scholarly journals Sedative, hypothermic, anxiolytic effects and rapid radical scavenging property of aqueous leaf extract of Vitex doniana (Lamiaceae) in mice

2020 ◽  
pp. 52
Author(s):  
Keyword(s):  
Leaf Extract ◽  
Radical Scavenging ◽  
Aqueous Leaf Extract ◽  
Vitex Doniana

scholarly journals Facile Green Synthesis and Characterization of Titanium Dioxide Nanoparticles Using Kigelia africana (Lam) Benth., Aqueous Leaf Extract and its Antioxidant and Antibacterial Activity

2022 ◽  
Vol 34 (2) ◽  
pp. 409-414
Author(s):  
N. Usha Rani ◽  
P. Pavani ◽  
P.T.S.R.K. Prasad Rao
Keyword(s):  
Titanium Dioxide ◽  
Green Synthesis ◽  
Tio2 Nanoparticles ◽  
Leaf Extract ◽  
Titanium Dioxide Nanoparticles ◽  
Average Particle Size ◽  
Radical Scavenging ◽  
Average Particle ◽  
Absorption Bands ◽  
Aqueous Leaf Extract

Titanium nanoparticles are toxic to bacteria and have a widespread applications in different fields of research. Hence the present study aimed to synthesize the titanium dioxide nanoparticles by adopting green synthesis methodology using Kigelia africana leave extract as a biological reducing agent. The UV absorption spectra show characteristic absorption maxima corresponding to TiO2 nanoparticles at a wavelength of 512 nm confirms the formation of nanosized tin particles. The FT-IR spectrum of TiO2 nanoparticles show absorption bands at 3609 cm-1 and 3227 cm-1 corresponding to O-H stretching in alcoholic and carboxylic compounds, respectively. Absorption peaks at 1607, 2834, 1654 and 1324 cm-1 correspond to aromatic C=C vibrations, C-H stretching in aldehydes, C-H bending vibrations and aromatic C-N stretching vibrations, respectively. This confirms the involvement of bioactive compounds from the plant extract. The SEM and EDX studies confirmed that the nanoparticles are spherical to oval shape with an average particle size of 46 nm. The metal content in the nanoparticles was found to be 58.71%. The synthesized nanoparticles have potential growth inhibition activity against Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli). The DPPH radical scavenging activity of the nanoparticles synthesized was compared with that of aqueous leaf extract and standard ascorbic acid and proved that the nanoparticles have enhanced activity than aqueous leaf extract. The IC50 of the leaf extract, nanoparticles and the standard was found to be 31.55, 75.82 and 84.95 μg/mL, respectively. Kigelia africana leaf is shown in this work to be a valuable bioagent in the biosynthesis of TiO2 nanoparticles with increased biological activity.

Investigation of Green Synthesized Silver Nanoparticles Using Aqueous Leaf Extract of Artemisia Argyi for Antioxidant and Antimicrobial Potentials

2017 ◽  
Vol 8 (04) ◽  
Author(s):  
Anto Cordelia T A D ◽  
Hng Huey Ping
Keyword(s):  
Silver Nanoparticles ◽  
Leaf Extract ◽  
Radical Scavenging ◽  
Diffusion Method ◽  
Total Phenolic ◽  
Dependent Manner ◽  
Face Centered Cubic ◽  
Artemisia Argyi ◽  
Esherichia Coli ◽  
Aqueous Leaf Extract

The current study employs green synthesis to acquire silver nanoparticles (AgNPs) using Artemisia argyi and appraise their antioxidant and antimicrobial potentials. AgNPs were synthesized using aqueous leaf extract of Artemisia argyi by sunlight irradiation. They were characterized using UV-visible spectrophotometer, FESEM, FTIR and XRD. The antioxidant capacity of AgNPs were evaluated using ABTS, DPPH, iron chelation, FRAP and NO radical scavenging methods. Antimicrobial activities of AgNPs were tested against Esherichia coli and Staphylococcus aureus using disc diffusion method. Descriptive statistical analysis was used to identify significant relationship between antioxidant activities of AgNPs. The synthesized AgNPs exhibited brown color light scattering and absorbed maximum wavelength of light at 450 nm. The synthesis of AgNPs was optimum at 0.01 M AgNO3. The green synthesized AgNPs were spherical in shape with size ranging from 16 nm to 32 nm. The FTIR analysis revealed the presence of proteins, phenolic and polar nitrile compounds in the AgNPs. The purified AgNPs possessed a face centered cubic structure with coexistence of silver chloride crystals. The total phenolic and flavonoid of AgNPs were found to be 77.45 mg GAE/g AgNPs and 205.29 mg GAE/g AgNPs respectively. The radical scavenging activity (EC50) showed highest activity for NO (31.33 μg/ml) followed by ABTS (128.82 μg/ml), DPPH (263.03 μg/ml) and Fe2+ (1445.44 μg/ml) with a FRAP value of 1.22 mmol Fe2+ /mg dry weight. AgNPs possessed inhibitory effect against both strains of bacteria in concentration dependent manner. This study discovered that green synthesized AgNPs using Artemisia argyi are promising sources of effective antioxidants and antimicrobial agents with a high surface area catalytic activity.

scholarly journals Evaluation of body weight, serum glucose level and oxidative stress parameters of diabetic rats administered phenolic aqueous leaf extract of Vitex doniana

2019 ◽  
Vol 6 (9) ◽  
pp. 3359-3367 ◽  
Author(s):  
Emmanuel Obasi ◽  
Kizito Iheanacho ◽  
Ngwu Nwachukwu ◽  
Nc Agha ◽  
Paul Chidoka Chikezie
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Body Weight ◽  
Leaf Extract ◽  
Serum Glucose ◽  
Oxidative Stress Parameters ◽  
Aqueous Leaf Extract ◽  
Vitex Doniana ◽  
And Oxidative Stress ◽  
Stress Parameters

Background: The present study evaluated the effect of phenolic aqueous leaf extract of Vitex doniana on body weight, serum glucose and oxidative stress parameters in diabetes mellitus (DM) rats. Methods: DM was induced in rats by intraperitoneal injection of 100 mg/kg alloxan monohydrate in phosphate buffered saline (PBS; pH = 7.4). A total of 36 adult male Wister albino rats were divided into 6 groups of 6 rats. The groups consist of normal untreated rats, untreated DM rats, DM rats treated with 500 mg/kg dimethylguanide (MetforminTM) and DM rats treated with 100, 200 and 400 mg/kg body weight of phenolic aqueous leaf extract of Vitex doniana. The rats were treated for 28 days. Serum glucose, malondialdehyde (MDA), glutathione (GSH) and ascorbic acid concentrations, and serum superoxide dismutase (SOD) and catalase (CAT) activities were measured using standard methods. The changes in body weight was also measured. Results: The results showed a significant reduction (p < 0.05) in serum glucose and MDA concentration, whereas serum SOD, CAT activities, as well as GSH and ascorbic acid concentration were significantly elevated (p < 0.05) in treated DM groups in a dose dependent manner. Conclusion: The results of the present study indicated that phenolic aqueous leaf extract of V. doniana promoted increased body weight, ameliorated DM and alleviated reduced antioxidant activities in alloxan-induced DM rats. Phenolic aqueous leaf extract of V. doniana could serve as a potential natural and safe remedy for the management of DM.  

scholarly journals Phytochemical Profiling and Antioxidant Activity of Aqueous Leaf Extract of Vitex negundo

2021 ◽  
pp. 22-32
Author(s):  
Govindarajan Umamaheswari ◽  
Kuppusamy Selvam ◽  
Palanisamy Prakash
Keyword(s):  
Vitamin C ◽  
Leaf Extract ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Vitex Negundo ◽  
Strong Activity ◽  
Aqueous Leaf Extract ◽  
Phytochemical Constituents ◽  
High Level ◽  
Antioxidant Mechanisms

Natural products from plants, animals and minerals are the basis for treating human diseases. The present investigation explains that the antioxidant potential of aqueous extract of vitex negundo leaves.  Phytochemical constituents, total phenolic and flavanoid content of aqueous analysis and   vitro methods such as 1,1-diphenyl-2picrylhydrazyl (DPPH), 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging assays and GC_MS studies are reported.  In addition, TPC and TFC of the extract were evaluated. It was observed that the leaf extract total phenol (14.3 mg) and flavanoids (8.5 mg) Quercetin equivalent (Q/g)  high level of Phenolic and flavonoid content that might have accounted for the strong activity observed ABTS 62% of inhibition  µg/ mL almost equivalent to that of standard vitamin C  and DPPH value of 66.32 µg/ mL almost equivalent to that of standard vitamin C  results revealed that leaves of vitex negundo have  Since this investigation is a preliminary study, a detailed study of the antioxidant mechanisms of specific phenol components is an absolute necessity. Many phytochemical constituents which may be responsible for many pharmacological activities.

scholarly journals Ascorbic Acid and Polyphenols Mediated Green Synthesis of Silver Nanoparticles from Tagetes erecta L. Aqueous Leaf Extract and Studied Their Antioxidant Properties

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Pankaj Kumar Tyagi ◽  
Shruti Tyagi ◽  
Deepak Gola ◽  
Arvind Arya ◽  
Seyed Abdulmajid Ayatollahi ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Free Radical ◽  
Leaf Extract ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Tagetes Erecta ◽  
Aqueous Leaf Extract ◽  
Tagetes Erecta L ◽  
Phenolic And Flavonoid

Silver nanoparticle synthesis of the leaf extract Tagetes erecta L. enriched with ascorbic acid and polyphenols has been investigated. The color of the golden yellow extract has changed to pinkish-brown due to the reduction of Ag+ to the colloidal solution of AgNPs and a sharp absorption peak at 420 nm under the UV-Vis spectrophotometer. In addition, the Fourier Transfer Infrared Spectroscopy (FTIR) estimation was completed in order to recognize and identify the biomolecules present in the extract acting as a reducing and capping agent for the AgNPs. The X-ray diffraction (XRD) peaks at (111), (201), (220), and (311) confirm the presence of monoclinic crystals in the solution. The morphology and size of the particles were provided by transmission electron microscopy (TEM) images of AgNPs. At a scale of 100 nm, synthesized AgNPs were predominantly spherical with a size range of 7-35 nm. In comparison to 7.39 mg/100 g in AgNPs, aqueous leaf extract was 55.14 mg/100 g higher in ascorbic acid. The phenolic and flavonoid content of extract was 52.54 ± 2.15  mg (GAE/100 g) and 15.43 ± 0.34  mg (QE/mL), and the colloidal AgNP solution was 21.45 ± 1.15  mg (GAE/100 g) and 8.05 ± 2.42  mg (QE/mL), respectively. Phenolic and flavonoid contents play a major role as a reducing agent and reduce the precursor AgNO3 into AgNPs. The DPPH scavenging assay also assessed the antioxidant properties of extract and its derived AgNPs. As compared antioxidant value to aqueous leaf extract (mg/mL), higher percentage inhibition (PI) was found in AgNPs and free-radical scavenging activity of extract and AgNPs were directly linked to their concentrations. Results of this research have discovered a higher potential for free-radical scavenging AgNPs and will help to develop new and more potent antioxidants for the treatment of different diseases caused by oxidative stress; the higher antioxidant properties bearing AgNPs might be used.

scholarly journals Biological activities and phytochemical screening of Elaeodendron croceum (Thunb.) DC. Leaves and Stem barks Extracts

2017 ◽  
Vol 9 (4) ◽  
pp. 566 ◽  
Author(s):  
Samuel Wale Odeyemi ◽  
Anthony Jide Afolayan
Keyword(s):  
Antibacterial Activity ◽  
Free Radical ◽  
Leaf Extract ◽  
Protein Denaturation ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Diffusion Method ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

<p><strong>Background:</strong> From reports <em>Elaeodendron croceum</em> has been used traditionally for spiritual cleansing, anti-obesity, anti-inflammatory and for the management of diabetes. The leaves and bark extracts were therefore analyzed for its biological activities.</p><p><strong>Materials and methods:</strong> The antibacterial activities of <em>E. croceum</em> leaves and stem barks were evaluated against both Gram positive and gram negative bacteria using agar well diffusion method. The analysis for the phytochemical contents, antioxidant and anti-inflammatory activities of the leaves and barks were determined using standard procedures.</p><p><strong>Results:</strong> The <em>S. aureus</em>, <em>S. flexneri</em>, <em>E. faecalis</em> and <em>S. typhimurium</em> were susceptible to the aqueous leaves and stem barks extracts of <em>Elaeodendron croceum</em> while <em>S. aureus </em>was susceptible to only the aqueous leaf extract. The antibacterial activity showed MIC ranging from 0.625 – 2.5 mg/ml. The composition of flavonoids (52.72 mg/g), proanthocyanidins (32.66 mg/g), alkaloids (65.44 mg/g) and saponins (68.21 mg/g) were significantly higher in the aqueous leaf extract while phenols (94.13 mg/g) content was higher in the aqueous bark extract. The free radical scavenging activity using ABTS, FRAP and DPPH showed that the extracts possess good free radical scavenging activities with different free radical species that is comparable with ascorbic acid and also showed significant inhibitory activity on protein denaturation as an indication of anti-inflammatory potential.</p><strong>Conclusion:</strong> These findings support the folkloric usage of <em>Elaeodendron croceum</em> and indicates that it can be used to manage diseases caused by the tested organisms. The presence of alkaloids, flavonoids, total phenols and proanthocyanidins, previously suggested to have antioxidant, anti-inflammatory and antibacterial activity indicate that <em>E. croceum</em> is a potential source of anti-inflammatory, free radical scavenging and antimicrobial agents.

Cytoprotective and antiadhesive effects of aqueous leaf extract from Orthosiphon aristatus against uropathogenic E. coli

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381 ◽  
Author(s):  
S Sarshar ◽  
MR Asadi Karam ◽  
M Habibi ◽  
S Bouzari ◽  
X Qin ◽  
...  
Keyword(s):  
Leaf Extract ◽  
E Coli ◽  
Aqueous Leaf Extract
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