Multivariate Logistic Analysis and Intervention Countermeasures on the Effects of Psychological Changes in Patients with COVID-19 during Treatment

Background:The goal of treatment in rheumatoid arthritis (RA) is to achieve remission. There is the patient with residual symptoms in the Japanese RA patient who achieved clinical remission. There are not many studies to examine the relation between everyday life, social activity and evaluation of disease activities using high-sensitivity image examinations (musculoskeletal ultrasound (MSKUS) and MRI).Objectives:To examine the relationship between subjective residual symptoms and imaging examinations in RA patients who have achieved clinical remission.Methods:30 RA patients who achieved SDAI remission during RA treatment. Age, sex, disease duration, physical findings, serological markers, disease activity, HAQ, EQ-5D-5L, FACIT-F, Patient Reported Outcomes (PROs), EGA and medications were evaluated. 44 joints were assessed by MSKUS with gray scale (GS) and power doppler (PD) and contrast-enhanced bilateral joint MRI scoring with OMERACT-RAMRIS scoring.Results:1. The mean SDAI of the 30 RA patients was 1.3. 2.In the analysis of the presence or absence of subjective residual symptoms that led to remission of SDAI (Table 1).Table 1.Subjective residual symptoms/presence (N=17)Subjective residual symptoms/absence (N=13)Univariate analysisp valueMultivariate logistic analysisp valueTJC0.0±0.00.3±0.50.0173HAQ0.4±0.40.05±0.10.00950.00181EQ5D-5L0.8±0.10.9±0.00.0001FACIT-F14.5±9.84.6±4.30.0233Morning stiffness (min)256.5±564.80.0±0.00.0210Pain (VAS) (mm)9.2±9.50.9±1.50.00440.0455PGA (mm)7.7±9.00.5±1.10.0013(1). In the univariate analysis, the number of tender joints, HAQ, EQ-5D-5L, FACIT-F, morning stiffness, and pain VAS were extracted with significant differences.(2). In multivariate logistic analysis, HAQ and pain VAS were extracted as independent factors with significant differences. 3.In univariate analysis of the association between HAQ and pain VAS extracted in multivariate logistic analysis and imaging examinations (MSKUS/MRI), MRI-synovitis was extracted with a significant difference in HAQ.Conclusion:1. It was suggested that Pain VAS and HAQ due to RA could be identified in patients reaching SDAI remission. 2. In patients reaching SDAI remission, Pain VAS ≤10 or HAQ ≤0.5 suggested that subjective residual symptoms may be eliminated. 3. HAQ ≤ 0.5 suggests that synovitis is less likely to be detected on MRI. 4. In patients who have reached SDAI remission, little residual inflammation was observed on US, suggesting that induction of remission is important not only to prevent joint destruction, but also to improve and maintain long-term QoL.Disclosure of Interests:MASAO NAWATA Grant/research support from: I have received research funding from Eli Lilly Japan K.K., Kazuki Someya: None declared, Takafumi Aritomi: None declared, Masashi funada: None declared, Katsumi Nakamura: None declared, SAITO KAZUYOSHI Grant/research support from: I have received research funding from Eli Lilly Japan K.K., Yoshiya Tanaka Speakers bureau: I have received speaking fees from Abbvie, Daiichi-Sankyo, Chugai, Takeda, Mitsubishi-Tanabe, Bristol-Myers, Astellas, Eisai, Janssen, Pfizer, Asahi-kasei, Eli Lilly, GlaxoSmithKline, UCB, Teijin, MSD, and Santen, Consultant of: I have received consulting fees from Abbvie, Daiichi-Sankyo, Chugai, Takeda, Mitsubishi-Tanabe, Bristol-Myers, Astellas, Eisai, Janssen, Pfizer, Asahi-kasei, Eli Lilly, GlaxoSmithKline, UCB, Teijin, MSD, and Santen, Grant/research support from: I have received research grants from Mitsubishi-Tanabe, Takeda, Chugai, Astellas, Eisai, Taisho-Toyama, Kyowa-Kirin, Abbvie, and Bristol-Myers

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Factors associated with the development of ocular candidiasis and ocular prognosis with echinocandin therapy for candidemia

Journal of Ophthalmic Inflammation and Infection ◽

10.1186/s12348-021-00248-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Daiki Sakai ◽

Wataru Matsumiya ◽

Sentaro Kusuhara ◽

Makoto Nakamura

Keyword(s):

Candida Albicans ◽

Medical Records ◽

Odds Ratio ◽

Adjusted Odds Ratio ◽

Patient Characteristics ◽

Antifungal Drugs ◽

Factors Associated ◽

Logistic Analysis ◽

Multivariate Logistic Analysis ◽

Systemic Antifungal Therapy

Abstract Purpose To evaluate the factors associated with the development of ocular candidiasis (OC) and ocular prognosis with echinocandin therapy for candidemia. Methods The medical records of 56 consecutive patients with a positive blood culture for Candida species between November 2016 and October 2019 were retrospectively reviewed. Information on patient characteristics, isolated Candida species, treatment details for candidemia, and ocular findings were extracted to identify factors associated with OC development. Results The leading pathogen of candidemia was Candida albicans (C.albicans) (41.1%). Of 56 patients, 18 (32.1%) were diagnosed with chorioretinitis, categorized as either probable (8 patients) or possible OC (10 patients). There was no case of endophthalmitis with vitritis. The incidence of probable OC was not significantly different between the groups treated with echinocandins and other antifungal drugs (15.2% vs. 11.1%, p = 1.00). In all probable OC cases, systemic antifungal therapy was switched from echinocandins to azoles, and no case progressed to endophthalmitis. A multivariate logistic analysis revealed that female sex (adjusted odds ratio [aOR], 8.93; 95% confidence interval [CI], 1.09–72.9) and C. albicans (aOR, 23.6; 95% CI, 1.8–281) were independent factors associated with the development of probable OC. Conclusion One-seventh of patients with candidemia developed probable OC. Given the evidence of female and C. albicans as the factors associated with OC development, careful ophthalmologic management is required with these factors, especially in candidemia. Although echinocandins had no correlation with OC development and did not lead to the deterioration of ocular prognosis, further investigation is required.

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Development and Validation of a Nomogram for Renal Involvement in Primary Sjögren Syndrome Patients: A Retrospective Analysis

Modern Rheumatology ◽

10.1093/mr/roab123 ◽

2021 ◽

Author(s):

Xinshi Huang ◽

Xiaobing Wang ◽

Dinglai Yu

Keyword(s):

Risk Factors ◽

Prediction Model ◽

Receiver Operating Characteristic ◽

Operating Characteristic ◽

Renal Involvement ◽

Calibration Plot ◽

Receiver Operating Characteristic Curves ◽

Logistic Analysis ◽

Validation Set ◽

Multivariate Logistic Analysis

Abstract Objective To establish and validate a nomogram for individualized prediction of renal involvement in pSS patients. Methods A total of 1293 patients with pSS from the First Affiliated Hospital of Wenzhou Medical University between January 2008 to January 2020 were recruited and further analyzed retrospectively. The patients were randomly divided into a development set (70%, n = 910) and a validation set (30%, n = 383). The univariable and multivariate logistic regression were performed to analyze the risk factors of renal involvement in pSS. Based on the regression β coefficients derived from multivariate logistic analysis, an individualized nomogram prediction model was developed. The prediction model of discrimination and calibration was evaluated with the area under the receiver operating characteristic curves and Calibration plot. Results Multivariate logistic analysis showed that hypertension, anemia, albumin, uric acid, anti-Ro52, hematuria and Chisholm-Mason grade were independent risk factors of renal involvement in pSS. The area under the receiver operating characteristic curves were 0.797 and 0.750 respectively in development set and validation set, indicating the nomogram had a good discrimination capacity. The Calibration plot showed nomogram had a strong concordance performance between the prediction probability and the actual probability. Conclusion The individualized nomogram for pSS patients those who had renal involvement could be used by clinicians to predict the risk of pSS patients developing into renal involvement and improve early screening and intervention.

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A Salmonella Typhimurium phage type (PT) U320 outbreak in England, 2008: continuation of a trend involving ready-to-eat products

Epidemiology and Infection ◽

10.1017/s0950268810003080 ◽

2011 ◽

Vol 139 (12) ◽

pp. 1936-1944 ◽

Cited By ~ 6

Author(s):

N. S. BOXALL ◽

G. K. ADAK ◽

E. DE PINNA ◽

I. A. GILLESPIE

Keyword(s):

Case Control Study ◽

Phage Type ◽

Case Control ◽

Protection Agency ◽

Retrospective Case ◽

Retail Chain ◽

Logistic Analysis ◽

Multivariate Logistic Analysis ◽

Epidemiological Link ◽

Control Study

SUMMARYIn March 2008, the Health Protection Agency in England conducted a retrospective case-control study to investigate the cause of 179 cases of the newly recognized, fully antimicrobial-sensitive Salmonella Typhimurium PT U320. Forty-three symptomatic laboratory-confirmed case-patients and 84 asymptomatic location-matched controls were interviewed by telephone about exposures in the 3 days prior to illness or interview. Multivariate logistic analysis indicated consumption of pre-packaged egg sandwiches (odds ratio 3·29, 95% confidence interval 1·19–9·09) was independently associated with illness. Eight of the 15 case-patients who consumed egg sandwiches did so from retail chain A (53·3%) whereas none of the eight controls consumed similar sandwiches (χ2=7·20, P⩽0·01). A review of the pre-packaged egg sandwich ingredients suggested this outbreak was probably caused by exposure to an ingredient common to pre-packaged sandwiches and prepared salads but we established a definitive epidemiological link with only the former. Short shelf-life, product diversity and investigation lag hinder epidemiological investigations of such popular products, providing continued challenges for food safety enforcement of freshly prepared produce.

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Radiomics Nomogram Based on Radiomics Score from Multiregional Diffusion-Weighted MRI and Clinical Factors for Evaluating HER-2 2+ Status of Breast Cancer

Diagnostics ◽

10.3390/diagnostics11081491 ◽

2021 ◽

Vol 11 (8) ◽

pp. 1491

Author(s):

Chunli Li ◽

Jiandong Yin

Keyword(s):

Breast Cancer ◽

Characteristic Curve ◽

Receiver Operator Characteristic Curve ◽

Clinical Factors ◽

Clinical Value ◽

Logistic Analysis ◽

Diffusion Weighted ◽

Apparent Diffusion ◽

Her 2 ◽

Multivariate Logistic Analysis

This study aimed to establish and validate a radiomics nomogram using the radiomics score (rad-score) based on multiregional diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) features combined with clinical factors for evaluating HER-2 2+ status of breast cancer. A total of 223 patients were retrospectively included. Radiomic features were extracted from multiregional DWI and ADC images. Based on the intratumoral, peritumoral, and combined regions, three rad-scores were calculated using the logistic regression model. Independent parameters were selected among clinical factors and combined rad-score (com-rad-score) using multivariate logistic analysis and used to construct a radiomics nomogram. The performance of the nomogram was evaluated using calibration, discrimination, and clinical usefulness. The areas under the receiver operator characteristic curve (AUCs) of intratumoral and peritumoral rad-scores were 0.824/0.763 and 0.794/0.731 in the training and validation cohorts, respectively. Com-rad-score achieved the highest AUC (0.860/0.790) among three rad-scores. ER status and com-rad-score were selected to establish the nomogram, which yielded good discrimination (AUC: 0.883/0.848) and calibration. Decision curve analysis demonstrated the clinical value of the nomogram in the validation cohort. In conclusion, radiomics nomogram, including clinical factors and com-rad-score, showed favorable performance for evaluating HER-2 2+ status in breast cancer.

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Association of Carboxyhemoglobin Levels with Peripheral Arterial Disease in Chronic Smokers Managed at Dr George Mukhari Academic Hospital

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17155581 ◽

2020 ◽

Vol 17 (15) ◽

pp. 5581

Author(s):

Mashudu Nemukula ◽

Motetelo Alfred Mogale ◽

Honey Bridget Mkhondo ◽

Lizette Bekker

Keyword(s):

Nitric Oxide ◽

Peripheral Arterial Disease ◽

Arterial Disease ◽

Academic Hospital ◽

Convenience Sample ◽

Logistic Analysis ◽

Arterial Dilation ◽

Peripheral Arterial ◽

Arterial Damage ◽

Multivariate Logistic Analysis

Chronic cigarette smokers (CCS) are known to have elevated levels of carboxyhemoglobin (COHb). However, it is not known whether increased levels of COHb are associated with endothelial dysfunction (ED), and therefore the development of peripheral arterial disease (PAD). The aim of the study was to investigate the association of blood COHb and plasma nitric oxide (NO) levels, and whether it is an independent risk factor in the development of PAD among CCS at Dr George Mukhari Academic Hospital (DGMAH). A sample of 120 CCS with PAD and a convenience sample of 100 CCS without PAD were recruited into the study. Blood COHb levels were measured using the ABL 90 FLEX CO-oximeter automated spectroscopy. Plasma nitric oxide (NO) levels were measure using ELISA. Logistic regression analysis was used to investigate the association of blood COHb and plasma NO with PAD. Blood COHb levels of CCS with PAD were significantly higher than those of CCS without PAD, and the NO levels of CCS with PAD were significantly lower than those of CCS without PAD. Although both the blood COHb and plasma NO in CCS were significantly associated with PAD in bivariate logistic analysis, only plasma NO was independently associated with PAD in multivariate logistic analysis. This finding is consistent with the hypothesis that COHb is a cause of arterial damage in PAD, leading to reduced NO, and therefore reduced arterial dilation.

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Multivariate logistic analysis of repeated cross-sectional surveys of Campylobacter fetus in dairy cattle

Preventive Veterinary Medicine ◽

10.1016/0167-5877(90)90046-k ◽

1990 ◽

Vol 10 (1-2) ◽

pp. 15-24 ◽

Cited By ~ 1

Author(s):

Saeed Akhtar ◽

Hans P. Riemann ◽

Mark C. Thurmond ◽

Thomas B. Farver ◽

Charles E. Franti

Keyword(s):

Dairy Cattle ◽

Cross Sectional ◽

Logistic Analysis ◽

Campylobacter Fetus ◽

Multivariate Logistic Analysis

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Surge potential and drainage-basin characteristics in East Greenland

Annals of Glaciology ◽

10.3189/172756403781816220 ◽

2003 ◽

Vol 36 ◽

pp. 142-148 ◽

Cited By ~ 39

Author(s):

Hester Jiskoot ◽

Tavi Murray ◽

Adrian Luckman

Keyword(s):

Remote Sensing ◽

Drainage Basin ◽

Remote Sensing Data ◽

Environmental Data ◽

Glacier Inventory ◽

East Greenland ◽

Sensing Data ◽

Logistic Analysis ◽

Geological Conditions ◽

Multivariate Logistic Analysis

AbstractWe introduce a new glacier inventory of central East Greenland and use the collected data to test proposed theories on surging. The glacier inventory contains 259 glaciers, of which 10 have observed surges and a further 61 are inferred surge-type. The total glaciated area is 5.5×103 km2. The inventory was created from a combination of remote-sensing data and maps, and some 24 glacial and geological inventory parameters were collected for each glacier. A multivariate logistic analysis is used to test which combination of glacial and environmental data is conducive to surging behaviour in East Greenland. Three different models suggest that glaciers with a large complexity, low slope and oriented in a broad arc from northeast to south are most likely to be of surge type. Geological conditions, and hence substrate character, appeared not to be related to surge potential. On the basis of these results and the surge dynamics in this region, we suggest a hydrologically controlled surge mechanism operates in central East Greenland.

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Albumin infusion reduces the risk of rebleeding and in-hospital mortality in cirrhotic patients admitted for acute gastrointestinal bleeding: retrospective analysis of a single institute

10.21203/rs.2.20564/v1 ◽

2020 ◽

Author(s):

Zhu Wang ◽

Ya-Wen Xie ◽

Qing Lu ◽

Hai-Lin Yan ◽

Xin-Bin Liu ◽

...

Keyword(s):

Blood Cell ◽

Gastrointestinal Bleeding ◽

Hospital Mortality ◽

Red Blood Cell ◽

Acute Gastrointestinal Bleeding ◽

Albumin Infusion ◽

Logistic Analysis ◽

Cirrhotic Patients ◽

Reduce Risk ◽

Multivariate Logistic Analysis

Abstract BackgroundTo investigate the effect of albumin infusion in cirrhotic patients admitted for acute gastrointestinal bleeding.MethodsMedical records of cirrhotic patients who admitted due to acute gastrointestinal bleeding through January 2009 to December 2018 were systemically reviewed. Clinical data and the total amount of albumin and red blood cell used during hospitalization were recorded. For patients with rebleeding, the amount of albumin and red blood cell used before rebleeding was also documented. The primary outcome was the occurrence of rebleeding and the second outcome was in-hospital mortality. Univariate and multivariate logistic analysis were performed to identify risk factors associated with rebleeding and in-hospital mortality.ResultsA total of 2239 cirrhotic patients were included in the analysis. There were 245 episodes of in-patient rebleeding occurred, while 135 patients died. Overall, more red blood cells and albumin were prescribed to patients who suffered rebleeding. In terms of the amount before rebleeding, the red blood cell was higher in patients with rebleeding, but the albumin infusion were similar. In the multivariate model, the albumin infusion was an independent risk factor associated with rebleeding (adjusted OR for ≤40g, 0.385 [0.252-0.588], p<0.001; OR for >40g, 0.295 [0.169-0.514], p<0.001). The use of albumin more than 40g during hospitalization reduces the risk of in-patient mortality (adjusted OR for ≤40g, 0.730 [0.375-1.423], p=0.356; OR for >40g, 0.389 [0.180-0.838], p=0.016).ConclusionsAlbumin infusion could reduce risk of in-hospital rebleeding. Moreover, more than 40g albumin infusion decrease numbers of mortality in cirrhosis admitted for acute gastrointestinal bleeding.

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Construction and Validation of Nomogram for Prediction of Metastasis in Osteosarcoma Patients

10.21203/rs.3.rs-293568/v1 ◽

2021 ◽

Author(s):

weilong xu ◽

wei niu

Keyword(s):

Predictive Factors ◽

High Performance ◽

Predictive Accuracy ◽

Malignant Tumors ◽

External Validation ◽

Tumor Grade ◽

Logistic Analysis ◽

Prediction Of Metastasis ◽

Selection Operator ◽

Multivariate Logistic Analysis

Abstract Background: Osteosarcoma is one of the most common malignant tumors of the bone with poor prognosis. The present study was aimed to establish and validate nomogram to predict the risk of metastasis for individual osteosarcoma patients.Methods: 2195 osteosarcoma patients were retrospectively collected from Surveillance, Epidemiology, and End Results (SEER) database. The least absolute shrinkage and selection operator regression model was applied to promote feature selection for the metastasis signature model. Univariate and multivariate logistic analysis were used to discern independent predictive factors. These predictive factors were included in the nomogram to evaluate metastasis probability in osteosarcoma patients. Nomogram was validated internally and externally. Results: We randomly assigned 2195 osteosarcoma patients into the training (n = 1464) and validation (n = 731) subgroups. Age, sex, tumor grade, tumor size and use of surgery were identified as the predictive factors for the risk of metastasis (all p<0.05) and further incorporated to develop the nomogram. Predictive accuracy (AUC) for metastasis prediction were 0.7427067 in the training subgroup and 0.6798374 in the external validation subgroup, respectively. And the decision curve analysis also proved the value of the model.Conclusions: We have constructed new high-performance nomogram to assist clinicians in identifying osteosarcoma patients with high risk of metastasis.

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