Preclinical Pharmacokinetics, Metabolism and Disposition of eFT508, a Highly Selective Clinical Stage Mitogen Activated Protein Kinase-Interacting Kinase (MNK) Inhibitor

2016 ◽  
Author(s):  
Sam Sperry
Keyword(s):  
Protein Kinase ◽  
Clinical Stage ◽  
Mitogen Activated Protein Kinase ◽  
Preclinical Pharmacokinetics ◽  
Mitogen Activated Protein

scholarly journals Correlation of P38 Mitogen-Activated Protein Kinase Expression to Clinical Stage in Nasopharyngeal Carcinoma

2018 ◽  
Vol 6 (11) ◽  
pp. 1982-1985 ◽  
Author(s):  
Farhat Farhat ◽  
Elvita Rahmi Daulay ◽  
Jessy Chrestella ◽  
Rizalina Arwinati Asnir ◽  
Ashri Yudhistira ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Nasopharyngeal Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Stage ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Keratinizing Squamous Cell Carcinoma ◽  
Kinase Expression

BACKGROUND: Nasopharyngeal carcinoma (NPC) is uncommon and usually diagnosed at the advanced stage. A subfamily of mitogen-activated protein kinase which is called p38 mitogen-activated protein kinase (MAPK) involved in response to stress, and plays an important role in cell regulation. There is a suggestion that p38 mitogen-activated protein kinase could be a potential biomarker to determine the clinical stage of nasopharyngeal carcinoma. AIM: The aim of this study is for observing and analysing the correlation of p38 mitogen-activated protein kinase expression in regards to nasopharyngeal carcinoma patient’s clinical stage. METHODS: This study involved 126 nasopharyngeal carcinoma patients admitted to Haji Adam Malik General Hospital. RESULTS: The result of this study indicates that nasopharyngeal carcinoma mostly found in the age group 41-60 years, male, non-keratinizing squamous cell carcinoma, and stage IV group. In immunohistochemistry evaluation, most of p38 mitogen-activated protein kinase overexpressed in non-keratinizing squamous cell carcinoma, T3-T4, N2-N3 and clinical stage III-IV. Spearman’s test for categorical correlation yield p-value of < 0.001. CONCLUSION: In conclusion, there is a significant correlation between p38 mitogen-activated protein kinase expression and the clinical stage of nasopharyngeal carcinoma.

Preclinical pharmacokinetics of SB-203580, a potent inhibitor of p38 mitogen-activated protein kinase

Xenobiotica ◽  
2001 ◽  
Vol 31 (11) ◽  
pp. 783-797 ◽  
Author(s):  
K. W. Ward ◽  
J. W. Proksch ◽  
L. M. Azzarano ◽  
J. A. Mumaw ◽  
T. J. Roethke ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Potent Inhibitor ◽  
Mitogen Activated Protein Kinase ◽  
Preclinical Pharmacokinetics ◽  
Mitogen Activated Protein ◽  
Sb 203580

Age-Related Changes in Activation of Mitogen-Activated Protein Kinase Cascades by Oxidative Stress

1998 ◽  
Vol 3 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Kathryn Z Guyton ◽  
Myriani Gorospe ◽  
Xiantao Wang ◽  
Yolanda D Mock ◽  
Gertrude C Kokkonen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Age Related ◽  
Mitogen Activated Protein ◽  
Age Related Changes
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