scholarly journals Acute onset supraclavicular lymphadenopathy coinciding with intramuscular mRNA vaccination against COVID-19 may be related to vaccine injection technique, Spain, January and February 2021

2021 ◽  
Vol 26 (10) ◽  
Author(s):  
María Fernández-Prada ◽  
Irene Rivero-Calle ◽  
Ana Calvache-González ◽  
Federico Martinón-Torres
Keyword(s):  
Lymph Nodes ◽  
Injection Site ◽  
Adverse Reactions ◽  
Vaccine Safety ◽  
Acute Onset ◽  
Injection Technique ◽  
Vaccine Injection ◽  
Limited Condition ◽  
Supraclavicular Lymph Nodes ◽  
New Vaccines

Monitoring adverse reactions following immunisation is essential, particularly for new vaccines such as those against COVID-19. We describe 20 cases of acute onset of a single supraclavicular lymphadenopathy manifesting between 24 h and 9 days after ipsilateral intramuscular administration of an mRNA-based COVID-19 vaccine, referred to our WHO Collaborating Centre for Vaccine Safety. Our results indicate that the swelling of supraclavicular lymph nodes following immunisation may constitute a benign and self-limited condition, related to a higher than recommended injection site.

scholarly journals The Safety of 4-valent Meningococcal Conjugate Vaccine in Two Years Old Children: Prospective Cohort Study in Sakhalin Region

2019 ◽  
Vol 18 (3) ◽  
pp. 175-179 ◽  
Author(s):  
Oxana V. Solonina ◽  
Tatiana M. Sy
Keyword(s):  
Adverse Effects ◽  
Injection Site ◽  
Conjugate Vaccine ◽  
Vaccine Safety ◽  
Medical Intervention ◽  
Safety Study ◽  
General Group ◽  
Actual Clinical Practice ◽  
Vaccine Injection ◽  
Practice Methods

Background. Acceptability of routine immunization with vaccine to meningococcus serogroups A, C, W, Y in Russian children have not been studied earlier. Objective. The aim of the study was to understand the safety of polyvalent meningococcal conjugate vaccine administration in two years old children in actual clinical practice. Methods. The vaccination of two years old children against meningococcal disease has been performing in Sakhalin region since April 2018. All children who received single 4-valent meningococcal conjugate vaccine to A, C, W, Y serogroups in the period from April to November 2018 were included into the research. The vaccine safety in general group was estimated by local pediatricians visiting due to general and local adverse effects on vaccine injection in one month period. Safety study for children vaccinated in the period from September to October 2018 was carried out by questioning parents. Results. 1250 children were vaccinated during this research. Local paediatricians has recorded 11 (0.9%) appointments due to adverse effects within 1 month after vaccination. All of them were mild: infiltrates in the vaccine injection site (4 cases), high temperature up to 38°C (7 cases). Survey of 100 parents has shown that at least one adverse effect in 4 weeks period was noted only in 23 children: local reactions (induration, redness at the injection site) in 14 cases, general reactions (temperature increase up to 38.7°C) in 9 cases. No adverse effects needed medical intervention. Conclusion. Adverse effects were recorded in less than 1% of all cases according to local paediatricians appointments and in every 4th case according to parents questioning among all two years old children who undergone immunization with 4-valent meningococcal conjugate vaccine to A, C, W, Y serogroups.

scholarly journals Adverse reactions of COVID-19 vaccine among frontline workers in Fujairah, UAE

2021 ◽  
Author(s):  
Yaser Al-Worafi ◽  
Long Ming ◽  
Wafa Alseragi ◽  
Abdullah Dhabali ◽  
Abdulkareem Al-Shami
Keyword(s):  
Health Care ◽  
Adverse Reaction ◽  
Adverse Effects ◽  
Injection Site ◽  
Health Care Professionals ◽  
Adverse Reactions ◽  
Frontline Workers ◽  
Vaccine Injection ◽  
Novel Coronavirus

Abstract This study explored the adverse reactions/effects prevalence, types, duration, and severity of inactivated novel coronavirus pneumonia (COVID-19) vaccine among adult frontline health care professionals and educators. A total of A total of 49 frontline workers in Fujairah, UAE (37 health care professionals and 12 educators) were interviewed over a period of three months. All participants were reported that they experienced at least one adverse reaction/effect. The range of COVID-19 vaccine adverse reactions/effects were one to three adverse effects Pain at the vaccine injection site reported by 49 out of 49 participants; swelling/redness of the vaccine injection site reported by 45 out of 49; fatigue reported by 19 out of 49; headache reported by eight; fever reported by one participant. Majority of the reported adverse reactions were described as moderate or mild and the duration was between one day and one week.

scholarly journals Cervical lymph node enlargement as the initial manifestation of rectal cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tong-Hui Xie ◽  
Peng Su ◽  
Jian-Guo Hong ◽  
Hui Zhang
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cervical Lymph Node ◽  
Clinical Manifestations ◽  
Initial Symptom ◽  
Cervical Lymph Nodes ◽  
Supraclavicular Lymph Nodes ◽  
Lymph Node Enlargement

Abstract Background Colorectal cancer is a very common malignant tumor worldwide. The clinical manifestations of advanced colorectal cancer include the changes in bowel habits, hematochezia, diarrhea, local abdominal pain and other symptoms. However, the colorectal cancer with an initial symptom of cervical lymph node enlargement is extremely rare. In this article, we report a case of rectal cancer presenting with cervical lymph nodes enlargement as the initial symptom. Case presentation A 57-year-old woman was admitted to our hospital for cervical lymph node enlargement which was accidentally detected during physical examination. Computed tomography scan revealed multiple enlarged lymph nodes in the neck. Cervical ultrasound showed normal thyroid gland and multiple left supraclavicular lymph nodes enlargement. The patient underwent lymph nodes biopsy and pathologic results showed metastatic adenocarcinoma. The subsequent lower gastrointestinal endoscopy revealed a mucosal bulge lesion located at rectus and biopsy revealed adenocarcinoma. The patient underwent rectal cancer resection. She is alive with no evidence of recurrence or new tumors 2 years after surgery. Conclusions Cervical lymph node metastasis is a rare metastatic way in colorectal cancer. This is the first case of rectal cancer presenting with cervical lymph nodes metastases as the initial symptom. Surgical resection combined with postoperative chemotherapy improved long-term prognosis of the patient. This rare metastatic way of rectal cancer should be paid attention for clinicians.

Recurrent Abscess Formation Following DTP Immunizations: Association with Hypersensitivity to Tetanus Toxoid

PEDIATRICS ◽  
1985 ◽  
Vol 75 (5) ◽  
pp. 899-900
Author(s):  
JOSEPH A. CHURCH ◽  
WARREN RICHARDS
Keyword(s):  
Injection Site ◽  
Tetanus Toxoid ◽  
Adverse Reactions ◽  
Antibody Responses ◽  
Abscess Formation ◽  
Intramuscular Injections ◽  
Pertussis Antigen ◽  
Dtp Vaccine ◽  
Local Reactions

Adverse local reactions to vaccines containing diphtheria and tetanus toxoids and pertussis antigen (DTP) are common, but generally benign. Most often, these reactions are manifested by erythema, induration, and tenderness occurring at the injection site 12 to 24 hours following immunization.1-3 Less frequently, abscess formation may complicate intramuscular injections and these may be staphylococcal, clostridial, or sterile in etiology.4 Tetanus toxoid has been associated with a reaction incidence of 3% to 13%,5,6 and adverse reactions appear to be related to the number of prior immunizations and the height of preexisting antibody responses.3,6 However, recurrent abscess formation associated with hypersensitivity to one or more of the components of the DTP vaccine has not been reported previously.

scholarly journals The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1068 ◽  
Author(s):  
Danijela Zukancic ◽  
Estelle J. A. Suys ◽  
Emily H. Pilkington ◽  
Azizah Algarni ◽  
Hareth Al-Wassiti ◽  
...  
Keyword(s):  
Lymph Node ◽  
Gene Delivery ◽  
Ethylene Glycol ◽  
Lymph Nodes ◽  
Injection Site ◽  
Targeted Delivery ◽  
Lipid Nanoparticles ◽  
Tween 20 ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery. Current gene delivery systems target mainly to the liver and typically exhibit off-target transfection at various tissues. Here we report novel lipid nanoparticles (LNPs) that can deliver plasmid DNA (pDNA) to a draining lymph node, thereby significantly enhancing transfection at this target organ, and substantially reducing gene expression at the intramuscular injection site (muscle). In particular, we discovered that LNPs stabilized by 3% Tween 20, a surfactant with a branched poly(ethylene glycol) (PEG) chain linking to a short lipid tail, achieved highly specific transfection at the lymph node. This was in contrast to conventional LNPs stabilized with a linear PEG chain and two saturated lipid tails (PEG-DSPE) that predominately transfected at the injection site (muscle). Interestingly, replacing Tween 20 with Tween 80, which has a longer unsaturated lipid tail, led to a much lower transfection efficiency. Our work demonstrates the importance of PEGylation in selective organ targeting of nanoparticles, provides new insights into the structure–property relationship of LNPs, and offers a novel, simple, and practical PEGylation technology to prepare the next generation of safe and effective vaccines against viruses or tumours.

scholarly journals Giant adrenal germ cell tumour in a 59-year-old woman

2016 ◽  
Vol 10 (5-6) ◽  
pp. 201
Author(s):  
Lei Chen ◽  
Lu Fang ◽  
Zhiqi Liu ◽  
Dexin Yu ◽  
Daming Wang ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Lymph Nodes ◽  
Germ Cell ◽  
Germ Cell Tumour ◽  
Malignant Tumour ◽  
Large Mass ◽  
Needle Aspiration ◽  
Cell Tumour ◽  
Supraclavicular Lymph Nodes ◽  
The Right

Adrenal germ cell tumour is very rare. We report a case of a 59-year-old woman who presented with right flank discomfort. The laboratory examinations were normal and the chest computed tomography (CT) showed right pleural effusion. The abdominal CT scan revealed a large mass on the right adrenal gland. The patient underwent an adrenalectomy. Histopathologic examination and immunohistochemical findings were consistent with mixed germ cell tumour. Three months later following the operation, the patient was admitted to our hospital again with chest tightness and shortness of breath. The chest CT showed right pleural effusion recurrence and enlargement of mediastinal lymph nodes and right hilar lymph nodes. The patient had right supraclavicular lymphadenectasis on physical examination. Fine needle aspiration cytology from the supraclavicular lymph nodes showed groups of malignant tumour cells. The patient died within 6 months postoperatively. In this case, the lymph node pathway played an important role in the metastatic procedure.

Sign in / Sign up

Export Citation Format

Share Document