A RAPID CERVICAL CANCER SCREENING METHOD – FLOATE RECEPTOR-MEDIATED STAINING OF CERVICAL NEOPLASTIC EPITHELIA (CIN2+)

Cervical cancer is the fourth most frequently occurring cancer in women around the world and can affect them during their reproductive years. Since the development of the Papanicolaou (Pap) test, screening has been essential in identifying cervical cancer at a treatable stage. With the identification of the human papillomavirus (HPV) as the causative agent of essentially all cervical cancer cases, HPV molecular screening tests and HPV vaccines for primary prevention against the virus have been developed. Accordingly, comparative studies were designed to assess the performance of cervical cancer screening methods in order to devise the best screening strategy possible. This review critically assesses the current cervical cancer screening methods as well as the implementation of HPV vaccination in Europe. The most recent European Guidelines and recommendations for organized population-based programs with HPV testing as the primary screening method are also presented. Lastly, the current landscape of cervical cancer screening programs is assessed for both European Union member states and some associated countries, in regard to the transition towards population-based screening programs with primary HPV testing.

Download Full-text

Computer-aided Cervical Cancer Screening Method based on Multi-spectral Narrow-band Imaging

Proceedings of the 2019 4th International Conference on Biomedical Signal and Image Processing (ICBIP 2019) - ICBIP '19 ◽

10.1145/3354031.3354037 ◽

2019 ◽

Author(s):

Zihan Yang ◽

Dingrong Yi ◽

Jiahao Shen

Keyword(s):

Cervical Cancer ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Narrow Band ◽

Narrow Band Imaging ◽

Screening Method ◽

Computer Aided

Download Full-text

Identification of ideal strategy of cervical cancer screening in Japan based on Fukui cervical cancer screening study.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e17025 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e17025-e17025

Author(s):

Tetsuji Kurokawa ◽

Akiko Shinagawa ◽

Yoko Chino ◽

Motohiro Kobayashi ◽

Yoshio Yoshida

Keyword(s):

Cervical Cancer ◽

Cancer Screening ◽

Positive Predictive Value ◽

Cervical Cancer Screening ◽

Predictive Value ◽

Screening Method ◽

Hpv Testing ◽

Abnormal Cytology ◽

Predictive Values ◽

Hpv Status

e17025 Background:The estimated age-standardized incidence rate for cervical cancer is higher in Japan than in North America and the UK. It is important to improve cancer screening. The introduction of HPV testing with cytology for triage of those that test positive for cervical cancer screening has been challenging. The Fukui Cervical Cancer Screening (FCCS) study was designed to determine the best cervical cancer screening method in the Japanese population. We performed a subanalysis using baseline data of FCCS study to determine the performance of cytology, the human papillomavirus (HPV) testing and cotesting with cytology and HPV testing, and to evaluate whether the stratification of HPV16, HPV18, and 12 other hrHPV types appropriately balances risks and harms in the Japanese cancer screening population. Methods:The study enrolled 7,584 women aged 25 years or older undergoing routine screening. All women underwent liquid-based cytology (LBC) and cobas HPV testing. Women with abnormal cytology regardless of the HPV status, women with positive hrHPV results regardless of cytology results, and women randomly selected from among those with normal cytology and negative hrHPV results were referred for colposcopy. Results:The prevalence of hrHPV, HPV16, and HPV18 was 6.8%, 1.2%, and 0.5%, respectively. The estimated sensitivities for cervical intraepithelial neoplasia (CIN) 2 or worse for cytology, HPV testing, and cotesting with cytology and HPV testing were 71%, 92%, and 100%, respectively. The estimated positive predictive values for cytology, HPV testing, and cotesting with cytology and HPV testing were 33%, 21% and 21%, respectively. Using a strategy whereby those with abnormal cytology or positive HPV16 genotype undergo colposcopy and biopsy results in a sensitivity of 85% and a positive predictive value of 33%. This strategy results in improved sensitivity while at the same time maintains the positive predictive value compared to screening with cytology alone. Conclusions:Baseline data from the FCCS study suggests that strategy of using colposcopy for women with abnormal cytology and/or HPV16 positivity appropriately balances risks and harms for Japanese women. Clinical trial information: UMIN000025977.

Download Full-text

Concordance in HPV Detection Between Self-Collected and Health Provider–Collected Cervicovaginal Samples Using careHPV in Tanzanian Women

JCO Global Oncology ◽

10.1200/go.20.00598 ◽

2021 ◽

pp. 985-991

Author(s):

Johnson J. Katanga ◽

Vibeke Rasch ◽

Rachel Manongi ◽

Andrea B. Pembe ◽

Julius D. Mwaiselage ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Screening ◽

High Risk ◽

Cervical Cancer Screening ◽

Screening Method ◽

Health Provider ◽

Limited Information ◽

Sample Collection ◽

Hpv Dna ◽

High Risk Hpv

PURPOSE Cervical cancer screening is one of the strategies to prevent the disease among women at risk. Human papillomavirus (HPV) DNA testing is increasingly used as the cervical cancer screening method because of its high sensitivity. Self-collection of cervical specimens has the potential to improve participation. However, there is only limited information on comparison between self-collected and provider-collected samples with regard to detection of high-risk HPV using the careHPV method. The study aimed to compare HPV detection by careHPV in self-collected and provider-collected cervical samples and to assess the acceptability of self-collection techniques. MATERIAL AND METHODS Women attending cervical cancer screening clinics at Ocean Road Cancer Institute, Kilimanjaro Christian Medical Centre or Mawenzi Hospital in Tanzania were included in the study. They underwent a face-to-face interview, HIV testing, and collected a self-sample using Evalyn Brush. Subsequently, they had a cervical sample taken by a health provider. Both samples were tested for high-risk HPV DNA using careHPV. RESULTS Overall, 464 women participated in the study. The high-risk HPV prevalence was 19.0% (95% CI, 15.6 to 22.9) in the health provider samples, but lower (13.8%; 95% CI, 10.9 to 17.3) in the self-collected samples. There was a good overall agreement 90.5% (95% CI, 87.5 to 93.0) and concordance (κ = 0.66; 95% CI, 0.56 to 0.75) between the two sets of samples. Sensitivity and specificity were 61.4% (95% CI, 50.4 to 71.6) and 97.3% (95% CI, 95.2 to 98.7), respectively, varying with age. Most women preferred self-collection (79.8%). CONCLUSION Overall, self-sampling seems to be a reliable alternative to health-provider collection and is acceptable to the majority of women. However, instructions on proper procedures for sample collection to the women are important.

Download Full-text

Acceptability and Feasibility of HPV Self-Sampling as an Alternative Primary Cervical Cancer Screening in Under-Screened Population Groups: A Cross-Sectional Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17176245 ◽

2020 ◽

Vol 17 (17) ◽

pp. 6245

Author(s):

Eliza Lai-Yi Wong ◽

Annie Wai-Ling Cheung ◽

Amy Yuen-Kwan Wong ◽

Paul Kay-Sheung Chan

Keyword(s):

Cervical Cancer ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Uptake Rate ◽

Screening Method ◽

Cross Sectional Study ◽

Cross Sectional ◽

Regular Screening ◽

Never Screened ◽

Primary Cervical Cancer Screening

Background: Cervical cancer is one of the most common cancers in women and about 90% of cervical cancer can be reduced by regular screening. The Pap smear has been well in place as a primary cervical screening method since 1950s; however, coverage is still not optimal. This study explored the feasibility of HPV self-sampling in two under-screened population groups in Hong Kong (HK): never screened and not regularly screened females, to estimate the uptake rate and preference rate in the future. Materials and Methods: This was a cross-sectional study to explore the acceptability and feasibility of HPV self-sampling in two age groups: aged 25–35 and aged ≥45, which were reported as the highest proportion of the under-screened population in HK between 2017 and 2018. The study invited eligible women from an HPV study cohort to perform HPV self-sampling at home by themselves. The number of specimens returned from participants was recorded and used to determine the feasibility of HPV self-sampling in the community. The participants were asked to fill in the questionnaires before and after HPV self-sampling to indicate their attitudes, acceptability, and future preference for HPV self-sampling as an acceptable alternative primary cervical cancer screening method. Results: A total of 177 subjects participated in the present study and have achieved a good overall uptake rate of 73% (129/177) who returned the self-collected cervicovaginal sample for HPV testing. Among the under-screened population, there was a higher response rate in aged ≥45 than those aged 25–35. The findings also revealed that women who were under-screened, including those who have never been screened, were more likely to prefer HPV self-sampling than those who had regular screening. This study found that the acceptability of HPV self-sampling was fairly positive among the respondents. The findings also indicated that HPV self-sampling was not only beneficial to enhance their health awareness but also to promote the cervical cancer screening uptake rate, especially among the under-screened or never screened populations. Conclusions: HPV self-sampling would be a solution to overcome the perceived barriers in clinician-based screening. The findings also indicated that it could be feasible to use as an alternative primary cervical cancer screening.

Download Full-text

Cervical Cancer Screening Program by Visual Inspection: Acceptability and Feasibility in Health Insurance Companies

Obstetrics and Gynecology International ◽

10.1155/2015/798453 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Apollinaire G. Horo ◽

Judith Didi-Kouko Coulibaly ◽

Abdoul Koffi ◽

Boris Tchounga ◽

Konan Seni ◽

...

Keyword(s):

Cervical Cancer ◽

Health Insurance ◽

Cancer Screening ◽

Diagnostic Accuracy ◽

Cervical Cancer Screening ◽

Visual Inspection ◽

Screening Program ◽

Cervical Screening ◽

Screening Method ◽

Insurance Company

Objective. To assess willingness to participate and diagnostic accuracy of visual inspection for early detection of cervical neoplasia among women in a health insurance company.Patients and Method. Cervical cancer screening was systematically proposed to 800 women after consecutive information and awareness sessions. The screening method was visual inspection with acetic acid (VIA) or Lugol’s iodine (VILI).Results. Among the 800 identified women, 640 (82%) have accepted the screening, their mean age was 39 years, and 12.0% of them were involved in a polygamist couple. 28.2% of women had prior cervical screening. VIA has been detected positive in 5.9% of women versus 8.6% for VILI. The sensitivity was 72.9% and specificity was 95.2% for VIA versus 71.2% and 97.3% for VILI respectively. The histological examination highlighted a nonspecific chronic cervicitis in 4.6%, CIN1 lesions in 5.91%, and CIN2/3 in 1.2% of the cases.Conclusion. Cervical cancer screening by visual inspection showed appropriate diagnostic accuracy when used to detect early cervical lesions. It is a simple and easy to perform method that could be introduced progressively in the health insurance policy while waiting for a national screening program.

Download Full-text

Economic Evaluations of Cervical Cancer Screening Methods: a Systematic Review

10.21203/rs.3.rs-1019410/v1 ◽

2021 ◽

Author(s):

Thatohatsi Sefuthi ◽

Lungiswa Leonora Nkonki

Keyword(s):

Systematic Review ◽

Cervical Cancer ◽

Cost Effectiveness ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Screening Method ◽

Health Economic Evaluation ◽

Economic Evaluations ◽

Screening Methods ◽

Model Based

Abstract Background: Cervical cancer screening is an important public health priority with the potential to improve the detection of pre-cancerous lesions in high-risk females for early intervention and disease prevention. Test performance and cost-effectiveness differs based on the specific screening method used across different platforms. There is a need to appraise existing economic evaluations of cervical cancer screening. The objective of the present systematic review was to identify primary and model-based economic evaluations of cervical cancer screening methods, and to provide a contextual summary of associated outcomes associated with screening modalities. Methods: The review considered primary-based and model-based full economic evaluations of cervical cancer screening methods. Such evaluations methods include cost-effectiveness analysis, cost-utility analysis, cost-minimization analysis, cost-benefit analysis, and cost-consequence analysis. We searched the following databases for full economic evaluations of cancer screening methods globally: SCOPUS, Pubmed, National Health Economic Evaluation Database (NH EED), Cochrane, and Health Economic Evaluation Database (HEED). No date restrictions were applied. Model-based and primary-based full economic evaluations were included. A critical appraisal of included studies was performed by the main investigator, while a second independent reviewer assessed critical appraisal findings for any inconsistencies. Data were extracted using a standardized data extraction tool for economic evaluations. Data extracted from included studies were analysed and summarised to answer the study objective using the Joanna Briggs Institute (JBI) Dominance Ranking Matrix (DRM).Results: Out of 671 screened studies, 44 met the study inclusion criteria. Forty-three studies were cost-effectiveness analyses while two studies reported cost-utilities of cervical cancer screening methods.HPV DNA testing was reported as a dominant standalone screening test by 14 studies, while 5 studies reported VIA as a dominant standalone screening test. Primary HPV screening strategies were dominant in 21 studies, while three studies reported Cytology-based screening strategies as the dominant screening method. Conclusions: Evidence indicates that HPV-based and VIA testing strategies are cost-effective, but this is influenced by setting. Our review suggests the limited cost-effectiveness of cytology-based testing, which may be due in part to the need for specific infrastructures and human resources. Systematic Review Prospero Registration: CRD42020212454. The review protocol may also be found on Prospero.

Download Full-text

Acceptability of Human Papillomavirus Self-Sampling for Cervical Cancer Screening in an Indigenous Community in Guatemala

Journal of Global Oncology ◽

10.1200/jgo.2016.005629 ◽

2017 ◽

Vol 3 (5) ◽

pp. 444-454 ◽

Cited By ~ 17

Author(s):

Anna Gottschlich ◽

Alvaro Rivera-Andrade ◽

Edwin Grajeda ◽

Christian Alvarez ◽

Carlos Mendoza Montano ◽

...

Keyword(s):

Cervical Cancer ◽

Latin America ◽

Human Papillomavirus ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Screening Method ◽

Indigenous Communities ◽

Developed Countries ◽

Indigenous Community ◽

Cervical Sample

Purpose Cervical cancer rates in Latin America are higher than those in developed countries, likely because of the lower prevalence of screening. Specifically, less than 40% of women in Guatemala are regularly screened and even fewer women are screened in indigenous communities. Current screening strategies—Pap smears and visual inspection with acetic acid—might not be the most effective methods for controlling cancer in these settings. We thus investigated the potential of self-collection of cervical samples with testing for human papillomavirus (HPV) to help prevent cervical cancer in an indigenous community in Guatemala. Patients and Methods A community representative random sample of 202 indigenous women age 18 to 60 years residing in Santiago Atitlan, Guatemala, were surveyed to assess knowledge of and risk factors for HPV and cervical cancer. Women were then invited to self-collect a cervical sample using HerSwab collection kits to assess the prevalence of HPV and the acceptability of self-sampling. Results Of 202 women who completed the survey, 178 (89%) provided a self-sample. In all, 79% of these women found the test comfortable, 91% found the test easy to use, and 100% reported they were willing to perform the test periodically as a screening method. Thirty-one samples (17%) were positive for at least one of 13 high-risk HPV types, and eight (4.5%) were positive for HPV 16/18. Conclusion HPV testing by using self-collected samples was well accepted, suggesting that it is a plausible modality for cervical cancer screening in indigenous communities. Further studies are needed to assess rates of follow-up after a positive test and to determine whether these findings extend to other indigenous and nonindigenous communities in Guatemala and Latin America.

Download Full-text