scholarly journals Analgetic effect of ozone therapy: myths of reality?

2020 ◽  
Author(s):  
Iryna Vladimirovna Baranova ◽  
Yurii A. Bezsmertnyi ◽  
Halyna V. Bezsmertnaya ◽  
Kateryna P. Postovitenko ◽  
Iryna A. Iliuk ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Musculoskeletal System ◽  
Chronic Back Pain ◽  
Pain Syndrome ◽  
Neurological Complications ◽  
Potential Effect ◽  
Intervertebral Disk ◽  
Ozone Therapy ◽  
Pain Syndromes ◽  
Innovative Techniques

Introduction: Administration of an oxygen-ozone mixture is one of the innovative techniques used in single-drug or complex therapeutic schemes for treatment of many degenerative-dystrophic pathologies of the musculoskeletal system and related neurological complications. Aim: The aim was to determine the mechanisms of physiological action of the oxygen-ozone mixture in order to substantiate its efficacy for treatment of chronic pain syndrome with underlying degenerative-dystrophic pathologies of the musculoskeletal system. Material and methods: The article covers biochemical and pathomorphological studies that explain the mechanism of the pain syndrome and the potential effect of the ozone therapy. Results and discussion: The treatment schemes and benefits of different routes of ozone administration (intramuscularly, intravenously, intradiscally and intraarticularly) were analyzed. Diverse research data demonstrated influence on the causes of chronic pain, pathophysiological phases, and possible complications. The prospects of further studies for development of the most effective techniques for treatment of various pain syndromes were assessed. Conclusions: Ozone therapy is one of the alternative rehabilitation methods with a substantial pain relieving effect. As of today, the possibility of using the oxygen-ozone mixture for treatment of chronic back pain related to intervertebral disk hernia and fibromyalgia has been substantially confirmed.

scholarly journals Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2431
Author(s):  
Natalia A. Shnayder ◽  
Marina M. Petrova ◽  
Tatiana E. Popova ◽  
Tatiana K. Davidova ◽  
Olga P. Bobrova ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Molecular Genetic ◽  
Pain Syndrome ◽  
Medical Problem ◽  
Single Nucleotide Variants ◽  
Genetic Studies ◽  
Pain Syndromes ◽  
Nos Inhibitors ◽  
Peripheral Pain

Chronic pain syndromes are an important medical problem generated by various molecular, genetic, and pathophysiologic mechanisms. Back pain, neuropathic pain, and posttraumatic pain are the most important pathological processes associated with chronic pain in adults. Standard approaches to the treatment of them do not solve the problem of pain chronicity. This is the reason for the search for new personalized strategies for the prevention and treatment of chronic pain. The nitric oxide (NO) system can play one of the key roles in the development of peripheral pain and its chronicity. The purpose of the study is to review publications devoted to changes in the NO system in patients with peripheral chronical pain syndromes. We have carried out a search for the articles published in e-Library, PubMed, Oxford Press, Clinical Case, Springer, Elsevier, and Google Scholar databases. The search was carried out using keywords and their combinations. The role of NO and NO synthases (NOS) isoforms in peripheral pain development and chronicity was demonstrated primarily from animal models to humans. The most studied is the neuronal NOS (nNOS). The role of inducible NOS (iNOS) and endothelial NOS (eNOS) is still under investigation. Associative genetic studies have shown that single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes encoding nNOS, iNOS, and eNOS may be associated with acute and chronic peripheral pain. Prospects for the use of NOS inhibitors to modulate the effect of drugs used to treat peripheral pain syndrome are discussed. Associative genetic studies of SNVs NOS1, NOS2, and NOS3 genes are important for understanding genetic predictors of peripheral pain chronicity and development of new personalized pharmacotherapy strategies.

scholarly journals The effects of a multiday (10–14 days) subanesthetic dose IV ketamine infusion in the treatment of refractory chronic pain

2021 ◽  
Author(s):  
Amokrane Chebini ◽  
Sina Marzoughi ◽  
Jason Randhawa ◽  
Daphne Guh ◽  
Stephen Wiseman ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Prospective Trial ◽  
Pain Syndrome ◽  
Chronic Patients ◽  
Chronic Neuropathic Pain ◽  
Chronic Noncancer Pain ◽  
Ketamine Infusion ◽  
Pain Syndromes ◽  
Clinically Significant ◽  
Noncancer Pain

Aim: Ketamine is an anesthetic agent that at lower doses can be a potent analgesic. There has been an interest in the use of low dose ketamine in treatment of chronic pain syndromes. Patients & methods: We report the results of a retrospective observational study for patients diagnosed with a chronic noncancer pain syndrome receiving a 2-week continuous subanesthetic IV ketamine infusion. Results & conclusion: We conclude that a 10–14 days of subanesthetic ketamine infusion in chronic patients results in clinically significant lowering of patients' numerical pain score. Further studies looking at subanesthetic ketamine infusion in a prospective trial of multi-day IV ketamine infusion in chronic refractory chronic neuropathic pain are needed to further assess the efficacy of ketamine.

RADIOFREQUENCY ABLATION OF FACET NERVES IN THE TREATMENT OF PAIN SYNDROMES IN DEGENERATIVE DISEASES OF THE SPINE

2021 ◽  
Vol 2 (5) ◽  
pp. 45-48
Author(s):  
K.R. Rakhmatov ◽  
Keyword(s):  
Back Pain ◽  
Radiofrequency Ablation ◽  
High Frequency ◽  
Chronic Back Pain ◽  
Incidental Finding ◽  
Pain Syndrome ◽  
Degenerative Diseases ◽  
Pain Syndromes ◽  
First Results ◽  
Asymptomatic Subjects

The first results of radiofrequency ablation of facet nerves and its effectiveness in eliminating local chronic back pain and reflected pain vertebrogenic syndromes were studied in 122 patients. Thebest results were obtained in patients with spondyloarthrosis with a positive test blockade of the facet nerves. Spondyloarthrosis is the most common condition presenting as neck pain, although it usually appears as an incidental finding in older asymptomatic subjects in cervical radiographs.Keywords: back pain, reflex, pain, syndrome, facet nerve, high-frequency, exposure, spondyloarthrosis, syndrome, radiofrequency ablation.

Chronic pain syndromes

2018 ◽  
pp. 623-642
Author(s):  
Gavin Clunie ◽  
Nick Wilkinson ◽  
Elena Nikiphorou ◽  
Deepak R. Jadon
Keyword(s):  
Chronic Pain ◽  
General Practitioner ◽  
Children And Adolescents ◽  
Complex Regional Pain Syndrome ◽  
Musculoskeletal Pain ◽  
Pain Syndrome ◽  
Pain Syndromes ◽  
Pain Medications ◽  
Cross Reference ◽  
Chronic Pain Syndromes

The Oxford Handbook of Rheumatology 4th edition, has been extensively updated to thoroughly review aspects of musculoskeletal pain. Pain pathophysiology is reviewed. Chronic pain and fibromyalgia in adults and in children and adolescents is dealt with in detail. The reader is advised to cross reference from this chapter to Chapters 1–3 in the Handbook, where regional musculoskeletal pain conditions are listed and reviewed. In localized pain syndromes, the chapter has an overview of complex regional pain syndrome (CRPS), which is not infrequently encountered in rheumatology and musculoskeletal clinics. Included in detail for this edition, is the assessment and management of pain in children, which is a highly specialized clinical area of medicine and will be of use to the adult rheumatologist and general practitioner as well as paediatric specialists. Readers should cross reference to Chapter 23 on medications, for ‘pain medications’ in the Handbook

Metabolic Therapy and Pain

2016 ◽  
Author(s):  
David N. Ruskin
Keyword(s):  
Chronic Pain ◽  
Pain Syndrome ◽  
Poor Quality ◽  
Fatty Acid Supplementation ◽  
Pain Syndromes ◽  
Drug Treatments ◽  
Dietary Treatments ◽  
Dietary Modifications ◽  
Chronic Pain Syndromes

Chronic pain is associated strongly with poor quality of life. Drug treatments for pain can be problematic; with the understanding that chronic pain syndromes often involve derangement of homeostasis, there is an increased interest in applying nonpharmacological metabolic therapies. This chapter surveys clinical and animal research into the effects of fasting, calorie restriction, ketogenic diet, and polyunsaturated fatty acid supplementation on pain. These dietary treatments can significantly ameliorate pain in inflammatory and neuropathic disorders. The choice among these treatments might depend on the specific pain syndrome and the tolerance of the patient for particular dietary modifications. Several possible mechanisms are discussed, some of which might be in common among these treatments, and some treatments might engage multiple mechanisms. Multiple mechanisms acting together could be ideal for restoring the disordered metabolism underlying some pain syndromes.

Multiple Sclerosis and Pain: A Medical Focus

2000 ◽  
Vol 2 (3) ◽  
pp. 40-47 ◽  
Author(s):  
Marilyn Kassirer
Keyword(s):  
Multiple Sclerosis ◽  
Chronic Pain ◽  
Joint Pain ◽  
Pain Syndrome ◽  
Surgical Interventions ◽  
Alternative Interventions ◽  
Pain Syndromes ◽  
Drug Treatments ◽  
Patients Experience ◽  
Iatrogenic Pain

Abstract About 65% of multiple sclerosis (MS) patients experience a broad range of both acute and subacute painful syndromes. Acute conditions (eg, trigeminal neuralgia and Lhermitte's syndrome) cause intense, unrelenting pain that may worsen with age and disease progression. Chronic pain (eg, joint pain) is also a component of MS. Pain syndromes, including optic neuritis, complex regional pain syndrome (CRPS), and other less well-known syndromes, may respond to a variety of pharmacologic, surgical, or alternative interventions. MS patients may also experience iatrogenic pain. Some successful drug treatments for pain that are used in combination or alone include anticonvulsants, tricyclics, methylprednisolone, and narcotics. Surgical interventions, percutaneous compression-balloons, and radiofrequency ablation are other viable options for some pain syndromes.

Abstract 326: Postural Orthostatic Tachycardia Syndrome and its Associated Chronic Pain Symptoms

2015 ◽  
Vol 117 (suppl_1) ◽  
Author(s):  
Chandralekha Ashangari ◽  
Amer Suleman
Keyword(s):  
Chronic Pain ◽  
Medical Records ◽  
Chronic Back Pain ◽  
Pain Syndrome ◽  
The Body ◽  
Postural Orthostatic Tachycardia Syndrome ◽  
Chronic Regional Pain Syndrome ◽  
High Prevalence ◽  
Pain Symptoms ◽  
Very High

Background and Purpose: The Postural Orthostatic Tachycardia Syndrome (POTS) affects primarily young women. POTS is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. The symptoms of POTS are widespread because the autonomic nervous system plays an extensive role in regulating functions throughout the body. The aim of this study is to determine the chronic pain symptoms in Postural Orthostatic tachycardia syndrome (POTS) patients. Method: Two hundred fifty-five (255) POTS patients were randomly selected from our clinic (January 2014 to March 2015) , reviewed the medical records of 255 POTS patients for chronic pain symptoms and performed data analysis. Results: Two hundred thirty-three of the 255 (91%) patients are females (n=233, age 29.20 ± 10.32), Twenty-three of the 255 (9%) patients are males (n=23, age 29.70 ± 14.52).63% (161 of the 255) had Joint Pain/aches, 51% (131 of the 255) had Chronic headache, 40% (102 of the 255) had chest pain, 31% (80 of the 255) had Migraine, 30% (76 of the 255) had Chronic back pain,16% (42 of the 255) had Heartburn,8%(20 of the 255) had Chronic pleurisy, Rheumatoid arthritis, Muscle aches, Chronic regional pain syndrome and Hip aches. Conclusion: Our study is the first to characterize that Patients with postural orthostatic tachycardia syndrome (POTS) have a very high prevalence of chronic pain symptoms.

Spinal disorders and back pain

2018 ◽  
pp. 605-622
Author(s):  
Gavin Clunie ◽  
Nick Wilkinson ◽  
Elena Nikiphorou ◽  
Deepak R. Jadon
Keyword(s):  
Chronic Pain ◽  
Back Pain ◽  
Children And Adolescents ◽  
Chronic Back Pain ◽  
Holistic Approach ◽  
Musculoskeletal Symptoms ◽  
Spinal Disorders ◽  
Specific Diagnosis ◽  
Pain Syndromes ◽  
Chronic Pain Syndromes

The Oxford Handbook of Rheumatology, 4th edition, chapter on ‘Spinal disorders and back pain’ brings together a pragmatic approach to categorizing back pain, how to investigate disorders presenting with back pain, and how to treat adults, children, and adolescents with back pain. In the chapter, the management of back pain is separated into acute, subacute, and chronic presenting scenarios and the text makes reference to other chapters in the book where there may be some additional useful information (e.g. spondyloarthritis-associated back pain in Chapter 8 and chronic pain syndromes in Chapter 22). Notably the chapter is best read in conjunction with relevant sections in Chapter 3 (‘Regional musculoskeletal symptoms: making a working diagnosis’). The chapter makes reference to the need for a rigorous diagnostic approach to all the conditions which cause back pain, and at whatever age. There are subsections on how to assess paediatric spinal disorders and how to take a broad holistic approach to managing chronic back pain where there is no specific diagnosis.

scholarly journals Classification of Chronic Pain at a Multidisciplinary Pain Rehabilitation Clinic

1998 ◽  
Vol 3 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Jan Lidbeck ◽  
Gertie IM Hautkamp ◽  
Ritva A Ceder ◽  
Urban LO Näslund
Keyword(s):  
Chronic Pain ◽  
Musculoskeletal Pain ◽  
Myofascial Pain ◽  
Pain Syndrome ◽  
Pain Clinic ◽  
Psychological Pain ◽  
Pain Syndromes ◽  
Epidemiological Surveys ◽  
Clinical Diagnoses ◽  
Chronic Pain Syndromes

OBJECTIVE: To make a detailed diagnostic analysis of patients with chronic pain syndromes, including classification according to the International Association for the Study of Pain (IASP).DESIGN: Descriptive study of consecutive referrals during a two-year period.SETTING: A multidisciplinary out-patient pain clinic focused on occupational rehabilitation.SUBJECTS: A total of 309 chronic pain patients.METHODS: After a standardized multimodal physical and psychological examination, the chronic pain syndrome of each patient was assigned one or more clinical diagnoses; assigned to an etiological pain category (nociceptive pain, non-nociceptive including idiopathic pain, and psychological pain); and coded diagnostically according to IASP taxonomy.RESULTS: In all, 397 clinical diagnoses were made (ie, a mean of 1.3 diagnoses per patient). A large majority (87%) received a diagnosis of myalgia. Myofascial pain (trigger point syndrome) was diagnosed in two-thirds of the patients and was the most frequent clinical pain syndrome. A total of 51.8% of the pain syndromes were categorized as nociceptive, 43.0% as idiopathic and less than 1% as pain of psychological origin. Classification using the IASP system yielded a very high proportion of nociceptive, musculoskeletal pain syndromes of high intensity, with widespread pain and/or pain located in the neck/shoulder/arm region, and of dysfunctional etiology.CONCLUSIONS: Musculoskeletal pain was very common in this series, and myofascial pain syndromes were the most frequent specific pain disorders. However, myofascial pain had generally gone unrecognized by the referring physician. In contrast to findings of other studies, the incidence of low back pain and of primary psychological pain was low. Comparison of the results with those of Swedish epidemiological surveys showed the frequencies of the diagnoses in this series to be representative of chronic pain syndromes in the Swedish general population.

scholarly journals Features of the cognitive component of chronic pain in young people with vertebral dorsalgia

2020 ◽  
pp. 10-13
Author(s):  
Nataliya Kufterina
Keyword(s):  
Chronic Pain ◽  
Cognitive Impairment ◽  
Back Pain ◽  
Analogue Scale ◽  
Chronic Back Pain ◽  
Young Patients ◽  
Control Group ◽  
Healthy Individuals ◽  
Cognitive Component ◽  
Pain Syndromes

Objective: to identify the presence and characteristics of the cognitive component of pain in young patients suffering from chronic dorsalgia. Material and methods: 97 patients with chronic vertebral pain syndromes of the cervicobrachial (50 patients) and lumbosacral localization (47 patients) and 20 healthy individuals in the control group. Pain assessment was carried out using Visual Analogue Scale, MMSE, Luria’s tests. It was shown, that the examined patients had cognitive impairment in the form of decrease in the concentration of attention and difficulties in the mental activity, more pronounced in patients with pain syndromes of the cervicobrachial localization. The severity of cognitive dysfunction is more associated with the severity of the muscle-tonic syndrome than with the intensity of pain. Cognitive impairment in patients with chronic back pain depends on the degree of muscle tonic syndrome pain intensity. Keywords: cognitive impairment, chronic back pain

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