SYNTHESIS OF SOME NOVEL TRIAZOLE DERIVATIVES AS SCHIFF BASES AND THEIR ANTIMICROBIAL EVALUATION

Objective: This work involves the synthesis of some novel schiff base derivatives synthesized from p-amino benzoic acid.Methods: A series of 4-[4-(arylidene amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl]-benzoic acid complexes were synthesized from 4-(4-amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl)-benzoic acid by reaction with different aromatic aldehydes. All the synthesized schiff base derivatives were characterized by using analytical techniques (FT-IR, 1H NMR and Mass spectroscopy). The title compounds were evaluated for antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Streptococcus pneumoniae) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and anti-fungal activity against (Candida albicans and Aspergillus niger).Results: Schiff base derivatives 5(a-h) were synthesized in good yields and showed antimicrobial activity, among them, compounds 5c, 5d, 5e and 5f were significantly active against gram positive, gram negative bacterial and fungal strains and rest of compounds showed moderate to weak activity.Conclusion: The Schiff base obtained showed variation in the antimicrobial and antifungal activity, based on the structure of the substituted aromatic aldehydes.

Download Full-text

Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones

E-Journal of Chemistry ◽

10.1155/2005/134830 ◽

2005 ◽

Vol 2 (2) ◽

pp. 109-112

Author(s):

A. K. Parekh ◽

K. K. Desai

Keyword(s):

Antibacterial Activity ◽

Spectral Data ◽

Elemental Analysis ◽

Aromatic Aldehydes ◽

Gram Negative Bacteria ◽

Gram Positive ◽

Gram Negative ◽

E Coli ◽

Gram Positive Bacteria ◽

H Nmr

Some new chalcones have been prepared by Claisen-schmidt condensation of ketone and different aromatic aldehydes. These chalcones on condensation with urea in presence of acid gave Pyrimidine-2-ones. The synthesized compounds have been characterized by elemental analysis, IR and1H NMR spectral data. They have been screened for their antibacterial activity against Gram positive bacteria B. subtillis & S. aureus and Gram negative bacteria E. coli & S. typhi.

Download Full-text

Synthesis, Characterization, and Antimicrobial Studies of Novel Series of 2,4-Bis(hydrazino)-6-substituted-1,3,5-triazine and Their Schiff Base Derivatives

Journal of Chemistry ◽

10.1155/2018/8507567 ◽

2018 ◽

Vol 2018 ◽

pp. 1-13 ◽

Cited By ~ 4

Author(s):

Hessa H. Al-Rasheed ◽

Essam N. Sholkamy ◽

Monirah Al Alshaikh ◽

Mohammed R. H. Siddiqui ◽

Ahmed S. Al-Obaidi ◽

...

Keyword(s):

Schiff Base ◽

Pathogenic Bacteria ◽

Specific Effect ◽

Antagonistic Effect ◽

Gram Positive ◽

Gram Negative ◽

Gram Positive Bacteria ◽

Antimicrobial Studies ◽

Schiff Base Derivatives ◽

Wide Range

The present work represents the synthesis, characterization, and antimicrobial studies of novel series of 2,4-bis(hydrazino)-6-substituted-1,3,5-triazine and their Schiff base derivatives. IR, NMR (H1 and C13), elemental analysis, and LC-MS characterized the prepared compounds. The biological activity of the target products was evaluated as well. Twenty-two of the prepared compounds were selected according to their solubility in aqueous DMSO. Only eight compounds showed good activity against the selected pathogenic bacteria and did not show antagonistic effect against fungus Candida albicans. Two compounds 4k and 5g have wide-range effect presently in Gram-positive and Gram-negative bacteria while other compounds (4f, 4i, 4m, 5d, 6i, and 6h) showed specific effect against the Gram-negative or Gram-positive bacteria. The minimum inhibitory concentration (MIC, μg/mL) of 4f, 4i, 4k, and 6h compounds against Streptococcus mutans was 62.5 μg/mL, 100 μg/mL, 31.25 μg/mL, and 31.25 μg/mL, respectively. The MIC of 4m, 4k, 5d, 5g, and 6h compounds against Staphylococcus aureus was 62.5 μg/mL, 31.25 μg/mL, 31.25 μg/mL, 100 μg/mL, and 62.5 μg/mL, respectively. The MIC of 4k, 5g, and 6i compounds against Salmonella typhimurium was 31.25 μg/mL, 100 μg/mL, and 62.5 μg/mL, respectively. The MIC of 6i compound against Escherichia coli was 62.5 μg/mL.

Download Full-text

Green synthesised silver nanoparticles incorporated electrospun poly(methyl methacrylate) nanofibers with different architectures for ophthalmologic alternatives

Journal of Bioactive and Compatible Polymers ◽

10.1177/0883911521997856 ◽

2021 ◽

Vol 36 (2) ◽

pp. 93-110

Author(s):

Princy Philip ◽

Tomlal Jose ◽

Sarath KS ◽

Sunny Kuriakose

Keyword(s):

Silver Nanoparticles ◽

Methyl Methacrylate ◽

Antibacterial Properties ◽

Analytical Techniques ◽

Morphological Properties ◽

Gram Positive ◽

Gram Negative ◽

Poly Methyl Methacrylate ◽

Antimicrobial Studies ◽

Eye Problems

Silver nanoparticles with 5–10 nm diameters are synthesised using Couroupita guianensis flower extract. The synthesised silver nanoparticles found to show good antimicrobial activity against gram negative and gram positive bacteria. Poly(methyl methacrylate) nanofibers with pristine, surface roughened and coaxial hollow forms are prepared by electrospinning. The structural and morphological properties of these pure and structurally modified poly(methyl methacrylate) nanofibers are evidenced by various analytical techniques. The antimicrobial studies of poly(methyl methacrylate) nanofibers having different architectures incorporated with silver nanoparticles are carried out. It is found that, all the three forms of poly(methyl methacrylate) nanofibers incorporated with silver nanoparticles show antibacterial properties against both gram positive and gram negative bacteria. Among these, surface roughened poly(methyl methacrylate) nanofibers incorporated with silver nanoparticles show highest antibacterial activity than the other two structural forms. The present study offers an alternative to the existing optical lenses. People especially those who suffer from eye problems can protect their eyes in a better way from infectious agents by wearing optical lens made from C. guianensis stabilised silver nanoparticles incorporated poly(methyl methacrylate) nanofibers than that made from pure poly(methyl methacrylate) nanofibers or films.

Download Full-text

Spectral Studies and Antibacterial Activity of Vanadium(III) Complexes of Heterocyclic Hydrazones

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22518 ◽

2020 ◽

Vol 32 (5) ◽

pp. 1059-1063

Author(s):

D. Kasimbi ◽

K. Hussain Reddy ◽

N. Devanna

Keyword(s):

Analytical Techniques ◽

Spectral Studies ◽

Bacterial Strains ◽

Gram Positive ◽

Tridentate Ligands ◽

Structure Comparison ◽

Gram Negative ◽

E Coli ◽

Physico Chemical ◽

Uv Visible

Vanadium(III) complexes having the composition VLCl3 [where L = 2-acetylpyridine acetoylhydrazone (APAH), 2-acetylpyridine benzoylhydrazone (APBH), 2-acetylthiophene acetoylhydrazone (ATAH) and 2-acetylthiophene benzoylhydrazone (ATBH)] have been investigated using physico-chemical and analytical techniques. Molar conductivity data suggested that the complexes are neutral. Structures of all the vanadium(III) complexes are determined based on infrared and UV-visible spectral data. Electronic spectra of vanadium(III) complexes show three peaks suggesting octahedral structure. Comparison of vibrational spectra of hydrazones and complexes suggest that the hydrazones act as neutral tridentate ligands. The ligands and their vanadium derivatives are screened for their bacteria destroying activity against pathogenic bacterial strains viz. Gram-negative E. coli, Gram-positive Bacillus, Gram-positive Staphylococcus aureus and Gram-negative P. aureoginosa. Bacteria destroying activities of present complexes are comparable to the activity of the streptomycin. Complexes show more activity than their respective ligands in the case of Gram-positive Bacillus and Gram-negative P. aureoginosa.

Download Full-text

Synthesis, Spectral and Microbial Studies of Some Novel Schiff Base Derivatives of 4-Methylpyridin-2-amine

E-Journal of Chemistry ◽

10.1155/2009/247209 ◽

2009 ◽

Vol 6 (4) ◽

pp. 1205-1210 ◽

Cited By ~ 3

Author(s):

J. J. Vora ◽

S. B. Vasava ◽

K. C. Parmar ◽

S. K. Chauhan ◽

S. S. Sharma

Keyword(s):

Schiff Base ◽

Antimicrobial Activities ◽

Dilution Method ◽

Mass Spectral ◽

H Nmr ◽

Schiff Base Derivatives ◽

Ft Ir ◽

Acid Catalyzed ◽

Derivatives Of ◽

Broth Dilution

Schiff base derivatives ofN-{(1E)-[3-(mono or di-substituted aryl)-1-phenyl-1H-pyrazol-4-yl]methylene{-4-methylpyridin-2-amine were synthesized by the acid catalyzed condensation of 3-(mono- or di- substituted aryl)-1-phenyl-1H-pyrazole-4-carbaldehyde derivatives with 4-methylpyridin-2-amine. Schiff base derivatives were characterized by FT-IR,1H-NMR, Mass spectral analysis and elemental analysis. All the synthesized compounds have been screened for their antimicrobial activities by using broth dilution method.

Download Full-text

Quercetin as a Precursor for the Synthesis of Novel Nanoscale Cu (II) Complex as a Catalyst for Alcohol Oxidation with High Antibacterial Activity

Bioinorganic Chemistry and Applications ◽

10.1155/2021/8818452 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Zahra Moodi ◽

Ghodsieh Bagherzade ◽

Janny Peters

Keyword(s):

Antibacterial Activity ◽

Schiff Base ◽

Biological Activities ◽

Schiff Base Complex ◽

13C Nmr Spectroscopy ◽

Inhibition Zone ◽

Gram Negative Bacteria ◽

Gram Positive ◽

Gram Negative ◽

High Antibacterial Activity

Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is one of the dietary flavonoids, distributed in medicinal plants, vegetables, and fruits. Quercetin has the ability to bind with several metal ions to increase its biological activities. In the last two decades, quercetin has attracted considerable attention due to the biological and pharmaceutical activities such as antioxidant, antibacterial, and anticancer. In the present study, quercetin and ethanolamine were used for the synthesis Schiff base complex, which was characterized by IR, 1H NMR, and 13C NMR spectroscopy. The Schiff base has been employed as a ligand for the synthesis of novel nanoscale Cu (II) complex. The product was characterized by FT-IR spectroscopy, FESEM, and XRD. Significantly, the product showed remarkable catalytic activity towards the oxidation of primary and secondary alcohols. The antibacterial activity of the final product was assessed against Staphylococcus aureus (Gram‐positive) and Escherichia coli (Gram‐negative) bacteria using an inhibition zone test. The synthesized nanoscale Cu (II) complex exhibited a strong antibacterial activity against both Gram-positive and Gram-negative bacteria.

Download Full-text

Chemical Composition and Antibacterial Activity of the Essential Oil of Phellodendron lavallei

Natural Product Communications ◽

10.1177/1934578x1701200135 ◽

2017 ◽

Vol 12 (1) ◽

pp. 1934578X1701200 ◽

Cited By ~ 2

Author(s):

Anna Lis ◽

Weronika Kowalska ◽

Monika Sienkiewicz ◽

Piotr Banaszczak

Keyword(s):

Antibacterial Activity ◽

Chemical Composition ◽

Nmr Spectroscopy ◽

Gram Negative Bacteria ◽

Gram Negative ◽

H Nmr ◽

Germacrene D ◽

Leaf Oil ◽

Weak Activity ◽

Fruit Oil

The essential oils from inflorescences, fruits and leaves of Phellodendron lavallei Dode were analyzed by GC, GC/MS and 1H NMR spectroscopy. About 100 compounds were identified. The principal components in the fruit oil were myrcene (47.7–52.0%) and limonene (38.4–40.9%), followed by germacrene D (1.2–3.2%) and ( E)-β-caryophyllene (2.4–2.9%). The inflorescence oil contained mainly myrcene (44.8%), limonene (43.2%) and ( E)-β-ocimene (4.1%). The main constituents of the leaf oil were limonene (26.7%) myrcene (22.1%), ( E,E)-α-farnesene (5.6%) and α-pinene (5.0%). The antibacterial activity was examined towards both Gram-positive and Gram-negative bacteria. The fruit oil showed weak activity against the bacteria tested.

Download Full-text

Characterization and identification of antimicrobial peptides with different functional activities

Briefings in Bioinformatics ◽

10.1093/bib/bbz043 ◽

2019 ◽

Vol 21 (3) ◽

pp. 1098-1114 ◽

Cited By ~ 8

Author(s):

Chia-Ru Chung ◽

Ting-Rung Kuo ◽

Li-Ching Wu ◽

Tzong-Yi Lee ◽

Jorng-Tzong Horng

Keyword(s):

Antimicrobial Peptides ◽

Hot Spot ◽

Gram Negative Bacteria ◽

Gram Positive ◽

Van Der Waals Volume ◽

Gram Negative ◽

Functional Activities ◽

Wide Range ◽

Anti Cancer ◽

Anti Fungal

Abstract In recent years, antimicrobial peptides (AMPs) have become an emerging area of focus when developing therapeutics hot spot residues of proteins are dominant against infections. Importantly, AMPs are produced by virtually all known living organisms and are able to target a wide range of pathogenic microorganisms, including viruses, parasites, bacteria and fungi. Although several studies have proposed different machine learning methods to predict peptides as being AMPs, most do not consider the diversity of AMP activities. On this basis, we specifically investigated the sequence features of AMPs with a range of functional activities, including anti-parasitic, anti-viral, anti-cancer and anti-fungal activities and those that target mammals, Gram-positive and Gram-negative bacteria. A new scheme is proposed to systematically characterize and identify AMPs and their functional activities. The 1st stage of the proposed approach is to identify the AMPs, while the 2nd involves further characterization of their functional activities. Sequential forward selection was employed to extract potentially informative features that are possibly associated with the functional activities of the AMPs. These features include hydrophobicity, the normalized van der Waals volume, polarity, charge and solvent accessibility—all of which are essential attributes in classifying between AMPs and non-AMPs. The results revealed the 1st stage AMP classifier was able to achieve an area under the receiver operating characteristic curve (AUC) value of 0.9894. During the 2nd stage, we found pseudo amino acid composition to be an informative attribute when differentiating between AMPs in terms of their functional activities. The independent testing results demonstrated that the AUCs of the multi-class models were 0.7773, 0.9404, 0.8231, 0.8578, 0.8648, 0.8745 and 0.8672 for anti-parasitic, anti-viral, anti-cancer, anti-fungal AMPs and those that target mammals, Gram-positive and Gram-negative bacteria, respectively. The proposed scheme helps facilitate biological experiments related to the functional analysis of AMPs. Additionally, it was implemented as a user-friendly web server (AMPfun, http://fdblab.csie.ncu.edu.tw/AMPfun/index.html) that allows individuals to explore the antimicrobial functions of peptides of interest.

Download Full-text

PRELIMINARY PHYTOCHEMICAL SCREENING AND IN VITRO ANTI-MICROBIAL ACTIVITY OF ETHANOLIC EXTRACTS OF SEEDS OF PUNICA GRANATUM AGAINST STANDARD PATHOGENIC STRAINS

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2018v10i4.28464 ◽

2018 ◽

Vol 10 (4) ◽

pp. 55

Author(s):

Aditya Jyoti Bora ◽

Biswajit Dash ◽

Sujata Paul ◽

Bikash Gupta

Keyword(s):

Antimicrobial Activity ◽

Microbial Activity ◽

Sulfhydryl Group ◽

Ethanolic Extract ◽

Punica Granatum ◽

Diffusion Method ◽

Gram Positive ◽

Gram Negative ◽

Gram Positive Bacteria ◽

Anti Fungal

Objective: To estimate the anti-microbial activity of ethanolic extract of Punica granatum seeds (family-Punicaceae) in association with phytochemical analysis.Methods: The ethanolic extract of the seeds of Punica granatum was prepared and investigate for phytochemical constituents using standard methods. Antimicrobial activities of ethanolic extract were carried out against one Gram positive bacteria (Staphylococcus aureus) and one Gram negative bacteria (Escherichia coli). The anti-fungal activity of the plant extract was evaluated on Candida albicans. The testing was done by the disc diffusion method. A zone of inhibition of ethanolic extract was compared with that of standard Tetracycline for anti-bacterial activities and Fluconazole for anti-fungal activity.Results: The result of this study showed a good antibacterial effect of pomegranate juice against both Gram negative and Gram positive bacteria. The antimicrobial activity of the fruit may be due to its high content of polyphenols which causes phenolic toxicity by interfering with the sulfhydryl group of the bacterial proteins and high content of tannins which interferes with bacterial membrane stability.Conclusion: The present study concluded that ethanolic extract of the seeds of Punica granatum contains the high existence of phytochemicals. The ethanolic extract of the plant was found to possess promising antimicrobial activity when compared with the standards.

Download Full-text

Synthesis and Pharmacological Evaluation of Some New 2-Phenyl benzimidazoles Derivatives and their Schiff's Bases

E-Journal of Chemistry ◽

10.1155/2009/604203 ◽

2009 ◽

Vol 6 (s1) ◽

pp. S342-S346 ◽

Cited By ~ 11

Author(s):

Y. S. Chhonker ◽

B. Veenu ◽

S. R. Hasim ◽

Niranjan Kaushik ◽

Devendra Kumar ◽

...

Keyword(s):

Antimicrobial Activities ◽

Benzimidazole Derivatives ◽

Spectroscopic Techniques ◽

Gram Negative Bacteria ◽

Gram Positive ◽

Gram Negative ◽

Gram Positive Bacteria ◽

H Nmr ◽

Ir Spectroscopic

Some new 2- phenyl benzimidazole derivatives were synthesised by cyclocondensation with appropriate reagents. The compounds synthesised were identified by1H NMR, FAB Mass and FT-IR spectroscopic techniques. All compounds studied in this work were screened for theirin vitroantimicrobial activities against the standard strains:Staphylococcus aureusATCC - 25923, ATCC - 441 andBacillus subtilisATCC- 6633 as gram positive,Escherichia coliATCC - 11775 andPseudomonas aeruginosaATCC 10145 as gram negative bacteria. Some of the compounds inhibited the growth of gram-positive bacteria (B. subtilisandS. aureus) at MIC values between 25 and 200 mg/mL. Some of the compounds exhibit antimicrobial activity against gram negative bacteria (E. coliandP. Aeruginosa) MIC values between 25 and 200 mg/mL.

Download Full-text