scholarly journals A fixed combination of amlodipine and losartan: effectiveness and safety in abnormal weather conditions in patients with arterial hypertension

2016 ◽  
Vol 13 (4) ◽  
Author(s):  
F.T. Ageev ◽  
M.D. Smirnova ◽  
T.V. Fofanova
2020 ◽  
pp. 19-28
Author(s):  
E. Yu. Ebzeeva ◽  
O. D. Ostroumova ◽  
N. M. Doldo ◽  
E. E. Pavleeva

Arterial hypertension (AH) remains one of the most significant medical and social problems in the world, its prevalence among the adult population is 30–45%. Along with this, the modern population is characterized by a high incidence of chronic kidney disease (CKD), including due to their secondary damage in the framework of hypertension. In turn, CKD is an important independent risk factor for the development and progression of cardiovascular diseases, including fatal ones. The use of existing approaches to nephroprotection in the treatment of patients with hypertension will significantly improve the prognosis both in patients with risk factors for developing renal dysfunction and in patients with pre-existing kidney disease. According to current recommendations for hypertension in such clinical situations, therapy should begin with fixed combinations of antihypertensive drugs. The combination of an angiotensin converting enzyme inhibitor (ACE) and a dihydropyridine calcium channel blocker (CCВ) demonstrated the greatest effectiveness according to evidence-based medicine in patients with high-risk hypertension, including from the standpoint of nephroprotection. In the presented clinical case, the successful use of a fixed combination of ACE and CCВ in a patient with hypertension and microalbuminuria is described.


Author(s):  
Tamara Muratovna Khokonova ◽  
Zaira Feliksovna Kharaeva ◽  
Rustam Khasanovich Keshokov ◽  
Sofiat Khasenovna Sizhazheva ◽  
Svetlana Sergeevna Solyanik

The effect of antihypertensive and hypolipidemic therapy with the use of a fixed combination of amlodipine, lisinopril and rosuvastatin on the parameters of cytokines (the level of the proinflammatory cytokine - interleukin-1β, anti-inflammatory cytokine - interleukin-10, ligand CD40 (CD40L)), central aortic pressure, arterial stiffness and the value of albuminuria in patients with stage 3 chronic kidney disease, both in combination with arterial hypertension (AH) of 1-2 degrees, and without it, and in patients with coronary artery disease in combination with AH. The results of the study allow to conclude that the proposed antihypertensive and hypolipidemic therapy significantly reduces the parameters of central hemodynamics and vascular stiffness, the levels of microalbuminuria (MAU) and blood creatinine in patients with stage 3 chronic kidney disease in combination with AH of 1-2 degrees, and significantly increases the values IL-10 in patients with hypertension and CKD.


2021 ◽  
Vol 93 (9) ◽  
pp. 1125-1131
Author(s):  
Valery I. Podzolkov ◽  
Anna Е. Bragina ◽  
Yulia N. Rodionova ◽  
Galina I. Bragina ◽  
Ekaterina E. Bykova

Results of foreign and Russian studies indicate a higher mortality rate of patients with concomitant cardiovascular diseases (CVD) due to the new coronavirus infection COVID-19. It has been proven that arterial hypertension, as one of the significant risk factors for the development of concomitant cardiovascular diseases, is associated with a more severe prognosis of COVID-19. This article presents the results of modern studies and large meta-analyzes of necessity and safety of the use of blockers of the renin-angiotensin-aldosterone system in patients with arterial hypertension and COVID-19. The data of studies show that an angiotensin-converting enzyme inhibitor (ACE inhibitor) and a thiazide-like diuretic is a pathogenetically rational combination. It realizes various ways of lowering blood pressure by reducing the activity of the renin-angiotensin-aldosterone system, which is achieved by using an ACE inhibitor, and natriuresis due to diuretics. As an example, a highly effective fixed combination of drugs is considered, characterized by good tolerance, which consists of an ACE inhibitor lisinopril and a thiazide-like diuretic indapamide of prolonged action. The authors expressed the opinion that the appointment of the fixed combination drug Diroton Plus (Gedeon Richter) will contribute to effective control of blood pressure and organoprotection in conditions of increased thrombogenic and prooxidative potential, characteristic of COVID-19 both in the acute stage and within the post-COVID Syndrome.


2019 ◽  
pp. 223-228
Author(s):  
Dmitry Dergachev ◽  
Marina Larkina ◽  
Valerii Petrov ◽  
Mikhail Pankin

Исследования интродуцированного японского сорта винограда Кёхо выполнены в нестабильных погодных условиях умеренно континентального климата юга России, в Черноморской зоне виноградарства Краснодарского края в условиях температурного и водного стрессов 2018 года. В период активной вегетации (май - август) сумма активных температур воздуха была на 197 °С больше среднемноголетней нормы, количество атмосферных осадков было меньше нормы в 3,7 раза и составило 47 мм. В аномальных погодных условиях интродуцированный сорт винограда Кёхо показал высокую адаптивность к нестабильным погодным условиям в форме активного роста и прохождения фенологических циклов. При остром дефиците атмосферных осадков и повышенной инсоляции продолжительность вегетации винограда Кёхо от распускания почек до полной физиологической зрелости ягод была равна 119 дней, на 5 дней меньше, чем у контрольного сорта Бригантина и на 3 дня меньше, чем в среднем по большой группе столовых сортов разного эколого-географического происхождения, расположенных рядом на Анапской ампелографической коллекции. Начало фазы распускания почек, роста побегов и соцветий наблюдалось 15 апреля, у контрольного сорта на 4 дня раньше, у сортов ампелографической коллекции на 6 дней позже. Продолжительность этой фазы вегетации у изучаемого сорта составила 54 дня, больше на 11 дней чем у контрольного сорта и на 9 дней чем у столовых сортов ампелоколлекции. Цветение у сорта Кёхо начиналось 7 июня, на 15 дней позже чем у контрольного сорта Бригантина и на 3 дня чем у группы столовых сортов на ампелоколлекции. Продолжительность периода от начала цветения до начала созревания ягод у сорта Кёхо в экологических условиях 2018 года составила 50 дней, что на 4 дня короче, чем у контрольного сорта и на 3 дня короче, чем у сортов на ампелоколлекции. Интенсивность роста ягод была более высокой по сравнению с контролем и группой столовых сортов в ампелоколлекции. Полная физиологическая зрелость ягод у изучаемого сорта наступила 11 августа, практически одновременно с контролем - 12 августа.The study of introduced Japanese grapevine cultivar ‘Kёho’ was carried out in unstable weather conditions of moderately continental climate of the South of Russia, in the Black Sea viticultural zone of the Krasnodar Krai under temperature and water stress of 2018. During the active vegetation season (May - August), the accumulated effective temperatures made 197 ° С above the long-time average annual, the amount of precipitation was 3.7 times less than normal, and amounted to 47 mm. Under the effect of abnormal weather conditions, the introduced grapevine cultivar ‘Kёho’ demonstrated high adaptability to erratic weather conditions during the active growth phase and passage of phenological cycles. Under acute atmospheric precipitation deficit and increased insolation, the duration of ‘Kёho’ grapevine vegetation from bud break to full physiological berry ripeness made 119 days, which is 5 days less as compared to control cultivar ‘Brigantina’ and 3 days less than the average for a large group of table cultivars of various ecological and geographical origin, located in the nearby Anapa ampelographic collection. The start of the bud break, shoot and inflorescence growth phase was observed on April 15; it happened 4 days earlier for the control cultivar, and 6 days later for the cultivars in the ampelographic collection. The duration of this vegetation phase for the studied cultivar was 54 days, which by 11 days exceeded that of the control cultivar and by 9 days that of the table cultivars in the ampelographic collection. The bloom of ‘Kёho’ began on June 7 - 15 days later than that of the control cultivar ‘Brigantina’ and 3 days later as compared to the group of table cultivars in the ampelographic collection. Duration of the early bloom to veraison period of ‘Kёho’ grapes in the ecological conditions of 2018 made 50 days, which was 4 days shorter than that of the control cultivar and 3 days shorter as compared to the cultivars in the ampelographic collection. The berry growth was more intensive as compared to the control and the group of table cultivars in the ampelographic collection. Berries of the studied cultivar reached full physiological ripeness on August 11, almost simultaneously with the control - on August 12.


Author(s):  
S. Nedogoda ◽  
T. Chalyabi ◽  
V. Tioina ◽  
Y. Brel ◽  
E. Prokhorova

The aim of the study was to compare i he clinical efficacy and tolerance of fixed combinations of angiotensin-converting enzyme (ACE) and diuretic noliprel and co-renitec in patients with mild and moderate arterial hypertension with high risk of cardiovascular events. All investigated patients didn't achieved normal AP level with monotherapy. The study was blinded, randomised and performed in parallel groups (20 subjects in each group). The clinical effects were evaluated after 6 months of therapy by 1 tablet of noliprel-forte (4 mg / 12.5 mg) or co-renitec (20 mg / 12.5 mg). The antihypertensive effect was comparable for both dings, but fixed combination of noliprel-forte show advantage in reducing of LV hypertrophy and improvement of arterial elasticity.


2020 ◽  
Vol 73 (6) ◽  
pp. 1241-1244
Author(s):  
Olena V. Litvin ◽  
Anatolii M. Kravchenko ◽  
Oleksandr V. Klymenko ◽  
Maksym M. Lytvyn ◽  
Liliana V. Klymenko

The aim of the study was to study the headache features in patients with dyscirculatory encephalopathy of different genesis. Materials and methods: Clinical-neurological and clinical-instrumental examination of 90 persons aged 40 to 68 was performed. The first group consisted of 60 patients with dyscirculatory encephalopathy and arterial hypertension (DE and AH), the second group – 30 patients with dyscirculatory encephalopathy and cerebral atherosclerosis (DE and CA). Results: In the study of headache in patients with DE + AH and DE + CA, the frequency of detection, the intensity on the VAS scale, and the nature of the headache, no significant difference was found between study groups. Conclusions: According to the results of the study, it was proved that patients with DE + CA had headache in the root area, with the circumstances of headache being significantly outweighed «for no apparent reason» (p = 0.007) and with changing weather conditions (р = 0.001). Arterial hypertension was a major factor in headache (p = 0.008) and in patients with DE + AH.


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