Electronic nose (AenoseTM) can detect colorectal carcinoma in exhaled breath: a pilot study

Author(s):  
Maud Jansen
2021 ◽  
Vol 10 (13) ◽  
pp. 2921
Author(s):  
Lisa Goudman ◽  
Julie Jansen ◽  
Nieke Vets ◽  
Ann De Smedt ◽  
Maarten Moens

The increased awareness of discrepancies between self-reporting outcome measurements and objective outcome measurements within the field of neuromodulation has accelerated the search towards more objective measurements. The aim of this study was to evaluate whether an electronic nose can differentiate between chronic pain patients in whom Spinal Cord Stimulation (SCS) was activated versus deactivated. Twenty-seven patients with Failed Back Surgery Syndrome (FBSS) participated in this prospective pilot study. Volatile organic compounds in exhaled breath were measured with electronic nose technology (AeonoseTM) during SCS on and off states. Random forest was used with a leave-10%-out cross-validation method to determine accuracy of discriminating between SCS on and off states. Our random forest showed an accuracy of 0.56, with an area under the curve of 0.62, a sensitivity of 62% (95% CI: 41–79%) and a specificity of 50% (95% CI: 30–70%). Pain intensity scores were significantly different between both SCS states. Our findings indicate that we cannot discriminate between SCS off and on states based on exhaled breath with the AeonoseTM in patients with FBSS. In clinical practice, these findings imply that with a noninvasive electronic nose, exhaled breath cannot be used as an additional marker of the effect of neuromodulation.


2016 ◽  
Vol 16 (14) ◽  
pp. 1610-1630 ◽  
Author(s):  
Giuseppe Santini ◽  
Nadia Mores ◽  
Andreu Penas ◽  
Rosamaria Capuano ◽  
Chiara Mondino ◽  
...  

Data in Brief ◽  
2021 ◽  
Vol 35 ◽  
pp. 106767
Author(s):  
Cristhian Manuel Durán Acevedo ◽  
Carlos A. Cuastumal Vasquez ◽  
Jeniffer Katerine Carrillo Gómez

2021 ◽  
pp. 118756
Author(s):  
Sa Liu ◽  
Eileen Ziyao Yan ◽  
Mary Ellen Turyk ◽  
Sankalp Srisai Katta ◽  
Arteen Fazl Rasti ◽  
...  
Keyword(s):  

ETRI Journal ◽  
2018 ◽  
Vol 40 (6) ◽  
pp. 802-812 ◽  
Author(s):  
Jin-Young Jeon ◽  
Jang-Sik Choi ◽  
Joon-Boo Yu ◽  
Hae-Ryong Lee ◽  
Byoung Kuk Jang ◽  
...  

2016 ◽  
Vol 42 (2) ◽  
pp. 143-145 ◽  
Author(s):  
Silvano Dragonieri ◽  
Vitaliano Nicola Quaranta ◽  
Pierluigi Carratu ◽  
Teresa Ranieri ◽  
Onofrio Resta

We aimed to investigate the effects of age and gender on the profile of exhaled volatile organic compounds. We evaluated 68 healthy adult never-smokers, comparing them by age and by gender. Exhaled breath samples were analyzed by an electronic nose (e-nose), resulting in "breathprints". Principal component analysis and canonical discriminant analysis showed that older subjects (≥ 50 years of age) could not be distinguished from younger subjects on the basis of their breathprints, as well as that the breathprints of males could not distinguished from those of females (cross-validated accuracy, 60.3% and 57.4%, respectively).Therefore, age and gender do not seem to affect the overall profile of exhaled volatile organic compounds measured by an e-nose.


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