scholarly journals Synthesis and Characterization of O-(carboxyl) Chitosan Schiff Base Derivatives and Study Antibacterial Activity

2020 ◽  
Vol 10 (03) ◽  
pp. 402-407
Author(s):  
Ruwaidah S. Saeed
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Analytical Data ◽  
Aromatic Aldehydes ◽  
Distilled Water ◽  
Chitosan Derivative ◽  
Scanning Calorimetry ◽  
Schiff Base Derivatives ◽  
Vis Spectroscopy ◽  
Chitosan Schiff Base

2-mercaptobenzothiazol [1] was reacted with anhydrous carbonate sodium and ClCH2COOH in distilled water to produce a compound [2]. Compound [3] was synthesized by reaction compound [2] with SOCl2 in benzene. O,N-chitosan derivative [4] had synthesized by reacted chitosan with compound [3] in trichloromethane and pyridine. O-chitosan derivative synthesized according to the method of Fischer and Speier from the reaction of chitosan with compound [2] in distilled water in acidic media to produce compound [5]. O-(carboxyl) chitosan Schiff base derivatives [6-9] had synthesized by reaction O-(carboxyl) chitosan [5] with aromatic aldehydes (syringaldehyde, 3-methoxy,4-hydroxybenzeldehyde, 4-nitrobenzeldehyde, 4-bromobenzeldehyde). The structure of produced compounds has been characterized through their spectral and analytical data, as in fourier transform infrared (FTIR) spectra,1H-NMR, UV-vis spectroscopy, elemental analysis (CHNS), scanning electron microscope (SEM), differential scanning calorimetry (DSC), and thermo gravimetry analysis (TGA). Finally, study the antibacterial activity of some prepared polymers.

scholarly journals Synthesis of Mn(II) Complexes-Carboxymethyl Chitosan Schiff Base Salicylaldehyde and Antibacterial Activity

2021 ◽  
Vol 7 (1) ◽  
pp. 10-21
Author(s):  
Ismiyarto Ismiyarto ◽  
Niken Windi Saputri ◽  
Liswinda Zafirah Rahmatia ◽  
Purbowatiningrum Ria Sarjono ◽  
Ngadiwiyana Ngadiwiyana ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Schiff Base ◽  
Carboxymethyl Chitosan ◽  
Diffusion Method ◽  
Clear Zone ◽  
Disc Diffusion Method ◽  
Zone Diameter ◽  
Chitosan Schiff Base

The development of compounds with a better antibacterial activity is highly needed. One way to achieve this is by modifying the structure of the compound using chitosan as a starting material, because of its abundant natural source in Indonesia, its biodegradable properties, and its structure where free amines are present. This study aims to obtain  Mn(II) -Carboxymethyl Chitosan Schiff Base-Salicylaldehyde complex to increase its antibacterial activity against Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative). Schiff Base carboxymethyl chitosan-salicylaldehyde was synthesized from carboxymethyl chitosan with salicylaldehyde. Next, the Schiff Base Carboxymethyl Chitosan-Salicylaldehyde was complexed with MnCl2.4H2O and then characterized by FTIR, UV-Vis Spectrophotometer, and AAS and tested for antibacterial activity with the disc diffusion method against Staphylococcus aureus and Escherichia coli. The product of Carboxymethyl Chitosan Schiff Base-salicylaldehyde is a brownish yellow solid with a yield of 64% (w/w) and has antibacterial activity against Staphylococcus aureus (clear zone diameter 11 mm) and Escherichia coli (clear zone diameter 13 mm). The product of Mn(II) Complexes-Carboxymethyl Chitosan Schiff Base-salicylaldehyde is a black solid with a yield of 59% (w/w) and has antibacterial activity against Staphylococcus aureus (clear zone diameter 13 mm) and Escherichia coli (clear zone diameter 17 mm).

Zinc(ii) centered biologically active novel N,N,O donor tridentate water-soluble hydrazide-based O-carboxymethyl chitosan Schiff base metal complexes: synthesis and characterisation

2019 ◽  
Vol 43 (24) ◽  
pp. 9540-9554 ◽  
Author(s):  
Manimohan Murugaiyan ◽  
S. Pugal Mani ◽  
Mohamed Aboobucker Sithique
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Base Metal ◽  
Carboxymethyl Chitosan ◽  
Water Soluble ◽  
Biologically Active ◽  
Schiff Base Derivatives ◽  
Schiff Base Metal Complexes ◽  
Potential Use ◽  
Chitosan Schiff Base

In this study, novel eco-friendly and water-soluble chitosan Schiff base derivatives have been designed for potential use in antimicrobial applications.

Synthesis, characterization and antioxidant activity of chitosan Schiff base derivatives bearing (−)-gossypol

2020 ◽  
Vol 240 ◽  
pp. 116333 ◽  
Author(s):  
Neslihan Beyazit ◽  
Halide Sinem Çakran ◽  
Ali Cabir ◽  
Yaşar Akışcan ◽  
Cahit Demetgül
Keyword(s):  
Antioxidant Activity ◽  
Schiff Base ◽  
Schiff Base Derivatives ◽  
Chitosan Schiff Base

scholarly journals SYNTHESIS OF SOME NOVEL TRIAZOLE DERIVATIVES AS SCHIFF BASES AND THEIR ANTIMICROBIAL EVALUATION

2016 ◽  
Vol 8 (9) ◽  
pp. 28
Author(s):  
Vaibhav Sharma ◽  
Dinesh Kumar Mehta ◽  
Rina Das ◽  
Preet Kawal Kaur
Keyword(s):  
Schiff Base ◽  
Benzoic Acid ◽  
Analytical Techniques ◽  
Aromatic Aldehydes ◽  
Gram Positive ◽  
Gram Negative ◽  
H Nmr ◽  
Schiff Base Derivatives ◽  
Weak Activity ◽  
Anti Fungal

<p><strong>Objective: </strong>This work involves the synthesis of some novel schiff base derivatives synthesized from <em>p-</em>amino benzoic acid.</p><p><strong>Methods: </strong>A series of 4-[4-(arylidene amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl]-benzoic acid complexes were synthesized from 4-(4-amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl)-benzoic acid by reaction with different aromatic aldehydes. All the synthesized schiff base derivatives were characterized by using analytical techniques (FT-IR, <sup>1</sup>H NMR and Mass spectroscopy). The title compounds were evaluated for antibacterial activity against Gram-positive bacteria (<em>Staphylococcus aureus </em>and <em>Streptococcus pneumoniae) </em>and Gram-negative bacteria (<em>Escherichia coli and Pseudomonas aeruginosa)</em> and anti-fungal activity against (<em>Candida albicans </em>and <em>Aspergillus niger).</em></p><p><strong>Results: </strong>Schiff base derivatives 5(a-h) were synthesized in good yields and showed antimicrobial activity, among them, compounds 5c, 5d, 5e and 5f were significantly active against gram positive, gram negative bacterial and fungal strains and rest of compounds showed moderate to weak activity.</p><p><strong>Conclusion: </strong>The Schiff base obtained showed variation in the antimicrobial and antifungal activity, based on the structure of the substituted aromatic aldehydes.</p>

Synthesis and spectroscopic and electrochemical studies of chitosan Schiff base derivatives

2013 ◽  
Vol 86 (11) ◽  
pp. 1791-1797 ◽  
Author(s):  
C. A. Caro ◽  
G. Cabello ◽  
E. Landaeta ◽  
J. Pérez ◽  
J. H. Zagal ◽  
...  
Keyword(s):  
Schiff Base ◽  
Electrochemical Studies ◽  
Schiff Base Derivatives ◽  
Chitosan Schiff Base

Synthesis, characterization and antimicrobial evaluation of two aromatic chitosan Schiff base derivatives

2016 ◽  
Vol 51 (10) ◽  
pp. 1721-1730 ◽  
Author(s):  
Tamer M. Tamer ◽  
Mohamed A. Hassan ◽  
Ahmed M. Omer ◽  
Walid M.A. Baset ◽  
Mohamed E. Hassan ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Derivatives ◽  
Antimicrobial Evaluation ◽  
Chitosan Schiff Base

scholarly journals Synthesis, characterization and anti-bacterial activity of novel schiff bases of pyridin-3 yl-carbohydrazide derivatives

2021 ◽  
pp. 23-26
Author(s):  
Ravi Kumar Konda ◽  
Anish Kumar K ◽  
Phani Lakshman M ◽  
Mohammed Asif ◽  
Anusha Reddy D
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Schiff Bases ◽  
Wide Spectrum ◽  
Cyclic Compound ◽  
Aromatic Aldehydes ◽  
Bacterial Activity ◽  
Schiff’S Bases ◽  
Ethyl Nicotinate ◽  
Schiff's Bases

Heterocyclic compounds are cyclic compounds containing carbon and other heteroatoms. The most common heteroatoms are oxygen, nitrogen, and Sulphur. A heterocyclic compound is a cyclic compound that has atoms at least two different elements as members of its ring. A Schiff base (azomethine) is named after its inventor, Hugo Schiff and it is a functional group that contains a carbon-nitrogen double bond with the nitrogen atom connected to an aryl or alkyl group but not hydrogen. Schiff bases of Pyridin-3 yl-carbohydrazide derivatives from ethyl nicotinate and different aromatic aldehydes. Schiff’s bases are aromatic substituted imine compounds. These compounds are very important in the medicinal and pharmaceutical fields because of their wide spectrum of biological activity. Schiff’s bases show antibacterial activity, antifungal activity, and also antitumor activity. Aromatic aldehydes were refluxed with ethyl nicotinate using ethanol as a solvent to form Schiff's bases. All chemicals are taken in equimolar concentrations. The synthesized compounds were characterized by melting point, solubility, percentage yield, TLC, and IR spectral analysis. All derivatives are evaluated for anti-bacterial activity by the cup plate method. The antibacterial activity of test compounds was compared against standard Streptomycin. The 5 synthesized compounds show moderate antimicrobial activity. The experimental work summarizes the synthesis and in-vitro antibacterial activity of Schiff base derivatives.

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