scholarly journals Eating disorders in patients with obesity and type 2 diabetes mellitus. Lecture for physicians

2021 ◽  
Vol 23 (4) ◽  
pp. 326-331
Author(s):  
Tatyana A. Zelenkova-Zakharchuk ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Eating Disorders ◽  
Type 2 Diabetes Mellitus ◽  
Weight Gain ◽  
Age Related ◽  
Obesity And Diabetes ◽  
Predominant Type ◽  
Treatment Of Obesity

Obesity and type 2 diabetes mellitus (DM 2) that result from eating disorders (ED) which lead to weight gain are endocrine diseases provoked (caused) by psychopathology, and are psychosomatic diseases. The clinical features of ED in obesity and diabetes mellitus 2 are that they rarely occur as independent psychopathological units and are mainly represented by syndromic classification in the structure of other mental disorders. Preference of the predominant type of overeating for certain types of ED onset was revealed. Thus, fetal onset is characterized by permanent overeating, pubertal one – by compulsive overeating, psychogenic one – evening overeating and menopausal/age-related hypoandrogenic one – by polysyndromic overeating. Psychopharmacotherapy and psychotherapy combination is used to treat ED in patients with DM 2 and obesity. For prevention of obesity, it is recommended to diagnose early signs of ED which lead to weight gain, and to initiate psychiatric and psychotherapeutic care as soon as possible if ED occurred. Recent 2021 clinical guidelines for the treatment of obesity were updated with recommendation that all obese patients after secondary causes for weight gain were excluded, should be consulted by a psychiatrist-psychotherapist specializing in the general somatic network.

scholarly journals A Narrative Review on Sarcopenia in Type 2 Diabetes Mellitus: Prevalence and Associated Factors

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 183
Author(s):  
Anna Izzo ◽  
Elena Massimino ◽  
Gabriele Riccardi ◽  
Giuseppe Della Pepa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Elderly Population ◽  
The Elderly ◽  
Narrative Review ◽  
Macrovascular Complications ◽  
Diabetic Patients ◽  
Age Related

Type 2 diabetes mellitus (T2DM) represents a major health burden for the elderly population, affecting approximately 25% of people over the age of 65 years. This percentage is expected to increase dramatically in the next decades in relation to the increased longevity of the population observed in recent years. Beyond microvascular and macrovascular complications, sarcopenia has been described as a new diabetes complication in the elderly population. Increasing attention has been paid by researchers and clinicians to this age-related condition—characterized by loss of skeletal muscle mass together with the loss of muscle power and function—in individuals with T2DM; this is due to the heavy impact that sarcopenia may have on physical and psychosocial health of diabetic patients, thus affecting their quality of life. The aim of this narrative review is to provide an update on: (1) the risk of sarcopenia in individuals with T2DM, and (2) its association with relevant features of patients with T2DM such as age, gender, body mass index, disease duration, glycemic control, presence of microvascular or macrovascular complications, nutritional status, and glucose-lowering drugs. From a clinical point of view, it is necessary to improve the ability of physicians and dietitians to recognize early sarcopenia and its risk factors in patients with T2DM in order to make appropriate therapeutic approaches able to prevent and treat this condition.

scholarly journals Approach to the Patient with Diabetes during Pregnancy

2010 ◽  
Vol 95 (8) ◽  
pp. 3578-3585 ◽  
Author(s):  
Jennifer Hone ◽  
Lois Jovanovič
Keyword(s):  
Public Health ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Weight Gain ◽  
Preconception Care ◽  
Fetal Outcomes ◽  
Optimal Outcomes

The epidemics of obesity and type 2 diabetes mellitus (T2DM) globally are paralleling an increase in the number of women with T2DM becoming pregnant. Because T2DM is frequently undiagnosed before pregnancy, the risk of major malformations in the developing fetus is increased due to uncontrolled hyperglycemia. The lack of preconception care and the increase in complications of pregnancy due to the coexistence of obesity and T2DM are of concern from both an individual and a public health standpoint. Rapid achievement of normoglycemia with limited weight gain is critical to optimize maternal and fetal outcomes in all women with diabetes during pregnancy, regardless of the type of diabetes. This article will focus on T2DM preceding pregnancy due to its increasing prevalence and potentially dire fetal and maternal consequences. Euglycemia before, during, and after all pregnancies complicated by diabetes results in the best opportunity for optimal outcomes for mother and infant.

scholarly journals Gestational microbiome: metabolic perturbations and developmental programming

Reproduction ◽  
2021 ◽  
Vol 162 (6) ◽  
pp. R85-R98
Author(s):  
Sophia Han ◽  
Charlotte C Ellberg ◽  
Isoken N Olomu ◽  
Arpita K Vyas
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Human Microbiome ◽  
Disease States ◽  
Microbial Dysbiosis ◽  
Obesity And Diabetes ◽  
Growing Body

A growing body of research suggests that alterations to the human microbiome are associated with disease states, including obesity and diabetes. During pregnancy, these disease states are associated with maternal microbial dysbiosis. This review discusses the current literature regarding the typical maternal and offspring microbiome as well as alterations to the microbiome in the context of obesity, type 2 diabetes mellitus, and gestational diabetes mellitus. Furthermore, this review outlines the proposed mechanisms linking associations between the maternal microbiome in the aforementioned disease states and offspring microbiome. Additionally, this review highlights associations between alterations in offspring microbiome and postnatal health outcomes.

scholarly journals Docking protein 1 and free fatty acids are associated with insulin resistance in patients with type 2 diabetes mellitus

2021 ◽  
Vol 49 (11) ◽  
pp. 030006052110482
Author(s):  
Xiaoqin Ha ◽  
Xiaoling Cai ◽  
Huizhe Cao ◽  
Jie Li ◽  
Bo Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Effective Means ◽  
Model Assessment ◽  
High Concentration ◽  
Obesity And Diabetes ◽  
Docking Protein

Objective Insulin resistance (IR) is a key defect in type 2 diabetes mellitus (T2DM); therefore, effective means of ameliorating IR are sought. Methods We performed a retrospective cohort study of 154 patients with T2DM and 39 with pre-diabetes (pre-DM). The effects of IR and a high concentration of FFA on gene expression were determined using microarray analysis and quantitative reverse transcription polymerase chain reaction (RT-qPCR) in patients with T2DM or pre-DM. Results Serum FFA concentration and homeostasis model assessment of IR (HOMA-IR) were significantly higher in patients with T2DM but no obesity and in those with pre-DM than in controls. HOMA-IR was significantly associated with T2DM. RT-qPCR showed that the expression of FBJ murine osteosarcoma viral oncogene homolog ( FOS) and AE binding protein 1 ( AEBP1) was much lower in the circulation of participants with obesity and diabetes. RT-qPCR showed that the expression of docking protein 1 ( DOK1) was significantly lower in the blood of participants with diabetes but no obesity and in those with pre-DM than in controls. Conclusions FFA and DOK1 are associated with IR in patients with T2DM but no obesity or pre-DM. The downregulation of DOK1 might inhibit lipid synthesis and induce lipolysis, inducing or worsening IR.

scholarly journals Advances in Acupuncture and its Associated Therapies for the Prevention and Treatment of Obesity Type 2 Diabetes Mellitus

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Kaiya Zhang ◽  
Yuanyuan Ren ◽  
Yanyan Zhou
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Clinical Practice ◽  
Clinical Symptoms ◽  
Embedding Therapy ◽  
Prevention And Treatment ◽  
Treatment Of Obesity

Obesity type 2 diabetes mellitus is a common metabolic disease in clinical practice, and its prevalence is increasing rapidly with the aging of the population and changes in lifestyle. Acupuncture, as a distinctive therapy, has its unique advantages in the treatment of obesity type 2 diabetes and has an irreplaceable role in a variety of treatment methods. The author organized the literature on acupuncture and its related therapies to prevent and treat obesity type 2 diabetes in recent years and found that acupuncture and its associated therapies to prevent and treat obesity type 2 diabetes mainly include: simple acupuncture, electroacupuncture, acupoint catgut embedding therapy, auricular-plaster therapy and other treatments, all of which can safely and effectively improve clinical symptoms, acupuncture and its related therapies to treat obesity type 2 diabetes has a broad prospect, worthy of further clinical promotion.

Ketogenic diets as treatment of obesity and type 2 diabetes mellitus

2020 ◽  
Vol 21 (3) ◽  
pp. 381-397 ◽  
Author(s):  
Felipe F. Casanueva ◽  
Marco Castellana ◽  
Diego Bellido ◽  
Pierpaolo Trimboli ◽  
Ana I. Castro ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ketogenic Diets ◽  
Treatment Of Obesity

scholarly journals Emirates Diabetes Society Consensus Guidelines for the Management of Type 2 Diabetes Mellitus – 2020

2020 ◽  
Vol 26 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Fatheya Alawadi ◽  
Salah Abusnana ◽  
Bachar Afandi ◽  
Khaled M. Aldahmani ◽  
Omniyat Alhajeri ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
United Arab Emirates ◽  
Management Practices ◽  
Local Population ◽  
International Diabetes Federation ◽  
Consensus Guidelines ◽  
Obesity And Diabetes

Rapid urbanisation and socioeconomic development in the United Arab Emirates (UAE) have led to the widespread adoption of a sedentary lifestyle and Westernised diet in the local population and consequently a high prevalence of obesity and diabetes. In 2019, International Diabetes Federation statistics reported a diabetes prevalence rate of 16.3% for the adult population in the UAE. In view of the wealth of recent literature on diabetes care and new pharmacotherapeutics, the Emirates Diabetes Society convened a panel of experts to update existing local guidelines with international management recommendations. The goal is to improve the standard of care for people with diabetes through increased awareness of these management practices among healthcare providers licensed by national health authorities. These consensus guidelines address the screening, diagnosis and management of type 2 diabetes mellitus in adults including individuals at risk of developing the disease.

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