scholarly journals Association of rs11196288 polymorphism with the development of acute cerebrovascular event

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
A Chernova ◽  
S Nikulina ◽  
D Nikulin
Keyword(s):  
Risk Factors ◽  
Genetic Research ◽  
Statistical Processing ◽  
Main Group ◽  
Control Group ◽  
Cerebrovascular Event ◽  
Siberian Population ◽  
Cardiovascular Pathology ◽  
Daily Monitoring ◽  
Arterial Blood

Abstract Purpose To study SNP rs11196288 (A> G) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results As a result of the conducted research in one of the analyzed groups and subgroups statistically significant associations of genotypes and alleles of polymorphism of rs11196288 were not revealed (A> G) with Acute Cerebrovascular Event. Conclusion SNP rs11196288 (A> G) has no significant effect on development of Acute Cerebrovascular Event in persons of the east Siberian population regardless of the previous cardiovascular pathology and risk factors. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Association of rs3025058 polymorphism with the development of acute cerebrovascular event

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
A Chernova ◽  
S Nikulina ◽  
D Nikulin
Keyword(s):  
Risk Factors ◽  
Genetic Research ◽  
Statistical Processing ◽  
Main Group ◽  
Control Group ◽  
Cerebrovascular Event ◽  
Siberian Population ◽  
Cardiovascular Pathology ◽  
Daily Monitoring ◽  
Arterial Blood

Abstract Purpose To study SNP rs3025058 association (5a/6a) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results In all analyzed groups and subgroups of patients statistically significant connection between a genotype of 5a/5a and an allele of 5a and in subgroup of women with Acute Cerebrovascular Event, subgroups of patients with AG and hypercoagulation of significant associations of polymorphism rs3025058 (5a/6a) with Acute Cerebrovascular Eventis not revealed. Conclusion A genotype 5a/5a and an allele 5a SNP rs3025058 (5a/6a) increase risk of development of an Acute Cerebrovascular Event in persons of the east Siberian population, including with such risk factors as atherosclerosis the brachiocephalic of arteries and a dislipidemiya. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Association of rs10507391 polymorphism with the development of acute cerebrovascular event

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
A Chernova ◽  
S Nikulina ◽  
D Nikulin
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Genetic Research ◽  
Statistical Processing ◽  
Main Group ◽  
Control Group ◽  
Cerebrovascular Event ◽  
Cardiovascular Pathology ◽  
Arterial Blood ◽  
Increased Risk

Abstract Purpose To study SNP rs10507391 association (A> T) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results When studying SNP rs10507391 association (A> T) connection between a rare genotype of a TT and an allele of T and the increased risk of Acute Cerebrovascular Event is established with development of Acute Cerebrovascular Event in all analyzed groups and subgroups of patients. Conclusion A genotype of a TT and an allele of T of SNP rs10507391 (A> T) increases risk of development of an acute disorder of cerebral circulation in patients regardless of the previous cardiovascular pathology and risk factors, including at patients with arterial hypertension, supraventricular tachyarrhythmias, atherosclerosis the brachiocephalic of arteries, disturbance of lipidic exchange and the system of a hemostasis. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Association of 12204590 polymorphism with the development of acute cerebrovascular event

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
A Chernova ◽  
S Nikulina ◽  
D Nikulin
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Genetic Research ◽  
Statistical Processing ◽  
Main Group ◽  
Control Group ◽  
Cerebrovascular Event ◽  
General Group ◽  
Cardiovascular Pathology ◽  
Arterial Blood

Abstract Purpose To study SNP rs12204590 (T > A) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results The connection of the genotype of TA SNP rs12204590 (T > A) with the development of Acute Cerebrovascular Event in a general group of patients was confirmed, but no statistically significant associations were obtained when patients were divided into subgroups depending on cardiovascular pathology and risk factors. Conclusion The genotype of TA SNP rs12204590 (T > A), compared to the genotypes of TT and AA, reduces the risk of developing Acute Cerebrovascular Event, including in patients with arterial hypertension. The genotype of AA SNP rs12204590 (T > A) increases the risk of developing Acute Cerebrovascular Event in males. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Association of rs3025058 polymorphism with the development of stroke in patients with cardiovascular pathology

2020 ◽  
Vol 92 (12) ◽  
pp. 25-30
Author(s):  
S. Yu. Nikulina ◽  
V. A. Shulman ◽  
A. A. Chernova ◽  
S. V. Prokopenko ◽  
D. A. Nikulin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Genetic Research ◽  
Main Group ◽  
Coagulation System ◽  
Control Group ◽  
Siberian Population ◽  
Single Nucleotide ◽  
Cardiovascular Pathology ◽  
Brachiocephalic Arteries

Aim.To study the association of single-nucleotide polymorphismrs3025058(5а/6а) with the development of stroke in patients of the East Siberian population with cardiovascular pathology and risk factors for its development. Materials and methods.The study involved 260 patients with stroke (age [57.0; 51.062.0]) and 272 patients of the control group (age [55.0; 51.062.0]). Among the patients who underwent stroke, 157 men and 103 women. The control group included 170 men and 102 women. The examination of the main group included: collection of complaints, anamnesis, clinical examination, computed tomography of the brain, electrocardiography, echocardioscopy, ultrasound duplex scanning of the extracranial brachiocephalic arteries, 24-hour monitoring of blood pressure and heart rate, analysis of the blood coagulation system. The patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of extracranial brachiocephalic arteries, disorders of the hemostasis system. The control group was examined within the framework of the international project HAPIEE. Molecular genetic research was carried out by real-time PCR. Statistical processing of the material was carried out using the Statistica for Windows 7.0, Excel and SPSS 22 application software. Results.The study established statistically significant associations between the 5a/5a genotype and the 5a allele and stroke in the general group of patients, as well as in the subgroup of men, subgroups of patients with extracranial brachiocephalic arteries atherosclerosis and dyslipidemia. In the subgroup of patients with cardiac arrhythmias, statistically significant results were obtained only for allele 5a, and in the subgroup of women with stroke, subgroups of patients with arterial hypertension and hypercoagulation, no significant associations ofrs3025058(5a/6a) polymorphism with stroke were found. Conclusion.Genotype 5a/5a and allele 5a of the single-nucleotide polymorphismrs3025058(5а/6а) increase the risk of stroke in individuals from the East Siberian population, including those in the presence of such risk factors as extracranial brachiocephalic arteries atherosclerosis and dyslipidemia.

scholarly journals Allelic variants of rs1800801 polymorphism in patients with stroke

2019 ◽  
Vol 10 (4) ◽  
pp. 29-33
Author(s):  
Svetlana Yu. Nikulina ◽  
Vladimir A. Shulman ◽  
Anna A. Chernova ◽  
Semen V. Prokopenko ◽  
Dmitrii A. Nikulin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Molecular Genetic ◽  
Statistical Processing ◽  
Control Group ◽  
Siberian Population ◽  
Single Nucleotide ◽  
Cardiovascular Pathology ◽  
Genetic Examination ◽  
Supraventricular Tachycardias ◽  
Application Programs

Aim. To study the association of single nucleotide polymorphism (SNP) rs556621 (G>T) with the development of stroke in patients of the East Siberian population with cardiovascular pathology and risk factors. Material and methods. The study involved 260 patients with stroke (157 men and 103 women) and 272 patients of the control group (170 men and 102 women). The following cardiovascular pathology and risk factors were present in the patients of the main group: arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of the brachiocephalic arteries, disorders of the hemostatic system. All patients underwent clinical, instrumental and molecular genetic examination. Statistical processing of the material was carried out using the set of application programs Statistica for Windows 7.0, Excel and SPSS 22. Results. As a result of the study, no statistically significant associations of genotypes and alleles of the rs1800801 polymorphism (C>T) with stroke were found in any of the analyzed groups and subgroups. Conclusion. SNP rs1800801 (C>T) does not have a significant effect on the development of stroke in people of the East Siberian population, regardless of the preceding cardiovascular pathology and risk factors.

Optimization of tactics of auxiliary genesial technologies at married couples with the burdened genetic anamnesis

2018 ◽  
pp. 103-106
Author(s):  
O.S. Darii ◽  
Keyword(s):  
Risk Factors ◽  
Correlation Analysis ◽  
Clinical Laboratory ◽  
Genetic Research ◽  
Married Couples ◽  
Control Group ◽  
Scientific Justification ◽  
Sterility Treatment ◽  
Laboratory Tool ◽  
And Control

The objective: rising of efficiency of treatment of sterility at married couples with the burdened genetic anamnesis on the basis of scientific justification and introduction of advanced algorithm of prognostic and treatment-and-prophylactic actions. Materials and methods. For the purpose of detection of risk factors of development of sterility and carrying out the correlation analysis were allocated the main group – 100 married couples with sterility in the anamnesis and control group of patients who had labors (n=100) in the anamnesis. The complex of the conducted researches included clinical, laboratory, tool and statistical methods of research. Results. Rising of efficiency of treatment of sterility at married couples with the burdened genetic anamnesis requires carrying out medicogenetic consultation with simultaneous planned preimplantation genetic research in programs of auxiliary genesial technologies. At a choice of this or that method of auxiliary genesial technologies at women with the burdened genetic anamnesis it is necessary to use a technique at which one spermatozoon is entered into an oocyte cytoplasma by means of equipment of a micromanipulation. In the program of training of doctors the obstetrician-gynecologists and urologists of an out-patient link it is necessary to loop thematic improvement concerning sterility treatment at married couples with use of auxiliary genesial technologies. Conclusion. Results of the conducted researches testify to need of rising of efficiency of auxiliary genesial technologies at married couples with the burdened genetic anamnesis. Use by our algorithm of prognostic and treatment-and-prophylactic actions allows to increase efficiency of auxiliary genesial technologies at married couples with the burdened genetic anamnesis for 26.7%. Key words: sterility at married couples, the auxiliary genesial technologies, the burdened genetic anamnesis.

scholarly journals Association of rs556621 Polymorphism with Development of Stroke in Patients with Cardiovascular Pathology

2019 ◽  
Vol 15 (5) ◽  
pp. 634-640
Author(s):  
S. Yu. Nikulina ◽  
V. A. Shulman ◽  
A. A. Chernova ◽  
S. V. Prokopenko ◽  
D. A. Nikulin ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Arterial Hypertension ◽  
Main Group ◽  
Lipid Lowering ◽  
Control Group ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Cardiovascular Pathology ◽  
Supraventricular Tachycardias ◽  
Brachiocephalic Arteries

Aim. To study the association of single nucleotide polymorphism rs556621 (G> T) with development of stroke in patients of the East Siberian population with cardiovascular pathology and risk factors.Material and methods. The study involved 260 patients (157 men and 103 women) with stroke (mean age 57.0 [51.0-62.0]) and 272 patients (170 men and 102 women) of the control group (mean age 55.0 [51.0-62.0]). The examination of the main group included: collection of complaints, anamnesis, clinical examination, computed tomography of the brain, electrocardiography, echocardioscopy, ultrasound duplex scanning of extracranial brachiocephalic arteries, daily blood pressure and heart rate monitoring, analysis of the blood coagulation system. The patients of the main group have arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of the brachiocephalic arteries, disorders of the hemostatic system. The control group was studied in the framework of the HAPIEE international project. Molecular genetic research was performed by real-time polymerase chain reaction.Results. There were no statistically significant differences in the frequencies of genotypes and single nucleotide polymorphism rs556621 alleles (G>T) in the subgroup of patients with stroke and those in the control group. The frequency of the rare TT genotype among patients with stroke was 13.3%±4.16, among healthy individuals – 8.8±3.37% (p=0.1). Gender differences when comparing the frequencies of genotypes and alleles were also not detected (p>0.05). The frequencies of the TT genotype were approximately the same in the subgroup of patients with arterial hypertension (13.1%±4.22) and in the control group (7.4±5.25%; p>0.05). No significant differences were observed in the frequencies of the rare genotype of the studied polymorphism in the subgroup of patients with supraventricular tachycardias (20.0±14.37%), hypercoagulability (15.9±7.64%) and the control group (8.8±3.37%), p>0.05. A statistically significant relationship was found between the rare genotype TT of single nucleotide polymorphism rs556621 (G>T) and the development of stroke in patients with dyslipidemia and atherosclerotic lesions of the coronary arteries (p=0.041; odds ratio 1.86, 95% confidence interval 1.02-3.41).Conclusion. The genotype of TTs of single nucleotide polymorphism rs556621 (G> T) increases the risk of developing stroke in patients with dyslipidemia and atherosclerosis of the brachiocephalic arteries compared with carriers of the GG and GT genotypes. The obtained data are recommended to be considered when prescribing lipid-lowering and antithrombotic therapy. 

scholarly journals Determining the risk factors for xerostomia in dental out-patients

2015 ◽  
Vol 96 (2) ◽  
pp. 174-177
Author(s):  
K V Komarova ◽  
N N Ratkina ◽  
V K Polenichkin ◽  
E P Karmanov
Keyword(s):  
Risk Factors ◽  
Musculoskeletal Diseases ◽  
Statistical Significance ◽  
Main Group ◽  
Control Group ◽  
Endocrine Disorders ◽  
Chi Square ◽  
Chi Square Test ◽  
Period Duration ◽  
Group 1

Aim. To determine the risk factors for xerostomia.Methods. The study included 137 patients aged 25 to 60 years (61 males, 76 females), the main group consisted of 40 patients with xerostomia (11 males, 29 females), with a median age of 44.5 years (38; 49.5). The control group included 97 patients without xerostomia (50 males, 47 females), median age - 42 years (36; 49). The questionnaire by V.V. Afanas’ev (1993) was used to collect the complaints, anamnesis and to determine the risk factors for xerostomia. Qualitative indicators are listed as absolute numbers and shares (%). In assessing the statistical significance of qualitative indicators differences, contingency tables with subsequent Pearson chi-square test were used.Results. Among the patients of the main group, 19 (47.5%) took medications decreasing the salivation, with intake period duration ranging from 1 to 4 months. When questioned, patients with xerostomia reported statistically significant increase in the rates of cardiovascular disorders (15 patients, 37.5%), gastrointestinal tract diseases (11 patients, 27.5%), endocrine diseases (10 patients, 25%), musculoskeletal diseases (9 patients, 22.5%). The combination of three or more positive answers on V.V. Afanas’ev questionnaire questions was revealed in 12 (30%) patients of the main group, which was significantly higher compared to the control group (1 patient, 1.03%).Conclusion. The most typical reasons for developing xerostomia were the following: taking medications decreasing the salivation, presence of cardiovascular, gastrointestinal, musculoskeletal and endocrine disorders. Three or more positive answers on V.V. Afanas’ev questionnaire questions increase the probability of detecting xerostomia in a respondent.

scholarly journals CORRECTION OF HYPODINAMY AS A FACTOR OF THE RISK OF OBESITY DEVELOPMENT IN FIRE-RESCUERS

2018 ◽  
Vol 25 (3) ◽  
pp. 40-45
Author(s):  
E. V. BURDYUKOVA ◽  
A. N. ARKHANGELSKAYA ◽  
S. N. ALEKSEENKO ◽  
I. A. YAKIREVICH ◽  
E. A. DMITRIEVA ◽  
...  
Keyword(s):  
High Efficiency ◽  
Statistical Processing ◽  
Main Group ◽  
The Body ◽  
Control Group ◽  
Test Results ◽  
Food Label ◽  
Development Indicators ◽  
History Of ◽  
In Fire

Aim. To evaluate the effectiveness of the developed special sports complex in the prevention of hypodynamia and obesity among firefighters-rescuers.Materials and methods. A survey of 490 men with no history of chronic infectious and non-infectious diseases aged 20-59 was conducted. 328 people were the main group, 162 people were the control group. The baseline data included anthropometric development indicators, bioimpedance test results, the extraction of biochemical blood test results; the body mass index (BMI) and the ratio of waist and hip circumference were determined. A questionnaire was conducted to identify hypodynamia (according to the IPAQ questionnaire) and the nutrition structure (according to the questionnaire on the food label literacy questionnaire, past). Both questionnaires were adapted to the Russian Federation. Statistica for Windows 8.0 was used for statistical processing. We used a comparison of the means of the Student method. To compare the values expressed in percent, the method of inverse trigonometric Fisher transformations was used.Results. We have developed and proposed for firefighters-rescuers, included in the main group, special sports complexes, which were used for 6 months. These complexes represent additional physical training by the developed method. There are two of them: one with an emphasis on the prevention and rehabilitation of people with osteochondrosis of the lumbar spine, and the other for cervical and thoracic localization, including with a syndrome of shoulder-scapular periarthritis.Classes were held 3 times a week, the duration of 1 session was 45-50 minutes. The choice of the complex was carried out at the request of firefighters-rescuers. The first complex was selected by 52 people. Based on the results of the study, against the background of the use of sports complexes, there was a 2-fold decrease in the incidence of obesity. Such a high efficiency is due to the fact that obesity of the I degree prevailed among the firefighters-rescuers. In addition, the frequency of occurrence of dyslipidemia, hyperglycemia, and hypodynamia decreased.Conclusion. The use of this sports complex can reduce the risk factors for development of disability among rescue firefighters by preventing hypodynamia and reducing the incidence of hyperglycemia and dyslipidemia, as factors in the development of obesity.

THE NEW GENETIC ASPECTS OF ATRIAL FIBRILLATION IN PERSONS OF THE RUSSIAN POPULATION

2020 ◽  
pp. 27-33
Author(s):  
Aksyutina N.V. ◽  
Shulman V.A. ◽  
Aldanova E.E. ◽  
Nikulina S.Yu. ◽  
Mordovskii V.S. ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Chronic Heart Failure ◽  
Molecular Genetic ◽  
Genetic Research ◽  
Heart Rhythm ◽  
Control Group ◽  
Atrial Remodeling ◽  
Cardiovascular Pathology ◽  
Heart Rhythm Disorders

Atrial fibrillation (AF) is one of the most common and dangerous heart rhythm disorders. Lone AF is due to a genetic predisposition. Foreign studies have proven the association of rs2200733 polymorphism of chromosome 4q25 with AF. No such studies have been conducted in the Russian Federation. Purpose of the study: to determine the association of the rs2200733 polymorphism of chromosome 4q25 with the development of AF, and to exclude the possible connection of the studied polymorphic marker with concomitant cardiovascular pathology. A total of 247 patients with AF were examined (113 from lone AF, 134 from secondary). Control group - 182 healthy people. Behavior: ECG, EchoCG, Holter ECG monitoring, blood test for thyroid hormones, VEM, CAG, molecular genetic research. In the group of patients with AF, the TT genotype was detected in 12.95%, which is statistically significant more often than in the control group (4.94%), p<0.05. In the presence of a genotype with a rare T allele, the risk of developing AF increases by 1.5 times. The TT genotype was statistically significant more often in the subgroup of patients with isolated AF (17.70%) in comparison with the control group (4.94%), p<0.05. The risk of developing isolated AF in the presence of a genotype with a rare allele T is 1.8 times increased. Chronic heart failure, no statistically significant differences were found (p>0.05). In patients with the TT genotype, the mean LA size was 3.738 ± 0.494 cm, it was statistically significantly smaller than in patients with the CC genotype, which corresponded to 3.925 ± 0.629 cm, p<0.05; and than in individuals with a heterozygous CT genotype, its value in this subgroup is 4.018 ± 0.639 cm, p<0.05. Conclusions: Homozygous genotype for the rare TT allele and the T allele of the rs2200733 polymorphism of chromosome 4q25 are predictors of lone AF. The rs2200733 polymorphism has no association with any cardiovascular pathology, such as hypertension, ischemic heart disease and chronic heart failure. The TT genotype and the T allele of the rs2200733 polymorphism do not affect left atrial remodeling in patients with AF.

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