scholarly journals Role of platelet parameters and hematological profile in dengue positive cases

2021 ◽  
Vol 8 (1) ◽  
pp. 23
Author(s):  
Rashim Passi ◽  
B. P. Baviskar ◽  
R. R. Karle
Keyword(s):  
Platelet Count ◽  
Hematological Parameters ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Care Hospital ◽  
Cross Sectional ◽  
Distribution Width ◽  
Platelet Indices ◽  
Ns1 Antigen

<p class="abstract"><strong>Background:</strong> Dengue is an endemic in tropical and sub-tropical regions of the world and also in various parts of India. Recent evidence indicates that platelet indices can be used to assess the severity and prognosis of dengue. This study aimed to assess the role of the platelet indices-mean platelet volume (MPV), platelet distribution width (PDW), platelet to large cell ratio (P-LCR), plateletcrit (Pct) and hematological parameters like hemoglobin (Hb), hematocrit (Hct) with the platelet count in dengue NS1 antigen positive cases.</p><p class="abstract"><strong>Methods:</strong> An observational cross-sectional study conducted on cases of dengue over a period of 3 months admitted with serological positivity (NS1 antigen) in a tertiary care hospital, Loni. The platelet indices like MPV, PDW, Pct, P-LCR and hematological parameters like Hb, Hct were noted using Sysmex XN-3100 Automated hematology analyzer and compared with platelet count.</p><p class="abstract"><strong>Results:</strong> Relationship between various platelet indices like MPV, PDW, P-LCR and PCT and hematological parameters like Hb, TLC and Hct were related with platelet count. Dengue positive cases were inversely related to MPV, PDW, P-LCR, Hb and Hct and directly related to Pct. In the present study Pct, P-LCR, Hb and Hct were statistically significant in correlation with platelet count.</p><p class="abstract"><strong>Conclusions:</strong> Pct, P-LCR, Hb and Hct along with platelet count can be used to assess the predictive outcomes in case of dengue infection.</p><p>.</p>

scholarly journals Role of platelet distribution width and plateletcrit in assessment of nonthrombocytopenic preeclampsia and eclampsia in a tertiary care hospital of Odisha: an observational study

2020 ◽  
Vol 9 (5) ◽  
pp. 1996
Author(s):  
Kirtirekha Mohapatra ◽  
Pranati Mohanty ◽  
Nahida Nigar Sultana
Keyword(s):  
Platelet Count ◽  
Observational Study ◽  
Severe Disease ◽  
Tertiary Care ◽  
Measurement Tool ◽  
Care Hospital ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Platelet Indices

Background: Preeclampsia (PE) is a major cause of maternal and foetal morbidity and mortality in pregnancy. A decreased platelet count is observed during the progression of preeclampsia, and is considered a marker of the severity of preeclampsia. Considering the role of the PDW, PCT and platelet indices during the disease, the aim of this study was to evaluate the feasibility of using platelet indices as a severity marker for PE.Methods: This was a prospective, observational study, hospital-based study, from 2017-19 with 400 pregnant women being included on the basis of a predefined inclusion and exclusion criteria, through antenatal clinic, and labour room of the department of obstetrics and gynecology, S. C. B. Medical College, Cuttack, Odisha, India.Results: Study found that platelet count and plateletcrit showed a significant negative correlation with MAP whereas platelet distribution width showed a maximum positive correlation. In the preeclampsia group, subjects with PCT <0.22% were at risk of developing severe disease with a sensitivity of 53.5% and a high specificity of 85.5%. The AUC of 0.75 showed that it has a good predictability. In the eclampsia group, subjects with PCT <0.16% had a risk of developing severe disease with a sensitivity of 89.5% and specificity of 73.7%. The AUC 0.9 shows PCT to be a good predictor for assessing severity of eclampsia.Conclusions: This study suggests that platelet distribution width and plateletcrit are useful in risk evaluation of preeclampsia. These are a valid measurement tool to predict the severe progression of PE even when normal platelet counts are observed.

scholarly journals Analysis of Platelet Indices and its correlation with platelet count In Dengue

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 284-289
Author(s):  
Dhanya Menon ◽  
Ganthimathy Sekhar ◽  
Siddharth A R ◽  
Sridevi M
Keyword(s):  
Platelet Count ◽  
Dengue Infection ◽  
Large Cell ◽  
Health Concern ◽  
P Value ◽  
Distribution Width ◽  
Platelet Indices ◽  
Ns1 Antigen ◽  
Automated Hematology Analyzer

Dengue is a global arboviral disease of growing public health concern. Several parameters have been used to detect the infection and severity of dengue. Recent evidence suggests that platelet indices can be used to assess the severity and prognosis of dengue infection. This retrospective study aims at assessing the role of the platelet indices – Mean Platelet Volume (MPV), Platelet Distribution Width, (PDW), P-LCR (Platelet Large Cell Ratio) and Plateletcrit (PCT) and its correlation with the platelet count in 50 Dengue NS1 antigen positive cases and to find the sex ratio and the age-wise distribution of the dengue cases. The indices were obtained using an Automated Hematology analyzer and were compared with the platelet count, considering p-value <0.05 as statistically significant. Thrombocytopenia was found in a majority of the cases and PDW and PLCR were found to be inversely proportional to the platelet count. MPV was found to have no correlation with the platelet count. Hence, we conclude that Platelet count, PDW, and P-LCR can be used as predictors of Dengue infection and severity, whereas MPV cannot be used as a predictor of Dengue infection or severity.

scholarly journals IMPACT OF COVID-19 ON HEMATOLOGICAL PARAMETERS-A SINGLE CENTRE STUDY, INDIA.

2020 ◽  
pp. 4-6
Author(s):  
Reshma Anegundi ◽  
Talari Rajeswari ◽  
Arathi C A ◽  
Raghavendra M S
Keyword(s):  
Complete Blood Count ◽  
Hematological Parameters ◽  
Demographic Data ◽  
Tertiary Care ◽  
Systemic Infection ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Single Centre ◽  
Cross Sectional ◽  
Distribution Width

Aims and Objectives: To analyze various hematological parameters in Covid-19 infected patients. Patients/Materials and Methods: This is a retrospective, single centre cross sectional study conducted in a tertiary care hospital, located in a tri-state region. Data was collected from patients admitted in Covid-19 ward and ICU between 28 July to 7 September 2020, confirmed positive for Covid-19 infection. Basic demographic data was collected from Laboratory Information System(LIS) of our hospital . Whole blood EDTA sample sent from Covid-19 ward and ICU were processed in LH780/DXH 500(Beckman coulter) for complete blood counts. Further patients laboratory features were analyzed . Results: Findings of 338 patients, both from ward and ICU, showed varied hematological parameters. Demographic data revealed age range from 1day to 86 years. Males constituted 205(60.65%) and females 133(39.34%).Complete blood count showed Hemoglobin(Hb) concentration ranged from 5.8 -18.5gm/dL and median value 13.6gm/dL. Red cell distribution width(RDW) ranged from 11.4-39.9% with median value of 13.6%. Leucocytosis was observed in 13.9% of patients, high absolute neutrophil count in 15.6% ,high Neutrophil to Lymphocyte ratio(NLR) in 10.05% patients and eosinophil count ranged from 0-15.3%. Conclusion: Baseline alterations in CBC parameters of 10-15% of patients in the present study along with articles reviewed from various countries indicate Covid -19 infection causes systemic infection involving multiple organs and systems.

scholarly journals A STUDY ON PLATELET COUNT AND PLATELET INDICES IN NEONATAL SEPSIS IN A TERTIARY CARE CENTER

2021 ◽  
Vol 5 (9) ◽  
Author(s):  
Neha Sharma ◽  
G S Senger ◽  
Seema Meena ◽  
Priyanka Sharma
Keyword(s):  
Platelet Count ◽  
Neonatal Sepsis ◽  
Hematological Parameters ◽  
Care Center ◽  
Tertiary Care ◽  
Clinical Signs ◽  
Sepsis Group ◽  
P Value ◽  
Distribution Width ◽  
Platelet Indices

Background: The present study is undertaken to evaluate Platelet count and platelet indices in diagnosis of neonatal sepsis. Methods: This prospective observational study was conducted on 100 consecutive neonates (both inborn and out born), with clinical signs and symptoms of sepsis along with either positive culture (confirmed neonatal sepsis ) or other laboratory findings suggestive of bacterial and fungal infection in absence of positive cultures (probable sepsis), were included after written informed consent from parents. Results: 71 (71.00%) out of 100 cases had increased values of Platelet Distribution Width. In Proven sepsis group 31(86.11%) cases had increased values of PDW, in Probable sepsis 31(63.27%) and in No sepsis group 9(60.00%) cases were having increased values of PDW. This difference was statistically not significant (P value is 0.08). Conclusion: Platelet count and platelet indices, which are easily available hematological parameters in remote & resource poor areas of our country, should be taken into consideration for suspected cases of neonatal sepsis so that prompt treatment can be given, and morbidity and mortality can be reduced. Keywords: Sepsis, TPC, MPV, PDW.

scholarly journals Clinico-Laboratory Observations and Outcome of Dengue Infection In a Tertiary Care Hospital of Western Nepal: An Observational Cross-Sectional Study

2018 ◽  
Vol 5 (2) ◽  
pp. 3-7
Author(s):  
Niraj Kumar Jaiswal ◽  
Shatdal Chaudhary ◽  
Nagendra Chaudhary
Keyword(s):  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Severe Thrombocytopenia ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Rapid Urbanization ◽  
South West

INTRODUCTION: Dengue fever (DF) is highly prevalent in tropical and subtropical countries all over the world. This study was done to study the clinico-laboratory profile of DF patients and their outcomes in a tertiary care hospital of western Nepal.MATERIAL & METHODS:  A prospective observational cross-sectional study conducted over 6 months (October 2016 to March 2017) in patients admitted to medical inpatient ward of a tertiary care referral hospital located at south west Nepal. All febrile patients underwent dengue antibody (IgM) testing. Patient details, clinical manifestations and laboratory parameters were recorded. Descriptive analysis was done as mean and percentage.RESULTS: Out of total 2653 hospital admissions, 1274 patients (male: 780, female: 494) presented with fever. Forty patients between 17 years to 84 years (Mean age ± SD: 40.3±17 years) were diagnosed as DF. All the age groups were almost equally affected. The average duration of hospital stay was 5.4±3.2 days. Fever (n=40, 100%), body ache (n=29, 74.4%) and headache (n=28, 70%) were three leading complaints in dengue patients. Only 22.5% (n=9) of the patients had thrombocytopenia (mild and moderate). Severe thrombocytopenia was not noticed. Only 10% of total dengue cases received platelet transfusion. The mean platelet count increased from day one to day seven gradually. All the patients recovered.CONCLUSION: DF is a well-established vector-borne disease in south west Nepal; may be due to rapid urbanization and poor hygiene facility. Appropriate disease control programme emphasizing on vector surveillance and control, early clinical diagnosis and treatment reduces the dengue-related deaths.Journal of Universal College of Medical Sciences (2017)Vol.05 No.02 Issue 16, page: 3-7

scholarly journals FREQUENCY AND SEVERITY OF LIVER INVOLVEMENT IN DENGUE VIRUS INFECTION.

2019 ◽  
Vol 26 (07) ◽  
pp. 1074-1078
Author(s):  
Masood Tareen ◽  
Riaz Hussain Awan ◽  
Seema Nayab ◽  
Khadim Hussain Awan
Keyword(s):  
Dengue Fever ◽  
Liver Enzymes ◽  
Early Recognition ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Liver Involvement ◽  
Care Hospital ◽  
Cross Sectional ◽  
Study Setting

Objectives: To determine the frequency & severity of liver involvement in dengue infection among adults at tertiary care hospital. Period: Six months (9th May 2016 to 9th Nov 2016). Study Design:  Cross-sectional study. Setting: Department of Gastroenterology and Department of Medicine Liaquat National Hospital, Karachi. Patients and Methods: Results: A total of 343 patients with Dengue fever were selected to conduct this study with mean age of 34.67±9.09 years. Mean duration of the fever was 7.31±1.62 days. Mean duration of hospital stay of the patients came out to be 3.50+0.82 days. Severity of liver enzymes derangement was mild in 80 patients (23%), moderate in 246 (72%) & severe in 17(5%). Mortality was seen in 14% (47 patients) & 100% mortality was seen in dengue fever patients with severely deranged Liver enzymes. Conclusion: Dengue fever patients with deranged liver enzymes had statistically worse outcome thus can lead to early recognition of high risk cases.

ASSOCIATION OF HEMATOCRIT-PLATELET INDEX AND HEMATOCRIT SHIFT WITH WARNING SIGNS AND HOSPITAL STAY IN DENGUE PATIENTS AT A TERTIARY CARE HOSPITAL

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S277-82
Author(s):  
Muhammad Fahd Bin Haider ◽  
Humaira Zafar ◽  
Syed Zubair Hussain Shah ◽  
Mobaila Akram ◽  
Kamran Malik ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Warning Signs ◽  
Care Hospital ◽  
Cross Sectional ◽  
Duration Of Stay ◽  
Platelet Indices ◽  
Significant Difference ◽  
Duration Of Hospitalization

Objective: To determine the relationship between hematocrit, platelet count, warning signs and duration ofhospitalization in indoor dengue patients. Study Design: Analytical, cross sectional study. Place and Duration of Study: Department of Medicine, Pakistan Air Force Hospital Islamabad and Departmentof Biochemistry and Molecular Biology, AM College, Rawalpindi, from Sep 2019 to Jun 2020. Methodology: A total of 100 indoor patients were recruited using convenience sampling. Their platelets, hema-tocrit and warning signs were recorded on arrival in the hospital. First two parameters were checked every day for the whole duration of stay in the hospital. The WHO standard treatment of dengue was given to the patients. Patient were divided into two groups based upon duration of hospitalization using cut-off of 3 days. Linear regression was used to analyze association of hematocrit-platelet index and hematocrit shift with presence of one or more warning signs and duration of hospital stay. Results: There was statistically significant difference in 3rd day Hematocrit Platelet Indices of patients with short and long hospital stay (p=0.003). 3rd day Hematocrit-platelet indices of patients with and without warning signs also showed statistically significant difference when compared with eachother (p=0.0001). It was stronger than Hematocrit Shift (p=0.82) and platelets considered alone. Conclusion: Day 3 Hematocrit Platelet Indexis more strongly associated with warning signs and duration of stay rather than hematocrit alone. It means both need to be taken into account while monitoring dengue patients. Hematocrit platelet index for severity and duration of hospitalization while Hematocrit shift for fluid therapy.

scholarly journals Endoscopic Retrograde Cholangiopancreatography Findings Differs From Ultrasound Results: A Study On Choledocholitihisis Patients In A Tertiary Care Hospital Of Bangladesh

2019 ◽  
Vol 30 (1) ◽  
pp. 5-8
Author(s):  
Tareq Mahmud Bhiuyan ◽  
Mousumi Sanyal ◽  
Sabrina Yesmin S
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Tertiary Care ◽  
Ampullary Carcinoma ◽  
Care Hospital ◽  
Endoscopic Retrograde ◽  
Cross Sectional ◽  
High Clinical Suspicion ◽  
Normal Ultrasound

Background: Endoscopic retrograde cholangio-pancreatography (ERCP) is a universally established modality in evaluation and treatment of pancreatico-biliary disorders. Choledocholothiasis is one of its common indications. In the context of Bangladesh, clinical studies on ERCP, specially, assessment of the role of pre-procedural Ultrasound as a screening tool, is relatively rare. In this work, we have analyzed the ERCP outcome of 95 patients and compared their pre-procedural ultrasound results afterwards. Methods: This cross-sectional observational study was conducted in the BIRDEM General Hospital during June 2013 to January2015 on 95 ERCP patients. Among 95 patients, maximum (27.7%) were diagnosed as Choledocholithiasis. The important diagnosis among the rest were, Chronic Calcific Pancreatitis (13.8%), Ca head of Pancreas (12.7%), Cholangiocarcinoma (11.7%), and peri- ampullary carcinoma (11.7%). Ultrasound could not detect common bile duct stone in 42% of choledocholithiasis patients. It detected dilated common bile duct in 30% patients and 15% patients had normal ultrasound report while they underwent ERCP due to high clinical suspicion and found to have duct stone afterwards. Conclusion: The role of ultrasound as a screening test for choledocholithiasis should be progressively assessed by comparing it with MRCP and ERCP results. This study will encourage further research to find correlation between the ERCP and Imaging (both ultrasound and MRCP) in choledocholithiasis patients Bangladesh J Medicine Jan 2019; 30(1) : 5-8

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