406 Effects of modified yeast cell wall extract on gut health and growth of newly weaned pigs under chronic dietary challenges of aflatoxin, deoxynivalenol, and fumonisin

2017 ◽  
Vol 95 (suppl_4) ◽  
pp. 200-200 ◽  
Author(s):  
I. Park ◽  
W. Parnsen ◽  
M. E. Duarte ◽  
A. Yiannikouris ◽  
S. W. Kim
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Yeast Cell Wall ◽  
Gut Health ◽  
Weaned Pigs ◽  
Cell Wall Extract

scholarly journals Impact of Chronic Levels of Naturally Multi-Contaminated Feed with Fusarium Mycotoxins on Broiler Chickens and Evaluation of the Mitigation Properties of Different Titers of Yeast Cell Wall Extract

Toxins ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 636
Author(s):  
Alexandra C. Weaver ◽  
W. D. King ◽  
Morgan Verax ◽  
Ursula Fox ◽  
Manoj B. Kudupoje ◽  
...  
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Production Efficiency ◽  
Yeast Cell Wall ◽  
Poultry Production ◽  
Gut Health ◽  
Feed Conversion ◽  
Fusarium Mycotoxins ◽  
Crypt Depth ◽  
Cell Wall Extract

The chronic intake of naturally multi-mycotoxin contaminated feed by broilers with or without titers of Yeast Cell Wall Extract (YCWE, a.k.a Mycosorb A+®), was investigated. Day-old male Cobb chicks (1600 birds, 64 pens, 25 birds/pen) were randomly allocated to diets of control (CON); diet containing mycotoxins (MT); CON + 0.2% YCWE; MT + 0.025% YCWE; MT + 0.05% YCWE; MT + 0.1% YCWE; MT + 0.2% YCWE; and MT + 0.4% YCWE. Growth performance, blood biochemical parameters and gut health were recorded over 42 days. Compared with CON, MT had reduced body weight (BW) and increased feed conversion ratio (FCR) on days 35 and 42 with increased duodenal crypt depth and fewer goblet cells. Furthermore, European Poultry Production Efficiency (EPEF) was reduced for MT versus CON. Feeding MT + 0.2% YCWE improved BW, lowered FCR, reduced crypt depth, increased goblet cell count and improved EPEF. Considering titration of YCWE (0 to 0.4%) during mycotoxin challenge, a cubic effect was observed for FCR with NC + 0.2% YCWE having the lowest FCR. These findings suggest that chronic consumption of multiple Fusarium mycotoxins present in common field concentrations can negatively impact broiler performance and gut health while inclusion of YCWE, particularly 0.2%, could be effective in counteracting mycotoxins.

scholarly journals Efficacy of a Yeast Cell Wall Extract to Mitigate the Effect of Naturally Co-Occurring Mycotoxins Contaminating Feed Ingredients Fed to Young Pigs: Impact on Gut Health, Microbiome, and Growth

Toxins ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 633 ◽  
Author(s):  
Sung Woo Kim ◽  
Débora Muratori Holanda ◽  
Xin Gao ◽  
Inkyung Park ◽  
Alexandros Yiannikouris
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Pathogenic Bacteria ◽  
Protein Carbonyl ◽  
Yeast Cell Wall ◽  
Gut Health ◽  
Villus Height ◽  
Ki 67 ◽  
Ileal Digestibility ◽  
Cell Wall Extract

Mycotoxins are produced by fungi and are potentially toxic to pigs. Yeast cell wall extract (YCWE) is known to adsorb mycotoxins and improve gut health in pigs. One hundred and twenty growing (56 kg; experiment 1) and 48 nursery piglets (6 kg; experiment 2) were assigned to four dietary treatments in a 2 × 2 factorial design for 35 and 48 days, respectively. Factors were mycotoxins (no addition versus experiment 1: 180 μg/kg aflatoxins and 14 mg/kg fumonisins; or experiment 2: 180 μg/kg aflatoxins and 9 mg/kg fumonisins, and 1 mg/kg deoxynivalenol) and YCWE (0% versus 0.2%). Growth performance, blood, gut health and microbiome, and apparent ileal digestibility (AID) data were evaluated. In experiment 1, mycotoxins reduced ADG and G:F, and duodenal IgG, whereas in jejunum, YCWE increased IgG and reduced villus width. In experiment 2, mycotoxins reduced BW, ADG, and ADFI. Mycotoxins reduced ADG, which was recovered by YCWE. Mycotoxins reduced the AID of nutrients evaluated and increased protein carbonyl, whereas mycotoxins and YCWE increased the AID of the nutrients and reduced protein carbonyl. Mycotoxins reduced villus height, proportion of Ki-67-positive cells, and increased IgA and the proportion of bacteria with mycotoxin-degrading ability, whereas YCWE tended to increase villus height and reduced IgA and the proportion of pathogenic bacteria in jejunum. The YCWE effects were more evident in promoting gut health and growth in nursery pigs, which showed higher susceptibility to mycotoxin effects.

Dietary hydrolysed yeast cell wall extract is comparable to antibiotics in the control of subclinical necrotic enteritis in broiler chickens

2019 ◽  
Vol 60 (6) ◽  
pp. 757-765
Author(s):  
E. U. Ahiwe ◽  
E. P. Chang’a ◽  
M. E. Abdallh ◽  
M. Al-Qahtani ◽  
S. K. Kheravii ◽  
...  
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Broiler Chickens ◽  
Yeast Cell Wall ◽  
Necrotic Enteritis ◽  
Cell Wall Extract

scholarly journals Yeast Cell Wall Extract Induces Disease Resistance against Bacterial and Fungal Pathogens in Arabidopsis thaliana and Brassica Crop

PLoS ONE ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. e0115864 ◽  
Author(s):  
Mari Narusaka ◽  
Taichi Minami ◽  
Chikako Iwabuchi ◽  
Takashi Hamasaki ◽  
Satoko Takasaki ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Cell Wall ◽  
Disease Resistance ◽  
Yeast Cell ◽  
Fungal Pathogens ◽  
Yeast Cell Wall ◽  
Brassica Crop ◽  
Cell Wall Extract

scholarly journals PSXIV-42 Late-Breaking: Effects of yeast cell wall product on growth performance, immune responses, and gene expression of tight junction proteins of weaned pigs

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 333-334
Author(s):  
Hyunjin Kyoung ◽  
Myungwoo Cho ◽  
Hanbae Lee ◽  
Sangwoo Park ◽  
Joowon Kang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Wall ◽  
Immune Responses ◽  
Tight Junction ◽  
Yeast Cell ◽  
Growth Performance ◽  
Experimental Period ◽  
Yeast Cell Wall ◽  
Weaned Pigs ◽  
Tnf Α

Abstract The study was conducted to investigate effects of yeast cell wall product on growth performance, immune responses, and gene expression of tight junction proteins of weaned pigs. A total of 112 weaned pigs (7.98 ± 0.43 kg BW) were randomly assigned to 2 dietary treatments (8 pigs/pen; 7 replicates/treatments) for 4 weeks in a randomized complete block design (block = BW). Dietary treatments were 1) a commercial basal nursery diet (CON) and 2) CON + 0.05% yeast cell wall product (YCW, EasyBio Inc., Seoul, Korea). Blood was collected from one randomly selected pig per pen on d 0, 7, and 14 after weaning. The randomly selected one pig per replicate was euthanized to collect ileum tissue samples at the end of the experimental period. Measurements were growth performance, number of white blood cells (WBC) by an automated hematology analyzer calibrated for porcine blood, cortisol, tumor necrosis factor-α (TNF-α), transforming growth factor-β1, interleukin-1β (IL-1β), and interleukin-6 (IL-6) by the ELISA, and gene expression of tight junction in ileum tissues. Data were analyzed using the PROC GLM procedure of SAS. The statistical model for every measurement included dietary effect and BW as a covariate. Pigs fed YCW had higher (P < 0.10) ADG than those fed CON during overall experimental period. Pigs fed YCW had lower WBC on d 14 (P < 0.10), TNF-α on d 7 (P < 0.10), and decreased IL-1β on d 14 (P < 0.05) than those fed CON. In addition, The YCW increased (P < 0.05) expression of Claudin family, Occludin, Muc1, INF-α, and IL-6, but decreased (P < 0.05) expression of TNF-α genes in the ileum tissues compared with CON. In conclusion, addition of yeast cell wall product in the nursery diet improved growth performance and gut health and modified immune responses of weaned pigs.

scholarly journals Investigation of the Efficacy of a Postbiotic Yeast Cell Wall-Based Blend on Newly-Weaned Pigs under a Dietary Challenge of Multiple Mycotoxins with Emphasis on Deoxynivalenol

Toxins ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 504
Author(s):  
Debora Muratori Holanda ◽  
Alexandros Yiannikouris ◽  
Sung Woo Kim
Keyword(s):  
Cell Wall ◽  
Body Weight ◽  
Yeast Cell ◽  
Growth Performance ◽  
Block Design ◽  
Nutrient Digestibility ◽  
Yeast Cell Wall ◽  
Jejunal Mucosa ◽  
Weaned Pigs ◽  
Two Factors

Pigs are highly susceptible to mycotoxins. This study investigated the effects of a postbiotic yeast cell wall-based blend (PYCW; Nicholasville, KY, USA) on growth and health of newly-weaned pigs under dietary challenge of multiple mycotoxins. Forty-eight newly-weaned pigs (21 d old) were individually allotted to four dietary treatments, based on a three phase-feeding, in a randomized complete block design (sex; initial BW) with two factors for 36 d. Two factors were dietary mycotoxins (deoxynivalenol: 2000 μg/kg supplemented in three phases; and aflatoxin: 200 μg/kg supplemented only in phase 3) and PYCW (0.2%). Growth performance (weekly), blood serum (d 34), and jejunal mucosa immune and oxidative stress markers (d 36) data were analyzed using MIXED procedure of SAS. Mycotoxins reduced (p < 0.05) average daily feed intake (ADFI) and average daily gain (ADG) during the entire period whereas PYCW did not affect growth performance. Mycotoxins reduced (p < 0.05) serum protein, albumin, creatinine, and alanine aminotransferase whereas PYCW decreased (p < 0.05) serum creatine phosphokinase. Neither mycotoxins nor PYCW affected pro-inflammatory cytokines and oxidative damage markers in the jejunal mucosa. No interaction was observed indicating that PYCW improved hepatic enzymes regardless of mycotoxin challenge. In conclusion, deoxynivalenol (2000 μg/kg, for 7 to 25 kg body weight) and aflatoxin B1 (200 μg/kg, for 16 to 25 kg body weight) impaired growth performance and nutrient digestibility of newly-weaned pigs, whereas PYCW could partially improve health of pigs regardless of mycotoxin challenge.

Agroecosystem Development of Industrial Fermentation Waste - Suppressive Effects of Beer Yeast Cell Wall Extract on Plant Diseases

2015 ◽  
Vol 1 (3) ◽  
pp. 207-211
Author(s):  
Malek Marian ◽  
Kiriko Ogawa ◽  
Yui Yoshikawa ◽  
Satoko Takasaki ◽  
Atsushi Usami ◽  
...  
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Plant Diseases ◽  
Yeast Cell Wall ◽  
Industrial Fermentation ◽  
Cell Wall Extract ◽  
Beer Yeast
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