DENTAL STATUS OF PATIENTS WITH TYPE 2 DIABETES

2021 ◽  
pp. 22-28
Author(s):  
Sultanshina A.R. ◽  
Kabirova M.F. ◽  
Bashirova T.V.
Keyword(s):  
Type 2 Diabetes ◽  
Oral Mucosa ◽  
Periodontal Diseases ◽  
Randomized Study ◽  
Main Group ◽  
Dental Status ◽  
Periodontal Tissues ◽  
High Prevalence ◽  
Destructive Processes

With diabetes, there is a violation of the microvasculature, a violation of the immune status, an increase in destructive processes in the bone tissue, which leads to the development and / or intensification of pathological processes. In the oral cavity, the most frequently diagnosed inflammatory periodontal diseases, chronic injuries of the oral mucosa (COP), recurrent aphthous stomatitis, COP candidiasis. The aim of our study was to study the dental status of patients with type 2 diabetes mellitus. Materials and Methods: A descriptive evaluative epidemiologically controlled, non-randomized study was conducted to determine the effect of type 2 diabetes on dental status. The main group (“case”) consisted of 68 patients with type 2 diabetes in the compensation phase (IA) and 56 patients in the subcompensation phase (IB). The comparison group included 60 patients without somatic pathology. All patients underwent a comprehensive dental examination, bacteriological and microscopic examination to identify fungi of the genus Candida. Results: in patients with subcompensated form of type 2 diabetes, there was an increase in the frequency of complaints of plaque on the tongue, burning sensation in the COP, dryness and changes in taste. Periodontal indices indicate that the patients of the main group have a high prevalence of inflammatory and destructive processes in the periodontal tissues (indices of PMA, KPI, Mullemann indices) with poor oral hygiene (OHI-S = 3.5 ± 0.4), which confirms the Friedman criterion (χ2 = 116.27; p = 0.0000) based on the calculation of Kendall's concordance coefficient (0.743). The diagnosis of oral mucosa candidiasis was confirmed in 74.6% of patients in the main group by bacteriological examination.

scholarly journals RESULTS OF CLINICAL STUDY OF COMPLEX TREATMENT OF GENERALIZED PERIODONTITIS WITH THE USE OF STRONTIUM DRUGS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2021 ◽  
pp. 37-43
Author(s):  
A. V. Samoilenko ◽  
L. M. Matvyeyenko
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Resorption ◽  
Strontium Ranelate ◽  
Alveolar Bone ◽  
Main Group ◽  
Complex Treatment ◽  
Periodontal Tissues

The most significant periodontal disorders associated with diabetes mellitus are due to changes in bone tissue. It has become necessary for specific osteotropic therapy that can normalize metabolic processes in the alveolar bone. In turn, currently the most promising in terms of improving osteogenic activity are strontium ions. Strontium ranelate is used to treat osteoporosis due to its antiresorptive and osteoanabolic action. However, its effectiveness against alveolar bone has not been sufficiently studied. The purpose of the work is to conduct a clinical study of complex treatment of generalized periodontitis, supplemented with strontium ranelate, in patients with type 2 diabetes mellitus. Materials and methods of the research. The study included 60 patients with generalized periodontitis of I-II degree of severity, chronic course, aged 35-45 years. Type 2 diabetes mellitus was diagnosed and two groups were formed. The traditional treatment regimen was used in the group of comparison (main group) where Strontium Ranelate was prescribed additionally. The treatment was evaluated according to the dynamics of clinical observations, orthopantomography and computed tomography data, the results of biochemical studies. As markers of bone resorption, tartrate-resistant acid phosphatase (TRAP) activity was determined in blood serum and the content of β-CrossLaps fragments was determined in urine. As markers of osteogenesis, the concentration of C-terminal propeptide type I procollagen (CICP) was detected in blood plasma, bone alkaline phosphatase (BAP) and osteocalcin were detected in serum. Serum parathyroid hormone concentrations, total blood calcium and total inorganic phosphorus in the blood were studied as indicators of mineral metabolism. Results of the research. In the earliest possible timeframe the complex treatment of generalized periodontitis was conducted during the observation which led to clinical stabilization of the inflammatorydestructive process in the periodontal tissues without a significant difference between the experimental groups (p ˃ 0.05). However, the condition of periodontal tissues in patients of the experimental groups differed in a year after treatment. In 16.7% of patients from the comparison group, recurrence of the inflammatory-destructive process in periodontal tissues was diagnosed, while the cases the deterioration of the pathological process was not detected in the main group. A significant difference was found for complex periodontal indices (Ramfjord, PI and SPITN) (p <0.05). Clinical and radiological stabilization was observed in 83.3% of patients of the comparison group and in 100% in the main group. According to the results of computed tomography of the alveolar bone, an increase in bone mineral density was established in both groups, but only in the main group the difference between indices before and after treatment was significant (p˂0.05). In patients of the main group a more pronounced decrease in the activity of tartrate-resistant acid phosphatase (TRAP) was found in the serum and the concentration of β-CrossLaps was found in the urine, indicating inhibition of bone resorption, as well as markers of bone formation the concentration of C-terminal propeptide (CICP) was found in blood plasma, bone alkaline phosphatase (BAP) was found in serum, osteocalcin (p <0.05). Indicators of mineral metabolism in bone tissue, both during treatment and for experimental groups, almost did not differ (p> 0.05). Thus, the use of strontium drugs in the complex treatment of generalized periodontitis in patients with type 2 diabetes mellitus provides a longer and more stable clinical and radiological stabilization of the pathological process in periodontal tissues, primarily by inhibiting bone resorption and enhancing osteogenesis. So, they can be recommended for the wide use in stomatological practice.

scholarly journals DENTAL STATUS OF PREGNANT WOMEN AND WAYS TO IMPROVE THE ORGANIZATION OF THERAPEUTIC AND PREVENTIVE MEASURES

2021 ◽  
Author(s):  
TAMAR SHISHNIASHVILI ◽  
ANA ZUBADALASHVILI ◽  
TAMAR SULADZE ◽  
RUSUDAN KVANCHAKHADZE
Keyword(s):  
Pregnant Women ◽  
Periodontal Diseases ◽  
Dental Health ◽  
Health Indicators ◽  
The Body ◽  
Dental Status ◽  
Second Trimester ◽  
Periodontal Tissues ◽  
High Prevalence ◽  
Dental Diseases

As a result of the continuing changes in the condition of tissues and organs of the dental cavity and the body as a whole, there is a rise in the intensity of tooth decay and periodontal diseases with the onset of pregnancy. The aim of our research was to look into the prevalence and severity of pathology in the hard tissues of teeth and periodontal tissues during pregnancy, as well as to figure out how to better organize therapeutic and prophylactic steps for pregnant women. A comprehensive epidemiological study of 170 pregnant women aged 18 to 40 living in Tbilisi was carried out according to the WHO method. The findings show a high prevalence of dental cavity (from 61 percent to 98.8%) and a high severity of dental caries among pregnant women (from 2.55 1.03 to 14.31 5.44). The intensity of caries indicators increased as the gestational stage lengthened, but the greatest increase was observed in the second trimester of pregnancy. The results indicate a substantial prevalence of periodontal pathology (according to the PMA index) among pregnant women, with the level of pathology increasing with their age and gestational age (from 41.7 percent to 78.8 percent). By the end of the second trimester of pregnancy, the most noticeable improvements in periodontal tissues had been observed. Oral hygiene played a big role in determining the presence and incidence of periodontal disease. Low dental health indicators and worsening dental status during pregnancy point to the need for a more comprehensive diagnosis of all risk factors for major dental diseases, as well as the implementation of all stages of therapeutic and prophylactic interventions during pregnancy, based on the findings of a complete dental examination.

Diagnostic value of microbiome biomarkers of the periodonite microbiome in patients with the association of chronic periodontitis and diabetes mellitus type 2

2021 ◽  
Vol 66 (11) ◽  
pp. 678-683
Author(s):  
I. P. Balmasova ◽  
V. N. Tsarev ◽  
K. G. Unanyan ◽  
E. V. Ippolitov ◽  
T. V. Tsareva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Diagnostic Value ◽  
High Tech ◽  
Periodontal Tissues ◽  
Systemic Pathology

The place of high-tech methods of molecular biology in clinical laboratory diagnostics of various diseases and the development of a system of biomarkers as an important component of diagnostic research is currently attracting the closest attention of the scientific community. In this paper, an attempt is made to use high-tech metagenomic analysis to solve problems that arise due to the high frequency of association of periodontal diseases with systemic pathology, in particular, with type 2 diabetes mellitus. The aim of the study was to determine the taxonomic and metabolic features of the microbiome of periodontal tissues in periodontal diseases associated with type 2 diabetes mellitus, as a model of the ratio of local and systemic effects of periodontal pathogenic bacteria. The study included 16S shotgun sequencing of bacterial DNA as part of biological material from periodontal pockets/dentoalveolar furrows of 46 people - 15 patients with chronic periodontitis associated with type 2 diabetes mellitus, 15 patients with chronic periodontitis unrelated to systemic pathology, as well as 16 healthy people in the control group, followed by bioinformatic processing of the data obtained. The obtained data allowed us to establish the taxonomic features of the periodontal microbiome in the association of chronic periodontitis with type 2 diabetes mellitus, which included the predominance of representatives of the families Prevotellaceae and Spirochaetaceae in its composition. The features of metabolic processes in periodontal tissues with the participation of the microbiome were also revealed, which consisted in an increase in the exchange of cysteine and methionine against the background of a decrease in the metabolism of pyrimidine, methane, sphingolipids, and the synthesis of fatty acids, which are of diagnostic value in assessing the condition of patients with type 2 diabetes mellitus.

Dental rehabilitation for periodontal and oral mucosa diseases in type 2 diabetes

2020 ◽  
Vol 25 (1) ◽  
pp. 27-31
Author(s):  
O. V. Prisyazhnyuk ◽  
A. K. Iordanishvili ◽  
M. I. Muzikin
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Oral Mucosa ◽  
Dental Care ◽  
Oral Hygiene ◽  
Periodontal Tissues ◽  
Dynamic Observation ◽  
Patients With Diabetes

Relevance. Medical and dental personnel suffering from type 2 diabetes mellitus are susceptible to changes in tissues, periodontal, oral mucosa, and also make oral hygiene, which makes treatment of major dental diseases ineffective, as well as worsening of ongoing periodontal and oral mucosa diseases.Purpose. Study the condition of periodontal tissues and oral mucosa of adults suffering from T2DM, including during dynamic monitoring by a dentist in the conditions of centralized treatment of patients with diabetes mellitus at the “Stomatological polyclinic № 29” of Frunzensky district, St. Petersburg.Materials and methods. 362 middle-aged women who were divided into 3 groups were examined. The 1st (control) group included 127 people who were practically healthy in their psychosomatic status. The 2nd group included 103 people suffering from type 2 diabetes mellitus (T2DM), who were visited by a dentist for treatment. The 3rd group consisted of 132 people, which took place over 2.5-3 years, were under dynamic observation by a dentist who treats patients with diabetes mellitus. During clinical trials, patients studied periodontology using methods of generally accepted methods of periodontology.Results. It was found that people with diabetes suffer from diabetes at the stomatological polyclinic number 29 of the Frunze district. St. Petersburg, with the usually observed 100% prevalence of periodontal inflammatory pathology and the high severity of its ducts, was overwhelmingly sanitized (95.45%), there are good individual oral hygiene (0.58 ± 0.18) and low need for in addition to gingivitis and periodontitis (17.42%), unlike people suffering from type 2 diabetes and visiting a dentist for treatment, where the need for inflammatory periodontal pathology is 100%.Conclusion. Created on the basis of dental clinic number 29 St. Petersburg. The dental care center for people suffering from T2DM syndrome showed that with early access to dental care and with their dynamic observation, it is possible to achieve a good level of dental health with a satisfactory aesthetic nature of the dentition and chewing functions.

scholarly journals High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes

Diabetologia ◽  
2012 ◽  
Vol 55 (8) ◽  
pp. 2154-2162 ◽  
Author(s):  
L. J. M. Boonman-de Winter ◽  
F. H. Rutten ◽  
M. J. M. Cramer ◽  
M. J. Landman ◽  
A. H. Liem ◽  
...  
Keyword(s):  
Heart Failure ◽  
Type 2 Diabetes ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
High Prevalence

scholarly journals Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees

2017 ◽  
Vol 115 (2) ◽  
pp. 379-384 ◽  
Author(s):  
Goo Jun ◽  
Alisa Manning ◽  
Marcio Almeida ◽  
Matthew Zawistowski ◽  
Andrew R. Wood ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mexican American ◽  
Complex Disease ◽  
Rare Variants ◽  
Whole Genome Analysis ◽  
Mexican American Families ◽  
Extended Pedigrees ◽  
High Prevalence ◽  
Study Designs

A major challenge in evaluating the contribution of rare variants to complex disease is identifying enough copies of the rare alleles to permit informative statistical analysis. To investigate the contribution of rare variants to the risk of type 2 diabetes (T2D) and related traits, we performed deep whole-genome analysis of 1,034 members of 20 large Mexican-American families with high prevalence of T2D. If rare variants of large effect accounted for much of the diabetes risk in these families, our experiment was powered to detect association. Using gene expression data on 21,677 transcripts for 643 pedigree members, we identified evidence for large-effect rare-variant cis-expression quantitative trait loci that could not be detected in population studies, validating our approach. However, we did not identify any rare variants of large effect associated with T2D, or the related traits of fasting glucose and insulin, suggesting that large-effect rare variants account for only a modest fraction of the genetic risk of these traits in this sample of families. Reliable identification of large-effect rare variants will require larger samples of extended pedigrees or different study designs that further enrich for such variants.

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