3, 3’-thiodipropionic acid: A versatile monomer to synthesis aliphatic random copolyesters with biological applications
A prime monomer 3,3’-thiodipropionic acid was mixed with other monomers such as 1,4 butanediol and 1,4 butanedioic acid to produce aliphatic random copolyester Poly(butylthiodipropionate-co-butylbu tanedioate) (PBTBB) by direct melt polycondensation method. The physical properties such as solubility by solubility test, inherent viscosity by Ubbelohde viscometer, Tg by differential scanning colorimetry (DSC) and the crystalline nature by X-ray diffraction (XRD) technique of synthesized polymer were investigated. The chemical structure of the obtained copolyester was studied by FTIR, 1H-NMR and 13CNMR spectroscopy. To resolve the biological applications, the synthesized copolyester was tested for human pathogenic bacteria using well diffusion method, in vitro cytotoxicity against normal Vero cell line, A549 lung cancer cell line by MTT assay and in vitro antioxidant property studied by Dot-Blot assay.