Acute Toxicity Study of Annona reticulata Leaves Extract in Swiss Albino Mice

The recent study was planned to determine the acute toxicity study of Apium leptophyllum pers. A single dose of 400,1200,2000 mg/ kg of ethanolic extract of Apium leptophyllum pers according to the OECD guidelines and the dose level was administrated orally into swiss albino mice. Oral administration of maximum level of ethanolic extract of Apium leptophyllum pers upto 2000 mg/kg body weight to experimental group of albino mice was evaluated. Biochemical, haematological and histopathological parameters were checked throughout the study. Signs of toxicity, mortality and body weight were monitored for 14 days post treatment of Apium leptophyllum pers . There is no substantial variations were noticed in control and treated groups. Result revealed that the ethanolic extract of Apium leptophyllum is safe and no toxicity was caused.

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Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice

Toxicology and Forensic Medicine - Open Journal ◽

10.17140/tfmoj-1-109 ◽

2016 ◽

Vol 1 (2) ◽

pp. 54-64 ◽

Cited By ~ 2

Author(s):

Saswata Sanyal ◽

◽

Pralay Maity ◽

Ananya Pradhan ◽

Madhubanti Bepari ◽

...

Keyword(s):

Acute Toxicity ◽

Toxicity Study ◽

Swiss Albino Mice ◽

Calotropis Gigantea ◽

Acute Toxicity Study ◽

Albino Mice

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Acute and 28-days repeated dose sub-acute toxicity study of gallic acid in albino mice

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2018.11.010 ◽

2019 ◽

Vol 101 ◽

pp. 71-78 ◽

Cited By ~ 7

Author(s):

Bhavesh C. Variya ◽

Anita K. Bakrania ◽

Prem Madan ◽

Snehal S. Patel

Keyword(s):

Acute Toxicity ◽

Gallic Acid ◽

Toxicity Study ◽

Repeated Dose ◽

Acute Toxicity Study ◽

Albino Mice

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Acute toxicity study of an aqueous extract of Ficus racemosa Linn. bark in albino mice

The Internet Journal of Toxicology ◽

10.5580/1094 ◽

2009 ◽

Vol 6 (1) ◽

Keyword(s):

Acute Toxicity ◽

Aqueous Extract ◽

Toxicity Study ◽

Acute Toxicity Study ◽

Ficus Racemosa ◽

Albino Mice

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An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

Clinical Phytoscience ◽

10.1186/s40816-020-00228-2 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Reshu Tiwari ◽

Mohammed Haris Siddiqui ◽

Tarique Mahmood ◽

Alvina Farooqui ◽

Paramdeep Bagga ◽

...

Keyword(s):

Body Weight ◽

Acute Toxicity ◽

Adverse Effects ◽

Lipid Profile ◽

Biochemical Parameter ◽

Normal Group ◽

Toxicity Study ◽

General Behaviour ◽

Swiss Albino Mice ◽

Acute Toxicity Study

Abstract Background Curcumin, quercetin and rutin are flavonoids having strong antioxidant potential, individually used in treatment of numerous ailments. The safety assessment of each of them is already established but no toxicological assessment has been done that would guarantee the safe use of these three flavonoids when used as a polyherbal combination (PHC). The aim of this study to evaluate the possible toxicological effect of polyherbal combination of these three flavonoids in female Swiss albino mice. Methods In acute toxicity study, the oral dose of poly herbal combination was administered to four groups stepwise in single dose and general behaviour, adverse effects and mortality were determined up to 14 days and compared to normal group. In sub-acute study, the tested poly herbal combination was administered orally for 28 days to the four experimental groups and their body weight was measured each alternate day from the first day of dosing. On 29th day the final body weight was recorded and euthanized by using thiopentone sodium, blood was collected and later haematological, lipid profile, biochemical parameter was evaluated and compared to normal group. Result In acute toxicity study, no abnormal general behaviour, adverse effects were reported. No significant changes were reported in body weight, haematological, lipid profile, biochemical parameter in sub-acute toxicity study. No mortality was reported in both the study. Histopathological examination revealed no alterations in clinical signs or organ weight at any dose. Conclusion The result concludes that the oral administration of Polyherbal combination did not produce any significant toxic effect in swiss albino mice. Hence, the Polyherbal combination can be utilized safely for therapeutic use.

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TOXICOLOGICAL STUDY OF SURYASHEKHARA RASA

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj0708102020 ◽

2020 ◽

Vol 8 (10) ◽

pp. 4610-4616

Author(s):

Shanta Patil ◽

Surekha S Medikeri

Keyword(s):

Acute Toxicity ◽

Functional Group ◽

Research Work ◽

Toxic Substance ◽

Signs And Symptoms ◽

Toxicity Study ◽

Acute Administration ◽

Acute Toxicity Study ◽

Albino Mice ◽

Harmful Effects

Suryashekhara Rasa is unique mercurial preparation, which contains Parada, Gandhaka, Hingula and Vatsanabha. The quantity of Vatsanabha is equal to the sum of other ingredients, and also its antidote (Tankana) is not mentioned in this formulation. To ensure that the drug is devoid of toxicity and harmful effects, assessing the level of toxicity is important. So, this research work is an attempt to perform acute and sub-acute toxicity evaluation of Suryashekhara Rasa. Acute toxicity study of test drug was carried at a limit dose of 2000mg/kg orally in albino mice. For sub-acute toxicity Suryashekhara rasa was adminis-tered at therapeutic equivalent dose (TED) (0.35mg/kg bw po), TED x 2 (0.70mg/kg bw po) TED x 5 (1.75 mg/kg bw po) for 28 days. Acute toxicity result showed that drug did not produce any signs and symptoms of toxicity or mortality up to an oral dose of 2000 mg/kg in albino mice. The data generated during sub-acute toxicity study are indicated that it is mild toxic substance for sub-acute administration at TED dose level, may be because of alkanes which are found in functional group of aconitum ferox.

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PHARMACOGNOSTIC, ANTIOXIDANT AND ACUTE TOXICITY STUDY OF Ficus sycomorus (Linn) (Moraceae) ROOT AND STEM BARK

FUDMA Journal of Sciences ◽

10.33003/fjs-2020-0402-244 ◽

2020 ◽

Vol 4 (2) ◽

pp. 605-614

Author(s):

Murtala M. Namadina ◽

H. Haruna ◽

U. Sanusi

Keyword(s):

Acute Toxicity ◽

Radical Scavenging ◽

Stem Bark ◽

The Body ◽

Toxicity Study ◽

Bark Extract ◽

Root Extract ◽

Acute Toxicity Study ◽

Radical Scavenging Ability ◽

Phytochemical Components

Most of biochemical reactions in the body generates Reactive Oxygen Species (ROS), which are involved in the pathogenesis of oxidative stress-related disorders like diabetes, nephrotoxicity, cancer, cardiovascular disorders, inflammation and neurological disorders when they attack biochemical molecules like proteins, lipids and nucleic acid. Antioxidants are used to protect the cells or tissues against potential attack by ROS. Most medicinal plants possess a rich source of antioxidants such as flavonoids, phenols, tannins, alkaloids among others. These phytochemicals are currently pursued as an alternative and complimentary drug. In this study, phytochemical components, antioxidant and acute toxicity study of the methanol extract of stem bark and root of F. sycomorus were carried out using standard methods. Findings from this study revealed the presence of some diagnostic microscopical features such as calcium oxalate, starch, gum/mucilage, lignin, Aleurone grain, suberized/Cuticular cell wall and inulin but calcium carbonate was absent in stem bark but present in the powdered root. Quantitative physical constants include moisture contents (6.40% and 7.82%), ash value (7.20% and 9.30 %) in stem bark and root respectively. Carbohydrates, alkaloid, flavonoids, saponins, tannins, glycoside, steroid, triterpenes and phenols were present in all the extracts. They were found to exhibit potent 1,1,-diphenyl 2-picryl hydrazyl (DPPH) free scavenging activity. The DPPH radical scavenging ability of the extracts showed the following trend Ascorbic acid < stem bark extract˃ root extract. The LD50 of the methanolic stem bark and root extracts were found to be greater than 5000 mg /kg and is considered safe for use. Nonetheless, further

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