◽  
Vol 2 (2) ◽  
pp. e201800204 ◽  
Author(s):  
Shan Jiang ◽  
Noriko Kamei ◽  
Jessica L Bolton ◽  
Xinyi Ma ◽  
Hal S Stern ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cell Fate ◽  
Early Life ◽  
Large Scale ◽  
Life Experience ◽  
Early Life Adversity ◽  
Health And Disease ◽  
Genetic And Environmental Factors ◽  
And Function ◽  
The Impact

Genetic and environmental factors interact during sensitive periods early in life to influence mental health and disease via epigenetic processes such as DNA methylation. However, it is not known if DNA methylation changes outside the brain provide an “epigenetic signature” of early-life experiences. Here, we used a novel intra-individual approach by testing DNA methylation from buccal cells of individual rats before and immediately after exposure to one week of typical or adverse life experience. We find that whereas inter-individual changes in DNA methylation reflect the effect of age, DNA methylation changes within paired DNA samples from the same individual reflect the impact of diverse neonatal experiences. Genes coding for critical cellular metabolic enzymes, ion channels, and receptors were more methylated in pups exposed to the adverse environment, predictive of their repression. In contrast, the adverse experience was associated with less methylation on genes involved in pathways of death and inflammation as well as cell-fate–related transcription factors, indicating their potential up-regulation. Thus, intra-individual methylome signatures indicate large-scale transcription-driven alterations of cellular fate, growth, and function.

scholarly journals Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tamara S. Adjimann ◽  
Carla V. Argañaraz ◽  
Mariano Soiza-Reilly
Keyword(s):  
Psychiatric Disorders ◽  
Early Life ◽  
Life Experience ◽  
Behavioral Outcomes ◽  
Behavioral Effects ◽  
Rodent Models ◽  
Environmental Perturbations ◽  
Early Life Experience ◽  
Early Life Exposure ◽  
The Impact

AbstractMental disorders including depression and anxiety are continuously rising their prevalence across the globe. Early-life experience of individuals emerges as a main risk factor contributing to the developmental vulnerability to psychiatric disorders. That is, perturbing environmental conditions during neurodevelopmental stages can have detrimental effects on adult mood and emotional responses. However, the possible maladaptive neural mechanisms contributing to such psychopathological phenomenon still remain poorly understood. In this review, we explore preclinical rodent models of developmental vulnerability to psychiatric disorders, focusing on the impact of early-life environmental perturbations on behavioral aspects relevant to stress-related and psychiatric disorders. We limit our analysis to well-established models in which alterations in the serotonin (5-HT) system appear to have a crucial role in the pathophysiological mechanisms. We analyze long-term behavioral outcomes produced by early-life exposures to stress and psychotropic drugs such as the selective 5-HT reuptake inhibitor (SSRI) antidepressants or the anticonvulsant valproic acid (VPA). We perform a comparative analysis, identifying differences and commonalities in the behavioral effects produced in these models. Furthermore, this review discusses recent advances on neurodevelopmental substrates engaged in these behavioral effects, emphasizing the possible existence of maladaptive mechanisms that could be shared by the different models.

scholarly journals Intra-individual methylomics detects the impact of early-life adversity

2018 ◽  
Author(s):  
Shan Jiang ◽  
Noriko Kamei ◽  
Jessica L. Bolton ◽  
Xinyi Ma ◽  
Hal S. Stern ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cell Fate ◽  
Early Life ◽  
Large Scale ◽  
Life Experience ◽  
Early Life Adversity ◽  
Health And Disease ◽  
Genetic And Environmental Factors ◽  
And Function ◽  
The Impact

AbstractGenetic and environmental factors interact during sensitive periods early in life to influence mental health and disease via epigenetic processes such as DNA methylation. However, it is not known if DNA methylation changes outside the brain provide an ‘epigenetic signature’ of early-life experiences. Here, we employed a novel intra-individual approach by testing DNA methylation from buccal cells of individual rats before and immediately after exposure to one week of typical or adverse life experience. We find that whereas inter-individual changes in DNA methylation reflect the effect of age, DNA methylation changes within paired DNA samples from the same individual reflect the impact of diverse neonatal experiences. Genes coding for critical cellular–metabolic enzymes, ion channels and receptors were more methylated in pups exposed to the adverse environment, predictive of their repression. In contrast, the adverse experience was associated with less methylation on genes involved in pathways of death and inflammation as well as cell-fate related transcription factors, indicating their potential upregulation. Thus, intra-individual methylome signatures indicate large-scale transcription-driven alterations of cellular fate, growth and function.

Problems of Implementation of an Import Substitution Policy in the Oil Industry

2019 ◽  
pp. 50-57
Author(s):  
Yu. V. Vertakova ◽  
A. S. Evtyukhin
Keyword(s):  
Import Substitution ◽  
Oil Industry ◽  
Investment Climate ◽  
Scientific Publications ◽  
Stage Of Development ◽  
Current Economic Situation ◽  
Negative Effect ◽  
Substitution Policy ◽  
Investment Process ◽  
The Impact

The presented study addresses the issues of implementation of an import substitution policy in the Russian oil industry. Support of domestic production is a key objective specified in the message of the President of the Russian Federation in 2019. In light of the current economic situation and considering the importance of the oil industry for the Russian economy, an import substitution policy could help achieve the objective set by the President.Aim. The study aims to identify the problems and ways of implementation of an import substitution policy in the Russian oil industry.Tasks. The authors analyze scientific publications on import substitution and the state of the Russian oil industry at the current stage of development; determine the directions and fundamental trends in the development of the oil industry; identify obstacles that hinder the implementation of an import substitution policy in the oil industry; describe conditions that facilitate the development of the  investment process in the oil industry; propose comprehensive methods and ways to intensify investments and optimize costs for enterprises in the oil industry.Methods. This study uses general scientific methods of cognition, comparative and statistical analysis to identify problems in the implementation of an import substitution policy in the oil industry.Results. Examination of the current state and development prospects of the oil industry allows the authors to identify obstacles to the development of import substitution. The study shows their impact on the potential of import substitution, which has a negative effect on the prospects of intensification of investment processes, and proposes comprehensive methods and mechanisms that could neutralize the impact of the identified obstacles, thus facilitating the formation of a positive investment climate. Conclusions. Investment climate is shown to have a decisive impact on the potential of import substitution in the Russian oil industry, and ways of overcoming negative trends in the development of the oil industry are proposed.

Important Terms And Conditions Of Marriage Agreement In Islamic Law

2020 ◽  
Vol 02 (11) ◽  
pp. 36-48
Author(s):  
Nigora Yusupova ◽  
Keyword(s):  
Islamic Law ◽  
Family Relations ◽  
Basic Principles ◽  
Religious Literacy ◽  
Relevant Today ◽  
Cultural Foundations ◽  
Stage Of Development ◽  
Scientific Analysis ◽  
Organizational Features ◽  
Comprehensive Study

Today, a comprehensive study of social aspects, cultural and spiritual, as well as socio-economic, legal, educational and organizational features of family relations is one of the questions of the hour. The relevance of the issue is that, first of all, at the present stage of development of our society, it is socially necessary to conduct a scientific analysis of the Islamic doctrine regarding family relations in the process of increasing the spirituality of the Uzbek people, including religious literacy. Secondly, when analyzing and studying the basic principles of Sharia norms, it is necessary to correctly use this knowledge in the search for solutions to issues, reasons, and the nature of growing family divorces, which is very relevant today. In this regard, this article highlights the essence and characteristics, as well as the socio-economic, spiritual and cultural foundations of the conditions and obstacles to marriage, in Islamic teachings, which were considered in the region as traditions. The article also examines and comparatively analyzes the religious, spiritual, legal, economic and educational factors of the conditions of marriage: free mutual consent to marriage, participation of witnesses in marriage, equality, makhr; circumstances that prevent marriage: a ban on marriage between relatives, issues of marriageable age under Islamic law with the norms of family law.

scholarly journals Factors Moderating the Impact of After Death Communications on Beliefs and Spirituality

2021 ◽  
pp. 003022282110291
Author(s):  
Jennifer K. Penberthy ◽  
Marieta Pehlivanova ◽  
Tevfik Kalelioglu ◽  
Chris A. Roe ◽  
Callum E. Cooper ◽  
...  
Keyword(s):  
Life Experience ◽  
Death And Dying ◽  
Emotional Reaction ◽  
Physical Contact ◽  
Fear Of Death ◽  
Future Directions ◽  
Life After Death ◽  
Moderating Factors ◽  
The Impact ◽  
Beliefs And Attitudes

After death communications(ADCs) are defined as perceived spontaneous contacts with living individuals by the deceased. This research presents on a subset of data from a recent large international survey of individuals who experienced ADCs and provided systematic information regarding these experiences. In our research we explore the impact of having an ADC on reported spirituality, religiosity, beliefs and attitudes about death and dying and also explore the moderating factors of this impact. We found that having an ADC was perceived as a positive life experience and that it was associated with a reduction in fear of death, belief in life after death and that the deceased could communicate with the living, and increased reported spirituality. Moderating factors include aspects of having or desiring physical contact with the deceased as well as perceiving some emotional reaction to the ADCs. Future directions for research exploration are also provided based on our findings.

scholarly journals Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Amelia Cuarenta ◽  
Stacey L. Kigar ◽  
Ian C. Henion ◽  
Liza Chang ◽  
Vaishali P. Bakshi ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Copy Number ◽  
Neonatal Period ◽  
Early Life Stress ◽  
Social Play ◽  
Psychological Disorders ◽  
Dna Copy Number ◽  
Juvenile Period ◽  
Stage Of Development

AbstractEarly life stress (ELS) has been shown to have a significant impact on typical brain development and the manifestation of psychological disorders through epigenetic modifications that alter gene expression. Line1, a retrotransposon associated with genetic diversity, has been linked with various psychological disorders that are associated with ELS. Our previous work demonstrated altered Line1 DNA copy number in the neonatal period following stressful experiences; we therefore chose to investigate whether early life stress altered Line1 retrotransposition persists into the juvenile period of development. Our study uses a neonatal predator odor exposure (POE) paradigm to model ELS in rats. We examined Line1 using qPCR to assess Line1 expression levels and DNA copy number in the male and female juvenile amygdala, hippocampus and prefrontal cortex—areas chosen for their association with affective disorders and stress. We report a sex difference in Line1 levels within the juvenile amygdala. We also find that ELS significantly increases Line1 DNA copy number within the juvenile amygdala which correlates with reduced juvenile social play levels, suggesting the possibility that Line1 may influence juvenile social development.

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