Clinical observation of a patient with thrombotic thrombocytopenic purpura with renal and intestinal lesions

2019 ◽  
Vol 91 (7) ◽  
pp. 106-110
Author(s):  
A G Stolyar ◽  
P V Avdonin ◽  
I E Valamina ◽  
E S Stolyarevich
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombotic Microangiopathy ◽  
Clinical Observation ◽  
Pathological Process ◽  
Thrombocytopenic Purpura ◽  
Intestinal Lesions ◽  
The Central Nervous System ◽  
Genetic Form

The article presents a brief description of a rare disease - thrombotic thrombocytopenic purpura (Moshkovits - disease), which is based on the deficiency of ADAMTS-13 metalloproteinase, leading to the development of thrombotic microangiopathy with the defeat of vital organs. The article also describes the clinical observation of a patient with the Moshkovits - disease. The features of the above observation are involvement in the pathological process of the kidneys and intestines, while in the classical descriptions of the disease there is a predominant lesion of the Central nervous system, as well as the genetic form of the disease.

scholarly journals A RARE PRESENTATION OF ATRIAL FIBRILLATION AND THROMBOTIC MICROANGIOPATHY, (THROMBOTIC THROMBOCYTOPENIC PURPURA - TTP) CAUSED BY ALCOHOL AND PRODUCTS OF CANNABIS (MARIJUANA)

2022 ◽  
Vol 54 (4) ◽  
pp. 373-376
Author(s):  
Samar Iltaf ◽  
Saira Awan ◽  
Saira Abbas ◽  
Salma Salman ◽  
Shariq Mirza
Keyword(s):  
Atrial Fibrillation ◽  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombotic Microangiopathy ◽  
Rare Presentation ◽  
Thrombocytopenic Purpura

Cannabis used as both for medicine as well as recreational purposes. Extensive use is associated with many documented central nervous system and hepatic manifestation. How-ever only few cases are reported in literature with cardiac and hematological manifestation. Our case report is one of its kinds where our patient presents with thrombotic thrombocytopenic purpura and atrial fibrillation and he required extensive treatment including plasmapharesis.

scholarly journals The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs

2019 ◽  
Vol 2019 ◽  
pp. 1-19 ◽  
Author(s):  
Chaoran Chen ◽  
Xiang Zhou ◽  
Jialiang He ◽  
Zhenxing Xie ◽  
Shufang Xia ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Vital Role ◽  
Pathological Process ◽  
Peripheral Organs ◽  
Multiple Organs ◽  
Long Time ◽  
The Central Nervous System

Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs. A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications. γ-Aminobutyric acid (GABA) has been known as a marker in I/R injury of the central nervous system (mainly in the brain) for a long time, and it may play a vital role in the occurrence of I/R injury. It has been observed that throughout cerebral I/R, levels, syntheses, releases, metabolisms, receptors, and transmissions of GABA undergo complex pathological variations. Scientists have investigated the GABAergic enhancers for attenuating cerebral I/R injury; however, discussions on existing problems and mechanisms of available drugs were seldom carried out so far. Therefore, this review would summarize the process of pathological variations in the GABA system under cerebral I/R injury and will cover corresponding probable issues and mechanisms in using GABA-related drugs to illuminate the concern about clinical illness for accurately preventing cerebral I/R injury. In addition, the study will summarize the increasing GABA signals that can prevent I/R injuries occurring in peripheral organs, and the roles of GABA were also discussed correspondingly.

CXCL12/CXCR4/CXCR7 Chemokine Axis in the Central Nervous System: Therapeutic Targets for Remyelination in Demyelinating Diseases

2017 ◽  
Vol 23 (6) ◽  
pp. 627-648 ◽  
Author(s):  
Tianci Chu ◽  
Lisa B. E. Shields ◽  
Yi Ping Zhang ◽  
Shi-Qing Feng ◽  
Christopher B. Shields ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Vital Role ◽  
Pathological Process ◽  
Demyelinating Diseases ◽  
Myelin Repair ◽  
Chemokine Cxcl12 ◽  
The Central Nervous System ◽  
Oligodendrocyte Precursor ◽  
Oligodendrocyte Development

The chemokine CXCL12 plays a vital role in regulating the development of the central nervous system (CNS) by binding to its receptors CXCR4 and CXCR7. Recent studies reported that the CXCL12/CXCR4/CXCR7 axis regulates both embryonic and adult oligodendrocyte precursor cells (OPCs) in their proliferation, migration, and differentiation. The changes in the expression and distribution of CXCL12 and its receptors are tightly associated with the pathological process of demyelination in multiple sclerosis (MS), suggesting that modulating the CXCL12/CXCR4/CXCR7 axis may benefit myelin repair by enhancing OPC recruitment and differentiation. This review aims to integrate the current findings of the CXCL12/CXCR4/CXCR7 signaling pathway in the CNS and to highlight its role in oligodendrocyte development and demyelinating diseases. Furthermore, this review provides potential therapeutic strategies for myelin repair by analyzing the relevance between the pathological changes and the regulatory roles of CXCL12/CXCR4/CXCR7 during MS.

Thrombotic microangiopathy isolated to the central nervous system

1991 ◽  
Vol 30 (6) ◽  
pp. 843-846 ◽  
Author(s):  
Ted M Dawson ◽  
Ehud Lavi ◽  
Eric C. Raps ◽  
Herbert I. Goldberg
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Thrombotic Microangiopathy ◽  
The Central Nervous System

scholarly journals VARIANT OF HERPES-ASSOCIATED DEMYELINATIONWITH MULTIPLE SCLEROSIS SYNDROME

2015 ◽  
Vol 7 (4) ◽  
pp. 101-104
Author(s):  
S V Lobzin ◽  
V I Golovkin ◽  
M V Fomintseva ◽  
E A Yurkina ◽  
I I Kula
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Clinical Observation ◽  
Herpes Viruses ◽  
The Central Nervous System ◽  
Demyelinating Process

The article presents its own clinical observation of the аssociation of neurotropic herpes viruses with demyelinating process in the central nervous system. An in-depth immunological and immunogenetic examination is carried out as an etiologic and pathogenetic diagnosis.

scholarly journals Biological Chemistry in Intermediate Lipid Metabolism Disorder

2019 ◽  
Vol 70 (7) ◽  
pp. 2647-2651
Author(s):  
Alina Plesea Condratovici ◽  
Alina Mihaela Elisei ◽  
Decebal Vasincu ◽  
Iulian Dan Cuciureanu ◽  
Aurel Nechita ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Abdominal Cavity ◽  
Intestinal Wall ◽  
Pathological Process ◽  
The Body ◽  
Lipid Metabolism Disorder ◽  
Fat Deposits ◽  
The Central Nervous System

Any pathological process is accompanied by quantitative and qualitative changes in metabolism, which is the main form of life manifestation. Metabolism disorders (it is the permanent exchange of substances between the body and the environment) arise if the activity of the central nervous system is affected; the trophic function of the nervous system directs nutrition and metabolism. In this function, the coordinating role belongs to the central nervous system and is made by means of the endocrine glands. Lipids introduced into the body are digested mainly with the help of the pancreatic and intestinal juice and are resorbed through the walls of the small intestine. Even in the intestinal wall, the re-synthesis of fatty acids and glycerine fat occurs. A certain amount of neutral fat is probably resorbed without being split into fatty acids and glycerine. Fats are mainly resorbed through the lymphatic system, in part (about 30%) by means of the portal vein system; the entire fat emulsion penetrates into the blood and its main mass is deposited in certain fat deposits: the adipose subcutaneous cell tissue, the epiploon and the mesenterium of the abdominal cavity, as well as in the fatty layers of the various organs. In fat deposits, processes of lipid formation from carbohydrates and of transformation of higher fatty acids can occur. Lipids from fat deposits are subject to oxidation, especially at the liver level.

scholarly journals REVIEW ON ELECTROENCEPHALOGRAPHIC FINDINGS IN PATIENTS WITH ALZHEIMER'S DISEASE

2021 ◽  
Vol 27 (1) ◽  
pp. 3529-3533
Author(s):  
Ivan Todorov ◽  
◽  
Kosta Kostov ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Impairment ◽  
Low Cost ◽  
The Elderly ◽  
Pathological Process ◽  
The Central Nervous System ◽  
Progressive Cognitive Impairment

Nowadays, with the constant enhancement of the longevity of the human population, the spreading of dementia is in steady rising. Among the many different sources of progressive cognitive impairment, Alzheimer's disease plays a major role being the most common reason for mental decline in the elderly population. Alzheimer's disease is a neurodegenerative disease of the central nervous system that leads to progressive cognitive impairment and has severe health, social and economic tolls. The lack of effective treatment and the problems of the daily living that the disease creates for the patients and their families raises many important issues in modern times. Due to the effect on the individuals and the need for a permanent caregiver, it is of high importance to have accessible tools for early diagnostic and assessment of the ongoing treatment. Electroencephalography is a noninvasive, easily reproductive diagnostic method with low cost that can be performed in different stages of the diseases of the central nervous system and give input on the current condition. This review presents the current achievements in the field of the usage of electroencephalography and its specific findings in patients with Alzheimer's disease and the qualitative and quantitative changes that appears and are important for early diagnosis, differential diagnostic, prediction of acceleration of the pathological process, distinguishing of co-existing conditions and follow-up of the effect of the administered treatment.

CHANGES OF PSYCHOMOTOR DEVELOPMENT IN CHILDREN WITH PERINATAL BRAIN HYPOXIA

2020 ◽  
Vol 3 (1) ◽  
pp. 35-37
Author(s):  
Saodat Igamova ◽  
◽  
Aziza Djurabekova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Environmental Factors ◽  
Pathological Process ◽  
The Body ◽  
Psychomotor Development ◽  
Predisposing Factor ◽  
Root Cause ◽  
The Central Nervous System

The central nervous system is the main mechanism that determines the nature of the reactivity and adaptation of the body to a set of environmental factors. At the same time, autonomic imbalance acts as the root cause of the pathological process or asa predisposing factor, and it is advisable to use the cardiovascular system as an indicator of neurohumoral regulationits reactions are associated with the activity of the central nervous system, autonomic nervous system and subcortical centers

scholarly journals Astrogliopathy in Tauopathies

Neuroglia ◽  
2018 ◽  
Vol 1 (1) ◽  
pp. 126-150 ◽  
Author(s):  
Isidro Ferrer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Glial Cells ◽  
Neuronal Damage ◽  
Pathological Process ◽  
Loss Of Function ◽  
System Integrity ◽  
The Central Nervous System ◽  
Astrocytic Plaques ◽  
Complex Scenario

Astrocytes are involved in many diseases of the central nervous system, not only as reactive cells to neuronal damage but also as primary actors in the pathological process. Astrogliopathy is a term used to designate the involvement of astrocytes as key elements in the pathogenesis and pathology of diseases and injuries of the central nervous system. Astrocytopathy is utilized to name non-reactive astrogliosis covering hypertrophy, atrophy and astroglial degeneration with loss of function in astrocytes and pathological remodeling, as well as senescent changes. Astrogliopathy and astrocytopathy are hallmarks of tauopathies—neurodegenerative diseases with abnormal hyper-phosphorylated tau aggregates in neurons and glial cells. The involvement of astrocytes covers different disease-specific types such as tufted astrocytes, astrocytic plaques, thorn-shaped astrocytes, granular/fuzzy astrocytes, ramified astrocytes and astrocytes with globular inclusions, as well as others which are unnamed but not uncommon in familial frontotemporal degeneration linked to mutations in the tau gene. Knowledge of molecular differences among tau-containing astrocytes is only beginning, and their distinct functional implications remain rather poorly understood. However, tau-containing astrocytes in certain conditions have deleterious effects on neuronal function and nervous system integrity. Moreover, recent studies have shown that tau-containing astrocytes obtained from human brain tauopathies have a capacity for abnormal tau seeding and spreading in wild type mice. Inclusive conceptions include a complex scenario involving neurons, glial cells and local environmental factors that potentiate each other and promote disease progression in tauopathies.

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