Concordance toward the expectation for medication among the patients of depressive, bipolar disorders and psychotic disorders

2018 ◽  
Author(s):  
Hoo Rim Song
Keyword(s):  
Psychotic Disorders ◽  
Bipolar Disorders

scholarly journals Risk of schizophrenia, schizoaffective, and bipolar disorders by migrant status, region of origin, and age-at-migration: a national cohort study of 1.8 million people

2018 ◽  
Vol 49 (14) ◽  
pp. 2354-2363 ◽  
Author(s):  
Jennifer Dykxhoorn ◽  
Anna-Clara Hollander ◽  
Glyn Lewis ◽  
Cecelia Magnusson ◽  
Christina Dalman ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Proportional Hazards ◽  
Bipolar Disorders ◽  
Cox Proportional Hazards ◽  
Migrant Status ◽  
Region Of Origin ◽  
Related Factors ◽  
Increased Risk ◽  
Age At Migration ◽  
National Cohort

AbstractBackgroundWe assessed whether the risk of various psychotic disorders and non-psychotic bipolar disorder (including mania) varied by migrant status, a region of origin, or age-at-migration, hypothesizing that risk would only be elevated for psychotic disorders.MethodsWe established a prospective cohort of 1 796 257 Swedish residents born between 1982 and 1996, followed from their 15th birthday, or immigration to Sweden after age 15, until diagnosis, emigration, death, or end of 2011. Cox proportional hazards models were used to model hazard ratios by migration-related factors, adjusted for covariates.ResultsAll psychotic disorders were elevated among migrants and their children compared with Swedish-born individuals, including schizophrenia and schizoaffective disorder (adjusted hazard ratio [aHR]migrants: 2.20, 95% CI 1.96–2.47; aHRchildren : 2.00, 95% CI 1.79–2.25), affective psychotic disorders (aHRmigrant1.42, 95% CI 1.25–1.63; aHRchildren: 1.22 95% CI 1.07–1.40), and other non-affective psychotic disorders (aHRmigrant: 1.97, 95% CI 1.81–2.14; aHRchildren: 1.68, 95% CI 1.54–1.83). For all psychotic disorders, risks were generally highest in migrants from Africa (i.e. aHRschizophrenia: 5.24, 95% CI 4.26–6.45) and elevated at most ages-of-migration. By contrast, risk of non-psychotic bipolar disorders was lower for migrants (aHR: 0.58, 95% CI 0.52–0.64) overall, and across all ages-of-migration except infancy (aHR: 1.20; 95% CI 1.01–1.42), while risk for their children was similar to the Swedish-born population (aHR: 1.00, 95% CI 0.93–1.08).ConclusionsIncreased risk of psychiatric disorders associated with migration and minority status may be specific to psychotic disorders, with exact risk dependent on the region of origin.

scholarly journals Oral health in individuals with psychotic disorders

2008 ◽  
Vol 55 (3) ◽  
pp. 180-187
Author(s):  
Svetlana Jovanovic ◽  
Ivanka Gajic
Keyword(s):  
Health Care ◽  
Oral Health ◽  
Oral Hygiene ◽  
Psychotic Disorders ◽  
Care Service ◽  
Dental Health ◽  
Health Care Service ◽  
Bipolar Disorders ◽  
Oral Diseases ◽  
Antipsychotic Therapy

Mental disorders are an important problem in every national health care service. The importance of psychotic disorders is not only their frequency but also their long-term character, recurrence, association with other diseases, costs and consequences for the family and society. Psychotic disorders (schizophrenia, schizoaffective disorder, bipolar disorders and depression) and their treatment may result in serious oral diseases. These disorders and medications used to treat them may lead to a series of oral complications and side effects, predominantly high prevalence of carious and extracted teeth, periodontal disease, inadequate oral hygiene, xerostomia, burning mouth syndrome, bad breath and gustatory sense dysfunction. Psychotic disorders affect oral and dental health in two ways. Behavioural changes affect the oral hygiene maintenance and lead to bad habits and attitudes towards oral health. Antipsychotic therapy has adverse effects on oral health. Literature data suggest that oral health in patients with psychotic disorders is poor and highlight the need to develop specific preventive programmes, which would be aimed at improving behaviour of this population at risk in the oral health care system.

Midline brain anomalies and schizophrenia in people with CATCH 22 syndrome

1998 ◽  
Vol 172 (6) ◽  
pp. 518-520 ◽  
Author(s):  
R. Vataja ◽  
Eero Elomaa
Keyword(s):  
Information Exchange ◽  
Psychotic Disorders ◽  
Single Case ◽  
Bipolar Disorders ◽  
Single Case Report ◽  
Brain Anomalies ◽  
Chromosome 22Q11 ◽  
High Incidence ◽  
Catch 22 ◽  
The Brain

BackgroundSince people with chromosome 22q11 deletion (CATCH 22 syndrome) have unexpectedly high incidence of major psychosis it has been suggested that 22q area might be involved in the pathogenesis of schizophrenia and bipolar disorders.MethodA single case report.ResultsA 32-year-old male patient with CATCH 22 syndrome and schizophrenia had extensive midline anomalies of the brain in the regions relevant to psychotic disorders.Conclusions22q11-dependent abnormalities in the midline structures of the brain may cause dysfunction in the limbic system and interfere with the interhemispheric information exchange thus predisposing people with CATCH 22 syndrome to psychotic disorders.

Metacognitive beliefs mediate the effect of emotional abuse on depressive and psychotic symptoms in severe mental disorders

2017 ◽  
Vol 47 (13) ◽  
pp. 2323-2333 ◽  
Author(s):  
T. Østefjells ◽  
J. U. Lystad ◽  
A. O. Berg ◽  
R. Hagen ◽  
R. Loewy ◽  
...  
Keyword(s):  
Emotional Abuse ◽  
Psychotic Disorders ◽  
Bipolar Disorders ◽  
Ordinary Least Squares ◽  
Psychotic Symptoms ◽  
Positive Symptoms ◽  
Moderate Amount ◽  
Metacognitive Beliefs ◽  
Early Trauma ◽  
The Relationship

BackgroundEarly trauma is linked to higher symptom levels in bipolar and psychotic disorders, but the translating mechanisms are not well understood. This study examines whether the relationship between early emotional abuse and depressive symptoms is mediated by metacognitive beliefs about thoughts being uncontrollable/dangerous, and whether this pathway extends to influence positive symptoms.MethodPatients (N= 261) with psychotic or bipolar disorders were assessed for early trauma experiences, metacognitive beliefs, and current depression/anxiety and positive symptoms. Mediation path analyses using ordinary least-squares regressions tested if the effect of early emotional abuse on depression/anxiety was mediated by metacognitive beliefs, and if the effect of early emotional abuse on positive symptoms was mediated by metacognitive beliefs and depression/anxiety.ResultsMetacognitive beliefs about thoughts being uncontrollable/dangerous significantly mediated the relationship between early emotional abuse and depression/anxiety. Metacognitive beliefs and depression/anxiety significantly mediated the relationship between early emotional abuse and positive symptoms. The models explained a moderate amount of the variance in symptoms (R2= 0.21–0.29).ConclusionOur results indicate that early emotional abuse is relevant to depression/anxiety and positive symptoms in bipolar and psychotic disorders, and suggest that metacognitive beliefs could play a role in an affective pathway to psychosis. Metacognitive beliefs could be relevant treatment targets with regards to depression/anxiety and positive symptoms in bipolar and psychotic disorders.

scholarly journals Risk of schizophrenia, schizoaffective, and bipolar disorders by migrant status, region of origin, and age-at-migration: A national cohort study of 1.8 million people

2018 ◽  
Author(s):  
Jen Dykxhoorn ◽  
Anna-Clara Hollander ◽  
Glyn Lewis ◽  
Cecelia Magnusson ◽  
Christina Dalman ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Proportional Hazards ◽  
Bipolar Disorders ◽  
Cox Proportional Hazards ◽  
Migrant Status ◽  
Region Of Origin ◽  
Related Factors ◽  
Increased Risk ◽  
Age At Migration ◽  
National Cohort

Background: We assessed whether risk of various psychotic disorders and non-psychotic bipolar disorder (including mania) varied by migrant status, region of origin, or age-at-migration, hypothesizing that risk would only be elevated for psychotic disorders. Methods: We established a prospective cohort of 1,796,257 Swedish residents born between 1982-97, followed from their 15th birthday, or immigration to Sweden after age 15, until diagnosis, emigration, death, or end of 2011. Cox proportional hazards models were used to model hazard ratios by migration-related factors, adjusted for covariates. Results: All psychotic disorders were elevated among migrants and their children compared with Swedish-born individuals, including schizophrenia and schizoaffective disorder (adjusted hazard ratio [aHR] - migrants: 2.20, 95%CI: 1.96-2.47; aHR-children: 2.00, 95%CI: 1.79-2.25), affective psychotic disorders (aHR-migrant: 1.42, 95%CI: 1.25-1.63; aHR-children: 1.22 95%CI: 1.07-1.40), and other non-affective psychotic disorders (aHR-migrant: 1.97, 95%CI: 1.81-2.14; aHR-children: 1.68, 95%CI: 1.54-1.83). For all psychotic disorders, risks were generally highest in migrants from Africa (i.e. aHR-schizophrenia: 5.24, 95%CI: 4.26-6.45) and elevated at most ages-of-migration. By contrast, risk of non-psychotic bipolar disorders was lower for migrants (aHR: 0.58, 95%CI: 0.52-0.64) overall, and across all ages-of-migration except infancy (aHR: 1.20; 95%CI: 1.01-1.42), while risk for their children was similar to the Swedish-born population (aHR: 1.00, 95%CI: 0.93-1.08). Conclusions: Increased risk of psychiatric disorders associated with migration and minority status may be specific to psychotic disorders, with exact risk dependent on region of origin.

Risk of dementia associated with psychotic disorders in later life: the health in men study (HIMS)

2018 ◽  
Vol 49 (2) ◽  
pp. 232-242 ◽  
Author(s):  
Osvaldo P. Almeida ◽  
Andrew H. Ford ◽  
Graeme J. Hankey ◽  
Bu B. Yeap ◽  
Jonathan Golledge ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
Psychotic Disorders ◽  
Age Of Onset ◽  
Bipolar Disorders ◽  
Later Life ◽  
International Classification Of Diseases ◽  
Renal Diseases ◽  
Increased Risk ◽  
Clinical Diagnoses ◽  
Classification Of Diseases

AbstractBackgroundRecent research has identified several potentially modifiable risk factors for dementia, including mental disorders. Psychotic disorders, such as schizophrenia and delusional disorder, have also been associated with increased risk of cognitive impairment and dementia, but currently available data difficult to generalise because of bias and confounding. We designed the present study to investigate if the presence of a psychotic disorder increased the risk of incident dementia in later life.MethodsProspective cohort study of a community-representative sample of 37 770 men aged 65–85 years who were free of dementia at study entry. They were followed for up to 17.7 years using electronic health records. Clinical diagnoses followed the International Classification of Diseases guidelines. As psychotic disorders increase mortality, we considered death a competing risk.ResultsA total of 8068 (21.4%) men developed dementia and 23 999 (63.5%) died during follow up. The sub-hazard ratio of dementia associated with a psychotic disorder was 2.67 (95% CI 2.30–3.09), after statistical adjustments for age and prevalent cardiovascular, respiratory, gastrointestinal and renal diseases, cancer, as well as hearing loss, depressive and bipolar disorders, and alcohol use disorder. The association between psychotic disorder and dementia risk varied slightly according to the duration of the psychotic disorder (highest for those with the shortest illness duration), but not the age of onset. No information about the use of antipsychotics was available.ConclusionOlder men with a psychotic disorder have nearly three times greater risk of developing dementia than those without psychosis. The pathways linking psychotic disorders to dementia remain unclear but may involve mechanisms other than those associated with Alzheimer's disease and other common dementia syndromes.

At-risk-states for bipolar disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 2099-2099
Author(s):  
P. Conus
Keyword(s):  
At Risk ◽  
Bipolar Disorder ◽  
Psychotic Disorders ◽  
Bipolar Disorders ◽  
Small Sample ◽  
First Episode ◽  
Prodromal Phase ◽  
Ultra High Risk ◽  
Risk Patients ◽  
New Research

Early intervention strategies have been developed over the past 20 years for psychotic disorders and recent studies have proven their efficacy. However, most of the attention has been drawn to schizophrenia, and affective psychoses have been neglected. In the recent past, new research has identified a similar need for earlier intervention in bipolar disorders, and prodrome to bipolar disorder has emerged as a key domain to investigate. Despite the complexity of this issue due to the lack of a clear consensus regarding definitions of the various stages of the disorder, some progress has been made in this domain.Two recent retrospective studies have identified a prodromal phase to first episode mania lasting between 6 and 18 months, and have identified a range of symptoms that occur during this period. It is however likely that on the basis of symptomatic profile, identification of at risk patients would be difficult, considering their low specificity. Two complementary directions have been recently proposed in order to refine such an approach. The first strategy, based on at-risk profiles inspired by the Ultra High Risk concept developed for psychosis, has yielded some promising results on a small sample of patients. The second is based on the combination of identified risk symptoms with both risk factors and markers of vulnerability into a First Episode Mania Prodrome Inventory which is currently under validation.

scholarly journals Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders

2019 ◽  
Vol 50 (4) ◽  
pp. 595-606 ◽  
Author(s):  
Nils Eiel Steen ◽  
Ingrid Dieset ◽  
Sigrun Hope ◽  
Trude S.J. Vedal ◽  
Olav B. Smeland ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Plasma Concentrations ◽  
Bipolar Disorders ◽  
Kynurenine Pathway ◽  
Xanthurenic Acid ◽  
Vanillylmandelic Acid ◽  
Healthy Controls ◽  
Schizophrenia Spectrum Disorders ◽  
Schizophrenia Spectrum ◽  
Metabolic Dysfunctions

AbstractBackgroundWe aimed at exploring potential pathophysiological processes across psychotic disorders, applying metabolomics in a large and well-characterized sample of patients and healthy controls.MethodsPatients with schizophrenia and bipolar disorders (N = 212) and healthy controls (N = 68) had blood sampling with subsequent metabolomics analyses using electrochemical coulometric array detection. Concentrations of 52 metabolites including tyrosine, tryptophan and purine pathways were compared between patients and controls while controlling for demographic and clinical characteristics. Significant findings were further tested in medication-free subsamples.ResultsSignificantly decreased plasma concentrations in patients compared to healthy controls were found for 3-hydroxykynurenine (3OHKY, p = 0.0008), xanthurenic acid (XANU, p = 1.5×10−5), vanillylmandelic acid (VMA, p = 4.5×10−5) and metanephrine (MN, p = 0.0001). Plasma concentration of xanthine (XAN) was increased in the patient group (p = 3.5×10−5). Differences of 3OHKY, XANU, VMA and XAN were replicated across schizophrenia spectrum disorders and bipolar disorders subsamples of medication-free individuals.ConclusionsAlthough prone to residual confounding, the present results suggest the kynurenine pathway of tryptophan metabolism, noradrenergic and purinergic system dysfunction as trait factors in schizophrenia spectrum and bipolar disorders. Of special interest is XANU, a metabolite previously not found to be associated with bipolar disorders.

scholarly journals In vivo amygdala nuclei volumes in schizophrenia and bipolar disorders

2020 ◽  
Author(s):  
Claudia Barth ◽  
Stener Nerland ◽  
Ann-Marie G de Lange ◽  
Laura Anne Wortinger ◽  
Eva Hilland ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Bipolar Disorders ◽  
Analysis Of Covariance ◽  
Intracranial Volume ◽  
Linear Regression Models ◽  
Basal Nucleus ◽  
Basal Nuclei ◽  
Central Nuclei ◽  
The Right

Background: Abnormalities in amygdala volume are well-established in schizophrenia and commonly reported in bipolar disorders. However, the specificity of volumetric differences in individual amygdala nuclei is largely unknown. Methods: Patients with schizophrenia disorders (SCZ, n=452, including schizophrenia, schizoaffective and other psychotic disorders, mean age 30.7±9.2 (SD), females 44.4%), bipolar disorders (BP, n=316, including bipolar I and II, 33.7±11.4, 58.5%) and healthy controls (n=753, 34.1±9.1, 40.9%) underwent T1-weighted magnetic resonance imaging. Total amygdala and nuclei volumes as well as intracranial volume (ICV) were estimated with Freesurfer (v6.0.0). Analysis of covariance and multiple linear regression models, adjusting for age, age2, ICV and sex, were fitted to examine diagnostic group and subgroup differences in volume, respectively. Results: Bilateral total amygdala and all nuclei volumes, except the medial and central nuclei, were significantly smaller in patients relative to controls. The largest effect sizes were found for the basal nucleus, accessory basal nucleus and cortico-amygdaloid transition area (partial η2 > 0.02). The diagnostic subgroup analysis showed that reductions in amygdala nuclei volume were most widespread in schizophrenia, with the lateral, cortical, paralaminar and central nuclei being solely reduced in this disorder. The right accessory basal nucleus was marginally smaller in SCZ relative to BP (t = 2.32, p = 0.05). Conclusions: Our study is the first to demonstrate distinct patterns of amygdala nuclei volume reductions in a well-powered sample of patients with schizophrenia and bipolar disorders. Volume differences in the basolateral complex (lateral, basal, accessory basal nuclei) may be putative neuroimaging markers for differentiating schizophrenia and bipolar disorders.

scholarly journals Oral health in individuals with psychotic disorders

2008 ◽  
Vol 55 (2) ◽  
pp. 115-121 ◽  
Author(s):  
Svetlana Jovanovic ◽  
Ivanka Gajic
Keyword(s):  
Health Care ◽  
Oral Health ◽  
Oral Hygiene ◽  
Psychotic Disorders ◽  
Care Service ◽  
Dental Health ◽  
Health Care Service ◽  
Bipolar Disorders ◽  
Oral Diseases ◽  
Antipsychotic Therapy

Mental disorders are an important problem in every national health care service. The importance of psychotic disorders is not only their frequency but also their long-term character, recurrence, association with other diseases, costs and consequences for the family and society. Psychotic disorders (schizophrenia, schizoaffective disorder, bipolar disorders and depression) and their treatment may result in serious oral diseases. These disorders and medications used to treat them may lead to a series of oral complications and side effects, predominantly high prevalence of carious and extracted teeth, periodontal disease, inadequate oral hygiene, xerostomia, burning mouth syndrome, bad breath and gustatory sense dysfunction. Psychotic disorders affect oral and dental health in two ways. Behavioral changes affect the oral hygiene maintenance and lead to bad habits and attitudes towards oral health. Antipsychotic therapy has adverse effects on oral health. Literature data suggest that oral health in patients with psychotic disorders is poor and highlight the need to develop specific preventive programmes, which would be aimed at improving behavior of this population at risk in the oral health care system.

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