A STUDY OF FIELD GEOTHERMAL POWER POTENTIAL & THERMODYNAMIC CONCEPTS OF PROSPECTIVE BINARY POWER CYCLE BASED GEOTHERMAL POWER PLANT FOR TATAPANI GEOTHERMAL FIELD.

Dyslexia is a neuro developmental reading disorder that degrades the speed and accuracy of word recogni- tion, and as a consequence, impedes reading fluency and text comprehension. Between 5 and 10 percent of the population are normally affected by it. It has long been known that the eye movements of dyslexic readers differ from those of typical readers. The dataset for this study has been taken from the dataset used by a similar study (Benfatto et al., 2016). The experiments reported by the authors are based on eye tracking data from 185 subjects participating in the Kronoberg reading development project, a longitudinal research project on reading development and reading disability in Swedish school children running between 1989 and 2010. For our present study, we use eye movement recordings made while the subjects were reading a short natural passage of text adapted to their age. Recordings were available for 185 subjects, 97 High Risk (HR) subjects (76 males and 21 females) and 88 Low Risk(LR) subjects (69 males and 19 females Machine learning based predictive model developed in this study employ feature set based on eye fixations and saccades parameters and can be used to give individual level diagnosis with high sensitivity and specificity. Using statistical cross-validation techniques on a sample of 97 dyslexic and 88 control subjects, we achieve a classification accuracy of over 96% with balanced levels of sensitivity and specificity. Diagnostic follow-up of a screening result is always necessary so that intervention strategies can be personalized. Nevertheless, early identification of individuals in need of support is the first important step in this process and using eye tracking along with this system during reading may prove very useful. The system’s accuracy can be further enhanced by collecting a larger sample and then training these and other classification models.

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Screening for Reading Difficulties: Comparing Eye Tracking Outcomes to Neuropsychological Assessments

Frontiers in Education ◽

10.3389/feduc.2021.643232 ◽

2021 ◽

Vol 6 ◽

Author(s):

Anna Carin Gran Ekstrand ◽

Mattias Nilsson Benfatto ◽

Gustaf Öqvist Seimyr

Keyword(s):

Eye Tracking ◽

Struggling Readers ◽

Reading Fluency ◽

Neuropsychological Test ◽

Reading Development ◽

Screening Method ◽

Cognitive Assessments ◽

Cognitive Difficulties ◽

Cognitive Limitations ◽

Early School

The use of eye tracking to assess reading fluency has been proposed as a novel and efficient screening method for identifying school children with atypical reading development or risk of dyslexia. Currently, however, little is known about the relationship between the predictive outcomes produced by eye tracking screening systems and specialist cognitive assessments. Here we investigate this relationship in the context of a neuropsychological case study involving eight subjects (9–10 years) who were identified as being at risk of dyslexia by an eye tracking screening system. We analyze to what extent these subjects displayed cognitive limitations when assessed with a neuropsychological test battery, and to what extent cognitive difficulties were limited to reading and decoding, or whether they extended to other domains as well. As a group, the subjects performed on average significantly worse in reading and decoding than in other cognitive domains. Five subjects performed more than 1.25 standard deviations below the mean for age. In line with empirical evidence, co-occurring difficulties in the attention domain were also observed in a few struggling readers. Overall, the results support the view that eye tracking can be a useful tool to assess and monitor children’s reading development during the early school years.

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Text Complexity Modulates Cross-Linguistic Sentence Integration in L2 Reading

Frontiers in Communication ◽

10.3389/fcomm.2021.651769 ◽

2021 ◽

Vol 6 ◽

Author(s):

Sibylla Leon Guerrero ◽

Veronica Whitford ◽

Laura Mesite ◽

Gigi Luk

Keyword(s):

Eye Tracking ◽

Reading Fluency ◽

Text Comprehension ◽

Semantic Knowledge ◽

L2 Reading ◽

Linguistic Resources ◽

Language Groups ◽

Component Skills ◽

Fluency And Comprehension ◽

Linear Regression Modeling

Cross-linguistic influences (CLI) in first-language (L1) and second-language (L2) reading have been widely demonstrated in experimental paradigms with adults at the word and sentence levels. However, less is known about CLI in adolescents during naturalistic text reading. Through eye-tracking and behavioral measures, this study investigated expository reading in functionally English monolingual and Spanish (L1) - English (L2) bilingual adolescents. In particular, we examined the role of L1 (Spanish) sentence integration skills among the bilingual adolescents when L2 school texts contained challenging syntactic structures, such as complex clauses, elaborated noun phrases, and anaphoric references. Results of generalized multilevel linear regression modeling demonstrated CLI in both offline comprehension and online eye-tracking measures that were modulated by school text characteristics. We found a positive relationship (i.e., facilitation) between L1 sentence integration skills and L2 English text comprehension, especially for passages with greater clause complexity. Similar main, but not modulatory, effects of sentence integration skill were found in online eye-tracking measures. Overall, both language groups appeared to draw upon similar reading component skills to support reading fluency and comprehension when component skills were measured only in English. However, differential patterns of association across languages became evident when those skills were measured in both L1 and L2. Taken together, our findings suggest that bilingual adolescents’ engagement of cross-linguistic resources in expository reading varies dynamically according to both language-specific semantic knowledge and language-general sentence integration skills, and is modulated by text features, such as syntactic complexity.

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Detector-C: A Blood-based IVD with High Sensitivity and Specificity for Early Detection and Screening of Colorectal Cancer

Zeitschrift für Gastroenterologie ◽

10.1055/s-0030-1263628 ◽

2010 ◽

Vol 48 (08) ◽

Author(s):

A Rosenthal ◽

H Köppen ◽

R Musikowski ◽

R Schwanitz ◽

J Behrendt ◽

...

Keyword(s):

Colorectal Cancer ◽

Early Detection ◽

Sensitivity And Specificity ◽

High Sensitivity

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Trends in Diagnosis for Active Tuberculosis Using Nanomaterials

Current Medicinal Chemistry ◽

10.2174/0929867325666180912105617 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1946-1959 ◽

Cited By ~ 3

Author(s):

Le Minh Tu Phan ◽

Lemma Teshome Tufa ◽

Hwa-Jung Kim ◽

Jaebeom Lee ◽

Tae Jung Park

Keyword(s):

Sensitivity And Specificity ◽

High Efficiency ◽

Point Of Care ◽

High Sensitivity ◽

Signs And Symptoms ◽

Diagnostic Methods ◽

Advantages And Disadvantages ◽

Treatment And Prevention ◽

Clinical Tools ◽

Diagnostic Applications

Background:Tuberculosis (TB), one of the leading causes of death worldwide, is difficult to diagnose based only on signs and symptoms. Methods for TB detection are continuously being researched to design novel effective clinical tools for the diagnosis of TB.Objective:This article reviews the methods to diagnose TB at the latent and active stages and to recognize prospective TB diagnostic methods based on nanomaterials.Methods:The current methods for TB diagnosis were reviewed by evaluating their advantages and disadvantages. Furthermore, the trends in TB detection using nanomaterials were discussed regarding their performance capacity for clinical diagnostic applications.Results:Current methods such as microscopy, culture, and tuberculin skin test are still being employed to diagnose TB, however, a highly sensitive point of care tool without false results is still needed. The utilization of nanomaterials to detect the specific TB biomarkers with high sensitivity and specificity can provide a possible strategy to rapidly diagnose TB. Although it is challenging for nanodiagnostic platforms to be assessed in clinical trials, active TB diagnosis using nanomaterials is highly expected to achieve clinical significance for regular application. In addition, aspects and future directions in developing the high-efficiency tools to diagnose active TB using advanced nanomaterials are expounded.Conclusion:This review suggests that nanomaterials have high potential as rapid, costeffective tools to enhance the diagnostic sensitivity and specificity for the accurate diagnosis, treatment, and prevention of TB. Hence, portable nanobiosensors can be alternative effective tests to be exploited globally after clinical trial execution.

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Value of Coronary Calcium Scoring in Symptomatic and Asymptomatic Coronary Artery Disease Patients

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405616666201023142030 ◽

2020 ◽

Vol 16 ◽

Author(s):

Hala T. Salem ◽

Eman A.S. Sabek

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Sensitivity And Specificity ◽

High Sensitivity ◽

Coronary Calcium ◽

Risk Estimate ◽

Calcium Scoring ◽

Coronary Calcium Scoring ◽

Framingham Risk ◽

Artery Disease

Aim and Objective: To estimate the relationship between Coronary Calcium Scoring (CCS)and presence of different degrees of obstructive coronary artery disease (CAD) to avoid unnecessary examinations and hence unnecessary radiation exposure and contrast injection. Background: Coronary Calcium Scoring (CCS) is a test uses x-ray equipment to produce pictures of the coronary arteries to determine the degree of its narrowing by the build-up of calcified plaques. Despite the lack of definitive data linking ionizing radiation with cancer, the American Heart Association supports widely that practitioners of Computed tomography Coronary Angiography (CTCA) should keep “patient radiation doses as low as reasonably achievable but consistent with obtaining the desired medical information”. Methods: Data obtained from 275 CTCA examinations were reviewed. Radiation effective doses were estimated for both CCS and CTCA, measures to keep it as low as possible were presented, CCS and Framingham risk estimate were compared to the final results of CTCA to detect sensitivity and specificity of each one in detecting obstructive lesions. Results: CCS is a strong discriminator for obstructive CAD and can with high sensitivity and specificity and correlates well with the degree of obstruction even more than Framingham risk estimate which has high sensitivity and low specificity. Conclusion: CCS helps reducing the effective radiation dose if properly evaluated to skip unnecessary CTCA if obstructive lesions was unlikely, and as a test does not use contrast material, harmful effect on the kidney will be avoided as most of coronary atherosclerotic patients have renal problems.

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Blood-Based Detection of Colorectal Cancer Using Cancer-Specific DNA Methylation Markers

Diagnostics ◽

10.3390/diagnostics11010051 ◽

2020 ◽

Vol 11 (1) ◽

pp. 51

Author(s):

Nam-Yun Cho ◽

Ji-Won Park ◽

Xianyu Wen ◽

Yun-Joo Shin ◽

Jun-Kyu Kang ◽

...

Keyword(s):

Colorectal Cancer ◽

Dna Methylation ◽

Sensitivity And Specificity ◽

Stage Iv ◽

High Sensitivity ◽

Liquid Biopsies ◽

Blood Leukocytes ◽

Marker Panel ◽

A Genome ◽

Methylight Assay

Cancer tissues have characteristic DNA methylation profiles compared with their corresponding normal tissues that can be utilized for cancer diagnosis with liquid biopsy. Using a genome-scale DNA methylation approach, we sought to identify a panel of DNA methylation markers specific for cell-free DNA (cfDNA) from patients with colorectal cancer (CRC). By comparing DNA methylomes between CRC and normal mucosal tissues or blood leukocytes, we identified eight cancer-specific methylated loci (ADGRB1, ANKRD13, FAM123A, GLI3, PCDHG, PPP1R16B, SLIT3, and TMEM90B) and developed a five-marker panel (FAM123A, GLI3, PPP1R16B, SLIT3, and TMEM90B) that detected CRC in liquid biopsies with a high sensitivity and specificity with a droplet digital MethyLight assay. In a set of cfDNA samples from CRC patients (n = 117) and healthy volunteers (n = 60), a panel of five markers on the platform of the droplet digital MethyLight assay detected stages I–III and stage IV CRCs with sensitivities of 45.9% and 95.7%, respectively, and a specificity of 95.0%. The number of detected markers was correlated with the cancer stage, perineural invasion, lymphatic emboli, and venous invasion. Our five-marker panel with the droplet digital MethyLight assay showed a high sensitivity and specificity for the detection of CRC with cfDNA samples from patients with metastatic CRC.

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