scholarly journals pengaruh penekanan pellet silika terhadap porositas dan permeabilitas

2021 ◽  
Vol 4 (01) ◽  
pp. 1-6
Author(s):  
Heri Fadli
Keyword(s):  
Polyethylene Glycol ◽  
Type Alloy ◽  
Aluminium Powder ◽  
Peg 400

Klasifikasi silika (SiO2) dibagi dalam empat karakter dasar silika yaitu struktur kristal, dispersitas, komposisi permukaan dan porositas. Sebelumnya pasir silika ini banyak digunakan oleh industri minyak dan gas sebagai proppant (pasir frak) maupun sebagai filter air. Pilihan proppant tergantung pada jenis permeabilitas atau kekuatan butir yang dibutuhkan. Dimana proppant dengan ukuran yang lebih besar akan memberikan permeabilitas rekahan yang lebih baik, karena nilai permeabilitas akan meningkat seiring dengan bertambahnya diameter dari butiran.  Penelitian ini bertujuan untuk mengetahui pengaruh penekanan pellet silika terhadap porositas dan permeabilitas. Penekanan pellet silika ini menggunakan mesin press hidrolik dengan type KW05-135 dan kapasitas 10.000 Kg. Peneliti membuat pellet silika dengan kandungan pasir silika berukuran butir seragam (100 mesh) sebanyak 8,74 g/cm3, menggunakan perekat jenis Polyethylene Glycol (PEG) 400 sebanyak 0,57 g/cm3, dan Aluminium Powder 3,42 g/cm3. Cetakan yang digunakan Mold Pellet Silika Type Alloy 410 dengan diameter dalam 27 mm, diameter luar 57 mm dan ketinggian lubang cetakan 89 mm dengan penekanan 1000 Kg, 3000 Kg, dan 5000 Kg, serta memberikan suhu sintering sebesar 1200°C. Adapun nilai porositas optimum yang diperoleh sebesar 39,25% dan nilai permeabilitas optimum yang di dapatkan sebesar 57 mD.

A Simple Approach to the One-Pot Three Component Synthesis of 4Hpyrimido [2,1-b] benzothiazole Derivatives Using Polyethylene Glycol (PEG-400)

2015 ◽  
Vol 12 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Prabhakar Rairala ◽  
Bandi Yadagiri ◽  
Rajashaker Bantu ◽  
Vijayacharan Guguloth ◽  
Lingaiah Nagarapu
Keyword(s):  
Polyethylene Glycol ◽  
Simple Approach ◽  
One Pot ◽  
Benzothiazole Derivatives ◽  
Peg 400 ◽  
The One

Extraction of polyethylene glycols with dicarbolide solutions in nitrobenzene

1990 ◽  
Vol 55 (8) ◽  
pp. 1959-1967 ◽  
Author(s):  
Petr Vaňura ◽  
Pavel Selucký
Keyword(s):  
Polyethylene Glycol ◽  
Molecular Mass ◽  
Extraction Constant ◽  
Metal Extraction ◽  
Polyethylene Glycols ◽  
Relative Molecular Mass ◽  
Published Data ◽  
Average Molecular Mass ◽  
Peg 400 ◽  
Extraction Constants

The extraction of polyethylene glycol of average molecular mass 400 (PEG 400) with dicarbolide solution in nitrobenzene and of longer-chain polyethylene glycol, of average molecular mass 1 500 (PEG 1 500), with chlorinated dicarbolide solution in nitrobenzene was studied. During the extraction of PEG 400, the polyethylene glycol solvates the Horg+ ion in the organic phase giving rise to the HLorg+ species (L is polyethylene glycol). The obtained value of the extraction constant Kex(HLorg+) = 933 is consistent with published data of metal extraction. Extraction of PEG 1 500 was treated applying the simplified assumption that the thermodynamic behaviour of PEG 1 500 is the same as that of n molecules of polyethylene glycol with relative molecular mass 1 500/n, each solvating one cation. For this model, the value of n = 3.2 ± 1.1 and the values of the extraction constants of the HL1/n,org+ and HL2/n,org+ species were obtained by using the adapted program LETAGROP. This value of n is consistent with published extraction data in the presence of polyethylene glycol with a relative molecular mass from 200 to 1 000.

ChemInform Abstract: Polyethylene Glycol (PEG-400): A Mild and Efficient Reaction Medium for One-Pot Synthesis of 3-Hydroxy-3-(pyridin-2-ylmethyl)indolin-2-ones.

ChemInform ◽  
2013 ◽  
Vol 44 (42) ◽  
pp. no-no
Author(s):  
M. Raghu ◽  
M. Rajasekhar ◽  
B. Chandra Obula Reddy ◽  
C. Suresh Reddy ◽  
B. V. Subba Reddy
Keyword(s):  
Polyethylene Glycol ◽  
Reaction Medium ◽  
One Pot ◽  
Peg 400 ◽  
One Pot Synthesis

Facile Polyethylene Glycol (PEG-400) Promoted Synthesis of Some New Heteryl (E)-styryl Sulfones

2009 ◽  
Vol 2009 (4) ◽  
pp. 237-239 ◽  
Author(s):  
Nalajam Guravaiah ◽  
Vedula Rajeswar Rao
Keyword(s):  
Polyethylene Glycol ◽  
Room Temperature ◽  
Reaction Medium ◽  
Peg 400 ◽  
Convenient Synthesis

An efficient and convenient synthesis of heteryl ( E)-styryl sulfones is described. Reaction of an 3-(2-bromoacetyl)coumarin with sodium ( E)-styrenesulfinates yields the corresponding styryl sulfones promoted by polyethylene glycol (PEG-400) as an efficient reaction medium at room temperature

scholarly journals FORMULATION AND EVALUATION OF ATORVASTATIN CALCIUM NANOCRYSTALS CONTAINING P-GLYCOPROTEIN INHIBITORS FOR ENHANCING ORAL DELIVERY

2021 ◽  
pp. 19-23
Author(s):  
SARAH LABIB ◽  
MOHAMED NASR ◽  
MOHAMED NASR
Keyword(s):  
Polyethylene Glycol ◽  
Oral Drug Delivery ◽  
Tween 80 ◽  
Degree Of Crystallinity ◽  
Oral Drug ◽  
Tween 20 ◽  
Atorvastatin Calcium ◽  
Peg 400 ◽  
P Glycoprotein ◽  
Saturated Solubility

Objective: The main objective of this study was to develop atorvastatin calcium (ATR) as an oral drug delivery system for a P-glycoprotein (P-gp) substrate drug using different pharmaceutical excipients that inhibit P-glycoprotein and evaluate the influence of nanocrystals on the dissolution characteristics and bioavailability compared to the plain drug. Methods: A nanosuspension was prepared by Solvent-antisolvent precipitation method using a solvent containing stabilizer that act as a p-gp inhibitor dissolved in distilled water as polyethylene glycol 300, polyethylene glycol 400 (PEG 300, PEG 400), tween 20 and tween 80 while the solvent selected for atorvastatin calcium was methanol. The concentrations were as follows: PEG 300 and 400 = 0.25% w/v, tween 20 and 80 = 0.75% v/v. Nanocrystals were extracted from the suspension and characterized. Results: Particle size of the drug was 1307±127.79 nm while the formulas prepared ranged from 223±17.67 to 887±58.12 nm. Pure ATR had a saturated solubility of 0.059±0.005 mg/ml and the prepared nanocrystals ranged from 0.32±0.021 to 0.88±0.019 mg/ml. The Percentage of drug released of plain atorvastatin calcium reached 41.49% while the formula ranged from 44.32 to 61.5%. Both XRD and SEM discussed the degree of crystallinity as follows: F1<F2<F4<F3<ATR. Conclusion: 0.3% of PEG 300 and PEG 400 were not enough to formulate proper nanocrystals while 0.75% tween 20 and tween 80 achieved acceptable formulas. F4 which is prepared with tween 80 exhibited the highest enhancement in saturated solubility, dissolution rate and subsequently expected to have improved oral bioavailability.

Polyethylene glycol (PEG-400): a mild and efficient reaction medium for one-pot synthesis of 3-hydroxy-3-(pyridin-2-ylmethyl)indolin-2-ones

2013 ◽  
Vol 54 (27) ◽  
pp. 3503-3506 ◽  
Author(s):  
M. Raghu ◽  
M. Rajasekhar ◽  
B. Chandra Obula Reddy ◽  
C. Suresh Reddy ◽  
B.V. Subba Reddy
Keyword(s):  
Polyethylene Glycol ◽  
Reaction Medium ◽  
One Pot ◽  
Peg 400 ◽  
One Pot Synthesis

Solubility and Thermodynamics of 6-Phenyl-4,5-dihydropyridazin-3(2H)-one in Various (PEG 400+Water) Mixtures

2019 ◽  
Vol 233 (2) ◽  
pp. 273-287 ◽  
Author(s):  
Mohd. Imran
Keyword(s):  
Polyethylene Glycol ◽  
Thermodynamic Analysis ◽  
Mole Fraction ◽  
Solubility Data ◽  
Polyethylene Glycol 400 ◽  
Isothermal Method ◽  
Peg 400 ◽  
Neat Water

Abstract The aim of this study was to determine the solubility of pyridazinone derivative 6-phenyl-4,5-dihydropyridazin-3(2H)-one (PDP-6) in different “polyethylene glycol 400 (PEG 400)+water” mixtures at temperatures “T=293.2 K to 313.2 K” and pressure “p=0.1 MPa”. The solubilities of PDP-6 were determined using an isothermal method and correlated with Apelblat, van’t Hoff and Yalkowsky–Roseman models. The maximum solubilities of PDP-6 in mole fraction were obtained in neat PEG 400 (8.46×10−2 at T=313.2 K). However, the minimum one was recorded in neat water (7.50×10−7 at T=293.2 K). Apparent thermodynamic analysis showed an endothermic dissolution of PDP-6 in all (PEG 400 water) mixtures. Based on the solubility data of the current study, PDP-6 has been considered as practically insoluble in water and soluble in PEG 400.

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