Study to find corellation and Severity of Diabetic Retinopathy and Central Corneal Thickness Changes

The purpose of the study was to evaluate central corneal thickness in diabetic patients and to compare the results with controls without diabetes mellitus. Sixty-five diabetic patients (65 eyes) constituted the study group, and 50 eyes were from the healthy control group (50 non-diabetic patients). The study group was subdivided into group 1 (no diabetic retinopathy, n = 35), group 2 (mild to moderate nonproliferative diabetic retinopathy, n = 20), and group 3 (proliferative diabetic retinopathy, n = 10). Central corneal thickness measurements in microns were determined using ultrasound pachymetry. The mean central corneal thickness was significantly greater in the study group (567.14 μm ± 14.63 μm) than in the control group (531.14 μm ± 5 μm). In addition, the mean central corneal thickness was found to be greater in group 3 (577 μm ± 12 μm) than in groups 1 (562 μm ± 13 μm) and 2 (566.86 μm ± 15 μm), but the difference did not reach statistical significance. We found that the mean central corneal thickness for diabetic patients was thicker than that of the healthy controls. Thicker central corneas associated with diabetes mellitus should be taken into consideration when obtaining accurate intraocular pressure measurements in diabetics.

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Relationship of Central Corneal Thickness with the Status of Diabetic Retinopathy and Level of HbA1C in Diabetic Patients

10.53350/pjmhs2115123387 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3387-3389

Author(s):

Iftikhar , Ahmad ◽

Fatima Akbar Shah ◽

Muhammad Abid Javed ◽

Muhammad Ahsen ◽

Hafiz Huzaifa Akhlaq ◽

...

Keyword(s):

Visual Acuity ◽

Diabetic Retinopathy ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Diabetic Patients ◽

Type 2 Dm ◽

The Status ◽

The Mean ◽

Relationship Of

Study Objectives: To determine the relationship of central corneal thickness with the status of diabetic retinopathy and level of HbA1c in diabetic patients. Study Design and Settings: Department of Ophthalmology, Allied Hospital/DHQ Hospital, Faisalabad Pakistan from Jan 2021 to June 2021. Patients and Methods: Out of the patients visiting OPD, 100 patients with clinically diagnosed type 2 DM which satisfied the range of selected standards and offered written informed agreement were involved in the research with the use of simple random sampling. Snellen’s visual acuity chart for distance vision and Jaeger’s chart for near vision were used to determine the best-corrected visual acuity. Wet Refraction and axial length was measured using A-scan. Goldmann applanation tonometry was used to measure the intraocular pressure. Results of the Study: In this research sixty two percent of the patients were men and thirty eight percent patients were women. Total 84 patients had type 2 DM of duration 5-10 years, and the remaining 16 patients had diabetes for over 10 years. Total 35 patients had HbA1c between 4-5.6%, 31 patients had HbA1c between 5.7- 6.5% and 34 patients had HbA1c ≥ 6.5%. From 100 patients with Diabetes Mellitus Type 2, 21 patients had no diabetic retinopathy, 28 patients had very minor and minor NPDR, 25 patients had average NPDR, 19 patients had critical and very acute NPDR and 7 patients had PDR. The mean HbA1c in patients with no diabetic retinopathy was 5.05%. The mean HbA1c in patients having minor and very little NPDR remained 5.64%. The mean HbA1c in patients with moderate NPDR was 6.36%. The mean HbA1c in patients with critical and very acute NPDR was 8.26%. The mean HbA1c in patients with severe PDR was 9.86%. This was a statistically significant survey (P-value = 0.01). Conclusion: This study showed a strong correlation between the central corneal thickness to the severity of diabetic retinopathy and HbA1c levels emphasizes the importance of evaluation of corneal endothelial morphology in the early screening and diagnosis of microvascular complications of DM Keywords: Central Corneal Thickness, Diabetic Retinopathy, HbA1c

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Central Corneal Thickness in Diabetics and its Relation with Severity of Diabetic Retinopathy and Hyperglycemia Assessed by Glycosylated Hemoglobin in Central India

International Journal of Current Research and Review ◽

10.31782/ijcrr.2021.13922 ◽

2021 ◽

Vol 13 (09) ◽

pp. 40-45

Author(s):

Eva Rani Tirkey ◽

Neha Adlakha ◽

Charudatt Chalisgaonkar ◽

Kailash Khairnar

Keyword(s):

Diabetic Retinopathy ◽

Central Corneal Thickness ◽

Glycosylated Hemoglobin ◽

Corneal Thickness ◽

Central India

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Comparative study of the central corneal thickness in healthy individuals and diabetic patients with and without retinopathy using anterior segment optical coherence tomography

QJM ◽

10.1093/qjmed/hcab109.012 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Tamer F El-Mekkawi ◽

Hazem O Rashed ◽

Hisham S. Saad Eldin ◽

Hagar M Faisal

Keyword(s):

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Comparative Study ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Anterior Segment ◽

Diabetic Patients ◽

Optical Coherence ◽

Chronic Hyperglycemia ◽

Significant Difference

Abstract Background Chronic hyperglycemia in diabetes mellitus causes different morphologic and functional corneal changes. Aim of the Work to assess the central corneal thickness in diabetic patients with and without diabetic retinopathy using anterior segment optical coherence tomography. Patients and Methods This comparative study was conducted at Ain Shams University hospitals . It included 45 eyes divided into three groups: Group A: 15 eyes of diabetic patients without diabetic retinopathy , Group B: 15 eyes of diabetic patients with diabetic retinopathy and Group C: 15 eyes of non-diabetic individuals. Results : The mean CCT in diabetic patients without diabetic retinopathy was 551.13µ ± 37.93 with range 475-622. Diabetics with retinopathy was 558.93µ ± 39.32 with range 508-618 and non diabetics 534.73µ ± 33.67 with range 475-588. There was no significant difference in corneal thickness between the three groups (p = 0.201) Conclusion : Diabetic corneas tended to be thicker though this was not statistically significant in our work.

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Panretinal photocoagulation laser in diabetic retinopathy patients

10.53350/pjmhs211561820 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1820-1823

Author(s):

Farshad Ostadian ◽

Fereydoun Farrahi ◽

Bahman Cheraghian

Keyword(s):

Diabetic Retinopathy ◽

Endothelial Cell ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Corneal Endothelial Cell ◽

Diabetic Patients ◽

Panretinal Photocoagulation ◽

Double Frequency ◽

Frequency Laser ◽

Photocoagulation Laser

Background: It was reported that corneal endothelial cell depletion is a complication of the retinal laser. In this study, the effect of panretinal laser on corneal endothelium was investigated. Method: A group consisting of 47 eyes of 47 Diabetic patients who need a panretinal photocoagulation laser was compared with another group of 47 diabetic patients who did not require a laser. The patient's age was chosen in the range of 50-70 and the tools included Ellex double frequency LASER, Specular microscopy, Pachymetry, and Condense Lens 90. Time course of coefficient of variation, endothelial cell density, hexagonal cells and central corneal thickness were evaluated. ANOVA, Dennett's, and Mann-Whitney test was used to compare the data. P-value of <0.05 was considered statistically significant. Results: We found no significant differences in age, gender between the two groups. There was no significant differences in hexagonal cells, coefficient of variation, endothelial cell density and central corneal thickness between the two groups at any time points. Conclusion: This study suggests that the "panretinal photocoagulation laser" conserves corneal endothelial cells of subsequent damage in diabetic retinopathy patients Keywords: photocoagulation laser, corneal, endothelial cell, argon laser, double frequency laser.

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Diabetic Retinopathy and Central Corneal Thickness

Journal of Ophthalmology & Clinical Research ◽

10.33140/jocr.03.03.01 ◽

2019 ◽

Vol 3 (3) ◽

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Diabetic Patients ◽

Type I ◽

Type Ii ◽

The Mean

Background: Diabetes mellitus (DM) is a metabolic disease that can lead to many ocular complications such as increased Central Corneal Thickness (CCT), cataracts, and diabetic retinopathy. The aim of this study was to compare the CCT between subjects with type I and type II diabetes. Method: This was a retrospective study which included subjects with diabetes (with and without Diabetic Retinopathy (DR)) aged between 18 to 80 years old. The data collected were type and duration of diabetes mellitus, diabetes treatment, glycated hemoglobin level, visual acuity, CCT, and intra ocular pressure. Subjects were divided into subgroup (with and without DR). Statistical program (SPSS) was used to compare the central corneal thickness between the groups. Result: A total of 205 subjects with type I (n=100) and type II (n=105) diabetes were included in this study. In type 1 DM, the mean CCT was 547.06±27.3 microns in patients with diabetic retinopathy (DR) and 533.85±26.8 microns in patients without DR. In type 2 DM, the mean CCT was 542.85±39.3 microns in patients with DR and 532.44±27.4 microns in patients without DR. The CCT in type 1 diabetic patients was higher in both groups (with and without DR) than the CCT in type 2 diabetic patients in both groups (with and without DR). However, this was not statistically significant. Conclusion: The type of diabetes mellitus did not affect CCT. The presence of diabetic retinopathy in either type I or type II diabetes mellitus can affect the measurements of CCT.

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The Effect of Diabetes Mellitus on Corneal Endothelial Cells and Central Corneal Thickness: A Case-Control Study

Ophthalmic Research ◽

10.1159/000507197 ◽

2020 ◽

Vol 63 (6) ◽

pp. 550-554

Author(s):

Panagiota Papadakou ◽

Irini Chatziralli ◽

Miltiadis Papathanassiou ◽

Vaia Lambadiari ◽

Charalambos S. Siganos ◽

...

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Endothelial Cell ◽

Cell Density ◽

Corneal Endothelium ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Endothelial Cell Density ◽

Corneal Endothelial Cells ◽

Factors Affecting

Purpose: The aim of this study was to evaluate the characteristics of corneal endothelial cells and central corneal thickness (CCT) in patients with diabetes mellitus (DM), comparing them with those of healthy subjects (controls) and to determine potential factors affecting the corneal parameters in patients with DM. Methods: Participants in this study were 72 patients with DM and 88 healthy controls. Diabetic patients were further classified into groups depending on the severity of diabetic retinopathy (no retinopathy, mild, moderate, severe non-proliferative diabetic retinopathy, and proliferative diabetic retinopathy). All participants underwent non-contact specular microscopy to evaluate corneal endothelium parameters and CCT, while factors affecting endothelial cell density and CCT in patients with DM were also analyzed. Results: Patients with DM presented significantly decreased endothelial cell density compared to controls (2,297.9 ± 311.3 and 2,518.3 ± 243.7 cells/mm2, respectively; p < 0.001), while the two groups did not differ significantly in any other measured corneal parameter. In the diabetic group, the multivariate analysis showed a significant association between decreased endothelial cell density and increased HbA1c (p < 0.001), longer DM duration (p = 0.003), and more severe diabetic retinopathy status (p = 0.008). Conclusion: DM seems to affect the corneal endothelium, since endothelial cell density was decreased in the diabetic group, while duration of disease, HbA1c levels, and severity of retinopathy were significantly associated with changes in endothelial cell density and should be taken into account.

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