scholarly journals Identification of Oral Strains of Lactobacillus species in Patients with Chronic Periodontitis and Healthy Individuals

2019 ◽  
Vol 8 (3) ◽  
pp. 272-280
Author(s):  
Enayat Kalantar ◽  
Arghavan Etebarian ◽  
Seyed Mahmood Amin Marashi ◽  
Koroush Kabir ◽  
Aboozar Moradi ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Lactobacillus Species ◽  
Healthy Individuals

scholarly journals Evaluation of PECAM-1 Gene Polymorphism in Patients with Periodontal Disease and Healthy Individuals

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Mahdi Kdkhodazadeh ◽  
Mehrdad Hajilooi ◽  
Behzad Houshmand ◽  
Sara Khazaei ◽  
Leila Gholami ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Aggressive Periodontitis ◽  
Genotype Distribution ◽  
Nucleotide Polymorphisms ◽  
Healthy Individuals ◽  
Single Nucleotide ◽  
Genotypic Distribution ◽  
Genotype Frequencies ◽  
Significant Difference ◽  
Polymerase Chain

Objective. Our aim in this paper was to investigate the possible genetic association between three Ser563Asn, Leu125Val and Arg670Gly polymorphisms of the PECAM-1 gene and periodontitis. Methods. Genomic DNA was isolated from whole blood of 105 periodontal patient (52 with chronic periodontitis and 53 with aggressive periodontitis) and 101 healthy individuals. Samples were genotyped and analyzed for the three single-nucleotide polymorphisms (SNPs) of PECAM-1 using polymerase chain reaction with sequence-specific primers (PCR-SSPs). Results. A statistically significant difference was found between the genotypic distribution of the Ser563Asn polymorphism in patients with periodontitis compared to controls (P=0.02). But there were no statistically significant difference between the allele frequencies in the different groups (P=0.05). The other two polymorphisms did not show a statistically significant difference in their allele and genotype frequencies between the groups. There was no statistically significant difference found for any of the polymorphisms allele and genotype distribution in aggressive and chronic periodontitis either. Conclusions. No significant association was found between the polymorphism tested and the subgroups of periodontitis, further research is still necessary to determine whether this polymorphism can be used as a genetic marker of periodontitis.

scholarly journals Hair Mercury Levels in Periodontal Patients in Comparison with Healthy Individuals

2014 ◽  
Vol 5 (3) ◽  
pp. 166-169 ◽  
Author(s):  
Soraya Khafri ◽  
Hamidreza Hasanjani Roushan ◽  
Hadi Parsian ◽  
Ramin Alijannia ◽  
Abbas Mosapour
Keyword(s):  
Chronic Periodontitis ◽  
Healthy Subjects ◽  
Periodontal Diseases ◽  
Mercury Level ◽  
Control Group ◽  
P Value ◽  
Healthy Individuals ◽  
Hair Mercury ◽  
Hair Samples ◽  
The Difference

ABSTRACT Introduction The clinical manifestation of periodontal diseases (such as gingivitis and chronic periodontitis) results from a complex interplay between the etiologic agents such as bacteria that present in the dental plaque, genetic factors, systemic diseases, smoking and exposure of some heavy metals, such as mercury. In this study, we aimed to evaluate hair mercury levels in healthy subjects in comparison with periodontal patients. Materials and methods One hundred twenty subjects were enrolled in this study. The included persons were divided into 3 groups: healthy subjects (n = 40), gingivitis (n = 40) and chronic periodontitis patients (n = 40). Hair samples were collected from occipital area of head. Total mercury levels were determined by atomic absorption spectrophotometry. Results The difference between mercury levels in three groups were statistically significant (p-value < 0.001). Mercury level in periodontitis patients was greater than the gingivitis group (p-value < 0.001). In addition the differences between mercury levels in periodontitis patients vs healthy individuals was significant (p-value = 0.048). The gingivitis patients had lower levels of mercury than the control group, but the difference was not significant (p-value = 0.170). Conclusion The results showed that the levels of mercury are to some extent differed in periodontal diseases in comparison with the healthy individuals. A study with larger sample size is needed for clarification of this issue. How to cite this article Roushan HH, Parsian H, Alijannia R, Mosapour A, Khafri S. Hair Mercury Levels in Periodontal Patients in Comparison with Healthy Individuals. World J Dent 2014;5(3):166-169.

scholarly journals Dyslipidemia rather than Type 2 Diabetes Mellitus or Chronic Periodontitis Affects the Systemic Expression of Pro- and Anti-Inflammatory Genes

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Rafael Nepomuceno ◽  
Bárbara Scoralick Villela ◽  
Sâmia Cruz Tfaile Corbi ◽  
Alliny De Souza Bastos ◽  
Raquel Alves Dos Santos ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Periodontitis ◽  
Healthy Individuals ◽  
Inflammatory Genes ◽  
Anti Inflammatory ◽  
Immune Related Genes

A high percentage of type 2 diabetes mellitus (T2D) patients are also affected by dyslipidemia and chronic periodontitis (CP), but no studies have determined the gene expression in patients that are simultaneously affected by all three diseases. We investigated the systemic expression of immune-related genes in T2D, dyslipidemia, and CP patients. One hundred and fifty patients were separated into five groups containing 30 individuals each: (G1) poorly controlled T2D with dyslipidemia and CP; (G2) well-controlled T2D with dyslipidemia and CP; (G3) normoglycemic individuals with dyslipidemia and CP; (G4) healthy individuals with CP; (G5) systemic and periodontally healthy individuals. Blood analyses of lipid and glycemic profiles were carried out. The expression of genes, includingIL10, JAK1, STAT3, SOCS3, IP10, ICAM1, IFNA, IFNG, STAT1,andIRF1,was investigated by RT-qPCR. Patients with dyslipidemia demonstrated statistically higher expression of theIL10andIFNAgenes, whileIFNG, IP10, IRF1, JAK1,andSTAT3were lower in comparison with nondyslipidemic patients. Anti-inflammatory genes, such asIL10, positively correlated with parameters of glucose, lipid, and periodontal profiles, while proinflammatory genes, such asIFNG, were negatively correlated with these parameters. We conclude that dyslipidemia appears to be the primary disease that is associated with gene expression of immune-related genes, while parameters of T2D and CP were correlated with the expression of these important immune genes.

scholarly journals Comparison of salivary Visfatin in patients with periodontitis and peri-implantitis in an Iranian population

2018 ◽  
Vol 8 (2) ◽  
pp. 37-42
Author(s):  
Mahdi Kadkhodazadeh ◽  
Reza Amid ◽  
Maryam Torshabi ◽  
Niknaz Yahyazadeh ◽  
Navid Yousefi ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Healthy Individuals ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Elisa Kit ◽  
Significant Relationships ◽  
Enhancing Factor ◽  
Whole Saliva ◽  
Salivary Biomarker ◽  
The Mean

Background. Visfatin (pre-B-cell colony-enhancing factor) is a salivary biomarker secreted from a variety of cells and is thought to have some proinflammatory and immune-modulating effects. This study compared salivary concentrations of visfatin in patients with chronic periodontitis and periimplantitis and healthy individuals. Methods. In this cross-sectional and descriptive trial, patients were selected on the basis of inclusion and exclusion criteria. The whole saliva samples were collected; then according to the measured clinical parameters the patients were categorized to peri-, chronic periodontitis and periodontally healthy individuals. The concentrations of visfatin were evaluated using a standard ELISA kit. The salivary concentrations of visfatin were statistically analyzed using Kruskal-Wallis test. A probability value of less than 0.05 was considered significant. Results. A total of 40 participants (21 females and 19 males) were enrolled in this study. The mean salivary visfatin concentrations in the periodontally healthy individuals, periimplantitis patients and chronic periodontitis patients were 23.97 ng/mL, 12.83 ng/mL and 11.95 ng/mL, respectively. However; visfatin levels were higher in healthy individuals compared to other groups No significant differences were found in salivary visfatin concentrations between the three groups. Conclusion. Under the limitations of this study, no significant relationships were found regarding salivary concentrations of visfatin among periimplantitis and chronic periodontitis patients as compared to healthy individuals; however, more studies are required in this regard.

scholarly journals The Comparison of Mandibular Radiomorphometric Indices in Panoramic Radiography between Patients with Chronic Periodontitis and Healthy Individuals

2014 ◽  
Vol 15 (4) ◽  
pp. 461-465 ◽  
Author(s):  
Amir Moeintaghavi ◽  
Hossein Hosseinizarch ◽  
Sara Mohammadzadeh Tabassi
Keyword(s):  
Older Women ◽  
Chronic Periodontitis ◽  
Panoramic Radiography ◽  
Panoramic Radiograph ◽  
Healthy Individuals ◽  
Dental Clinics ◽  
Bone Damage ◽  
The Mean ◽  
Different Origins ◽  
The Relationship

ABSTRACT Aim Osteoporosis and periodontitis are two separate diseases with different origins and manifestations. It is believed that these diseases linked together, because they both lead to bone damage, some risk factors are similar, they both have the highest prevalence in middle-aged and older women. Some studies showed that the use of panoramic radiography and special indices could be reliable tools for osteoporosis screening. This study was performed to evaluate the relationship between periodontal disease and jaw osteoporotic indices. Materials and methods Eighty-two patients with chronic periodontitis and 80 healthy individuals were selected, they had been referred to a private oral and maxillofacial radiology clinic to take a panoramic radiograph. Then panoramic indicators; including the mandibular cortical index (MCI), mental index (MI), and panoramic mandible index (PMI) in both groups were measured, recorded and analyzed. Results The mean age of investigated individuals was 39/8 ± 9/33. 58.6% of participants were females and 41.4% were males. MI and PMI levels in the periodontal group were more than the periodontally healthy group, but the differences between the two groups was not statistically significant (p = 0.808 and p = 0.102 respectively). The MCI level was significantly different between two groups (p = 0.028). Conclusion The results of this study showed that there is significant relationship between MCI in panoramic radiography and chronic periodontitis. It is suggested to perform more studies to confirm if this index could be used for screening and indicating of bone status in high risk individuals. This study did not show a strong evidence of a relationship between osteoporosis and periodontitis. Clinical significance Since panoramic radiographs are routinely used for screening in dental practice, any association between radiomorphometric indices of mandible in periodontitis patients might be useful in prediction of osteoporosis in patients referring to dental clinics. How to cite this article Moeintaghavi A, Hosseinizarch H, MohammadzadehTabassi S. The Comparison of Mandibular Radiomorphometric Indices in Panoramic Radiography between Patients with Chronic Periodontitis and Healthy Individuals. J Contemp Dent Pract 2014;15(4):461-465.

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