scholarly journals Polymorphic variants of DNA repair enzyme genes in the pathogenesis of lung cancer in women

2020 ◽  
pp. 86-87
Author(s):  
Р.А. Титов ◽  
В.И. Минина ◽  
М.Л. Баканова ◽  
Я.А. Савченко
Keyword(s):  
Lung Cancer ◽  
Case Control Study ◽  
Smoking Status ◽  
Newly Diagnosed ◽  
Lung Cancer Patients ◽  
Regional Center ◽  
Healthy Donors ◽  
Polymorphic Variants ◽  
Oncology Center ◽  
Control Study

Обследовано 540 жительниц Кемеровской области: 270 человек, первично обратившиеся для диагностики и лечения в Кемеровский областной онкологический диспансер и 268 человек - здоровые женщины доноры Кемеровского областного центра крови (группа сравнения). Цель: изучение роли полиморфизма генов репарации ДНК в формировании рака легкого у женщин. Типирование полиморфных вариантов генов APEX1 (rs1130409), XRCC1 (rs25489), hOGG1 (rs1052133), XPD (rs13181), XPG (rs17655), XPC (rs2228001), ADPRT (rs1136410), АТМ (rs18015), NBS1 (rs1805794) осуществляли методом аллель-специфической ПЦР. Стaтистическую обрaботку результатов проводили с использованием программ: SNPstats (http://bioinfo.iconcologia.net/SNPstats), «Statistica 10.0» (StatSoft, Inc., USA). Выявлены ассоциации полиморфных вариантов генов APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489), АТМ (rs18015), XPC (rs2228001) c формированием рака легкого у женщин. In the presented «case-control» study 540 residents of the Kemerovo Region subject to age, sex and smoking status were included. We formed two groups: 1) «Case» - 270 newly diagnosed lung cancer patients undergoing a medical treatment in the Kemerovo Regional Oncology Center; 2) «Control» - 268 healthy donors of the Kemerovo Regional Center of Blood Transfusion. Statistical analysis were performed using SNPstats (http://bioinfo.iconcologia.net/SNPstats), «Statistica 10.0» (StatSoft, Inc., USA). A significant association obtained between the APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489), АТМ (rs18015), XPC (rs2228001)) and lung cancer.

scholarly journals Associations genetic polymorphism of xenobiotic biotransformation enzymes and risk of lung adenocarcinoma

2020 ◽  
pp. 79-80
Author(s):  
М.Л. Баканова ◽  
В.И. Минина ◽  
Я.А. Савченко ◽  
А.Н. Глушков
Keyword(s):  
Lung Adenocarcinoma ◽  
Case Control Study ◽  
Smoking Status ◽  
Newly Diagnosed ◽  
Biotransformation Enzymes ◽  
Regional Center ◽  
Healthy Donors ◽  
Xenobiotic Biotransformation ◽  
Oncology Center ◽  
Control Study

Обследовано 670 жителей Кемеровской области: 304 человека, первично обратившиеся для диагностики и лечения в Кемеровский областной онкологический диспансер (диагноз аденокарцинома легкого (АКЛ)) и 366 человек - здоровые доноры Кемеровского областного центра крови, которые составили группу сравнения. Цель: анализ генов ферментов биотрансформации ксенобиотиков у больных АКЛ и индивидов, не имеющих онкологических заболеваний, проживающих в той же местности. Исследование полиморфных вариантов генов CYP1A1 (rs4646903Т>С), CYP1A2 (rs762551-163 C>A), GSTM1 (del), GSTT1 (del) осуществляли методом real-time ПЦР (ООО «СибДНК», г. Новосибирск). Стaтистическaя обрaботкa мaтериaлa проводилaсь с использовaнием программ: SNPstats (http://bioinfo.iconcologia.net/SNPstats), «Statistica 10.0» (StatSoft, Inc., USA). Выявлены ассоциации АКЛ с генотипом ТС гена CYP1A1 (rs4646903Т>С) и делецией гена GSTТ1(del). In the presented “case-control” study 670 residents of the Kemerovo Region subject to age, sex, ethnicity and smoking status were included. We formed two groups: 1) “Case” - 304 newly diagnosed lung adenocarcinoma patients undergoing a medical treatment in the Kemerovo Regional Oncology Center; 2) “Control” - 366 healthy donors of the Kemerovo Regional Center of Blood Transfusion. Statistical analysis were performed using SNPstats (http://bioinfo.iconcologia.net/SNPstats), «Statistica 10.0» (StatSoft, Inc., USA). A significant association obtained between the CYP1A1 (rs4646903Т>С), GSTТ1(del) and lung adenocarcinoma.

scholarly journals Case-Control Study of the D2 Dopamine Receptor Gene and Smoking Status in Lung Cancer Patients

1998 ◽  
Vol 90 (5) ◽  
pp. 358-363 ◽  
Author(s):  
Margaret R. Spitz ◽  
Huihui Shi ◽  
Fang Yang ◽  
Karen Suchanek Hudmon ◽  
Hong Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Smoking Status ◽  
Receptor Gene ◽  
Case Control ◽  
D2 Dopamine Receptor ◽  
Lung Cancer Patients ◽  
D2 Dopamine Receptor Gene ◽  
Control Study

A case‐control study of serum vitamins A, E, and C in lung cancer patients

1990 ◽  
Vol 14 (2) ◽  
pp. 133-140 ◽  
Author(s):  
Barbara Y. LeGardeur ◽  
Alfredo Lopez‐S ◽  
William D. Johnson
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Lung Cancer Patients ◽  
Control Study

scholarly journals Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: A multi-institutional case–control study

2012 ◽  
Vol 413 (13-14) ◽  
pp. 1115-1120 ◽  
Author(s):  
Matthias Zimmermann ◽  
Stefanie Nickl ◽  
Christopher Lambers ◽  
Stefan Hacker ◽  
Andreas Mitterbauer ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Clinical Stages ◽  
Control Study

scholarly journals A Single Nucleotide Polymorphism in the MMP9 Promoter Affects Lung Cancer and Clinicopathological Properties in Iranian Population

2021 ◽  
Vol 2 (12) ◽  
pp. 1274-1282
Author(s):  
Somayeh Taghvaei ◽  
Leila Saremi ◽  
Majid Motovali-bashi
Keyword(s):  
Lung Cancer ◽  
Family History ◽  
Cancer Patients ◽  
Odds Ratio ◽  
Case Control Study ◽  
Positive Family History ◽  
Case Control ◽  
Healthy Controls ◽  
Lung Cancer Patients ◽  
Control Study

Background: Lung cancer is the most common cancer with 2,206,771 new cases in 2020 in worldwide. MMP9 is a member of matrix metalloproteinase family that is also known as gelatinase B or IV type collagenase (92KD). MMP9 through degrading of Extracellular Matrix (ECM) and releasing of growth factors has fundamental role in the tumorigenesis process. The C -1562 T SNP in the MMP9 promoter increases MMP9 expression and susceptibility to lung cancer. Then, the aim of this present case-control study was to investigate whether genetic variations of the MMP9 gene may constitute markers for lung cancer risk in males and in positive family history people in Iran. Methods: This is a case-control study including 120 lung cancer patients and 100 healthy controls. Polymorphism in the C -1562 T region was genotyped by PCR-RFLP assay. Odds Ratio (ORs) and 95% Confidence Intervals (CIs) were estimated by chi-square test from comparison of genotypes between lung cancer patients and healthy controls, using SPSS version 26.0. T-test and Image J software was also used. Results: The distribution of C-1562T genotype was significantly associated with the risk of lung cancer (Odds Ratio [OR] = 2.56, 95% Confidence Interval [CI] = 0.06-23.82). The further stratification analyses shown that males and patients with positive family history may increase risk of lung cancer. Conclusion: Our results indicated that the MMP9 C -1562 T polymorphism affects risk of lung cancer. In addition, men with T allele (OR = 3.94, CI = 1.47-10`.55) and patients with TT genotype and family history (OR = 2.18, CI = 1.03-4.59) exposure to higher risk of lung cancer.

scholarly journals Residential Radon Exposure and Cigarette Smoking in Association with Lung Cancer: A Matched Case-Control Study in Korea

2020 ◽  
Vol 17 (8) ◽  
pp. 2946
Author(s):  
Eung Joo Park ◽  
Hokyou Lee ◽  
Hyeon Chang Kim ◽  
Seung Soo Sheen ◽  
Sang Baek Koh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cigarette Smoking ◽  
Case Control Study ◽  
Smoking Status ◽  
Case Control ◽  
Radon Exposure ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study ◽  
Residential Radon

Residential radon exposure and cigarette smoking are the two most important risk factors for lung cancer. The combined effects thereof were evaluated in a multi-center matched case-control study in South Korea. A total of 1038 participants were included, comprising 519 non-small cell lung cancer cases and 519 age- and sex- matched community-based controls. Residential radon levels were measured for all participants. Multivariate logistic regression was used to calculate odds ratios (OR) for lung cancer according to radon exposure (high ≥ 100 Bq/m3 vs. low < 100 Bq/m3), smoking status, and combinations of the two after adjusting for age, sex, indoor hours, and other housing information. The median age of the participants was 64 years, and 51.3% were women. The adjusted ORs (95% confidence intervals [CIs]) for high radon and cigarette smoking were 1.56 (1.03–2.37) and 2.53 (1.60–3.99), respectively. When stratified according to combinations of radon exposure and smoking status, the adjusted ORs (95% CIs) for lung cancer in high-radon non-smokers, low-radon smokers, and high-radon smokers were 1.40 (0.81–2.43), 2.42 (1.49–3.92), and 4.27 (2.14–8.52), respectively, with reference to low-radon non-smokers. Both residential radon and cigarette smoking were associated with increased odds for lung cancer, and the difference in ORs according to radon exposure was much greater in smokers than in non-smokers.

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