scholarly journals Acute toxicity study of ethanolic extract of Apium leptophyllum pers in swiss albino mice

2019 ◽  
Vol 10 (4) ◽  
pp. 3750-3754
Author(s):  
Siva Ganesh M ◽  
Radhika J
Keyword(s):  
Body Weight ◽  
Single Dose ◽  
Acute Toxicity ◽  
Ethanolic Extract ◽  
Maximum Level ◽  
Toxicity Study ◽  
Swiss Albino Mice ◽  
Acute Toxicity Study ◽  
Albino Mice ◽  
Experimental Group

The recent study was planned to determine the acute toxicity study of Apium leptophyllum pers. A single dose of 400,1200,2000 mg/ kg of ethanolic extract of Apium leptophyllum pers according to the OECD guidelines and the dose level was administrated orally into swiss albino mice. Oral administration of maximum level of ethanolic extract of Apium leptophyllum pers upto 2000 mg/kg body weight to experimental group of albino mice was evaluated. Biochemical, haematological  and histopathological parameters were checked throughout the study. Signs of toxicity, mortality and body weight were monitored for 14 days post treatment of Apium leptophyllum pers . There is no substantial variations were noticed in control and treated groups. Result revealed that the ethanolic extract of Apium leptophyllum is safe and no toxicity was caused. 

scholarly journals Preliminary acute toxicity study on imidacloprid in Swiss albino mice

2013 ◽  
Vol 6 (12) ◽  
pp. 955-959 ◽  
Author(s):  
Preeti Bagri ◽  
Vinod Kumar ◽  
Anil Kumar Sikka ◽  
Joginder Singh Punia
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Swiss Albino Mice ◽  
Acute Toxicity Study ◽  
Albino Mice

scholarly journals An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Reshu Tiwari ◽  
Mohammed Haris Siddiqui ◽  
Tarique Mahmood ◽  
Alvina Farooqui ◽  
Paramdeep Bagga ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Adverse Effects ◽  
Lipid Profile ◽  
Biochemical Parameter ◽  
Normal Group ◽  
Toxicity Study ◽  
General Behaviour ◽  
Swiss Albino Mice ◽  
Acute Toxicity Study

Abstract Background Curcumin, quercetin and rutin are flavonoids having strong antioxidant potential, individually used in treatment of numerous ailments. The safety assessment of each of them is already established but no toxicological assessment has been done that would guarantee the safe use of these three flavonoids when used as a polyherbal combination (PHC). The aim of this study to evaluate the possible toxicological effect of polyherbal combination of these three flavonoids in female Swiss albino mice. Methods In acute toxicity study, the oral dose of poly herbal combination was administered to four groups stepwise in single dose and general behaviour, adverse effects and mortality were determined up to 14 days and compared to normal group. In sub-acute study, the tested poly herbal combination was administered orally for 28 days to the four experimental groups and their body weight was measured each alternate day from the first day of dosing. On 29th day the final body weight was recorded and euthanized by using thiopentone sodium, blood was collected and later haematological, lipid profile, biochemical parameter was evaluated and compared to normal group. Result In acute toxicity study, no abnormal general behaviour, adverse effects were reported. No significant changes were reported in body weight, haematological, lipid profile, biochemical parameter in sub-acute toxicity study. No mortality was reported in both the study. Histopathological examination revealed no alterations in clinical signs or organ weight at any dose. Conclusion The result concludes that the oral administration of Polyherbal combination did not produce any significant toxic effect in swiss albino mice. Hence, the Polyherbal combination can be utilized safely for therapeutic use.

scholarly journals Hepatoprotective effect of Helicanthus elastica

2016 ◽  
Vol 11 (2) ◽  
pp. 525 ◽  
Author(s):  
K.N. Sunil Kumar ◽  
R. Rajakrishnan ◽  
J. Thomas ◽  
G. Aadinaath Reddy
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Dose Level ◽  
Video Clip ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Acute Toxicity Study ◽  
Whole Plant

<p class="Abstract">Search for medicinal plants to treat liver disorders is an important research topic on herbs. Acute toxicity study is a prerequisite for safety and dose fixation for further pharmacological actions. In the present study, aqueous and 95% ethanolic extract of whole plant of <em>Helicanthus elastica</em> were subjected to acute oral toxicity. The aqueous and ethanolic extract revealed no observable changes in the rats up to the dose level of 2,000 mg /kg body weight. The extracts were then screened for paracetamol-induced hepatic injury at dose levels of 200 and 400 mg/kg body weight (1/10 and 1/5 LD<sub>50 </sub>based on toxicity study). The aqueous extract of whole plant of <em>H. elastica</em> was found to produce significant (p&lt;0.05) reversal of the paracetamol-induced changes in the measured biochemical and histopathological parameters at lower dose of 200 mg/kg which was found to be better than ethanol extract at the same dose level.</p><p class="Abstract"><strong>Video Clip:</strong></p><p class="Abstract"><a href="https://www.youtube.com/v/cO6HI1Kikxs">Acute toxicity study and others:</a> 5 min 38 sec</p><p> </p>

scholarly journals Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice

2016 ◽  
Vol 1 (2) ◽  
pp. 54-64 ◽  
Author(s):  
Saswata Sanyal ◽  
◽  
Pralay Maity ◽  
Ananya Pradhan ◽  
Madhubanti Bepari ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Swiss Albino Mice ◽  
Calotropis Gigantea ◽  
Acute Toxicity Study ◽  
Albino Mice

Acute and 28-days repeated dose sub-acute toxicity study of gallic acid in albino mice

2019 ◽  
Vol 101 ◽  
pp. 71-78 ◽  
Author(s):  
Bhavesh C. Variya ◽  
Anita K. Bakrania ◽  
Prem Madan ◽  
Snehal S. Patel
Keyword(s):  
Acute Toxicity ◽  
Gallic Acid ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Acute Toxicity Study ◽  
Albino Mice
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