A case of severe corneal-conjunctival xerosis caused by long-term local use of inocaine in a patient with viral conjunctivitis (COVID-19)

2021 ◽  
pp. 68-70
Author(s):  
A.E. Babushkin ◽  
◽  
G.R. Saitova ◽  
E.N. Matyukhina ◽  
G.Z. Israfilova ◽  
...  
Keyword(s):  
Outpatient Treatment ◽  
Inpatient Treatment ◽  
Tear Film ◽  
Chronic Dacryocystitis ◽  
Superficial Ulcer ◽  
Gradual Development ◽  
The Stability ◽  
The Right ◽  
Local Use

The article describes a rare case of conjunctivitis in a 25-year-old patient that developed 5 days before the first typical signs of COVID-19 disease appeared, and led to cicatricial changes in the conjunctiva in the form of bilateral partial external symblepharon and mild dry eye syndrome, and later chronic dacryocystitis of the right eyes. Surgical treatment of simblepharon led to its relapse in the right eye with gradual development of severe DES with a significant decrease in visual acuity. The prescribed complex therapy with drops of dexamethasone, restasis, vitabact and tear-suppressing drugs (Oftagel, Vita Pos ointment) for several days, however, led to extensive detachment of the corneal epithelium and the development of a superficial ulcer of the right eye with a keratomalacia area in its lower part. In the process of inpatient treatment recommended to the patient at one of the councils, it suddenly turned out that the patient had been periodically instilling inocaine into his right eye for anesthesia for several months on his own. It was the decrease in sensitivity against the background of prolonged instillations of the local anesthetic inocaine that aggravated the violation of the stability of the tear film, led to a significant decrease in tear secretion and a cytotoxic effect, which gradually led to the development of severe corneal-conjunctival xerosis. The performed inpatient treatment and subsequent outpatient treatment led to the relief of inflammation, epithelialization of the ulcer. Key words: conjunctivitis, COVID-19, complication, simblefaron, inocaine anesthetic, corneal-conjunctival xerosis.

scholarly journals Periocular Cutaneous Mucormycosis Caused by Saksenaea erythrospora

2017 ◽  
Vol 14 (04) ◽  
pp. 209-212
Author(s):  
Bunyada Putthirangsiwong ◽  
Pornchai Mahaisavariya ◽  
Weerawan Chokthaweesak ◽  
Dinesh Selva
Keyword(s):  
Complete Recovery ◽  
Molecular Techniques ◽  
First Case ◽  
Chronic Dacryocystitis ◽  
Oral Itraconazole ◽  
Periocular Region ◽  
Cutaneous Mucormycosis ◽  
The Right

Abstract Saksenaea erythrospora is a rare pathogen in humans. Ten adult cases have been previously reported, eight manifested with cutaneous infection, and two presented with invasive rhinosinusitis infection. The authors present a 16-month-old boy with progressive painful mass at the right medial canthus and upper cheek that was unresponsive to broad-spectrum antibiotics. He underwent an anterior orbitotomy and biopsy. Histopathology revealed broad nonseptate sterile hyphae and grew S. erythrospora, which was confirmed by molecular techniques. The patient was treated with intravenous liposomal amphotericin B and oral itraconazole combined with aggressive surgical debridement. The patient made a complete recovery without long-term complications at 4 months of follow-up. Primary cutaneous mucormycosis caused by S. erythrospora may rarely involve the periocular region and mimic chronic dacryocystitis. We report the first case of pediatric periocular cutaneous mucormycosis caused by S. erythrospora.

scholarly journals THE COVID-19 PANDEMIC - HOW WELL ARE WE BALANCING HEALTH, FREEDOM, AND THE ECONOMY?

2020 ◽  
Author(s):  
Fedeli Piergiorgio ◽  
◽  
Cingolani Mariano ◽  
Nunzia Cannovo ◽  
Roberto Scendoni ◽  
...  
Keyword(s):  
Careful Analysis ◽  
Right To Health ◽  
Negative Consequences ◽  
Right To Work ◽  
The Stability ◽  
The Individual ◽  
The Right ◽  
Individual Choices ◽  
National Governments

The worsening healthcare emergency with the COVID-19 pandemic has demanded a prompt reaction from authorities to contain the damage related to the spread of the virus. Our aim is to provide a bioethical contribution, with a careful analysis about the balance of individual rights with those of the whole community. The protection of the right to health in the emergency phase, with the restriction of the right to work and other rights, can have long-term negative consequences on the economy, with fallout affecting funding for the healthcare system as well. The right to health in its community dimension can sometimes clash with the protection of the sacrosanct dignity of the individual. Choices to protect health may have social and economic repercussions that could undermine the stability of many national governments.

Technological Analysis of the Orientation of the Pitched Icelandic Turf Roof to the Cardinal Points and their Effect on the Stability of the Vegetative Layers

2014 ◽  
Vol 1041 ◽  
pp. 19-22 ◽  
Author(s):  
Petr Selnik ◽  
Klara Necadova ◽  
Martin Mohapl
Keyword(s):  
Functional Condition ◽  
Local Climate ◽  
Climate Conditions ◽  
Long Term Stability ◽  
The Stability ◽  
The Right ◽  
Weather Impacts ◽  
Technological Analysis ◽  
Made In

This article is focused on the assessment of the pitched turf green roof to the cardinal points, its permanent sustainable functional condition and investigation of a possible damage caused by local climate. The solution of these problems is the crucial factor in next development, use and expansion of this type of roofing in European broader range. This study of the roof construction that was made in Iceland offers conclusion based on quick changes of the local climate conditions and demanding extreme weather impacts. The main aim of this research is proposed the right possible solution and design of this construction including dealing with the details, select the convenient orientation to the cardinal points and surroundings to provide long-term stability of this construction.

scholarly journals Zoledronic acid and teriparatide have a complementary therapeutic effect on aseptic loosening in a rabbit model

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Peng Wang ◽  
Guang-qian Shang ◽  
Shuai Xiang ◽  
Hai-ning Zhang ◽  
Ying-zhen Wang ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Aseptic Loosening ◽  
Rabbit Model ◽  
Acid Group ◽  
Control Group ◽  
Periprosthetic Osteolysis ◽  
The Stability ◽  
The Right ◽  
Masson Trichrome Staining

Abstract Background Revisions are mainly caused by wear debris-induced aseptic loosening. How to effectively suppress debris-induced periprosthetic osteolysis has become an urgent problem. Both zoledronic acid and teriparatide can increase the bone mass around prostheses and increase the stability of prostheses. A hypothesis was proposed: the combination of the two drugs may have a better treatment effect than the use of either drug alone. Methods We created a rabbit model to study the effect and mechanism of the combination of zoledronic acid and teriparatide in the treatment of aseptic loosening. Thirty-two adult male New Zealand white rabbits were selected and treated with TKA surgery, and a titanium rod prosthesis coated evenly with micrometre-sized titanium debris was implanted into the right femoral medullary cavity. All rabbits were randomized into four groups (control group = 8, zoledronic acid group = 8, teriparatide group = 8, and zoledronic acid + teriparatide group = 8). All the animals were sacrificed in the 12th week, and X-ray analyses, H&E staining, Goldner-Masson trichrome staining, von Kossa staining, and RT-PCR and Western blotting of the mRNA and protein of OCN, OPG, RANKL and TRAP5b in the interface membrane tissues around the prostheses were immediately carried out. Results The results shown that both zoledronic acid and teriparatide could inhibit debris-induced peri-prosthetic osteolysis and promote new bone formation. Zoledronic acid was more capable of inhibiting osteoclast activation and peri-prosthetic osteolysis, while teriparatide was more capable of promoting osteoblast function and peri-prosthetic bone integration. Conclusion This research confirmed that the combination of zoledronic acid and teriparatide could prevent and treat aseptic loosening of the prosthesis more effectively. However, the safety of this combination and the feasibility of long-term application have not been ensured, and the clinical application requires further experiments and clinical research support.

Patients considered in need of new long-term compulsory inpatient treatment

2011 ◽  
Vol 38 (S 01) ◽  
Author(s):  
R van den Brink ◽  
G Kranenburg ◽  
W Mulder ◽  
D Wiersma
Keyword(s):  
Inpatient Treatment

The Stability of the WHO Reference Thromboplastin NIBS & C 67/40

1979 ◽  
Vol 42 (04) ◽  
pp. 1135-1140 ◽  
Author(s):  
G I C Ingram
Keyword(s):  
Human Brain ◽  
Collaborative Study ◽  
Calibration Constant ◽  
Long Term Stability ◽  
Freeze Dried ◽  
Show Evidence ◽  
Human Material ◽  
Reference Preparation ◽  
The Stability

SummaryThe International Reference Preparation of human brain thromboplastin coded 67/40 has been thought to show evidence of instability. The evidence is discussed and is not thought to be strong; but it is suggested that it would be wise to replace 67/40 with a new preparation of human brain, both for this reason and because 67/40 is in a form (like Thrombotest) in which few workers seem to use human brain. A �plain� preparation would be more appropriate; and a freeze-dried sample of BCT is recommended as the successor preparation. The opportunity should be taken also to replace the corresponding ox and rabbit preparations. In the collaborative study which would be required it would then be desirable to test in parallel the three old and the three new preparations. The relative sensitivities of the old preparations could be compared with those found in earlier studies to obtain further evidence on the stability of 67/40; if stability were confirmed, the new preparations should be calibrated against it, but if not, the new human material should receive a calibration constant of 1.0 and the new ox and rabbit materials calibrated against that.The types of evidence available for monitoring the long-term stability of a thromboplastin are discussed.

Moyamoya Syndrome in a Child with β-Thalassemia Major

2020 ◽  
Vol 18 (04) ◽  
pp. 214-216
Author(s):  
Soumya Roy
Keyword(s):  
Magnetic Resonance ◽  
Cerebrovascular Accident ◽  
Muscle Wasting ◽  
Thalassemia Major ◽  
Blood Transfusions ◽  
Moyamoya Syndrome ◽  
Magnetic Resonance Angiogram ◽  
Joint Contractures ◽  
Gradual Development ◽  
The Right

AbstractA 9-year-old girl patient presented with left-sided weakness and joint contractures developing over a period of 18 months. She was known to be suffering from β-thalassemia major and was on regular blood transfusions. Eighteen months ago, she had suffered from an episode of ischemic cerebrovascular accident affecting the right side of her brain. Magnetic resonance angiogram revealed vaso-occlusive disease affecting mainly the anterior cerebral circulation, resembling Moyamoya disease. She was advised to carry out regular physiotherapy but her parents discontinued it, which resulted in the gradual development of joint contractures and muscle wasting.

Symmetrizable Difference Dchemes

2005 ◽  
Vol 5 (1) ◽  
pp. 3-50 ◽  
Author(s):  
Alexei A. Gulin
Keyword(s):  
Initial Data ◽  
Difference Scheme ◽  
Difference Schemes ◽  
Time Dependent ◽  
Stability Boundaries ◽  
Typical Representative ◽  
Variable Weight ◽  
The Stability ◽  
Conditions Of Stability ◽  
The Right

AbstractA review of the stability theory of symmetrizable time-dependent difference schemes is represented. The notion of the operator-difference scheme is introduced and general ideas about stability in the sense of the initial data and in the sense of the right hand side are formulated. Further, the so-called symmetrizable difference schemes are considered in detail for which we manage to formulate the unimprovable necessary and su±cient conditions of stability in the sense of the initial data. The schemes with variable weight multipliers are a typical representative of symmetrizable difference schemes. For such schemes a numerical algorithm is proposed and realized for constructing stability boundaries.

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