scholarly journals PHYSICO-CHEMICAL AND PHYTOCHEMICAL SCREENING OF n-HEXANE EXTRACT OF LEPTADENIA HASTATA LEAVES: A PROPOSED HERBAL REMEDY IN THE TREATMENT OF DIABETES MELLITUS

2019 ◽  
Vol 7 (2) ◽  
pp. 45-57
Author(s):  
Attah M.O.O ◽  
Jacks T.W ◽  
Garba S.H. ◽  
Mshelia H.E.
Keyword(s):  
Diabetes Mellitus ◽  
Herbal Remedy ◽  
Hexane Extract ◽  
Phytochemical Analysis ◽  
Climbing Plant ◽  
Physico Chemical ◽  
Treatment Of Diabetes ◽  
Nutritive Composition ◽  
Control And Management ◽  
Physical And Chemical

Background:  Leptadenia hastata is a leafy, climbing plant of whose root, leaf and bark is widely consumed in Northern Nigeria. Decoctions made from the leaf is locally used in treatment of diabetes as well as for numerous trado-medicinal processes. This study investigates the physico-chemical as well as phytochemical compounds present in the n-hexane extract of Leptadenia hastata. Method: Physical and chemical profile was determined using Smart Spectro test kits and a mass spectrometer to determine the presence of elements and physical properties. Results: Phytochemical analysis revealed the presence of steroids, triterpenoids and cardiac glycosides. The elemental analysis revealed that Na, SO4 and PO4 had the highest levels in the extract. Pb, Hg and Cd were not detected which showed that the plant extract was not toxic. Other elements (NO4, Mn, Fe, K, Ni, Si, Cn, Zn, Ca, Mg, NH4, Cr and F) were present in varying concentrations which may contribute to its nutritive composition. Conclusions: Various elements present in Leptadenia hastata may have either a direct or indirect role in the control and management of diabetes mellitus, since diabetes is associated with marked alterations in trace elements concentrations and may replace diminished element stores in the treatment of diabetes mellitus.

Treatment of diabetes mellitus: Implications of the use of oral agents

1999 ◽  
Vol 138 (4) ◽  
pp. s334-s337 ◽  
Author(s):  
S RAO ◽  
A BETHEL ◽  
M FEINGLOS
Keyword(s):  
Diabetes Mellitus ◽  
Oral Agents ◽  
Treatment Of Diabetes

Insulin Initiation and Concomitant OHA (Oral Hypoglycaemic Agents) in Treatment of Diabetes Mellitus—Results of the Indian Human Insulin Registry (INHIRIT)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2293-PUB ◽  
Author(s):  
VEERANNA KARADI ◽  
DILIP PAWAR ◽  
SARAH JABEEN ◽  
SANDEEP S. ◽  
SAPTARSHI BOSE ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Human Insulin ◽  
Insulin Initiation ◽  
Oral Hypoglycaemic Agents ◽  
Hypoglycaemic Agents ◽  
Treatment Of Diabetes

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

Authenticity Identification of Carbonated Alcochol-Free Beverages

Food Industry ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 16-22
Author(s):  
Irina Reznichenko ◽  
Maria Kondratieva
Keyword(s):  
Mass Fraction ◽  
Soft Drinks ◽  
Alcoholic Beverages ◽  
Consumer Market ◽  
Score System ◽  
Regulatory Documents ◽  
Chemical Indicators ◽  
Physico Chemical ◽  
Alcoholic Drinks ◽  
Physical And Chemical

The article concerns the counterfeiting problem of non-alcoholic drinks sold on the consumer market of the Russian Federation; provides data on drinks fraud methods (assortment, qualitative, quantitative and informational types). Strengthening quality control of soft drinks is one of the main directions of providing consumers with qualitative products. The authors presented authenticity identification results of carbonated soft drinks sold on the Kemerovo consumer market for compliance with the current regulatory documents requirements; run the consumer criteria analysis for the drinks identification of various brands. They obtained data on the labeling and packaging identification of selected non-alcoholic carbonated drinks samples for the compliance with current regulatory documents. A man recorded the compliance. There was an absence of the quantitative counterfeiting identification. The study described results of the organoleptic and physico-chemical quality indicators research. According to the GOST 28188-2014 “Non-Alcoholic Beverages. General Technical Conditions” the authors evaluated beverages quality by such physical and chemical indicators as the mass fraction of dry substances, acidity, and the mass fraction of carbon dioxide. The researchers run the organoleptic indicators analysis according to a score system. Authenticity identification of the selected drinks samples showed that there are no signs of counterfeiting and the products are of high quality.

Metabolic surgery, a new paradigm for the treatment of diabetes

2019 ◽  
Vol 30 (4) ◽  
pp. 477-485
Author(s):  
R Balongo García ◽  
D Bejarano Gómez-Serna ◽  
A de la Rosa Báez ◽  
D Molina García ◽  
B García del Pino ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Surgery ◽  
New Paradigm ◽  
Calidad De Vida ◽  
Treatment Of Diabetes ◽  
Sistemas Sanitarios

Resumen La diabetes mellitus tipo II (DM2) es una enfermedad crónica, progresiva e incurable, que ocasiona una reducción de la esperanza y de la calidad de vida. Se está produciendo un incremento epidémico global de la misma asociada a la obesidad, y a largo plazo se convertirá en la mayor carga sobre los sistemas sanitarios. Aunque existe un tratamiento efectivo para la diabetes, muchos de los pacientes sólo con el tratamiento médico no consiguen los objetivos terapéuticos mínimos para el control del riesgo microvascular. Las técnicas quirúrgicas para la obesidad mórbida han demostrado que pueden controlar la hiperglucemia, y existe consenso para su uso como forma de tratamiento para algunos pacientes desde 2015. Dado que los objetivos, el tipo de respuesta y los criterios de efectividad no están relacionados directamente con el sobrepeso, estamos ante un nuevo paradigma, definido por el término cirugía metabólica.

Berberine in the treatment of diabetes mellitus: a review

2020 ◽  
Vol 20 ◽  
Author(s):  
Aleksandra Baska ◽  
Kamil Leis ◽  
Przemysław Gałązka
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Intestinal Flora ◽  
Glucose Absorption ◽  
Hepatocyte Nuclear Factor ◽  
Peripheral Tissues ◽  
Macrophages Polarization ◽  
Treatment Of Diabetes ◽  
Hepatocyte Nuclear Factor 4

: Berberine is an alkaloid found in plants. It has e.g. neuroprotective, anti-inflammatory and hypolipidemic activity. The research proves that it also strongly impacts the carbohydrate metabolism. The compound also protects pancreatic βcells and increases sensitivity to insulin in peripheral tissues via the induction of GLUT-1, GLUT-4 and insulin type 1 (Ins1) receptors activity. It also stimulates glycolysis and leads to a decrease in insulin resistance by macrophages polarization, lipolytic processes induction and energy expenditure enhancement (by reducing body mass and limiting insulin resistance caused by obesity). In liver berberine inhibits FOX01, SREBP1 and ChREBP pathways, and HNF-4α (hepatocyte nuclear factor 4 alpha) mRNA that hinder gluconeogenesis processes. In intestines it blocks α-glucosidase contributing to glucose absorption decrease. Its interference in intestinal flora reduces levels of monosaccharides and suppresses diabetes mellitus complications development.

Nucleophilicity and its parametrization

1989 ◽  
Vol 54 (1) ◽  
pp. 117-135
Author(s):  
Oldřich Pytela ◽  
Vítězslav Zima
Keyword(s):  
Regression Analysis ◽  
Linear Correlation ◽  
Correlation Equation ◽  
Chemical Processes ◽  
General Tendency ◽  
Orbital Interaction ◽  
Physico Chemical ◽  
Physical And Chemical ◽  
Two Parameter ◽  
Better Than

The method of conjugate deviations based on the regression analysis has been suggested for construction of a new nucleophilicity scale. This method has been applied to a set of 28 nucleophiles participating in 47 physical and chemical processes described in literature. The two-parameter nucleophilicity scale obtained represents-in the parameter denoted as ND-the general tendency to form a bond to an electrophile predominantly on the basis of the orbital interaction and-in the parameter denoted as PD-the ability to interact with a centre similar to the proton (basicity). The linear correlation equation involving the ND, PD parameters and the charge appears to be distinctly better than the most significant relations used. The correlation dependences have the physico-chemical meaning. From the position of individual nucleophiles in the space of the ND and PD parameters, some general conclusions have been derived about the factors governing the reactivity of nucleophiles.

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