Pharmacoeconomic advantages of using intrauterine levonorgestrel containing Mirena system in conjunction with the transdermal estrogen containing drugs for the treatment of menopausal syndrome and contraception during the menopausal transition

GYNECOLOGY ◽  
2016 ◽  
Vol 18 (6) ◽  
Author(s):  
N.G. Baeva ◽  
Yu.A. Filyaeva
Keyword(s):  
Menopausal Transition ◽  
Menopausal Syndrome ◽  
Transdermal Estrogen

Vaginal microbiota during the menopausal transition: the role of lactobacilli

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (3) ◽  
pp. 214-221
Author(s):  
Yulia E. Dobrokhotova ◽  
Polina A. Shadrova ◽  
Vladimir I. Komagorov
Keyword(s):  
Urinary Tract ◽  
Hormone Therapy ◽  
Urinary Tract Infections ◽  
Ovarian Function ◽  
Vaginal Microbiota ◽  
Menopausal Transition ◽  
Menopausal Syndrome ◽  
Recurrent Urinary Tract Infections ◽  
Tract Infections

Physiological loss of ovarian function during the menopausal transition often leads to the development of unfavorable symptoms associated with vulvovaginal atrophy, recurrent urinary tract infections and dyspareunia. Currently, the scientific community is actively discussing the risks and benefits of prescribing menopausal hormone therapy to relieve the consequences of estrogen deficiency. The study of vaginal microbiota in dynamics made it possible to take a deeper look at the development of genitourinary menopausal syndrome and associate several microorganisms with specific undesirable manifestations. The link between recurrent urinary tract infections during menopause and physiological replacement of microbiota by opportunistic flora with the development of unpleasant symptoms resolves doctors to resort to irrational courses of antibiotic therapy. The review is devoted to the generalization of information on microbiological changes in the vagina during perimenopause, the possibilities of choosing the optimal hormone therapy for the correction of symptoms, the use of new promising methods, including management by modulating the vaginal microbiota.

Possible ways to correct severe forms of climacteric syndrome in women with endometriosis

2018 ◽  
pp. 96-101
Author(s):  
N.F. Zakharenko ◽  
◽  
N.V. Kovalenko ◽  
I.N. Retunska ◽  
◽  
...  
Keyword(s):  
Hormone Therapy ◽  
Therapy Group ◽  
Elimination Rate ◽  
Reproductive Function ◽  
Clinical Effectiveness ◽  
Menopausal Hormone Therapy ◽  
Climacteric Syndrome ◽  
Menopausal Syndrome ◽  
Short Period ◽  
Transdermal Estrogen

Modern demographic changes in society are accompanied by an increase of women of the older age group in the general population. During this age period, along with the elimination of reproductive function in women, a complex of pathological symptoms often develops – climacteric syndrome (CS), which displays the maladaptation of various organs and systems that have estrogen receptors. An extremely topical problem of climacteric syndrome is for patients with endometriosis whose quantity is about 50% of the population. The objective: the determination of the effectiveness of the complex of medical therapy developed by us in women with severe forms of COP in the context of endometriosis. Materials and methods. Within 3 months we actively observed 60 women with an endometriosis in the anamnesis and manifestations of severe CS. By randomization, the women were divided into 2 groups depending on the chosen therapy: group 1 consisted of 30 women who, taking into account the above mentioned advantages, received the transdermal estrogen Estrogel, group 2 – 30 patients, whom a therapy by estrogen, phenibut and mebicar was assigned. Patients of both groups were given an intrauterine system with levonorgestrel. In order to conduct a comparative assessment of the clinical effectiveness of various treatment methods, the integral pathology index (IPI) was used in dynamics – before treatment, after 1, 2 and 3 months of therapy. The improvement degree (ID) of the disease clinical picture was also determined. Statistical analysis of the data was carried out on a personal computer using the programs SPSS 2000 (SPSSInc., USA) and Exel 2000 (MicrosoftInc., USA). Results. Our analysis found that as a result of the therapy received, a significant improvement in the scores was observed among patients of both subgroups. During the first two months, the effectiveness of combining menopausal hormone therapy with anti-stress medications in women with severe CS was almost 2 times greater than monotherapy with menopausal hormone therapy (Coefficient of Efficacy 1 = 2.68, Coefficient of Efficacy 2 = 1.62), indicating a faster elimination rate of CS’ symptoms using this combination. The overall effectiveness of the combination of phenybut with mebikar against the background of the use of Estrogel with an intrauterine system with levonorgestrel was 1.41 times higher compared to effectiveness of Estrogel and the levonorgestrel intrauterine system only use. Conclusion. Administration of anti-stress drugs Fenibut&Mebikar combination along with use of menopausal hormone therapy allows to reduce quickly the severity of CS manifestations, especially psychoemotional disorders almost to their full elimination in a relatively short period of time. The proposed scheme of treatment helps to eliminate quickly the symptoms of menopausal syndrome in women with endometriosis, improve and stabilize their psychological profile, restore working capacity, improve adaptation and quality of life. Key words: climacteric syndrome, endometriosis, anti-stress therapy, phenibut, mebicar, transdermal estrogen, Estrogel, intrauterine system with levonorgestrel.

Complex non-drug correction of menopausal disorders in patients with metabolic syndrome

2021 ◽  
Author(s):  
Rumisa Berihanova ◽  
Inessa Minenko
Keyword(s):  
Metabolic Syndrome ◽  
Lifestyle Modification ◽  
Pelvic Floor Muscle ◽  
The State ◽  
Menopausal Transition ◽  
Menopausal Syndrome ◽  
Blood Profile ◽  
Moderate Severity ◽  
Markers Of Inflammation ◽  
Wide Range

The monograph is devoted to the complex non-drug correction of menopausal disorders in patients with metabolic syndrome in the period of menopausal transition. Modern ideas about menopausal and metabolic syndromes are presented, a review of modern approaches to their treatment is carried out. A complex personalized system of non-drug correction of functional disorders in patients with metabolic syndrome and menopausal syndrome of mild and moderate severity in the period of menopausal transition is presented, including preformed therapeutic factors (vibrotherapy, chromotherapy, aeroionotherapy, musicotherapy (melotherapy), aromatherapy), physical therapy with pelvic floor muscle training, drinking balneotherapy, vitamins and minerals against the background of lifestyle modification. The algorithm of dynamic clinical and laboratory examination of women with menopausal disorders of mild and moderate severity and metabolic syndrome in the period of menopausal transition has been developed, including a general clinical examination, assessment of alimentary, thyroid, psycho-emotional, gynecological, urological statuses, the state of the intestinal microbiota, the function of the hypothalamic-pituitary complex, biochemical blood profile, hemostasis, levels of markers of inflammation, assessment of the state of the musculoskeletal system, sexual function, allowing to get an idea of the state of mental and physical health of patients, evaluate the effectiveness of the complex of measures, optimize therapeutic tactics. It is addressed to a wide range of readers interested in women's health. It can be useful for students, postgraduates, teachers of medical universities, obstetricians, gynecologists, endocrinologists, cardiologists, specialists of restorative medicine.

Menopausal Syndrome

2020 ◽  
Author(s):  
Keyword(s):  
Menopausal Syndrome

THE TREATMENT OF THE MENOPAUSAL SYNDROME WITH DHEA-SULFATE

1969 ◽  
Vol 61 (1_Suppl) ◽  
pp. S230 ◽  
Author(s):  
Walther Rindt ◽  
G. Heinen ◽  
G. W. Oertel
Keyword(s):  
Menopausal Syndrome

Possibilities of correction of menopausal disorders in women with the use of medicine Menopace

2016 ◽  
pp. 95-100
Author(s):  
G.I. Reznichenko ◽  
◽  
N.Yu. Reznichenko ◽  
V.Yu. Potebnya ◽  
K.I. Kovalenko ◽  
...  
Keyword(s):  
General Condition ◽  
Clinical Symptoms ◽  
Average Score ◽  
Control Group ◽  
Climacteric Syndrome ◽  
Basic Subgroup ◽  
Menopausal Syndrome ◽  
Natural Menopause ◽  
Surgical Menopause ◽  
Observation Period

The objective: to determine the efficacy of medicine «Menopace» in treatment of women with natural and surgical menopause. Patients and methods. 20 women (I group) with a natural menopause were examined (basic subgroup consisted of 10 patients who used Menopace for 3 months; control subgroup consisted of 10 patients). 20 women (II group) with surgical menopause were examined (basic subgroup consisted of 10 patients who received Menopace for 3 months; control subgroup consisted of 10 patients). Results. The average score of neurovegetative and emotional manifestations of climacteric syndrome during the observation period decreased in women with natural and surgical menopause who used Menopace, compared with subgroups of patients who had not used the medicine. Conclusions. 1. The use of the medicine Menopace in women with natural menopause after 3 months showed the disappearance of clinical symptoms of climacteric syndrome in 70% of the cases, and significant improvement in general condition in 30% of cases. 2. During surgical menopause after 1 month of treatment with Menopace manifestations of sweating were observed 4.5 times less often than in control group, tides were observed 7 times less often than in control group. Neurovegetative and psychoemotional symptoms of menopause were absent in 80% of women after 3 months of treatment and in 20% of cases significant improvement was shown. 3. The obtained results give grounds to recommend wide use of Menopace in practical work for the treatment of menopausal syndrome during natural and surgical menopause. Key words: menopause, therapy, Menopace.

Ladder of life of a modern woman: how to maintain health. Opportunities and prospects of phytotherapy (to help a practitioner)

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (2) ◽  
pp. 12-17 ◽  
Author(s):  
Vera N Prilepskaya ◽  
Elena G Nazarenko
Keyword(s):  
Reproductive System ◽  
Premenstrual Syndrome ◽  
Herbal Remedies ◽  
Herbal Therapy ◽  
Menopausal Syndrome ◽  
Safety And Efficacy ◽  
Modern View ◽  
Pathological Conditions

The article provides a modern view on features of different stages of a woman’s life. It presents information on pathogenetic basis and effectiveness of modern phytotherapy with a use of certified agents for a treatment of main pathological conditions associated with different stages of a woman’s life when the hypothalamic-pituitary-ovarian system’s function is formed, actively functions and then undergoes a gradual involution. The features of the use of herbal remedies in pathological conditions of the reproductive system (premenstrual syndrome, hyperprolactinemia, menopausal syndrome, mastalgia, etc.) are described. The article is illustrated with figures and tables for better understanding by clinicians. It emphasis on the features of herbal therapy, its high acceptability, safety and efficacy in the age aspect.

Dynamics of symptoms of genitourinary menopausal syndrome and the frequency of recurrence of lower urinary tract infection in women in periand postmenopausal patients with combined therapy with Trioginal®

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (6) ◽  
pp. 67-72
Author(s):  
D Yu Pushkar ◽  
M Yu Gvozdev
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Urine Culture ◽  
Objective Assessment ◽  
Control Group ◽  
Urination Disorders ◽  
Menopausal Syndrome ◽  
Tract Infections ◽  
Two Stages ◽  
Lower Urinary

Material and methods. The study included patients (n=164) in peri- and postmenopause, having a laboratory-confirmed picture of the genitourinary menopausal syndrome - atrophic vulvovaginitis and suffering from recurrent lower urinary tract infections (UTI) - cystitis and urethritis. All patients underwent standard antibacterial therapy (ABT) UTI in accordance with the results of bacteriological urine culture according to Russian clinical guidelines on urology. Against the background of ABT, 164 patients received additional therapy with Trioginal® (the study group - SG) containing estriol, micronized progesterone and Lactobacillus casei rhamnosus Doderleini 35 (LCR 35) lactobacillus strain. Trioginal® was administered intravaginally in two stages: for 20 days, 2 capsules per day, then for 10 days, 1 capsule per day. In the comparison group - CG (n=67) with ABT, Ovipol Klio® (estriol monopreparation) was additionally intravaginally used in two stages: for 14 days, 1 suppository per day, then for 2 weeks, 1 suppository 2 times a week. The control group consisted of 30 patients receiving only standard ABT UTI, local hormone therapy for vulvovaginal atrophy (VVA) was not performed. The observation period was 12 months after the end of the course of therapy. At all stages of treatment, a subjective and objective assessment of the severity of urination disorders and urogenital atrophy (UDI-6 questionnaire), their impact on the quality of life of patients (questionnaire IIQ-7), indicators of bacteriuria, bacterial urine culture and vaginal biocenosis, frequency of undesirable phenomena were carried out. According to the initial characteristics of the group of patients were comparable. Results. At all stages of the study, in the group of patients who received therapy with the use of the Trioginal® drug, there was a significant improvement in the clinical picture of urination disorders compared to the CG and the control (main) group - MG (in SG - 18% at the end of therapy versus 100% before the start of therapy; CG - 26 % versus 100% respectively; Ledger - 58% versus 100% respectively; p

Pomegranate Extract Improves Menopausal Syndrome in Ovariectomized Rats

2015 ◽  
Vol 44 (4) ◽  
pp. 506-515
Author(s):  
Ji-Hyang Wee ◽  
Hyun Jung Jung ◽  
Kyung Ok Jung ◽  
Hea Mi Sung ◽  
Yu-Rim Shin ◽  
...  
Keyword(s):  
Ovariectomized Rats ◽  
Menopausal Syndrome
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