scholarly journals Analysis of Platelet Indices and its correlation with platelet count In Dengue

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 284-289
Author(s):  
Dhanya Menon ◽  
Ganthimathy Sekhar ◽  
Siddharth A R ◽  
Sridevi M
Keyword(s):  
Platelet Count ◽  
Dengue Infection ◽  
Large Cell ◽  
Health Concern ◽  
P Value ◽  
Distribution Width ◽  
Platelet Indices ◽  
Ns1 Antigen ◽  
Automated Hematology Analyzer

Dengue is a global arboviral disease of growing public health concern. Several parameters have been used to detect the infection and severity of dengue. Recent evidence suggests that platelet indices can be used to assess the severity and prognosis of dengue infection. This retrospective study aims at assessing the role of the platelet indices – Mean Platelet Volume (MPV), Platelet Distribution Width, (PDW), P-LCR (Platelet Large Cell Ratio) and Plateletcrit (PCT) and its correlation with the platelet count in 50 Dengue NS1 antigen positive cases and to find the sex ratio and the age-wise distribution of the dengue cases. The indices were obtained using an Automated Hematology analyzer and were compared with the platelet count, considering p-value <0.05 as statistically significant. Thrombocytopenia was found in a majority of the cases and PDW and PLCR were found to be inversely proportional to the platelet count. MPV was found to have no correlation with the platelet count. Hence, we conclude that Platelet count, PDW, and P-LCR can be used as predictors of Dengue infection and severity, whereas MPV cannot be used as a predictor of Dengue infection or severity.

scholarly journals Role of platelet parameters and hematological profile in dengue positive cases

2021 ◽  
Vol 8 (1) ◽  
pp. 23
Author(s):  
Rashim Passi ◽  
B. P. Baviskar ◽  
R. R. Karle
Keyword(s):  
Platelet Count ◽  
Hematological Parameters ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Care Hospital ◽  
Cross Sectional ◽  
Distribution Width ◽  
Platelet Indices ◽  
Ns1 Antigen

<p class="abstract"><strong>Background:</strong> Dengue is an endemic in tropical and sub-tropical regions of the world and also in various parts of India. Recent evidence indicates that platelet indices can be used to assess the severity and prognosis of dengue. This study aimed to assess the role of the platelet indices-mean platelet volume (MPV), platelet distribution width (PDW), platelet to large cell ratio (P-LCR), plateletcrit (Pct) and hematological parameters like hemoglobin (Hb), hematocrit (Hct) with the platelet count in dengue NS1 antigen positive cases.</p><p class="abstract"><strong>Methods:</strong> An observational cross-sectional study conducted on cases of dengue over a period of 3 months admitted with serological positivity (NS1 antigen) in a tertiary care hospital, Loni. The platelet indices like MPV, PDW, Pct, P-LCR and hematological parameters like Hb, Hct were noted using Sysmex XN-3100 Automated hematology analyzer and compared with platelet count.</p><p class="abstract"><strong>Results:</strong> Relationship between various platelet indices like MPV, PDW, P-LCR and PCT and hematological parameters like Hb, TLC and Hct were related with platelet count. Dengue positive cases were inversely related to MPV, PDW, P-LCR, Hb and Hct and directly related to Pct. In the present study Pct, P-LCR, Hb and Hct were statistically significant in correlation with platelet count.</p><p class="abstract"><strong>Conclusions:</strong> Pct, P-LCR, Hb and Hct along with platelet count can be used to assess the predictive outcomes in case of dengue infection.</p><p>.</p>

scholarly journals Platelet indices evaluation in patients with dengue fever

2018 ◽  
Vol 6 (6) ◽  
pp. 2054 ◽  
Author(s):  
Payal Mukker ◽  
Smitha Kiran
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Mean Platelet Volume ◽  
Dengue Infection ◽  
P Value ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Platelet Indices ◽  
Significant Difference

Background: Platelet indices (PIs)-Platecrit, mean platelet volume (MPV) and platelet distribution width (PDW)-are a group of platelet parameters obtained as a part of complete blood count using automated hematology analyzers. Evidence suggests that PIs may have diagnostic and prognostic value in febrile thrombocytopenia. This study aims to understand the profile of PIs in dengue fever. Aims and objectives was to study the platelet indices in patients with dengue fever.Methods: The present study is a retrospective observational study conducted in a tertiary hospital in Kerala. Platelet count, mean platelet volume (MPV), platecrit and Platelet distribution width (PDW) along with routine blood parameters hemoglobin(Hb), hematocrit, WBC, Platelet count, serum bilirubin, liver enzymes (AST, ALT) of 123 patients were collected. These 123 patients were grouped into three according to the platelet count (<20000,20000-100000, >100000). All the test results are available in hospital database. This was accessed using inpatient numbers obtained from medical records department of our institution. All analysis was done using free to use software R and values were rounded off to the nearest decimal point. Non normally distributed parameters were expressed as median (IQR). Parameters which did not follow normal distribution were analyzed with Kruskall Wallis test and the values are expressed as mean (SD) and a p value <0.05 was considered statistically significant.Results: Platelet indices PDW (57±13.8 vs. 55.4±6.9, p value 0.001) and MPV (9.2±0.09 vs. 13.8±1.3fL, p value <0.001) values were significantly altered in dengue fever with platelet counts below 20,000 compared to platelet count more than one lakh group. Similarly, the Platelet index (MPVxPDW\PLCxPCT), MPV\PLC, MPV\Platecrit, PDW\PLC and PDW\Platecrit ratio showed statistically significant difference between the different platelet groups.Conclusions: Platelet indices are useful parameters in dengue infection. Other than platelet count, PDW, MPV, platecrit are useful to monitor dengue fever.

scholarly journals Role of platelet distribution width and plateletcrit in assessment of nonthrombocytopenic preeclampsia and eclampsia in a tertiary care hospital of Odisha: an observational study

2020 ◽  
Vol 9 (5) ◽  
pp. 1996
Author(s):  
Kirtirekha Mohapatra ◽  
Pranati Mohanty ◽  
Nahida Nigar Sultana
Keyword(s):  
Platelet Count ◽  
Observational Study ◽  
Severe Disease ◽  
Tertiary Care ◽  
Measurement Tool ◽  
Care Hospital ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Platelet Indices

Background: Preeclampsia (PE) is a major cause of maternal and foetal morbidity and mortality in pregnancy. A decreased platelet count is observed during the progression of preeclampsia, and is considered a marker of the severity of preeclampsia. Considering the role of the PDW, PCT and platelet indices during the disease, the aim of this study was to evaluate the feasibility of using platelet indices as a severity marker for PE.Methods: This was a prospective, observational study, hospital-based study, from 2017-19 with 400 pregnant women being included on the basis of a predefined inclusion and exclusion criteria, through antenatal clinic, and labour room of the department of obstetrics and gynecology, S. C. B. Medical College, Cuttack, Odisha, India.Results: Study found that platelet count and plateletcrit showed a significant negative correlation with MAP whereas platelet distribution width showed a maximum positive correlation. In the preeclampsia group, subjects with PCT <0.22% were at risk of developing severe disease with a sensitivity of 53.5% and a high specificity of 85.5%. The AUC of 0.75 showed that it has a good predictability. In the eclampsia group, subjects with PCT <0.16% had a risk of developing severe disease with a sensitivity of 89.5% and specificity of 73.7%. The AUC 0.9 shows PCT to be a good predictor for assessing severity of eclampsia.Conclusions: This study suggests that platelet distribution width and plateletcrit are useful in risk evaluation of preeclampsia. These are a valid measurement tool to predict the severe progression of PE even when normal platelet counts are observed.

scholarly journals Platelet Parameters Assessment among Sudanese Pregnant Women with Preeclampsia Attending Wad Medani Obstetrics and Gynecology Teaching Hospital

2021 ◽  
Author(s):  
Ejlal Omer FadlElseed ◽  
Khalid Abdelsamea Mohamedahmed ◽  
Aboagala Mustafa Mohamed ◽  
Muatez Ibrahim Hassan ◽  
Yousif E/Hameed Mohammed ◽  
...  
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Teaching Hospital ◽  
Venous Blood ◽  
Obstetrics And Gynecology ◽  
P Value ◽  
Major Health ◽  
Platelet Indices ◽  
Study Results ◽  
Automated Hematology Analyzer

Abstract Background: Preeclampsia is considered one of the major health problems associated with pregnancy and one of the causes of maternal mortality. The pathogenesis of preeclampsia associated with platelet activation.Methods: This is a case-control laboratory-based study carried out in Wad Medani Obstetrics and Gynecology Teaching Hospital, Gezira State, Sudan from January to November 2020. The study aimed to evaluate the platelet parameters (platelet count and platelet indices) in pregnant women with preeclampsia. A total of 50 pregnant women with preeclampsia as cases (32.20 ± 3.21 years) and 50 normotensive pregnant women as controls (30.68 ± 2.85 years) participated in this study. Three ml of venous blood samples were collected from all participants in K3 EDTA containers. platelet parameters (platelet count and platelet indices) were determined using Mindray BC 3000 Automated Hematology Analyzer. Data were analyzed using the SPSS computer program (version 22). Results: The study results showed that the thrombocytopenia account for 56 %, all cases with low PCT (100%). Furthermore the means of PLTs count, PCT and PDW in cases were (144.40 ± 31.80 × 109/L, 0.13 ± 0.03 % and 15.80 ± 0.45 fl respectively) versus controls (269.40 ± 72.50 × 109/L, 0.22 ± 0.05 % and 15.50 ± 0.29 fl respectively), giving statistically significant differences (P value = 0.000, 0.003 and 0.022 respectively). The mean of PCT of mild cases was lower than severe cases (P value = 0.004); but there were no significant differences in PLTs count, MPV and PDW (P value = 0.379, 0.283 and 0.075 respectively).Conclusion: The study concluded that platelet count (PLTs count) and plateletcrit (PCT) were significantly decreased in pregnant women with preeclampsia especially; so platelet parameters especially (PLTs count and PCT) should be included for assessing and predicting the risk of severe preeclampsia.

scholarly journals Impact of Preeclampsia onPlatelet Count and Platelet Indices among Sudanese Pregnant Women in Gezira State

2021 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Venous Blood ◽  
P Value ◽  
Major Health ◽  
Platelet Indices ◽  
Study Results ◽  
The Mean ◽  
Automated Hematology Analyzer ◽  
Program Version

Background: Preeclampsia is considered one of the major health problems is associated with pregnancy and one of the causes of maternal mortality. The pathogenesis of preeclampsia associated with platelets activation. Objectives: The aim of this study was to evaluate the platelets parameters (platelet count and platelet indices) in pregnant women with preeclampsia. Methodology: This is a case-control laboratory-basedstudy carried out in Wad Medani Obstetrics and Gynecology Teaching Hospital, Gezira State, Sudan from January to November 2020. A total of 50 pregnant women with preeclampsia as cases (32.20 ± 3.21 years) and 50 normotensive pregnant women as controls (30.68 ± 2.85 years)participated in this study. Three ml of venous blood samples were collected from all participants in K3 EDTA containers. platelets parameters (platelet count and platelet indices) were determined using Mindray BC 3000 Automated Hematology Analyzer. Data were analyzed usingthe SPSS computer program (version 22). Results: The study results showed that the thrombocytopenia account for 56 %, all cases with low PCT (100%). Furthermore, the means of PLTs count, PCT and PDW in cases were (144.40 ± 31.80 × 109/L, 0.13 ± 0.03 % and 15.80 ± 0.45 fl respectively) versus controls (269.40 ± 72.50 × 109/L, 0.22 ± 0.05 % and 15.50 ± 0.29 fl respectively), giving statistically significant differences (P value = 0.000, 0.003 and 0.022 respectively). The mean of PCT of mild cases was lower than severe cases (P value = 0.004); but there were no significant differences in PLTs count, MPV and PDW (P value = 0.379, 0.283 and 0.075 respectively). Conclusion: The study concluded that platelet count (PLTs count) and plateletcrit (PCT) were significantly decreased in pregnant women with preeclampsia especially, so, platelets parameters especially (PLTs count and PCT) should beincluded for assessing and predictingthe risk of severe preeclampsia.

scholarly journals JUMLAH PLATELET PADA PENDERITA PRE-EKLAMPSIA

2016 ◽  
Vol 20 (1) ◽  
pp. 43
Author(s):  
M. Arif Muchlis ◽  
Suci Aprianti ◽  
Hj. Darmawati ER
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Secondary Data ◽  
Large Cell ◽  
Endothelial Damage ◽  
Control Group ◽  
P Value ◽  
Distribution Width ◽  
Significant Difference ◽  
The Mean

In pregnant women who previously did not have hypertension pre-eclampsia is a pregnancy complication, which characterized by the increased of blood pressure, proteinuria and/or oedema. One of theory about aetiology of pre-eclampsia suggests that this is caused by endothelial damage that can lead to adhesion and platelet aggregation. The aim of this study was to know the platelet count and indices by analyzing, such as mean platelet volume (MPV), its distribution width (PDW) and the large cell ratio (P-LCR) for diagnostic confirmation in pre-eclampsia patients. This research was a retrospective study using secondary data of routine blood test from medical records of pre eclampsia patients who were treated at Dr. Wahidin Sudirohusodo Hospital during the period of January to December 2011 and the normal pregnant women data that were taken as control. The data obtained were platelet count, MPV, PDW, P-LCR and analyzed using independent T test. The results showed that the mean platelet count in pre-eclampsia patients was lower than the control but had no statistically significant difference (p=0.325) whereas the mean of MPV, PDW and P-LCR in pre-eclampsia patients increased compared to the control group and was statistically significant with p value of MPV (p=0.003), PDW (p=0.002) and P-LCR (p=0.010). In conclusion, platelet indices can be used as diagnostic confirmation markers in pre-eclampsia patients.

scholarly journals The Effect of Metformin and Glimepiride on Platelet Count and Indices Among Diabetic Patients Attending Jaber Abu Aliz Diabetic Center in Khartoum State

2021 ◽  
Author(s):  
Hussein Abker Hussein ◽  
Dalia Mohammed Babikir ◽  
Fatima-Elzhra Ahmed Elmagzoub ◽  
Mouna Adel Samaan
Keyword(s):  
Platelet Count ◽  
Hba1c Level ◽  
Venous Blood ◽  
Large Cell ◽  
Drug Dose ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Distribution Width ◽  
Accelerated Atherosclerosis ◽  
Platelet Indices

Abstract BackgroundDiabetes mellitus (DM) is a global pandemic, Platelets have crucial role in accelerated atherosclerosis and thrombosis which characterize DM.AimThe aim of the study was to detect the effect of two major oral hypoglycemic drugs (Metformin and Glimepiride) on platelet count and indices MPV (Mean platelet volume), PLCR (platelet large cell ratio), PDW (platelet distribution width). Beside, to study the effects of variation in Age, sex, duration of the drug, dose of drug, HbA1C level and associated complications.Material and methods96 diabetic patients have been included in this study in addition 50 apparently healthy non-diabetic matching for age and sex subjects have been tested as control group.EDTA anti-coagulated venous blood samples has been taken from each , platelet count and indices were measured using automatic blood counter (Sysmex KX-21N) and HbA1C was Measured using Ichroma II . Statistics was performed by SPSS (version 22). ResultsThe results showed that both types of treatment have reduced platelets indices but the reduction in Glimepiride was insignificant except in PDW when compared with control. Also both have no effect on platelet count. Both treatments have insignificant variation on measured parameters when considering age, gender, dose and treatment duration though significant variation in Glimepiride study population was detected due to associated complications and HbA1C level.ConclusionIt is concluded that both types of drugs reduce platelet indices which have a good prognostic effect on the Pro-thrombotic state and accelerated atherosclerosis which is associated with type 2 Diabetic patients. Metformin have better effect on platelet indices than Glimepiride. Further case control trails are required.

scholarly journals THE EFFECT OF METFORMIN AND GLIMEPIRIDE ON PLATELET COUNT AND INDICES AMONG DIABETIC PATIENTS WERE ATTENDING JABER ABU ALIZ DIABETIC CENTER IN KHARTOUM STATE

2021 ◽  
Vol 10 (1) ◽  
pp. 93-98
Author(s):  
Hussein Abker Hussein ◽  
Fatima-Elzhra Ahmed Elmagzoub ◽  
Dalia Mohammed Babikir ◽  
Mouna Adel Samaan
Keyword(s):  
Diabetes Mellitus ◽  
Platelet Count ◽  
Hba1c Level ◽  
Venous Blood ◽  
Large Cell ◽  
Control Group ◽  
Diabetic Patients ◽  
Distribution Width ◽  
Accelerated Atherosclerosis ◽  
Platelet Indices

Diabetes mellitus (DM) is a global pandemic, Platelets have crucial role in accelerated atherosclerosis and thrombosis which characterize DM. Aim The aim of the study was to detect the effect of two major oral hypoglycemic drugs (Metformin and Glimepiride) on platelet count and indices{ MPV (Mean platelet volume), PLCR (platelet large cell ratio),PDW (platelet distribution width)}.Beside, to studythe effects of variation induration of the drug, dose of drug, HbA1C level and associated complications. Material and methods A case control study was performed 146subjects 50 were using metformin, 46 were using Glimepiride in addition to 50 apparently healthy non-diabetic matching for age and sex subjects have been tested as control group. EDTA anti-coagulated venous blood samples has been taken from eachsubject , platelet count and indices were measured using automatic blood counter (Sysmex KX-21N) and HbA1C was Measured using Ichroma II . Statistics was performed by SPSS (version 22). Results The results showed that both types of treatment (Metformin, Glimepiride)have reduced the platelets indices but the reduction in Glimepiride was insignificant except in PDW when comparedwith controls. Also both treatments have no effect on platelet count and there was insignificant variation between different doses of metformin and Glimepiride.Glimepiride diabetic patients from 15 to 20 yearshave increased platelet count in contrast to patients whom used glimepiride for less than 15 years.there was increased platelet count and decreased platelet indices in patients with foot ulcers whom using glimepiride than patients without complications. Also increased platelet indices in patients with HbA1C level less than 6% in contrast to those with HbA1C more than 7%. Conclusion It is concluded that both types of drugsreduce platelet indices. Glimepiride have a good prognostic effect on the Pro-thrombotic state and accelerated atherosclerosis which is associated with type 2 study population because the platelet indices were insignificant compared withcontrols. Keywords: Diabetes Mellitus, Metformin, Glimepiride, platelet count and indices

scholarly journals Study of Platelet Indices and Their Interpretation in Thrombocytopenia in a Tertiary Care Hospital

2021 ◽  
Vol 10 (7) ◽  
pp. 435-439
Author(s):  
Vani Mittal ◽  
Munesh Munesh ◽  
Irbinder Kour Bali ◽  
Sunil Arora ◽  
Jyoti Singh ◽  
...  
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Large Cell ◽  
Care Hospital ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Cell Ratio ◽  
Platelet Indices ◽  
Significant Difference

BACKGROUND Thrombocytopenia may either be due to increased destruction or impaired production of platelets. Platelet count alone is not enough to determine the mechanism of low platelets. Platelet indices like mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR) and platelet crit (PCT) can help determine the cause and we aimed at finding their role and function in cases of thrombocytopenia. METHODS An observational cross-sectional study of 155 patients with thrombocytopenia and 71 controls was done for a period of six months in SGT Hospital, Gurugram, to determine the mechanism behind the low platelet count with the help of these indices. RESULTS The mean values of the platelet indices (PDW, P-LCR and PCT) were found to be higher in accelerated destruction group (P < 0.05) in comparison to hypoproductive group, whereas, mean MPV values were higher in the former, but was not statistically significant. On comparison with the controls, both the groups of thrombocytopenia showed a statistically significant difference with P < 0.005 in all the four indices. Mean PCT values showed a highly significant difference between the two groups as well as with controls (P < 0.001) and also the relationship of PCT with severity of thrombocytopenia showed a direct relationship which was also significant (P < 0.001). CONCLUSIONS In distinguishing between the cause of thrombocytopenia i.e., hypoproductive or hyper destruction, platelet parameters play an important role. These platelet indices are easily available with the help of automated haematology analysers and can reduce the need for costly and invasive tests for evaluation of thrombocytopenia. KEY WORDS Mean Platelet Volume, Platelet crit, Platelet Distribution Width, Platelet Large Cell Ratio, Thrombocytopenia

scholarly journals A PROSPECTIVE OBSERVATIONAL STUDY FOR RELATIONSHIP BETWEEN THROMBOCYTOPENIA AND CULTURE POSITIVE NEONATAL BACTERIAL SEPSIS

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Anita Devi ◽  
Rakesh Kumar Sharma ◽  
Kapil Kumar
Keyword(s):  
Platelet Count ◽  
Observational Study ◽  
Neonatal Sepsis ◽  
Prospective Observational Study ◽  
Hematological Parameters ◽  
Clinical Signs ◽  
Sepsis Group ◽  
P Value ◽  
Distribution Width ◽  
Platelet Indices

Background: Changes in Platelet parameters like Mean Platelet Volume and Platelet Distribution Width are helpful in diagnosis of neonatal sepsis but these indices have not been extensively studied in neonatal sepsis. Hence, the present study is undertaken to evaluate Platelet count and platelet indices in diagnosis of neonatal sepsis. Methods: This prospective observational study was conducted over a period of 4 months i.e from December 2019 to March 2020 in neonatal intensive care unit of Jhalawar Medical College & Attached Hospitals, Jhalawar. During the study period 154 consecutive neonates (both inborn and out born), with clinical signs and symptoms of sepsis along with either positive culture (confirmed neonatal sepsis ) or other laboratory findings suggestive of bacterial and fungal infection in absence of positive cultures (probable sepsis), were included after written informed consent from parents. Results: Out of total (154), 81.8%, 76% and 67.5% of cases had thrombocytopenia, raised MPV (>10.8) and raised PDW respectively. As compared to Non-sepsis group, MPV values were raised in more cases of Sepsis proven group (88%) and the difference was statistically significant with P value of 0.011. PDW values were also more increased in Sepsis proven group compared to Non-sepsis group. Conclusion: Platelet count and platelet indices, which are easily available hematological parameters in remote & resource poor areas of our country, should be taken into consideration for suspected cases of neonatal sepsis so that prompt treatment can be given, and morbidity and mortality can be reduced. Keywords: Sepsis, CRP, MPV, PDW.

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