Microcirculation and tissue oxygenation in the head and limbs during hyperbaric oxygen treatment

Introduction: Hyperbaric oxygen (HBO) exposure for 10−15 min has been shown to reduce peripheral blood flow due to vasoconstriction. However, the relationship between decreased peripheral blood flow and the therapeutic effects of HBO treatment on peripheral circulatory disorders remain unknown. Longer exposures have been reported to have vasodilatory effects and increase peripheral blood flow. This study investigated the effect of HBO treatment on blood flow and transcutaneous oxygen pressure (TcPO2). Methods: Twenty healthy volunteers aged 20-65 years (nine males) participated in this study. All participants breathed oxygen for 60 min at 253.3 kPa. Peripheral blood flow using laser Doppler flowmetry and TcPO2 on the ear, hand, and foot were continuously measured from pre-HBO exposure to 10 min post-exposure. Results: Peripheral blood flow in each body part decreased by 7-23% at the beginning of the HBO exposure, followed by a slow increase. Post-exposure, peripheral blood flow increased 4-76% in each body part. TcPO2 increased by 840-1,513% during the exposure period, and remained elevated for at least 10 min after the exposure. Conclusions: The findings of the current study suggest vasoconstriction during HBO treatment is transient, and even when present does not inhibit the development of increased tissue oxygen partial pressure. These findings are relevant to studies investigating changes in peripheral blood flow during HBO treatment in patients with circulatory disorders.

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Effect of Artificial Carbon Dioxide-Rich Water Immersion on Peripheral Blood Flow in Healthy Volunteers: Preliminary Study about Artificial Carbon Dioxide-Rich Water

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.6591 ◽

2021 ◽

Vol 9 (A) ◽

pp. 527-531

Author(s):

Andi Rizky Arbaim Hasyar ◽

Haerani Rasyid ◽

Irfan Idris ◽

Irawan Yusuf

Keyword(s):

Carbon Dioxide ◽

Blood Flow ◽

Healthy Volunteers ◽

Peripheral Blood ◽

Water Immersion ◽

Treatment Options ◽

Peripheral Blood Flow ◽

Mixed Solution ◽

Doppler Flowmetry ◽

Improvement Effect

BACKGROUND: Peripheral blood circulation disorder is one of the global health problems. Balneotherapy that uses CO2 springs may be one of the complementary treatment options. The device to produce artificial CO2-rich water is needed to achieve an improvement effect, at least almost like the improvement effect of natural balneotherapy. AIM: This study aims to investigate the effect of artificial CO2-rich water immersion on peripheral blood flow using Bicarbonated JesC CREA BC-2000. METHODS AND MATERIALS: Thirty-nine healthy volunteers participated in this study. Each subject immersed both of their legs in a mixed solution from water and CO2 at temperature 38°C. This solution was mixed using a device, namely, “Bicarbonated JesC CREA BC-2000”. Peripheral blood flow was measured for 5 min before immersion (in this study, we denoted it as the mean basal blood flow), 10 min during immersion, and 5 min after immersion using pocket JMS laser Doppler flowmetry MBF-IIA. Repeated analysis of variance was used for statistical analysis. RESULTS: There is the difference in peripheral blood flow among before, during, and after immersing the legs into artificial CO2-rich water using Bicarbonated JesC CREA BC-2000 (p < 0.001). CONCLUSION: Bicarbonated JesC CREA BC-2000 may be used as the device to produce an artificial CO2-rich water bath that may affect peripheral blood flow in healthy volunteers.

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STUDY OF HEMOMICROCIRCULATION IN UPPER- EXTREMITYSKIN IN HEALTHY MEN IN NORMAL CONDITIONS WITH ACCOUNT OF H

Archiv Euromedica ◽

10.35630/2199-885x/2020/10/4.13 ◽

2020 ◽

Vol 10 (4) ◽

pp. 63-65

Author(s):

Vadim Astashov ◽

Valentin Kozlov ◽

Victor Sidorov, ◽

Mihail Uloga ◽

Inna Borodina ◽

...

Keyword(s):

Blood Flow ◽

Laser Doppler Flowmetry ◽

Peripheral Blood ◽

Upper Extremities ◽

Laser Doppler ◽

Peripheral Blood Flow ◽

Doppler Flowmetry ◽

Healthy Men ◽

Young Males ◽

Blood Microcirculation

In this study we used laser doppler flowmetry to investigate the parameters of peripheral blood flow in the upper extremities in young males both right- and left-handers. Based on the data obtained we found that in right-handers (dextrals) active mechanisms of regulation of blood microcirculation prevail on the leading hand, In left-handers (sinestrals) active and passive mechanisms of its regulation are involved in the regulation of blood flow on the leading hand (left) and on the opposite (right). However, the contribution of active mechanisms is lower than that of right-handers.

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Forearm Skin Blood Flow After Kinesiology Taping in Healthy Soccer Players: An Exploratory Investigation

Journal of Athletic Training ◽

10.4085/1062-6050-50.9.08 ◽

2015 ◽

Vol 50 (10) ◽

pp. 1069-1075 ◽

Cited By ~ 9

Author(s):

Kirsty A. Woodward ◽

Vish Unnithan ◽

Nicola D. Hopkins

Keyword(s):

Blood Flow ◽

Skin Blood Flow ◽

Outcome Measure ◽

Local Heating ◽

Primary Outcome Measure ◽

Soccer Players ◽

Adolescent Male ◽

Peripheral Blood Flow ◽

Therapeutic Effects ◽

Doppler Flowmetry

Context Kinesiology tape (KT) has become popular among athletes for both injury prevention and rehabilitation due to its reported therapeutic effects, including facilitation of lymphatic flow and enhanced peripheral blood flow. However, evidence to support such claims is insufficient. Objective To determine whether KT improves skin blood flow (SkBF) responses in young, elite soccer players. Design Randomized crossover study. Setting Research laboratory. Patients or Other Participants Thirteen healthy, elite, adolescent male soccer players (age = 14.7 ± 0.6 years). Intervention(s) Participants completed 2 experimental trials; during trial 1, the volar aspect of the dominant forearm was taped. Forearm SkBF was measured within the taped area and 3 cm lateral to the taped area. During trial 2, no tape was applied to either site. Both trials were performed within 7 days. Main Outcome Measure(s) Baseline and maximal thermally (42°C) stimulated SkBF responses were assessed using laser Doppler flowmetry. Continuously measured SkBF and derived mean arterial pressure obtained at 5-minute intervals were used to calculate cutaneous vascular conductance (CVC), the primary outcome measure. Results No differences were observed for baseline SkBF or CVC between trials or measurement sites. After local heating, no differences were evident for SkBF or CVC between trials or measurement sites. Conclusions Our findings suggest that, in healthy, trained adolescent males, KT was not associated with increased forearm SkBF.

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CALCIUM CHANNEL BLOCKADE AND FUNCTIONAL MICROCIRCULATION CHANGES IN HYPERTENSIVE PATIENTS WITH DIFFERENT INDIVIDUAL AND TYPOLOGICAL CHARACTERISTICS

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2013-5-4-10 ◽

2013 ◽

Vol 12 (5) ◽

pp. 4-10

Author(s):

A. P. Vasiliev ◽

N. N. Streltsova ◽

E. A. Shumeiko

Keyword(s):

Blood Flow ◽

Single Dose ◽

Peripheral Blood ◽

Peripheral Blood Flow ◽

Dose Administration ◽

Doppler Flowmetry ◽

Single Dose Administration ◽

Marked Variability ◽

Number Of Patients ◽

Functional Features

Aim. To identify individual and typological functional features of peripheral blood flow and assess microcirculation (MC) dynamics after a single-dose administration of nifedipine in patients with arterial hypertension (AH).Material and methods. Laser Doppler flowmetry (LDF) was used for the MC assessment in 39 patients with Stage II–III AH.Results. Marked variability in peripheral blood flow parameters was demonstrated for AH patients. Three main LDF types were identified: aperiodic (ApT), hyperemic, and hypoemic. Single-dose administration of nifedipine (20 mg) resulted in a similar antihypertensive effect across all patient groups. Positive MC dynamics was observed, which manifested in a marked increase in the number of patients with ApT (the most balanced type of peripheral blood flow regulation) and increased input of pulse blood filling into hemoperfusion.Conclusion. In AH patients, nifedipine-induced changes in peripheral blood flow were associated with an increased number of participants with ApT, as the most balanced type of MC regulation.

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Peripheral blood flow in patients with graves’ disease depending on level of thyroid status compensation

Kazan medical journal ◽

10.17816/kmj1794 ◽

2013 ◽

Vol 94 (6) ◽

pp. 804-807 ◽

Cited By ~ 1

Author(s):

I S Kulabukhova ◽

L N Eliseeva

Keyword(s):

Blood Flow ◽

Peripheral Blood ◽

Vascular Tone ◽

Control Group ◽

Graves Disease ◽

Peripheral Blood Flow ◽

Average Dose ◽

Thyroid Status ◽

Total Recovery ◽

Doppler Flowmetry

Aim. To study the features of peripheral blood flow using laser Doppler flowmetry in patients with Graves’ disease depending on level of thyroid status compensation. Methods. 45 patients with Graves’ disease were divided into three groups 15 patients each depending on level of thyroid status compensation. The first group included patients with compensated hyperthyroidism, the second - with subcompensated hyperthyroidism, the third - with decompensated hyperthyroidism. All patients received combined thyrotropic (thiamazole 15-30 mg, average dose 22.4±1.7 mg) and cardio- and vasotropic therapy (metoprolol 50-100 mg, average dose 72.1±3.3 mg, and fozinopril 10-20 mg, average dose 17.8±2.4 mg), doses were individually adjusted. Results were compared with the control group (15 healthy patients). The peripheral blood flow was evaluated using LAKK-01 («LAZMA», Russia) device. Results. The comparison of control group and patients with Graves’ disease depending on level of thyroid status compensation demonstrated substantial differences. Doppler flowmetry registered increased blood flow, square deviation, variation coefficient in patients with diffuse thyrotoxic goitre, reflecting increase of tissue blood perfusion and reduced vascular tone. The analysis of the frequency histogram showed that the increase of average blood flow amplitude in case of hyperthyroidism was initiated by increase in amplitudes of all flaxmotions characterizing metabolic processes in capillaries. The relevant correlation between registered variables of blood flow and level of thyroid status compensation was registered. The most marked changes were revealed in patients with subcompensated and decompensated hyperthyroidism. In patients with compensated hyperthyroidism, the blood flow was altered the least compared to control group. Increased impact of active blood flow modulation mechanisms due to neurogenic activity and vascular tone was revealed. At the same time, endothelial activity was decreased. Predominance of sympathetic stimuli and compensatory mechanisms intensifying were discovered. Conclusion. The changes of peripheral blood flow in patients with Graves’ disease were typical for congestive-hyperemic type of microcirculation. Intensity of blood flow alterations is defined by thyroid status compensation. However, even the complete clinical and laboratory compensation doesn’t result in total recovery of capillary blood flow compared to healthy people.

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Respiratory modulation of peripheral vasoconstriction: a modeling perspective

Journal of Applied Physiology ◽

10.1152/japplphysiol.00111.2019 ◽

2019 ◽

Vol 127 (5) ◽

pp. 1177-1186 ◽

Cited By ~ 3

Author(s):

Michael C. K. Khoo ◽

Patjanaporn Chalacheva

Keyword(s):

Blood Flow ◽

Peripheral Blood ◽

Convincing Evidence ◽

Peripheral Blood Flow ◽

Sinus Arrhythmia ◽

Doppler Flowmetry ◽

Noninvasive Measurements ◽

Great Utility ◽

Respiratory Modulation ◽

Cumulative Knowledge

Although respiratory sinus arrhythmia and blood pressure variability have been investigated extensively, there have been far fewer studies of the respiratory modulation of peripheral blood flow in humans. Existing studies have been based primarily on noninvasive measurements using digit photoplethysmography and laser-Doppler flowmetry. The cumulative knowledge derived from these studies suggests that respiration can contribute to fluctuations in peripheral blood flow and volume through a combination of mechanical, hemodynamic, and neural mechanisms. However, the most convincing evidence suggests that the sympathetic nervous system plays the predominant role under normal, resting conditions. This mini-review provides a consolidation and interpretation of the key findings reported in this topical area. Given the need to extract dynamic information from noninvasive measurements under largely “closed-loop” conditions, we propose that the application of analytical tools based on systems theory and mathematical modeling can be of great utility in future studies. In particular, we present an example of how the transfer relation linking respiration to peripheral vascular conductance can be derived using measurements recorded during spontaneous breathing, spontaneous sighs, and ventilator-induced sighs.

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