scholarly journals Early-menarche as Determinant Factor for Metabolic-risks: An Epidemiology Perspectives among Adolescent Girls aged 13-15 years old in Jakarta-Indonesia

2018 ◽  
Vol 1 (2) ◽  
pp. 66
Author(s):  
Ririn Hariani ◽  
Vikie Nouvrisia ◽  
Dhevinia Yustikarani ◽  
Saptawati Bardosono ◽  
Noorwati Sutandyo

Background and Objectives:Early menarche predicts higher body mass index (BMI) and adiposity in adult life, and it has been associated with risk factors of cardiometabolic diseases such as elevated triglycerides and waist circumferences also higher risk of adult diabetes. This study aims to explore early-menarche as determinant factor for metabolic-risks among adolescent girls aged 13-15 years old.Methods and Study Design:This cross-sectional study was undertaken in adolescent girls aged 13-15 years in all five municipalities in Jakarta-Indonesia, from January 2014 to Mei 2016. Data collected by using standardized measures for dietary intake, nutritional status indicators, physical activity level, blood pressure, blood glucose and lipid profile, and statistically analyzed by independent-t or Mann-Whitney test, and Pearson or Spearman correlation test.Results and Conclusions:A total of 194 adolescent girls were participated in this study. Early menarche was found in 22.68% of all subjects. There was no association between menarche status and daily macronutrients intake pattern and physical activity level score. Early menarche subjects had significantly higher BMI (p<0.001), CDC-percentile (p<0.001), WHO Z-score (p<0.001), and waist circumference values (p=0.02). Furthermore, early menarche subjects also had higher systolic blood pressure (p=0.035), total cholesterol level (p=0.028), LDL-cholesterol level (p=0.013), and triglyceride level (p=0.026). There was no association between menarche status and diastolic blood pressure, fasting blood glucose, HDL-C level, lipid profile ratio. In conclusion, early menarche is an important determinant factor of metabolic risks, and balance between dietary intake and physical activity level should be prioritized among them. 

2009 ◽  
Vol 17 (4) ◽  
pp. 462-467 ◽  
Author(s):  
Larissa Castelo Guedes Martins ◽  
Nirla Gomes Guedes ◽  
Iane Ximenes Teixeira ◽  
Marcos Venícios de Oliveira Lopes ◽  
Thelma Leite de Araujo

This study aimed to analyze the level of physical activity for people with high blood pressure cared for in a health center. This cross-sectional study was conducted with 310 individuals between 18 and 69 years of age through the International Physical Activity Questionnaire (IPAQ). The majority (80%) of participants presented low or moderate levels of physical activity. The analysis of association between sociodemographic variables and physical activity level revealed that older men from the interior of the state with higher educational levels have a greater chance of exhibiting lower levels of physical activity. The logistic regression model revealed that origin, schooling and diabetes are predictors of low physical activity level. The conclusion is that part of the sample does not match the desirable profile to practice regular physical activity.


2021 ◽  
Vol 12 ◽  
Author(s):  
Marcin Grandys ◽  
Joanna Majerczak ◽  
Justyna Zapart-Bukowska ◽  
Krzysztof Duda ◽  
Jan K. Kulpa ◽  
...  

The negative relationship between testosterone and inflammatory cytokines has been reported for decades, although the exact mechanisms of their interactions are still not clear. At the same time, little is known about the relation between androgens and acute phase proteins. Therefore, in this investigation, we aimed to study the relationship between androgen status and inflammatory acute phase reactants in a group of men using multi-linear regression analysis. Venous blood samples were taken from 149 men ranging in age from 18 to 77 years. Gonadal androgens [testosterone (T) and free testosterone (fT)], acute phase reactants [C-reactive protein (CRP), ferritin (FER), alpha-1-acid glycoprotein (AAG), and interleukin-6 (IL-6)], cortisol (C), and lipid profile concentrations were determined. It was demonstrated that the markers of T and fT were negatively correlated with all acute phase proteins (CRP, FER, and AAG; p &lt; 0.02) and the blood lipid profile [total cholesterol (TC), low-density lipoprotein (LDL), and triglycerides (TG); p &lt; 0.03]. Multivariate analysis showed that T, fT, and the fT/C ratio were inversely correlated with the CRP, AAG, and FER concentrations independently of age and blood lipids. When adjustment for BMI was made, T, fT, and the fT/C ratio were negatively correlated with the AAG concentrations only. In addition, it was demonstrated that gonadal androgens were positively correlated with physical activity level (p &lt; 0.01). We have concluded that a lowered serum T concentration may promote inflammatory processes independently of adipose tissue and age through a reduced inhibition of inflammatory cytokine synthesis, which leads to enhanced acute phase protein production. Therefore, a low serum T concentration appears to be an independent risk factor in the development of atherosclerosis and cardiovascular diseases. Moreover, the positive correlation between testosterone and physical activity level suggests that exercise training attenuates the age-related decrease in gonadal androgens and, in this way, may reduce the enhancement of systemic low-grade inflammation in aging men.


2002 ◽  
Vol 87 (3) ◽  
pp. 261-266
Author(s):  
Mosdøl A.* ◽  
B. Christensen ◽  
L. Retterstøl ◽  
D.S. Thelle

2013 ◽  
Vol 17 (4) ◽  
pp. 803-809 ◽  
Author(s):  
Maryam Rafraf ◽  
Saadat Karimi Hasanabad ◽  
Mohammad Asghari Jafarabadi

AbstractObjectiveTo investigate vitamin D status and its association with components of the metabolic syndrome (MetS) in adolescent girls attending high school in Boukan, Iran during winter 2012.DesignA cross-sectional study.SettingHigh schools of Boukan city, Iran.SubjectsA sample of 216 girls aged 14–17 years was selected by multistage random sampling from four districts of Boukan. Weight, height, waist circumference, blood pressure, daily energy intake, physical activity and serum 25-hydroxyvitamin D (25(OH)D), fasting blood glucose, TAG and HDL-cholesterol levels of all participants were evaluated. Serum 25(OH)D level <20 ng/ml was defined as vitamin D deficiency.ResultsMean serum 25(OH)D was 7·26 (sd 2·81) ng/ml and 96 % of the participants had vitamin D deficiency. According to age-modified definitions of the National Cholesterol Education Program Adult Treatment Panel III, MetS was diagnosed in 10·6 % of the participants. In multivariable regression analysis after adjustment for BMI, energy intake and physical activity level, serum 25(OH)D was inversely associated with fasting blood glucose (β = −0·143, P = 0·04). No significant relationship was found between serum 25(OH)D and other components of MetS.ConclusionsThe high prevalence of vitamin D deficiency warrants national polices and interventions towards improving this major health problem among adolescent girls. Low 25(OH)D level was significantly associated with increased fasting blood glucose. Prospective studies are needed to determine the effects of vitamin D deficiency on the development of MetS and related metabolic diseases in adolescent girls.


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