Association of rs3025058 polymorphism with the development of stroke in patients with cardiovascular pathology

Aim.To study the association of single-nucleotide polymorphismrs3025058(5а/6а) with the development of stroke in patients of the East Siberian population with cardiovascular pathology and risk factors for its development. Materials and methods.The study involved 260 patients with stroke (age [57.0; 51.062.0]) and 272 patients of the control group (age [55.0; 51.062.0]). Among the patients who underwent stroke, 157 men and 103 women. The control group included 170 men and 102 women. The examination of the main group included: collection of complaints, anamnesis, clinical examination, computed tomography of the brain, electrocardiography, echocardioscopy, ultrasound duplex scanning of the extracranial brachiocephalic arteries, 24-hour monitoring of blood pressure and heart rate, analysis of the blood coagulation system. The patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of extracranial brachiocephalic arteries, disorders of the hemostasis system. The control group was examined within the framework of the international project HAPIEE. Molecular genetic research was carried out by real-time PCR. Statistical processing of the material was carried out using the Statistica for Windows 7.0, Excel and SPSS 22 application software. Results.The study established statistically significant associations between the 5a/5a genotype and the 5a allele and stroke in the general group of patients, as well as in the subgroup of men, subgroups of patients with extracranial brachiocephalic arteries atherosclerosis and dyslipidemia. In the subgroup of patients with cardiac arrhythmias, statistically significant results were obtained only for allele 5a, and in the subgroup of women with stroke, subgroups of patients with arterial hypertension and hypercoagulation, no significant associations ofrs3025058(5a/6a) polymorphism with stroke were found. Conclusion.Genotype 5a/5a and allele 5a of the single-nucleotide polymorphismrs3025058(5а/6а) increase the risk of stroke in individuals from the East Siberian population, including those in the presence of such risk factors as extracranial brachiocephalic arteries atherosclerosis and dyslipidemia.

Download Full-text

Association of rs3025058 polymorphism with the development of acute cerebrovascular event

European Heart Journal ◽

10.1093/eurheartj/ehab724.2052 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

A Chernova ◽

S Nikulina ◽

D Nikulin

Keyword(s):

Risk Factors ◽

Genetic Research ◽

Statistical Processing ◽

Main Group ◽

Control Group ◽

Cerebrovascular Event ◽

Siberian Population ◽

Cardiovascular Pathology ◽

Daily Monitoring ◽

Arterial Blood

Abstract Purpose To study SNP rs3025058 association (5a/6a) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results In all analyzed groups and subgroups of patients statistically significant connection between a genotype of 5a/5a and an allele of 5a and in subgroup of women with Acute Cerebrovascular Event, subgroups of patients with AG and hypercoagulation of significant associations of polymorphism rs3025058 (5a/6a) with Acute Cerebrovascular Eventis not revealed. Conclusion A genotype 5a/5a and an allele 5a SNP rs3025058 (5a/6a) increase risk of development of an Acute Cerebrovascular Event in persons of the east Siberian population, including with such risk factors as atherosclerosis the brachiocephalic of arteries and a dislipidemiya. FUNDunding Acknowledgement Type of funding sources: None.

Download Full-text

Association of rs556621 Polymorphism with Development of Stroke in Patients with Cardiovascular Pathology

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2019-15-5-634-640 ◽

2019 ◽

Vol 15 (5) ◽

pp. 634-640

Author(s):

S. Yu. Nikulina ◽

V. A. Shulman ◽

A. A. Chernova ◽

S. V. Prokopenko ◽

D. A. Nikulin ◽

...

Keyword(s):

Single Nucleotide Polymorphism ◽

Arterial Hypertension ◽

Main Group ◽

Lipid Lowering ◽

Control Group ◽

Nucleotide Polymorphism ◽

Single Nucleotide ◽

Cardiovascular Pathology ◽

Supraventricular Tachycardias ◽

Brachiocephalic Arteries

Aim. To study the association of single nucleotide polymorphism rs556621 (G> T) with development of stroke in patients of the East Siberian population with cardiovascular pathology and risk factors.Material and methods. The study involved 260 patients (157 men and 103 women) with stroke (mean age 57.0 [51.0-62.0]) and 272 patients (170 men and 102 women) of the control group (mean age 55.0 [51.0-62.0]). The examination of the main group included: collection of complaints, anamnesis, clinical examination, computed tomography of the brain, electrocardiography, echocardioscopy, ultrasound duplex scanning of extracranial brachiocephalic arteries, daily blood pressure and heart rate monitoring, analysis of the blood coagulation system. The patients of the main group have arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of the brachiocephalic arteries, disorders of the hemostatic system. The control group was studied in the framework of the HAPIEE international project. Molecular genetic research was performed by real-time polymerase chain reaction.Results. There were no statistically significant differences in the frequencies of genotypes and single nucleotide polymorphism rs556621 alleles (G>T) in the subgroup of patients with stroke and those in the control group. The frequency of the rare TT genotype among patients with stroke was 13.3%±4.16, among healthy individuals – 8.8±3.37% (p=0.1). Gender differences when comparing the frequencies of genotypes and alleles were also not detected (p>0.05). The frequencies of the TT genotype were approximately the same in the subgroup of patients with arterial hypertension (13.1%±4.22) and in the control group (7.4±5.25%; p>0.05). No significant differences were observed in the frequencies of the rare genotype of the studied polymorphism in the subgroup of patients with supraventricular tachycardias (20.0±14.37%), hypercoagulability (15.9±7.64%) and the control group (8.8±3.37%), p>0.05. A statistically significant relationship was found between the rare genotype TT of single nucleotide polymorphism rs556621 (G>T) and the development of stroke in patients with dyslipidemia and atherosclerotic lesions of the coronary arteries (p=0.041; odds ratio 1.86, 95% confidence interval 1.02-3.41).Conclusion. The genotype of TTs of single nucleotide polymorphism rs556621 (G> T) increases the risk of developing stroke in patients with dyslipidemia and atherosclerosis of the brachiocephalic arteries compared with carriers of the GG and GT genotypes. The obtained data are recommended to be considered when prescribing lipid-lowering and antithrombotic therapy.

Download Full-text

Association of rs10507391 polymorphism with the development of acute cerebrovascular event

European Heart Journal ◽

10.1093/eurheartj/ehab724.2051 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

A Chernova ◽

S Nikulina ◽

D Nikulin

Keyword(s):

Risk Factors ◽

Arterial Hypertension ◽

Genetic Research ◽

Statistical Processing ◽

Main Group ◽

Control Group ◽

Cerebrovascular Event ◽

Cardiovascular Pathology ◽

Arterial Blood ◽

Increased Risk

Abstract Purpose To study SNP rs10507391 association (A> T) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results When studying SNP rs10507391 association (A> T) connection between a rare genotype of a TT and an allele of T and the increased risk of Acute Cerebrovascular Event is established with development of Acute Cerebrovascular Event in all analyzed groups and subgroups of patients. Conclusion A genotype of a TT and an allele of T of SNP rs10507391 (A> T) increases risk of development of an acute disorder of cerebral circulation in patients regardless of the previous cardiovascular pathology and risk factors, including at patients with arterial hypertension, supraventricular tachyarrhythmias, atherosclerosis the brachiocephalic of arteries, disturbance of lipidic exchange and the system of a hemostasis. FUNDunding Acknowledgement Type of funding sources: None.

Download Full-text

Association of 12204590 polymorphism with the development of acute cerebrovascular event

European Heart Journal ◽

10.1093/eurheartj/ehab724.2048 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

A Chernova ◽

S Nikulina ◽

D Nikulin

Keyword(s):

Risk Factors ◽

Arterial Hypertension ◽

Genetic Research ◽

Statistical Processing ◽

Main Group ◽

Control Group ◽

Cerebrovascular Event ◽

General Group ◽

Cardiovascular Pathology ◽

Arterial Blood

Abstract Purpose To study SNP rs12204590 (T > A) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results The connection of the genotype of TA SNP rs12204590 (T > A) with the development of Acute Cerebrovascular Event in a general group of patients was confirmed, but no statistically significant associations were obtained when patients were divided into subgroups depending on cardiovascular pathology and risk factors. Conclusion The genotype of TA SNP rs12204590 (T > A), compared to the genotypes of TT and AA, reduces the risk of developing Acute Cerebrovascular Event, including in patients with arterial hypertension. The genotype of AA SNP rs12204590 (T > A) increases the risk of developing Acute Cerebrovascular Event in males. FUNDunding Acknowledgement Type of funding sources: None.

Download Full-text

Association of rs11196288 polymorphism with the development of acute cerebrovascular event

European Heart Journal ◽

10.1093/eurheartj/ehab724.2050 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

A Chernova ◽

S Nikulina ◽

D Nikulin

Keyword(s):

Risk Factors ◽

Genetic Research ◽

Statistical Processing ◽

Main Group ◽

Control Group ◽

Cerebrovascular Event ◽

Siberian Population ◽

Cardiovascular Pathology ◽

Daily Monitoring ◽

Arterial Blood

Abstract Purpose To study SNP rs11196288 (A> G) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results As a result of the conducted research in one of the analyzed groups and subgroups statistically significant associations of genotypes and alleles of polymorphism of rs11196288 were not revealed (A> G) with Acute Cerebrovascular Event. Conclusion SNP rs11196288 (A> G) has no significant effect on development of Acute Cerebrovascular Event in persons of the east Siberian population regardless of the previous cardiovascular pathology and risk factors. FUNDunding Acknowledgement Type of funding sources: None.

Download Full-text

Allelic variants of rs1800801 polymorphism in patients with stroke

Cardiosomatics ◽

10.26442/22217185.2019.4.190608 ◽

2019 ◽

Vol 10 (4) ◽

pp. 29-33

Author(s):

Svetlana Yu. Nikulina ◽

Vladimir A. Shulman ◽

Anna A. Chernova ◽

Semen V. Prokopenko ◽

Dmitrii A. Nikulin ◽

...

Keyword(s):

Risk Factors ◽

Molecular Genetic ◽

Statistical Processing ◽

Control Group ◽

Siberian Population ◽

Single Nucleotide ◽

Cardiovascular Pathology ◽

Genetic Examination ◽

Supraventricular Tachycardias ◽

Application Programs

Aim. To study the association of single nucleotide polymorphism (SNP) rs556621 (G>T) with the development of stroke in patients of the East Siberian population with cardiovascular pathology and risk factors. Material and methods. The study involved 260 patients with stroke (157 men and 103 women) and 272 patients of the control group (170 men and 102 women). The following cardiovascular pathology and risk factors were present in the patients of the main group: arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of the brachiocephalic arteries, disorders of the hemostatic system. All patients underwent clinical, instrumental and molecular genetic examination. Statistical processing of the material was carried out using the set of application programs Statistica for Windows 7.0, Excel and SPSS 22. Results. As a result of the study, no statistically significant associations of genotypes and alleles of the rs1800801 polymorphism (C>T) with stroke were found in any of the analyzed groups and subgroups. Conclusion. SNP rs1800801 (C>T) does not have a significant effect on the development of stroke in people of the East Siberian population, regardless of the preceding cardiovascular pathology and risk factors.

Download Full-text

Optimization of tactics of auxiliary genesial technologies at married couples with the burdened genetic anamnesis

HEALTH OF WOMAN ◽

10.15574/hw.2018.134.103 ◽

2018 ◽

pp. 103-106

Author(s):

O.S. Darii ◽

Keyword(s):

Risk Factors ◽

Correlation Analysis ◽

Clinical Laboratory ◽

Genetic Research ◽

Married Couples ◽

Control Group ◽

Scientific Justification ◽

Sterility Treatment ◽

Laboratory Tool ◽

And Control

The objective: rising of efficiency of treatment of sterility at married couples with the burdened genetic anamnesis on the basis of scientific justification and introduction of advanced algorithm of prognostic and treatment-and-prophylactic actions. Materials and methods. For the purpose of detection of risk factors of development of sterility and carrying out the correlation analysis were allocated the main group – 100 married couples with sterility in the anamnesis and control group of patients who had labors (n=100) in the anamnesis. The complex of the conducted researches included clinical, laboratory, tool and statistical methods of research. Results. Rising of efficiency of treatment of sterility at married couples with the burdened genetic anamnesis requires carrying out medicogenetic consultation with simultaneous planned preimplantation genetic research in programs of auxiliary genesial technologies. At a choice of this or that method of auxiliary genesial technologies at women with the burdened genetic anamnesis it is necessary to use a technique at which one spermatozoon is entered into an oocyte cytoplasma by means of equipment of a micromanipulation. In the program of training of doctors the obstetrician-gynecologists and urologists of an out-patient link it is necessary to loop thematic improvement concerning sterility treatment at married couples with use of auxiliary genesial technologies. Conclusion. Results of the conducted researches testify to need of rising of efficiency of auxiliary genesial technologies at married couples with the burdened genetic anamnesis. Use by our algorithm of prognostic and treatment-and-prophylactic actions allows to increase efficiency of auxiliary genesial technologies at married couples with the burdened genetic anamnesis for 26.7%. Key words: sterility at married couples, the auxiliary genesial technologies, the burdened genetic anamnesis.

Download Full-text

BIOMARKERS OF OSTEO-DEFFICIENCY IN THE COURSE OF SECONDARY OSTEOPOROSIS IN PATIENTS WITH COMORBID CHRONIC PANCREATITIS AND ARTERIAL HYPERTENSION

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії ◽

10.31718/2077-1096.20.4.16 ◽

2020 ◽

Vol 20 (4) ◽

pp. 16-20

Author(s):

T.I. Viun ◽

L.M. Pasieshvili ◽

S.V. Viun ◽

A.S. Marchenko ◽

O.V. Karaya

Keyword(s):

Chronic Pancreatitis ◽

Acid Phosphatase ◽

Arterial Hypertension ◽

Comparison Group ◽

Practical Importance ◽

Main Group ◽

Secondary Osteoporosis ◽

Control Group ◽

Tartrate Resistant Acid Phosphatase ◽

Detection Of Biomarkers

The prevalence of comorbidities has been growing for the last decades. Therefore, the detection of biomarkers for diagnostic and prognostic purposes is of great practical importance. The aim of this study was to assess the biomarkers of osteo-defficiency in the course of secondary osteoporosis in patients with comorbid chronic pancreatitis and arterial hypertension. We examined 110 patients with chronic pancreatitis: 70 of them had comorbid hypertension, and 40 patients were found as having no comorbidities. The age of patients ranged from 33.2 ± 2.1 (main group) and 32.9 ± 3.1 years (comparison group); women predominated (72.9% and 70%, respectively). The control group includes 78 healthy individuals of the same age and sex. Diagnostic investigation included studying clinical and anamnestic characteristics of patients (duration of the disease, manifestations of the course, frequency of recrudescence, fractures) and biochemical parameters of bone metabolism: osteocalcin, total bone phosphatase and tartrate-resistant acid phosphatase and the establishment of correlations between these parameters and incidence of complications. It was found that in the isolated course of chronic pancreatitis there is a high (R = 0.60) statistically significant (p <0.01) correlation between the levels of osteocalcin and pancreatic elastase-1. A negative statistically significant (p <0.01) mean correlation (R = -0.49) was found between the content of tartrate-resistant acid phosphatase and age of the patients having comorbidity of chronic pancreatitis and hypertension, as well as there is a moderate correlation between the content of tartrate-resistant acid phosphatase and the duration of hypertension, which is statistically significant (R = 0.36, p <0.01). The levels of total bone phosphatase and tartrate-resistant acid phosphatase in the main group exceeded the reference values in 2.5 and 1.9 times respectively (CMU; U = 866.0; p <0.01), while in the comparison group were 2 times (total bone phosphatase) and 1.3 times higher (tartrate-resistant acid phosphatase) times, respectively (CMU; U = 821.0; p <0.01) that enables to diagnose the development of osteopenic conditions. That is, the combined course of chronic pancreatitis and hypertension should be considered as unfavourable tandem in the development of secondary osteoporosis and requires early osteoporotic screening.

Download Full-text

Determining the risk factors for xerostomia in dental out-patients

Kazan medical journal ◽

10.17750/kmj2015-174 ◽

2015 ◽

Vol 96 (2) ◽

pp. 174-177

Author(s):

K V Komarova ◽

N N Ratkina ◽

V K Polenichkin ◽

E P Karmanov

Keyword(s):

Risk Factors ◽

Musculoskeletal Diseases ◽

Statistical Significance ◽

Main Group ◽

Control Group ◽

Endocrine Disorders ◽

Chi Square ◽

Chi Square Test ◽

Period Duration ◽

Group 1

Aim. To determine the risk factors for xerostomia.Methods. The study included 137 patients aged 25 to 60 years (61 males, 76 females), the main group consisted of 40 patients with xerostomia (11 males, 29 females), with a median age of 44.5 years (38; 49.5). The control group included 97 patients without xerostomia (50 males, 47 females), median age - 42 years (36; 49). The questionnaire by V.V. Afanas’ev (1993) was used to collect the complaints, anamnesis and to determine the risk factors for xerostomia. Qualitative indicators are listed as absolute numbers and shares (%). In assessing the statistical significance of qualitative indicators differences, contingency tables with subsequent Pearson chi-square test were used.Results. Among the patients of the main group, 19 (47.5%) took medications decreasing the salivation, with intake period duration ranging from 1 to 4 months. When questioned, patients with xerostomia reported statistically significant increase in the rates of cardiovascular disorders (15 patients, 37.5%), gastrointestinal tract diseases (11 patients, 27.5%), endocrine diseases (10 patients, 25%), musculoskeletal diseases (9 patients, 22.5%). The combination of three or more positive answers on V.V. Afanas’ev questionnaire questions was revealed in 12 (30%) patients of the main group, which was significantly higher compared to the control group (1 patient, 1.03%).Conclusion. The most typical reasons for developing xerostomia were the following: taking medications decreasing the salivation, presence of cardiovascular, gastrointestinal, musculoskeletal and endocrine disorders. Three or more positive answers on V.V. Afanas’ev questionnaire questions increase the probability of detecting xerostomia in a respondent.

Download Full-text

THE IMPACT OF FAMILY ENVIRONMENT ON PREVALENCE OF ARTERIAL HYPERTENSION AMONG SCHOOLCHILDREN

Medical Journal of the Russian Federation ◽

10.18821/0869-2106-2017-23-2-60-63 ◽

2017 ◽

Vol 23 (2) ◽

pp. 60-63

Author(s):

Arzu F. Mekhtieva

Keyword(s):

Risk Factors ◽

Arterial Pressure ◽

Arterial Hypertension ◽

Family Environment ◽

Tobacco Smoking ◽

Well Being ◽

Control Group ◽

Weak Intensity ◽

Material Conditions ◽

The Impact

The purpose of study. To investigate characteristics of family environment as risk factors of development of arterial hypertension and high normal arterial pressure in school children.The methods. The thrice-repeated measurement of arterial pressure was implemented among 662 schoolchildren and questionnaire survey of their parents as well. The questionnaire included issues related to conditions of living, dimensions of housing area, material well-being and effect of passive tobacco smoking. The schoolchildren with arterial hypertension resided in 107 families, schoolchildren with high normal arterial pressure - in 78 families and other schoolchildren without arterial hypertension and high normal arterial pressure - in 477 families (control group).The results. The most exposure of arterial hypertension in schoolchildren was observed in families with unsatisfactory hygienic conditions of residence - 47.7±4.9% of cases; with housing, less than 4.0 m2 per one schoolchild - 27,1±4,3% of cases; and also in families with unfavorable material conditions - 62,6±4,7% of cases. The exposure of high normal arterial pressure is analogous. At strong intensity of tobacco smoking of parents’ exposure of arterial hypertension among schoolchildren made up to 45,8±4,8% of cases; at medium intensity - 33,6±4,6% of cases; at weak intensity - 12,1±3,2% of cases and in absence of passive tobacco smoking - 8,4±2,7% of cases. The similar picture is observed and at exposure of high normal arterial pressure.The conclusion. As far as positive social economic transformations are occurring and well-being of population is ameliorating, with time the impact of the first three noted risk factors of family environment of schoolchildren will become weaker. Yet, the impact of passive tobacco smoking on organisms of children can be minimized by force of available controlled explanatory work with parents.

Download Full-text