scholarly journals Platelet Parameters Assessment among Sudanese Pregnant Women with Preeclampsia Attending Wad Medani Obstetrics and Gynecology Teaching Hospital

2021 ◽  
Author(s):  
Ejlal Omer FadlElseed ◽  
Khalid Abdelsamea Mohamedahmed ◽  
Aboagala Mustafa Mohamed ◽  
Muatez Ibrahim Hassan ◽  
Yousif E/Hameed Mohammed ◽  
...  
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Teaching Hospital ◽  
Venous Blood ◽  
Obstetrics And Gynecology ◽  
P Value ◽  
Major Health ◽  
Platelet Indices ◽  
Study Results ◽  
Automated Hematology Analyzer

Abstract Background: Preeclampsia is considered one of the major health problems associated with pregnancy and one of the causes of maternal mortality. The pathogenesis of preeclampsia associated with platelet activation.Methods: This is a case-control laboratory-based study carried out in Wad Medani Obstetrics and Gynecology Teaching Hospital, Gezira State, Sudan from January to November 2020. The study aimed to evaluate the platelet parameters (platelet count and platelet indices) in pregnant women with preeclampsia. A total of 50 pregnant women with preeclampsia as cases (32.20 ± 3.21 years) and 50 normotensive pregnant women as controls (30.68 ± 2.85 years) participated in this study. Three ml of venous blood samples were collected from all participants in K3 EDTA containers. platelet parameters (platelet count and platelet indices) were determined using Mindray BC 3000 Automated Hematology Analyzer. Data were analyzed using the SPSS computer program (version 22). Results: The study results showed that the thrombocytopenia account for 56 %, all cases with low PCT (100%). Furthermore the means of PLTs count, PCT and PDW in cases were (144.40 ± 31.80 × 109/L, 0.13 ± 0.03 % and 15.80 ± 0.45 fl respectively) versus controls (269.40 ± 72.50 × 109/L, 0.22 ± 0.05 % and 15.50 ± 0.29 fl respectively), giving statistically significant differences (P value = 0.000, 0.003 and 0.022 respectively). The mean of PCT of mild cases was lower than severe cases (P value = 0.004); but there were no significant differences in PLTs count, MPV and PDW (P value = 0.379, 0.283 and 0.075 respectively).Conclusion: The study concluded that platelet count (PLTs count) and plateletcrit (PCT) were significantly decreased in pregnant women with preeclampsia especially; so platelet parameters especially (PLTs count and PCT) should be included for assessing and predicting the risk of severe preeclampsia.

scholarly journals Impact of Preeclampsia onPlatelet Count and Platelet Indices among Sudanese Pregnant Women in Gezira State

2021 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Venous Blood ◽  
P Value ◽  
Major Health ◽  
Platelet Indices ◽  
Study Results ◽  
The Mean ◽  
Automated Hematology Analyzer ◽  
Program Version

Background: Preeclampsia is considered one of the major health problems is associated with pregnancy and one of the causes of maternal mortality. The pathogenesis of preeclampsia associated with platelets activation. Objectives: The aim of this study was to evaluate the platelets parameters (platelet count and platelet indices) in pregnant women with preeclampsia. Methodology: This is a case-control laboratory-basedstudy carried out in Wad Medani Obstetrics and Gynecology Teaching Hospital, Gezira State, Sudan from January to November 2020. A total of 50 pregnant women with preeclampsia as cases (32.20 ± 3.21 years) and 50 normotensive pregnant women as controls (30.68 ± 2.85 years)participated in this study. Three ml of venous blood samples were collected from all participants in K3 EDTA containers. platelets parameters (platelet count and platelet indices) were determined using Mindray BC 3000 Automated Hematology Analyzer. Data were analyzed usingthe SPSS computer program (version 22). Results: The study results showed that the thrombocytopenia account for 56 %, all cases with low PCT (100%). Furthermore, the means of PLTs count, PCT and PDW in cases were (144.40 ± 31.80 × 109/L, 0.13 ± 0.03 % and 15.80 ± 0.45 fl respectively) versus controls (269.40 ± 72.50 × 109/L, 0.22 ± 0.05 % and 15.50 ± 0.29 fl respectively), giving statistically significant differences (P value = 0.000, 0.003 and 0.022 respectively). The mean of PCT of mild cases was lower than severe cases (P value = 0.004); but there were no significant differences in PLTs count, MPV and PDW (P value = 0.379, 0.283 and 0.075 respectively). Conclusion: The study concluded that platelet count (PLTs count) and plateletcrit (PCT) were significantly decreased in pregnant women with preeclampsia especially, so, platelets parameters especially (PLTs count and PCT) should beincluded for assessing and predictingthe risk of severe preeclampsia.

scholarly journals Analysis of Platelet Indices and its correlation with platelet count In Dengue

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 284-289
Author(s):  
Dhanya Menon ◽  
Ganthimathy Sekhar ◽  
Siddharth A R ◽  
Sridevi M
Keyword(s):  
Platelet Count ◽  
Dengue Infection ◽  
Large Cell ◽  
Health Concern ◽  
P Value ◽  
Distribution Width ◽  
Platelet Indices ◽  
Ns1 Antigen ◽  
Automated Hematology Analyzer

Dengue is a global arboviral disease of growing public health concern. Several parameters have been used to detect the infection and severity of dengue. Recent evidence suggests that platelet indices can be used to assess the severity and prognosis of dengue infection. This retrospective study aims at assessing the role of the platelet indices – Mean Platelet Volume (MPV), Platelet Distribution Width, (PDW), P-LCR (Platelet Large Cell Ratio) and Plateletcrit (PCT) and its correlation with the platelet count in 50 Dengue NS1 antigen positive cases and to find the sex ratio and the age-wise distribution of the dengue cases. The indices were obtained using an Automated Hematology analyzer and were compared with the platelet count, considering p-value <0.05 as statistically significant. Thrombocytopenia was found in a majority of the cases and PDW and PLCR were found to be inversely proportional to the platelet count. MPV was found to have no correlation with the platelet count. Hence, we conclude that Platelet count, PDW, and P-LCR can be used as predictors of Dengue infection and severity, whereas MPV cannot be used as a predictor of Dengue infection or severity.

ASSESSMENT OF THE PLATELET COUNT IN THE PREGNANT WOMEN IN IGIMS, PATNA, BIHAR

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Tanwi Singh ◽  
Anshuman Sinha
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Screening Test ◽  
Low Cost ◽  
Medical Science ◽  
Cost Effective ◽  
Platelet Indices ◽  
Increased Risk ◽  
Low Platelet Count ◽  
Severity Of The Disease

The major risk associated with low platelet count in pregnancy is the increased risk of bleeding during the childbirth or post that. There is an increased blood supply to the uterus during pregnancy and the surgical procedure requires cutting of major blood vessels. Women with thrombocytopenia are at increased risk of losing excessive blood. The risk is more in case of caesarean delivery as compared to vaginal delivery. Hence based on above findings the present study was planned for Assessment of the Platelet Count in the Pregnant Women in IGIMS, Patna, Bihar. The present study was planned in Department of Pathology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India. The present study was planned from duration of January 2019 to June 2019. In the present study 200 pregnant females samples received for the platelet estimation were enrolled in the present study. Clinically platelet indices can be a useful screening test for early identification of preeclampsia and eclampsia. Also platelet indices can assess the prognosis of this disease in pregnant women and can be used as an effective prognostic marker because it correlates with severity of the disease. Platelet count is a simple, low cost, and rapid routine screening test. Hence the data generated from the present study concludes that platelet count can be used as a simple and cost effective tool to monitor the progression of preeclampsia, thereby preventing complications to develop during the gestational period. Keywords: Platelet Count, Pregnant Women, IGIMS, Patna, Bihar, etc.

scholarly journals A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259543
Author(s):  
Solomon Gebre Bawore ◽  
Wondimagegn Adissu ◽  
Berhanu Niguse ◽  
Yilma Markos Larebo ◽  
Nigussie Abebe Ermolo ◽  
...  
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Mean Platelet Volume ◽  
Case Control Study ◽  
Case Control ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Platelet Indices ◽  
Control Study

Introduction Preeclampsia is the most serious health risk during pregnancy for both the mother and the fetus. Even though platelet parameters are among the proposed biomarkers for the prediction of preeclampsia, the use of its indices in the diagnosis of preeclampsia is not increasing in Ethiopia. There is little information on platelet patterns in preeclampsia and normal pregnancy. The purpose of this study was to determine the pattern of platelet indices in women with preeclampsia in our study setting. Methods A case-control study was conducted among 180 pregnant women who attended anti-natal follow-ups from January 1 to April 3, 2019. An Ethylene Diamine Tetra Acetic Acid anti-coagulated venous blood was collected and analyzed using a hematology analyzer (MINDRAY®-BC-300Plus, Shenzhen China). The SPSS software version 26 was used to run the Mann Whitney U test, Kruskal-Wallis H test, and Kolmogorov-Smirnov normality test, Post-hock test augmented with Benforeni, receiver operating characteristics curve, and Spear Man rank-order correlation. A P-value of <0.05 was considered statistically significant. Results A total of 180 pregnant women were included in the study. Platelet count and platelet crit levels tend to decrease as pre-eclampsia becomes more severe. In contrast, the mean platelet volume and platelet distribution widths were significantly increased with the severity of preeclampsia (P<0.001). Platelet distribution width (rho = 0.731, p<0.001) and mean platelet volume (rho = 0.674, p<0.001) had statistically significant positive relationships with mean arterial pressure. The best metric for predicting preeclampsia was platelet distribution width (AUC = 0.986; 95%CI; 0.970, 1). Conclusions Platelet indices, including platelet count, mean platelet volume, platelet distribution width, and Platelet crit, have been identified as promising candidate markers for predicting preeclampsia in pregnant women. In the future, a serial examination of these indicators during several trimesters of pregnancy should be conducted.

scholarly journals Hypoxia Inducible Factor1α in Correlation with Preeclampsia

2016 ◽  
Author(s):  
Hendrik Juarsa ◽  
Hermie M M Tendean ◽  
John E Wantania
Keyword(s):  
Pregnant Women ◽  
Positive Relationship ◽  
Obstet Gynecol ◽  
Venous Blood ◽  
Hypoxia Inducible Factor ◽  
Obstetrics And Gynecology ◽  
Elisa Method ◽  
Cross Sectional ◽  
Normotensive Pregnancy ◽  
Venous Blood Sampling

Objective: To know the correlation between Hypoxia Inducible Factor (HIF)-1α level with preeclampsia. Method: The study was conducted at the Obstetrics and Gynecology Department of Prof. Dr. R. D. Kandou Hospital. This research was carried out from April to June 2014. This study is a cross-sectional analytic approach in preeclampsia and normotensive pregnancy. We perform cubital venous blood sampling for inspection by 5 ml of serum and stored it in a refrigerator (-20°C). The level of HIF-1α serum was done by quantitative ELISA method in Prodia Lab Jakarta. Result: Seventy six pregnant women with 38 normotensive pregnancies and 38 preeclampsia, showed a significant association between the average levels of HIF-1α in the serum of pregnant women with preeclampsia compared to normotensive pregnancies (p = 0.000). Conclusion: There is a positive relationship between the levels of HIF-1α in serum of preeclampsia, in which HIF-1α levels in preeclampsia was higher than normotensive pregnancies. [Indones J Obstet Gynecol 2016; 1: 19-22] Keywords: hypoxia inducible factor-1α, preeclampsia

scholarly journals Prevalence and Demographic Correlates of Seropositive HIV and HBsAg Cases among Women Booking for Antenatal Care at the Rivers State University Teaching Hospital, Nigeria

2019 ◽  
pp. 1-9
Author(s):  
P. A. Awoyesuku ◽  
D. A. Macpepple ◽  
B. O. Altraide ◽  
D. H. John
Keyword(s):  
Pregnant Women ◽  
Teaching Hospital ◽  
Educational Status ◽  
University Teaching ◽  
P Value ◽  
Seroprevalence Rate ◽  
State University ◽  
Global Public Health ◽  
The Mean ◽  
Rivers State

Background: Infection with hepatitis B (HBV) and human immunodeficiency virus (HIV) are global public health problems. These infections during pregnancy increase the risk of maternal morbidity and mortality, and also pose a risk to the fetus due to mother to child transmission. Objective: To determine the prevalence of seropositive HIV and HBsAg cases amongst pregnant women at the Rivers State University Teaching Hospital (RSUTH). Methodology: A retrospective review of hospital and laboratory records of all pregnant women booked at RSUTH in two years, from May 2017 to April 2019, was carried out. Data on patients’ age, parity and educational level and reactivity of HIV and HBsAg test at booking were retrieved using structured proforma and analyzed using Epi Info Version 7. Test for significance using Chi-square was set at a significant level of P<0.05. Results: 3560 patients had HIV and HBsAg screening out of which 148 (4.2%) and 9 (0.3%) respectively were positive. The comorbidity rate in this study was 0.06%. The mean age was 31.5±4.7 years and the mean gestational age at booking was 22.1±6.8 weeks. There was no significant relationship between their age (χ2 = 2.690, p-value=0.442) and parity (χ2 = 3.759, p-value = 0.145) with HIV seropositivity, but these were significant for HBsAg (χ2 = 13.691, p-value = 0.003) (χ2 = 13.121, p-value=0.001).  Educational status was significant for HIV (χ2 = 16.188, p-value=0.000) but not for HBsAg (χ2 = 0.229, p-value=0.892). Conclusion: The seroprevalence rate of HIV and HBsAg in this study were low. HIV seroprevalence was significantly affected by lower education, while HBsAg seroprevalence was significantly affected by younger maternal age and nulliparity. Continued screening of pregnant women for these infections remains valuable and further community-based studies to identify risk factors are recommended.

scholarly journals Prevalence of Seropositive VDRL Cases amongst Pregnant Women at the Rivers State University Teaching Hospital, Nigeria: Is Routine Screening for Syphilis Using VDRL Still Relevant?

2019 ◽  
pp. 1-7
Author(s):  
P. A. Awoyesuku ◽  
D. A. MacPepple ◽  
N. J. Kwosah
Keyword(s):  
Pregnant Women ◽  
Teaching Hospital ◽  
University Teaching ◽  
P Value ◽  
Seroprevalence Rate ◽  
State University ◽  
Serological Screening ◽  
Specific Test ◽  
The Mean ◽  
Rivers State

Background: Untreated maternal syphilis is strongly associated with adverse birth outcomes. The WHO recommends routine serological screening in pregnancy. Some workers have advised a reappraisal of this practice, having demonstrated low seroprevalence in their antenatal population. Objective: To determine the prevalence of seropositive VDRL cases amongst pregnant women at the Rivers State University Teaching Hospital (RSUTH) in order to justify the need and cost-effectiveness for continued routine syphilis screening using VDRL alone. Methodology: A retrospective review of hospital and laboratory records of all pregnant women booked for antenatal care (ANC) at RSUTH in a two-year period, from May 2017 to April 2019, was carried out. Data on patients’ age, parity and educational level, and reactivity of VDRL test at booking were retrieved using structured pro-forma and analyzed using Epi Info Version 7. Test for significance using Chi-square was set at significant level of P<0.05. Results: 3560 clinic patients had VDRL screening out of which 63 were positive. The overall prevalence rate in this study was 1.8%. The mean age was 31.5±4.7 years and the mean gestational age at booking was 22.1±6.8 weeks. There was no significant relationship between their age (χ2 = 0.403, p-value=0.940), parity (χ2 = 3.707, p-value=0.0.157), and educational status (χ2 = 1.853, p-value=0.396), and seropositivity. The cost of VDRL test per patient in RSUTH is $3, to detect the 63 cases the sum of $10,680 was spent. Conclusion: The seroprevalence rate of syphilis in this study was low. Initial screening using VDRL alone is neither justified nor cost effective. Selective screening based on risk factors and specific test with TPHA is recommended.

scholarly journals Fetal Fibronectin (fFN) on the Imminent Premature Parturition in Correlation with Incidence of Preterm Labor

2016 ◽  
Author(s):  
Kusnarman Keman ◽  
Prasetyorini Nugrahanti ◽  
Ni Wayan Supriany
Keyword(s):  
Pregnant Women ◽  
Preterm Labor ◽  
Obstet Gynecol ◽  
Obstetrics And Gynecology ◽  
P Value ◽  
Fetal Fibronectin ◽  
Preterm Group ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship

Objective: To determine the relationship of fFn levels in cervicovaginal discharge of pregnant women who experience imminent premature parturition with the incidence of preterm labor. Method: The study was carried out with Analytic Observational Prospective Cohort using cervicovaginal discharge of pregnant women that experienced imminent premature parturition taken from the delivery room of Obstetrics and Gynecology department dr. Saiful Anwar Hospital, Malang as well as Bangil Hospital and Ngudi Waluyo Wlingi Hospital. Statistical analysis was performed using the Shapiro-Wilk test and comparison test used independent samples t test for normal data, Mann-Whitney test if not. All analysis used SPSS for Windows 19.0 software. Result: Thirty two patient samples was examined, 14 patients (43.75%) were primigravida and 18 patients (52.56%) is multigravida. 17 of these patients (53.13%) experienced aterm labor and 15 patients (46.87%) experienced preterm labor. Mann-Whitney test of the mean fFN levels between the aterm group (13.01 ± 7.57 ng/ml) and the preterm group (56.29 ± 27.77 ng/ml) showed a significant difference (p-value = 0.000 > 0.05). Moreover, Spearman’s Rho correlation test also showed a strong correlation between fFN level and incidence of preterm labor (R = 0.797, p < 0.05). Conclusion: fFN levels is significantly increase in cervicovaginal discharge from pregnant women with imminent premature parturition who experience preterm labor than pregnant women who experience aterm labor. Therefore, this result suggests that fFN has potential ability to become useful modality in preterm labor diagnosis. [Indones J Obstet Gynecol 2016; 1: 8-14] Keywords: cervicovaginal discharge, fFN, imminent premature parturition, preterm labor

scholarly journals JUMLAH PLATELET PADA PENDERITA PRE-EKLAMPSIA

2016 ◽  
Vol 20 (1) ◽  
pp. 43
Author(s):  
M. Arif Muchlis ◽  
Suci Aprianti ◽  
Hj. Darmawati ER
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Secondary Data ◽  
Large Cell ◽  
Endothelial Damage ◽  
Control Group ◽  
P Value ◽  
Distribution Width ◽  
Significant Difference ◽  
The Mean

In pregnant women who previously did not have hypertension pre-eclampsia is a pregnancy complication, which characterized by the increased of blood pressure, proteinuria and/or oedema. One of theory about aetiology of pre-eclampsia suggests that this is caused by endothelial damage that can lead to adhesion and platelet aggregation. The aim of this study was to know the platelet count and indices by analyzing, such as mean platelet volume (MPV), its distribution width (PDW) and the large cell ratio (P-LCR) for diagnostic confirmation in pre-eclampsia patients. This research was a retrospective study using secondary data of routine blood test from medical records of pre eclampsia patients who were treated at Dr. Wahidin Sudirohusodo Hospital during the period of January to December 2011 and the normal pregnant women data that were taken as control. The data obtained were platelet count, MPV, PDW, P-LCR and analyzed using independent T test. The results showed that the mean platelet count in pre-eclampsia patients was lower than the control but had no statistically significant difference (p=0.325) whereas the mean of MPV, PDW and P-LCR in pre-eclampsia patients increased compared to the control group and was statistically significant with p value of MPV (p=0.003), PDW (p=0.002) and P-LCR (p=0.010). In conclusion, platelet indices can be used as diagnostic confirmation markers in pre-eclampsia patients.

scholarly journals Maternally requested caesarean delivery: Popularity amongst pregnant women at a South West Nigerian teaching hospital

2021 ◽  
Vol 3 (1) ◽  
pp. 019-030
Author(s):  
Ramon Sunday Omotayo ◽  
Abayomi Logo ◽  
Adetayo Bade-Adefioye ◽  
Oluseyi Adewale ◽  
Ayomide Emmanuel Sanni
Keyword(s):  
Caesarean Section ◽  
Pregnant Women ◽  
Teaching Hospital ◽  
Antenatal Clinic ◽  
Medical Sciences ◽  
Cultural Economic ◽  
Cross Sectional ◽  
Maternal Request ◽  
Study Results ◽  
Do So

Caesarean Section on maternal request is a planned surgery performed without medical indication, where the wish of the woman compensates for the lack of medical reasons. Preferences for caesarean section are often associated with some factors that may be cultural, economic, religious or social. Some women are said to suffer from tocophobia which is the fear of childbirth and may be a major psychological cause for caesarean section due to maternal request (CSMR). This study explored the popularity of maternally requested caesarean section amongst pregnant women in the Antenatal clinic of University of Medical Sciences Teaching Hospital, Akure. Method: It was a cross-sectional descriptive study. Results: Willingness to request for caesarean section if not indicated is found to be low with only about 10% indicating that they can do so. Rather, refusal to undergo caesarean section when medically indicated is found to be relatively high with 43 % of respondents indicating their unwillingness to have caesarean section even if indicated. Fear of adverse occurrence to mother or baby is the major reason for avoiding caesarean section Conclusion: Maternally requested caesarean section is not popular amongst pregnant women while aversion to indicated caesarean section is high in the study area. There is need for massive education and enlightenment on caesarean section in order to improve its acceptability.

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