scholarly journals Analysis of Routine Blood Profile as Data Supporting for Nursing Assessment in Breast Cancer Patients Undergoing Chemotherapy Treatment at the RSU. Dr. Wahidin Sudirohusodo

2020 ◽  
Vol 3 (3S) ◽  
pp. 136-140
Author(s):  
Yuliana Syam ◽  
Prihantono Prihantono ◽  
Elly Lilianty Sjattar ◽  
Arnis Puspitha
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Red Blood Cells ◽  
Cancer Patients ◽  
Blood Cells ◽  
Survey Method ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment ◽  
Blood Profile ◽  
Routine Blood

Chemotherapy is one of the modality therapies given to breast cancer patients to inhibit cancer cell metastases. The side effects of chemotherapy can suppress the hematopoietic system in the bone marrow and progressively affect the patient's prognosis. The aim of study was to analyze routine blood profiles as supporting data in developing nursing care for breast cancer patients undergoing chemotherapy at the RSU. Dr. Wahidin Sudirohusodo Makassar, Indonesia, from June to September 2018. This research was a descriptive research with descriptive survey method. This research was conducted at the RSU Surgical Polyclinic. Dr. Wahidin Sudirohusodo. The sampling technique used was Non-Probability Sampling a purposive sampling method. The participants of this study were patients with breast cancer who undergo chemotherapy treatment with a number of samples that meet the inclusion criteria as many as 32 people. of the 17 routine blood components which were assessed as one of the investigations in 32 patients were found to be 4 abnormal components, red blood cells mean ± SD (3.99 10^6/ uL ± 0.51), hemoglobin mean ± SD (11.18 gr/l ± 1.09), hematocrit mean ± SD (34.96% ± 3.96), and mean ± SD monocyte (15,043 10^3/uL ± 8.95). due to metastasis and side effects of chemotherapy treatment decrease red blood cells, hemoglobin, hematocrit, and increase in specific immune response through increase of monocytes indicator that performing phagocytosis.

scholarly journals Fatigue dan status nutrisi pada pasien dengan kanker payudara yang menjalani kemoterapi

2020 ◽  
Vol 13 (4) ◽  
pp. 278-283
Author(s):  
Sapti Ayubbana ◽  
Sari Narulita
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Nursing Intervention ◽  
P Value ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment ◽  
Cross Sectional ◽  
Breast Cancer Chemotherapy

Fatigue and nutritional status in patients with breast cancer undergoing chemotherapyBackground: Breast cancer is one type of cancer and is one of the leading causes of death in the world. Cancer patients who receive chemotherapy are at risk of impaired nutritional status due to the disease and its treatment. Chemotherapy treatment can have side effects on the gastrointestinal system such as nausea, vomiting, stomatitis, anorexia, changes in taste. These side effects can cause the patient's nutritional intake to decrease. Cancer and its treatment can cause fatigue complaints.Purpose: to identify the relationship between fatigue and nutritional status in patients with breast cancer patients undergoing chemotherapyMethods: The design of this study was quantitative using a cross sectional approach. The population in this study were patients with breast cancer undergoing chemotherapy. This research was conducted at Dr.H. Abdul Moeloek Hospital of Lampung Province with 42 respondents.Results: Spearman correlation test results found that nutritional status variables have a significant relationship with fatigue (p value = 0.031) with moderate correlation strength (r = 0.471).Conclusion: The nursing intervention on the side effects of chemotherapy treatment which has a positive effect on nutritional conditions in an effort to overcome nutritional disorders and complaints of fatigue in cancer patients.Keywords: Breast Cancer; Chemotherapy; Fatigue; Nutritional StatusPendahuluan: Kanker payudara merupakan salah satu jenis kanker dan menjadi salah satu penyebab kematian di dunia. Pasien kanker yang menerima kemoterapi memiliki resiko gangguan status nutrisi akibat penyakit dan pengobatannya. Pengobatan kemoterapi dapat memberikan efek samping terhadap sistem ganstrointestinal seperti mual, muntah, stomatitis, anoreksia, perubahan rasa. Efek samping tersebut dapat menyebabkan asupan nutrisi pasien dapat mengalami penurunan. Kanker dan pengobatannya dapat menyebabkan keluhan fatigue.Tujuan: Mengetahui adanya hubungan antara status nutrisi terhadap fatigue pada pasien kanker payudara yang menjalani kemoterapi.Metode: Desain penelitian ini adalah kuantitatif dengan menggunakan pendekatan cross sectional . Populasi pada penelitian ini adalah pasien dengan kanker payudara yang menjalani kemoterapi. Penelitian ini dilakukan di RSUD Dr.H. Abdul Moeloek Provinsi Lampung dengan 42 responden.Hasil: Pada uji korelasi spearman didapatkan bahwa variabel status nutrisi mempunyai hubungan yang bermakna dengan fatigue ( p value = 0,031) dengan kekuatan korelasi sedang (r = 0,471).Simpulan: Kesimpulan diperlukan intervensi keperawatan terhadap efek samping pengobatan kemoterapi yang berdapak terhadap kondisi nutrisi dalam upaya mengatasigangguan nutrisi dan keluhan fatigue pada pasien kanker 

Rubidium-86 uptake by red blood cells of breast cancer patients

1981 ◽  
Vol 16 (2) ◽  
pp. 159-165
Author(s):  
Nancy Telfer ◽  
Yeu-Tsu N. Lee ◽  
Quenious Merrill ◽  
Franz K. Bauer
Keyword(s):  
Breast Cancer ◽  
Red Blood Cells ◽  
Cancer Patients ◽  
Blood Cells ◽  
Breast Cancer Patients

scholarly journals Gambaran Tingkat Stres, Ansietas Dan Depresi Pada Pasien Kanker Payudara Yang Menjalani Kemoterapi di RSUP H. Adam Malik Medan

2018 ◽  
Vol 1 (1) ◽  
pp. 107-113
Author(s):  
Yenni Epriyanta Br. Sitepu ◽  
Sri Eka Wahyuni
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Health Service ◽  
Cancer Patients ◽  
Psychological Problem ◽  
Anxiety And Depression ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment ◽  
Length Of Treatment ◽  
Long Term Treatment

Breast cancer attacks a lot of women with the rate of the incidence increases each year and it is very dangerous since it causes death. It can be handled by carrying out chemotherapy treatment although it takes a long time with a lot of its side effects plus the side effect of the cancer itself so that patients will undergo psychological problem which causes them to stop the treatment. The objective of the research was to find out the description of the level of stress, anxiety, and depression in breast cancer patients who were under chemotherapy treatment. The research was descriptive. The population was 41 breast cancer patients who were under chemotherapy treatment in the inpatient wards of RSUP H. Adam Malik, Medan, and all of them were used as the samples (total sampling). The data were gathered from May 20 until June 20, 2016 by using DASS 42. The result of the research showed that 73.2% of the respondents did not have any stress, 58.5% of the respondents did not have any anxiety, and 80.5% of the respondents did not have any depression. It is recommended that the health service team involve patients’ families in providing correct intervention for the breast cancer patients who undergo stress, anxiety, and depression so that the length of treatment can be reduced, cost can be saved, and productivity can be increased. Incidence of Breast cancer in women is increasing every year. This cancer is very dangerous because it leads to death. However, breast cancer cells can be killed by chemotherapy. chemotherapy is a long term treatment and causes side effects, most patients suffered psychological problems. This sometimes leads to unwillingness of patients to continue their treatment. The objective of this study was to determine the level of stress, anxiety, and depression of breast cancer patients who underwent chemotherapy. This study employed a descriptive study . The population was 41 breast cancer patients who underwent chemotherapy in inpatient wards in H. Adam Malik Hopital Medan, and all of them were used as samples (total sampling). The data were collected from May 20 to June 20, 2016 by using DASS 42. The results showed that 73.2% of the respondents did not have any stress, 58.5% of the respondents did not have any anxiety, and 80.5% of the respondents did not have any depression. It is recommended that the health service team involve patients’ families in providing correct intervention for the breast cancer patients who got stress, anxiety, and depression so that the length of treatment can be reduced, cost can be saved, and productivity can be increased.

scholarly journals Red blood cells protein profile is modified in breast cancer patients

2022 ◽  
Author(s):  
Thais Pereira-Viega ◽  
Susana B. Bravo ◽  
Antonio Gomez-Tato ◽  
Celso Yáñez-Gómez ◽  
Carmen Abuín ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Red Blood Cells ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Blood Cells ◽  
Metastatic Breast ◽  
Potential Contribution ◽  
Breast Cancer Patients ◽  
Healthy Donors

Metastasis is the primary cause of death for most breast cancer patients who succumb to the disease. During the haematogenous dissemination, circulating tumor cells interact with different blood components. Thus, there are micro-environmental and systemic processes contributing to cancer regulation. We have published that Red Blood Cells (RBCs) that accompany circulating tumor cells have prognostic value in metastatic breast cancer patients. Although the principal known role of RBCs is gas transport, it has been recently assigned additional functions as regulatory cells on circulation. Hence, to explore their potential contribution to tumor progression, we characterized the proteomic composition of RBCs from 53 breast cancer patients, compared with 33 healthy donors. RBCs from breast cancer patients showed a different proteomic profile compared to healthy donors. The differential proteins were mainly related to extracellular components, proteasome, and metabolism. Besides, LAMP2 emerge as a new RBCs marker with diagnostic and prognostic potential for metastatic patients. Seemingly, RBCs are acquiring modifications in their proteomic composition that probably represents the systemic cancer disease, conditioned by the tumor microenvironment.

scholarly journals Comparing the efficacy and side-effects of PDLASTA® (Pegfilgrastim) with PDGRASTIM® (Filgrastim) in breast cancer patients: a non-inferiority randomized clinical trial

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Safa Najafi ◽  
Maryam Ansari ◽  
Vahid Kaveh ◽  
Shahpar Haghighat
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Single Dose ◽  
Side Effects ◽  
Randomized Clinical Trial ◽  
Cancer Patients ◽  
Injection Site Reaction ◽  
Study Groups ◽  
Breast Cancer Patients ◽  
Significant Difference

Abstract Background The objective of this study was to compare the efficacy and side effects of a single dose (Pegfilgrastim or PDL) or repeated six daily injections (Filgrastim or PDG) during chemotherapy courses in breast cancer patients in a non-inferiority clinical trial. Methods In this randomized clinical trial, 80 patients were recruited and allocated randomly to two equal arms. In one group, a single subcutaneous dose of PDL was injected the day after receiving the chemotherapy regimen in each cycle. The second arm received a subcutaneous injection of PDG for six consecutive days in each cycle of treatment. The side effects of GCF treatment and its effect on blood parameters were compared in each cycle and during eight cycles of chemotherapy. Results Hematologic parameters showed no significant differences in any of the treatment courses between the two study groups. The comparison of WBC (p = 0.527), Hgb (p = 0.075), Platelet (p = 0.819), Neutrophil (p = 0.575), Lymphocyte (p = 705) and ANC (p = 0.675) changes during the eight courses of treatment also revealed no statistically significant difference between the two study groups. Side effects including headache, injection site reaction and muscle pain had a lower frequency in patients receiving PDL drugs. Conclusion It seems that PDL is non-inferior in efficacy and also less toxic than PDG. Since PDL can be administered in a single dose and is also less costly, it can be regarded as a cost-effective drug for the treatment of chemotherapy-induced neutropenia. Trial registration IRCT20190504043465N1, May 2019.

scholarly journals The impact of hyperbaric oxygen therapy on late radiation toxicity and quality of life in breast cancer patients

2021 ◽  
Author(s):  
Marilot C. T. Batenburg ◽  
Wies Maarse ◽  
Femke van der Leij ◽  
Inge O. Baas ◽  
Onno Boonstra ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Side Effects ◽  
Cancer Patients ◽  
Oxygen Therapy ◽  
Radiation Toxicity ◽  
Breast Pain ◽  
Breast Cancer Patients

Abstract Purpose To evaluate symptoms of late radiation toxicity, side effects, and quality of life in breast cancer patients treated with hyperbaric oxygen therapy (HBOT). Methods For this cohort study breast cancer patients treated with HBOT in 5 Dutch facilities were eligible for inclusion. Breast cancer patients with late radiation toxicity treated with ≥ 20 HBOT sessions from 2015 to 2019 were included. Breast and arm symptoms, pain, and quality of life were assessed by means of the EORTC QLQ-C30 and -BR23 before, immediately after, and 3 months after HBOT on a scale of 0–100. Determinants associated with persistent breast pain after HBOT were assessed. Results 1005/1280 patients were included for analysis. Pain scores decreased significantly from 43.4 before HBOT to 29.7 after 3 months (p < 0.001). Breast symptoms decreased significantly from 44.6 at baseline to 28.9 at 3 months follow-up (p < 0.001) and arm symptoms decreased significantly from 38.2 at baseline to 27.4 at 3 months follow-up (p < 0.001). All quality of life domains improved at the end of HBOT and after 3 months follow-up in comparison to baseline scores. Most prevalent side effects of HBOT were myopia (any grade, n = 576, 57.3%) and mild barotrauma (n = 179, 17.8%). Moderate/severe side effects were reported in 3.2% (n = 32) of the patients. Active smoking during HBOT and shorter time (i.e., median 17.5 vs. 22.0 months) since radiotherapy were associated with persistent breast pain after HBOT. Conclusion Breast cancer patients with late radiation toxicity reported reduced pain, breast and arm symptoms, and improved quality of life following treatment with HBOT.

A Pilot Study: Application of Hemoglobin and Cortisol Levels, and A Memory Test to Evaluate the Quality of Life of Breast Cancer Patients on Chemotherapy

2013 ◽  
Vol 28 (4) ◽  
pp. 348-356 ◽  
Author(s):  
Wings TY Loo ◽  
Michael CW Yip ◽  
Louis WC Chow ◽  
Qing Liu ◽  
Elizabeth LY Ng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Blood Cells ◽  
Healthy Subjects ◽  
Short Term Memory ◽  
White Blood Cells ◽  
Breast Cancer Patients ◽  
Cortisol Levels

Background Short-term memory (STM) decline in breast cancer patients resulting from chemotherapy was evaluated by means of blood biomarkers, a questionnaire, and a computerized STM test. Methods This study was conducted from January 2013 to June 2013, recruiting 90 subjects: 30 breast cancer patients beginning the 3rd of 4th cycles of docetaxel and cyclophosphamide chemotherapy, 30 recovered patients (who completed 4 cycles of docetaxel for a minimum of 6 months), and 30 healthy subjects (disease-free females). The levels of hemoglobin, red and white blood cells, and cortisol in serum, and a computerized STM test were analyzed to estimate the effects of chemotherapy on STM. A questionnaire was given to all subjects to assess quality of life. Results Statistically significant differences were observed for the blood parameters (hemoglobin, red and white blood cells, and cortisol levels) between healthy and on-treatment subjects (respectively 13.47±0.96 g/dL vs 5.37±0.38 g/dL, 4.58±0.41 1012/L vs 2.07±0.13 1012/L, and 6.15±1.03 109/L vs 0.86±0.41 109/L). Scores of the STM test were significantly lower for patients compared to healthy subjects. As indicated by the results of the questionnaire, breast cancer patients had a higher tendency to forget than healthy controls (X2=3.15; p<0.0001) and recovered subjects (X2=3.15; p<0.0001). Conclusion We found depleted levels of hemoglobin, red and white blood cells as a result of chemotherapy, and elevated levels of stress correlated with poor performances in the computerized STM test. A higher cortisol level might be an important precursor of STM deterioration. Monitoring cortisol would be beneficial for evaluating the quality of life of breast cancer patients on chemotherapy.

Systemic NF-κB activation in blood cells of breast cancer patients

Redox Report ◽  
2006 ◽  
Vol 11 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Miroslav Adžić ◽  
Ana Nićiforović ◽  
Vesna Vučić ◽  
Zora Nešković-Konstantinović ◽  
Snežana D. Spasić ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Blood Cells ◽  
Breast Cancer Patients
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