Assessment of role of consanguinity in formation of cleft lip and cleft palate

Consanguinity is considered a significant factor in autosomal recessive diseases; it has also been associated with congenital anomalies such as hydrocephalus, polydactilia and Cleft Lip and Palate deformities. The risk of congenital conditions is higher in subjects born of first degree consanguineous parents compared with those of non-consanguineous marriages. The aim of this study is to evaluate the prevalence of consanguinity with formation of cleft lip/ cleft palate formation in Tamil, Telugu population. This is a retrospective study. The details of 86,000 patient records were reviewed and analysed, out of which 76 patients who had undergone surgical treatment for cleft lip and cleft palate deformities between June 2019 to march 2020 were included in this study. The details like age, gender, family history and cleft diagnosis were evaluated and entered in SPSS and analysed through a chi-square test. It was observed that 11% of patients reported with history of consanguineous marriages which was associated with formation of cleft lip/palate. Within the limits of the study, it was concluded that consanguinity had a significant role in formation of cleft lip/cleft palate.

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Incidence of Orofacial Clefts in Kumasi, Ghana

ISRN Plastic Surgery ◽

10.5402/2013/280903 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

P. Agbenorku ◽

M. Yore ◽

K. A. Danso ◽

C. Turpin

Keyword(s):

Cleft Palate ◽

Congenital Anomalies ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Orofacial Clefts ◽

Female Ratio ◽

Live Births ◽

Male Female Ratio ◽

Cleft Lip Palate ◽

History Of

Background. Cleft lip and cleft palate are among the most common orofacial congenital anomalies. This study is to establish Orofacial Clefts Database for Kumasi, Ghana, with a view to extend it to other cities in future to obtain a national orofacial anomaly database. Methods. A descriptive prospective survey was carried out at eleven selected health facilities in Kumasi. Results. The total number of live births recorded was 27,449. Orofacial anomalies recorded were 36, giving an incidence of 1.31/1000 live births or 1 in 763 live births. The mean maternal age of cleft lip/palate babies was 29.85 years (range 18–40 years). The male : female ratio for the orofacial anomalies babies was 1.3 : 1; the male : female ratio was 0.5 : 1 in the cleft lip group, 1.3 : 1 in the cleft lip and palate group, and 4 : 1 in the cleft palate group. The majority of clefts were unilateral (69.4%, n=25), with females (n=14) outnumbering males (n=11). A family history of cleft was recorded with five babies (13.9%). Associated congenital anomalies were recorded in seven (19.4%) cleft lips and/or palates. Conclusion. The incidence of 1 in 763 live births found in this study indicates that cleft lip/palate is a common congenital anomaly in Kumasi.

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Association of the profile of individuals with cleft lip/palate with the beginning of orthopedic/ orthodontic treatment

RSBO ◽

10.21726/rsbo.v14i2.644 ◽

2017 ◽

Vol 14 (2) ◽

pp. 86-93

Author(s):

Madiana Magalhães Moreira ◽

Pedro Diniz Rebouças ◽

Maria Lúcia Bonfim Chagas ◽

Luan Cartaxo Félix ◽

Paulo Goberlânio de Barros Silva ◽

...

Keyword(s):

Orthodontic Treatment ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Geographic Origin ◽

Panoramic Radiograph ◽

Mixed Dentition ◽

Chi Square ◽

Reference Hospital ◽

Cleft Lip Palate ◽

Chi Square Test

Cleft lip and palate (CLP) is the most frequent congenital malformation among the anomalies of the head and neck. The orthopedic/orthodontic treatment is included in the rehabilitation of these individuals, however there is no consensus in the literature regarding the ideal time for its beginning. Objective: To verify and characterize the profile of individuals with CLP treated at a reference hospital of the northeast of Brazil from 1998 to 2013 and its association with the beginning of the orthopedic/ orthodontic treatment. Material and methods: Through direct observation of medical records, panoramic radiograph, and study casts of 323 individuals, data regarding sex, cleft type, origin and age of beginning of the orthopedic/orthodontic treatment were surveyed and analyzed using the chi-square test, considering a 5% level of significance. Results: Most of the individuals had transforamen and the unilateral cleft was the most prevalent (p<0.05). Females were statistically more affected by post-foramen cleft and males by trans-foramen cleft (p><0.05). Most individuals with trans-foramen cleft and post-foramen cleft started the orthopedic/ orthodontic treatment between 8 and 12 years old (p><0.05). No statistically significant differences occurred relating the beginning><0.05). Females were statistically more affected by post-foramen cleft and males by trans-foramen cleft (p<0.05). Most individuals with trans-foramen cleft and post-foramen cleft started the orthopedic/ orthodontic treatment between 8 and 12 years old (p<0.05). No statistically significant differences occurred relating the beginning> <0.05). No statistically significant differences occurred relating the beginning of the orthopedic/orthodontic treatment with geographic origin and sex of, although most of them have started treatment at late mixed dentition. Conclusion: Regardless of gender, origin, or cleft type, most patients started orthopedic treatment up to 12 years-old, an age considered ideal by most protocols. Unilateral and trans-foramen cleft were the most prevalent cleft types. post-foramen cleft affected more females, while trans-foramen cleft affected more males.

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Prevalence of cleft lip and palate in Bauru, SP – concordance among registries of HRAC/USP, DNV and SINASC

Brazilian Dental Science ◽

10.14295/bds.2021.v24i4.2652 ◽

2021 ◽

Vol 24 (4) ◽

Author(s):

Kelly Fernanda Molena ◽

Vivian Patricia Saldias Vargas Winckler ◽

Gisele da Silva Dalben

Keyword(s):

Cleft Palate ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Congenital Defects ◽

Test Results ◽

Chi Square ◽

The Public ◽

Number Of Children ◽

Chi Square Test ◽

The City

Objective: Congenital defects, including cleft lip and palate, increase the morbidity and mortality in the affected population. This study aimed to determine the prevalence of cleft lip and palate in the city of Bauru, Brazil, by evaluation of registry in the Brazilian Livebirth Certificate (DNV) and the Information System on Livebirths (SINASC), and analyzed the concordance of diagnosis compared with registries of the Hospital for Rehabilitation of Craniofacial Anomalies (HRAC/USP), located in the same city. Material and Methods: This retrospective observational study comprised analysis of all DNVs and identification of individuals with clefts born and living in Bauru, comparing with data from HRAC/USP. The prevalence was calculated by dividing the number of children born with clefts in the study period by the total number of livebirths registered. The reporting of different types of clefts was compared by the chi-square test. Results: Overall, 50,898 DNV were evaluated, among which there were 25 reported cases of cleft lip and/or palate. In the same period, HRAC/USP registered 77 cases born in Bauru, representing 67.5% of underreporting of the occurrence of clefts. Cleft palate was the most prevalent (34.9%), followed by cleft lip and palate (31.7%) and cleft lip (30.2%), mostly affecting males (58.5%). The reporting of cleft palate (16.12%) was lower compared to cleft lip (43.75%) and cleft lip and palate (54.54%). Conclusion: The study revealed predominance of cleft palate, with significant underreporting of clefts in the public health system, especially for cleft palate as compared to cleft lip and cleft lip and palate. Keywords Cleft lip; Cleft palate; Epidemiology; Prevalence; Reporting.

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Association of the profile of individuals with cleft lip/palate with the beginning of orthopedic/ orthodontic treatment

RSBO ◽

10.21726/rsbo.v1i2.408 ◽

2017 ◽

Vol 1 (2) ◽

pp. 86 ◽

Cited By ~ 1

Author(s):

Madiana Magalhães Moreira ◽

Pedro Diniz Rebouças ◽

Maria Lúcia Bonfim Chagas ◽

Luan Cartaxo Félix ◽

Mário Rogério Mota

Keyword(s):

Orthodontic Treatment ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Geographic Origin ◽

Panoramic Radiograph ◽

Mixed Dentition ◽

Chi Square ◽

Reference Hospital ◽

Cleft Lip Palate ◽

Chi Square Test

Cleft lip and palate (CLP) is the most frequent congenital malformation among the anomalies of the head and neck. The orthopedic/orthodontic treatment is included in the rehabilitation of these individuals, however there is no consensus in the literature regarding the ideal time for its beginning. Objective: To verify and characterize the profile of individuals with CLP treated at a reference hospital of the northeast of Brazil from 1998 to 2013 and its association with the beginning of the orthopedic/ orthodontic treatment. Material and methods: Through direct observation of medical records, panoramic radiograph, and studycasts of 323 individuals, data regarding sex, cleft type, origin and age of beginning of the orthopedic/orthodontic treatment were surveyed and analyzed using the chi-square test, considering a 5% level of significance. Results: Most of the individuals had transforamen and the unilateral cleft was the most prevalent (p<0.05). Females were statistically more affected by post-foramen cleftand males by trans-foramen cleft (p<0.05). Most individuals with trans-foramen cleft and post-foramen cleft started the orthopedic/ orthodontic treatment between 8 and 12 years old (p<0.05). No statistically significant differences occurred relating the beginning of the orthopedic/orthodontic treatment with geographic origin and sex of, although most of them have started treatment at late mixed dentition. Conclusion: Regardless of gender, origin, or cleft type, most patients started orthopedic treatment up to 12 years-old, an age considered ideal by most protocols. Unilateral and trans-foramen cleft were the most prevalent cleft types. post-foramen cleft affected more females, while trans-foramen cleft affected more males.

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Tooth malposition in patients with cleft lip and/or palate in a Brazilian population

Dentistry 3000 ◽

10.5195/d3000.2015.38 ◽

2015 ◽

Vol 3 (1) ◽

pp. 32-37 ◽

Cited By ~ 1

Author(s):

Mario Rodrigues Melo Filho ◽

Verônica Oliveira Dias ◽

Daniella Reis Martelli ◽

Lívia Ribeiro Paranaíba ◽

Mário Sérgio Oliveira Swerts ◽

...

Keyword(s):

Cleft Palate ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Statistical Significance ◽

Dental Anomalies ◽

Chi Square ◽

Oral Clefts ◽

Chi Square Test ◽

Cross Tabulation ◽

Definition Of

The purpose of the present study was to evaluate the prevalence of teeth malposition (rotated) in Brazilian patients with oral clefts and to contribute to the definition of subphenotypes. This study included 317 patients with nonsyndromic cleft lip with or without cleft palate. Tooth malposition was assessed clinically, through radiographs, and medical history records for each individual. Only teeth malpositions outside the area of the clefts were included. Comparisons were assessed by cross-tabulation and standard chi-square test, and statistical significance was set at p≤0.05. Cleft lip and palate was more prevalent in males, while cleft palate was more common in females. Regarding the presence of tooth malposition, of the 317 patients, 92 (29.02%) had at least one tooth with the dental anomaly. Tooth malposition was more common in patients with cleft lip and palate (16.1%), followed by, respectively, cleft palate (6.9%) and cleft lip (6%) (p=0.112). The highest occurrence of tooth malposition was in the mandible and involved the canines (p<0.01). Few studies have investigated the prevalence of tooth malposition in individuals with nonsyndromic cleft lip with or without cleft palate. Our results confirmed the highest occurrence of dental anomalies, particularly tooth malposition, in patients with oral clefts. Our findings also highlight that there was a higher occurrence of this condition in the mandible and not the maxilla.

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Morphological Presentation of Orofacial Clefts: An Epidemiological Study of 5004 Patients in a Tertiary Care Hospital of Central India

The Cleft Palate-Craniofacial Journal ◽

10.1177/10556656211057739 ◽

2021 ◽

pp. 105566562110577

Author(s):

Jaideep Singh Chauhan ◽

Sarwpriya Sharma

Keyword(s):

Cleft Palate ◽

Epidemiological Study ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Tertiary Care ◽

Central India ◽

Care Hospital ◽

Orofacial Clefts ◽

Chi Square ◽

The Right

Objective: To analyse the morphological presentation of orofacial clefts, gender, syndromes and systemic anomalies associated with them. Design: This was an epidemiological study performed in the patients who were registered for cleft lip and palate surgeries in our centre. The data was evaluated both retrospectively as well as prospectively. Patients/ Participants: The patients registered from November 2006 to April 2021 were studied. Out of 5276 patients, data of 5004 cases were analysed, rest 272 patients were excluded due to lack of information. Statistical analysis and Chi square test were applied. Results: Cleft deformities were more common in males than females. Cleft lip with palate was the commonest phenotype (52.2%). It was followed by isolated cleft lip (22.9%), isolated cleft palate (22.1%), rare clefts (1.62%) and syndromic clefts (1.18%). Unilateral variants were more frequent than bilateral. In unilateral, left side was more common than the right side. Among bilateral, most of the cases had premaxillary protrusion. In the present study, 3.46% of all the patients had associated anomalies affecting their other organs. Less common cleft phenotypes like microform cleft lip and submucous cleft palate ± bifid uvula showed frequency of 0.62% and 0.64% respectively. Conclusion: Thorough examination of cleft deformity should be done as it may appear as an isolated deformity or part of a syndrome and have associated systemic anomalies. This may help us to deliver comprehensive care to the patients and can prevent potential operative complications.

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Reproductive History of Mothers of Children with Solitary, Nonsyndromic Cleft Lip and/or Palate

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569_1992_029_0470_rhomoc_2.3.co_2 ◽

1992 ◽

Vol 29 (5) ◽

pp. 470-474 ◽

Cited By ~ 3

Author(s):

Bente Felix-Schollaart ◽

Jan B. Hoeksma ◽

Jean Paul Van De Velde ◽

Jerôme I. Puyenbroek ◽

Birte Prahl-Andersen

Keyword(s):

Maternal Health ◽

Cleft Palate ◽

Vaginal Bleeding ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Fetal Loss ◽

Reproductive History ◽

Drug Consumption ◽

Spontaneous Abortions ◽

History Of

The reproductive history was studied to evaluate if the three types of solitary, nonsyndromic clefts: cleft lip (CL), cleft lip and palate (CLP), and cleft palate (CP) are homogeneous entities. Occurrence of fetal loss, maternal health, and drug consumption of the mother during the pregnancy were compared in cases involving three types of clefts. Data was gathered from 87 children with clefts, 55 males and 32 females. Spontaneous abortions and vaginal bleeding were found to occur significantly more often in the (older) mother of a CLP child. This suggests that the factors involved in the etiology of CLP differ from the factors involved in CL and CP. Therefore, grouping of data of the three types of clefts in studies on the etiology should be avoided.

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Association between speech and dental occlusion changes in children with cleft lip and palate and time of primary plastic surgeries

Revista CEFAC ◽

10.1590/1982-0216/202123412420 ◽

2021 ◽

Vol 23 (4) ◽

Author(s):

Gabriela Ribeiro Schilling ◽

Maria Cristina de Almeida Freitas Cardoso ◽

Paulo Sérgio Gonçalves da Silva ◽

Marcia Angélica Peter Maahs

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Cross Sectional Study ◽

Dental Occlusion ◽

Chi Square ◽

Cross Sectional ◽

Significance Level ◽

Exact Test ◽

Chi Square Test ◽

Incisive Foramen

ABSTRACT Purpose: to describe the changes in speech and dental occlusion in children with cleft lip and palate and verify their association with each other and with the time of primary plastic surgeries. Methods: a cross-sectional study with collected data on the subjects’ identification, age at the time of primary surgeries, and clinical assessment of speech and dental occlusion. The chi-square test, Fisher's exact test, and t-test were used to verify the associations between the variables at the 5% significance level (p < 0.05). Results: the sample comprised 11 children aged 6 to 10 years, most of whom were males, self-reported white, with trans-incisive foramen cleft, predominantly on the left side. The mean age at lip repair surgery was 6 months, and 13 months at palatoplasty. Among the main dental occlusion changes, posterior and anterior crossbite stood out. All the subjects presented changed speech, with a prevalence of cases with dentoalveolar and palatine deformities, followed by passive and active changes. Subjects with anterior crossbite tended to have undergone primary lip repair surgery at a mean of four months earlier than the subjects without anterior crossbite. Conclusions: the associations between speech and dental occlusion changes, and between these and the time of primary plastic surgeries were not statistically significant. Even though it is known that early lip repair surgery is ideal to favor oral functions and aesthetics, the results revealed a tendency towards anterior crossbite, in these subjects.

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Prevalence of Cleft Lip/Palate in the Fangshan District of Beijing, 2006-2012

The Cleft Palate-Craniofacial Journal ◽

10.1177/1055665618767115 ◽

2018 ◽

Vol 55 (9) ◽

pp. 1296-1301 ◽

Cited By ~ 2

Author(s):

Yanfen Yang ◽

Hui Liu ◽

Ruixin Ma ◽

Lei Jin

Keyword(s):

Data Analysis ◽

Cleft Palate ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Upward Trend ◽

Live Births ◽

Cleft Lip Palate ◽

Obstetric Services ◽

Permanent Residents ◽

Beijing China

Objective: To estimate the cleft lip with or without cleft palate (CL/P) prevalence among births between 2006 and 2012 in Fangshan district of Beijing, China. Design: Surveillance data analysis. Setting: All hospitals that provide obstetric services in the district. Patients: The CL/P cases presented for this report were from 13 weeks’ gestation to 7 days postpartum. Main Outcome Measures: The CL/P prevalence was defined as the number of cases per 10 000 births, including live births and stillbirths at 28 weeks’ gestation or beyond. Results: The overall CL/P prevalence was 18.9 (95% confidence interval [CI]: 15.1-22.7) per 10 000 births. From 2006 to 2012, the CL/P prevalence was 19.3, 20.2, 10.9, 16.1, 17.5, 25.4, and 22.3 per 10 000 births; annually, no significant change was noted ( Pfor trend = .311). The prevalence of cleft palate, cleft lip, and cleft lip and palate were 3.4 (95% CI: 2.0-5.4), 6.2 (95% CI: 4.2-8.8), and 9.4 (95% CI: 6.9-12.4) per 10 000 births, respectively. The CL/P prevalence among the nonpermanent residents (31.4 per 10 000 births) was 2.31 times that of permanent residents (13.6 per 10 000 births). Among nonpermanent residents, the CL/P prevalence showed an upward trend over the study period ( Pfor trend = .036), that increased from 38.8 (95% CI: 16.5-76.6) per 10 000 births in 2006 to 54.6 (95% CI: 25.7-100.4) per 10 000 births in 2012. Conclusions: The overall CL/P prevalence was stable in the Fangshan district. However, the CL/P prevalence of the nonpermanent residents increased significantly.

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Dentoalveolar Cleft Treatment Outcome Using Modified Huddart-Bodenham Index and Regression Analysis of Associated Factors

The Cleft Palate-Craniofacial Journal ◽

10.1177/1055665618758278 ◽

2018 ◽

Vol 55 (5) ◽

pp. 682-687 ◽

Cited By ~ 1

Author(s):

Anas Imran Arshad ◽

Mohammad Khursheed Alam ◽

Mohammad Fadhli Khamis

Keyword(s):

Treatment Outcome ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Chi Square ◽

Total Occlusion ◽

Final Model ◽

History Of ◽

Permanent Molars ◽

Dental Models ◽

Postnatal Factors

Objectives: The aim of this study is to assess the treatment outcome of complete unilateral cleft lip and palate (CUCLP) patients using modified Huddart/Bodenham scoring system (MHB). To determine whether there is an association of congenital and postnatal factors with the treatment outcome. Design: Retrospective observational study. Setting: Two regional cleft-referral centers. Main Outcome Measures: In the current study, 101 pairs of dental models of non-syndromic CUCLP patients were retrieved from hospital archives. Each occlusal relationship from central incisor till the first permanent molars were scored except the lateral incisor. Sum of 10 occlusal relationships in each study sample gave a total occlusion score. The primary outcome was the mean total occlusion score. Results: According to MHB, a mean (standard deviation) total occlusion score of –8.92 (6.89) was determined. Based on treatment outcome, 66 cases were favorable (grades 1, 2, and 3) and 35 cases were unfavorable (grades 4 and 5). Chi-square tests indicated, difference of cheiloplasty ( P = .001) and palatoplasty ( P < .001) statistically significant. Five variables—gender, family history of cleft, cleft side, cheiloplasty, and palatoplasty—were analyzed with a logistic regression model. Conclusions: Final model indicated that cases treated with modified Millard technique (cheiloplasty) and Veau-Wardill-Kilner method (palatoplasty) had higher odds of unfavorable treatment outcome.

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