scholarly journals The necessity of holistic approach to treatment of telogen hair loss associated with iron deficiency in women

2020 ◽  
Vol 96 (5) ◽  
pp. 39-46
Author(s):  
T. A. Gaydina ◽  
S. A. Shcherbina ◽  
P. A. Skripkina ◽  
A. A. Silin

The relationship between disorders of iron metabolism and alopecia, in particular telogen hair loss (THL), remains poorly understood and requires further research. Goal. To assess changes in the dynamics of growth and hair condition in women with an iron deficiency state during systemic therapy with iron supplements in combination with and without physiotherapy. Methods. An open-label, randomized, comparative interventional study with a duration of 6 months included 26 female aged 19 to 54 years (38.8 8.9 years) with complaints of hair loss, changes in their structure, dryness and / or hair brittleness; with preserved menstrual cycle and mild iron deficiency anemia (IDA, Hb 101120 g/l). Trichoscopy and phototrichogram were performed with processing of the results in the TrichoScienceProv1.1 program. The changes in the dynamics of hair growth and condition were assessed against the background of the use of iron supplements in combination with physiotherapy and without physiotherapy. Pulsed alternating sinusoidal current of high frequency, high voltage and low strength was chosen as a physiotherapeutic method for the treatment of THL. Results. Against the background of the therapy, an increase in the Hb level (p 0.001) and a positive dynamics of trichological parameters in all patients were noted, the severity of which was higher when the therapy with iron supplements was combined with physiotherapy. Conclusion. Our findings confirm that the complex treatment of patients with telogen alopecia on the background of an iron deficiency state may achieve positive dynamics of trichological indicators.

2020 ◽  
Vol 96 (5) ◽  
pp. 39-46
Author(s):  
T. A. Gaydina ◽  
S. A. Shcherbina ◽  
P. A. Skripkina ◽  
A. A. Silin

The relationship between disorders of iron metabolism and alopecia, in particular telogen hair loss (THL), remains poorly understood and requires further research. Goal. To assess changes in the dynamics of growth and hair condition in women with an iron deficiency state during systemic therapy with iron supplements in combination with and without physiotherapy. Methods. An open-label, randomized, comparative interventional study with a duration of 6 months included 26 female aged 19 to 54 years (38.8 8.9 years) with complaints of hair loss, changes in their structure, dryness and / or hair brittleness; with preserved menstrual cycle and mild iron deficiency anemia (IDA, Hb 101120 g/l). Trichoscopy and phototrichogram were performed with processing of the results in the TrichoScienceProv1.1 program. The changes in the dynamics of hair growth and condition were assessed against the background of the use of iron supplements in combination with physiotherapy and without physiotherapy. Pulsed alternating sinusoidal current of high frequency, high voltage and low strength was chosen as a physiotherapeutic method for the treatment of THL. Results. Against the background of the therapy, an increase in the Hb level (p 0.001) and a positive dynamics of trichological parameters in all patients were noted, the severity of which was higher when the therapy with iron supplements was combined with physiotherapy. Conclusion. Our findings confirm that the complex treatment of patients with telogen alopecia on the background of an iron deficiency state may achieve positive dynamics of trichological indicators.


2021 ◽  
pp. 1-10
Author(s):  
Pablo E. Pergola ◽  
Diogo Belo ◽  
Paul Crawford ◽  
Moustafa Moustafa ◽  
Wenli Luo ◽  
...  

<b><i>Introduction:</i></b> Ferric citrate (FC) is indicated as an oral iron replacement for iron deficiency anemia in adult patients with chronic kidney disease (CKD) not on dialysis. The recommended starting dose is one 1-g tablet three times daily (TID). This study investigated long-term efficacy and safety of different FC dosing regimens for treating anemia in nondialysis-dependent CKD (NDD-CKD). <b><i>Methods:</i></b> In this phase 4, randomized, open-label, multicenter study, patients with anemia with NDD-CKD (estimated glomerular filtration rate, ≥20 mL/min and &#x3c;60 mL/min) were randomized 1:1 to one FC tablet (1-g equivalent to 210 mg ferric iron) TID (3 g/day) or 2 tablets twice daily (BID; 4 g/day). At week 12, dosage was increased to 2 tablets TID (6 g/day) or 3 tablets BID (6 g/day) in patients whose hemoglobin (Hb) levels increased &#x3c;0.5 g/dL or were &#x3c;10 g/dL. Primary endpoint was mean change in Hb from baseline to week 24. <b><i>Results:</i></b> Of 484 patients screened, 206 were randomized and 205 received FC. Mean (standard deviation) changes from baseline in Hb at week 24 were 0.77 (0.84) g/dL with FC TID 3 g/day and 0.70 (0.98) g/dL with FC BID 4 g/day. <b><i>Discussion/Conclusions:</i></b> FC administered BID and TID for 48 weeks was safe and effective for treating anemia in this population, supporting potentially increased dosing flexibility.


1970 ◽  
Vol 53 (4) ◽  
pp. 791-800
Author(s):  
Gwendolyn W Pla ◽  
James C Fritz

Abstract The high incidence of iron deficiency anemia in the United States and elsewhere is caused by insufficient iron intake, plus poor utilization of many dietary sources of iron. There is need to select assimilable sources of iron for fortification of foods; animal studies show that many of the iron compounds used for cereal enrichment are poorly utilized. A method to measure availability of iron is proposed and is currently being studied collaboratively. Preliminary data indicate that in vitro solubility tests are not satisfactory to evaluate availability of iron supplements.


2019 ◽  
Vol 10 (2) ◽  
pp. 723-732 ◽  
Author(s):  
Fengzheng Gao ◽  
Wei Guo ◽  
Mingyong Zeng ◽  
Yinong Feng ◽  
Guangxin Feng

Microalgae are functional iron nutritive fortifiers that can supply more intestinal nanosized iron.


Talanta ◽  
2017 ◽  
Vol 170 ◽  
pp. 523-529 ◽  
Author(s):  
Uenderson Araujo-Barbosa ◽  
Elena Peña-Vazquez ◽  
Maria Carmen Barciela-Alonso ◽  
Sergio Luis Costa Ferreira ◽  
Ana Maria Pinto dos Santos ◽  
...  

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