Investigation of the Role of Mental Workload, Fatigue, and Sleep Quality in the Development of Musculoskeletal Disorders

Abstract Background and aims Serotonin affects intestinal physiology, mood, as well as circadian rhythm. Moreover, serotonin has proinflammatory function. Therefore, the aim of this study was to investigate the role of serotonin in clinical severity of Crohn’s Disease (CD) and its effect on pain and sleep quality. Methods Fifty-nine CD patients (34 in exacerbation and 25 in remission according to the Harvey-Bradshaw Index-HBI) and 25 health control individuals(HC) were recruited. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI) and subjective severity of pain by the Visual Analog Scale (VAS). Seventeen patients were treated with anti-TNF-α induction therapy for 14 weeks. Results Serotonin level was higher in CD (145.12ng/mL, IQR:98.14–179.25) compared to HC (87.52ng/mL, IQR:70.04–129.39; p=0.002) and in exacerbation of CD (157.66ng/mL, IQR:111.94–197.64) compared to remission (122.33ng/mL, IQR:83.28–163.67; p=0.029). Serotonin level with cut-off point of 92.45 ng/mL is useful for distinguishing participants with CD from HC (sensitivity: 78%, specificity: 60%, positive predictive value: 82%). Positive correlation between serotonin and HBI (r=0.279, p=0.032) and severity of diarrhoea (r=0.260, p=0.047) were found. Serotonin does not correlate with PSQI (r=0.152, p=0.168), but correlates with presence of sleep fragmentation for example by getting up to use the bathroom (joined 5b-5j PSQI questions; r=0.270, p=0.039). Correlations between serotonin and VAS were also obtained (r=0.220, p=0.045). Moreover, serotonin level significantly decreased after anti-TNF-α therapy (192.35ng/mL, IQR:150.36–225.56 vs. 121.11ng/mL, IQR:91.28–188.87; p=0.006). The study was funded by National Science Centre, Poland (#2018/31/N/NZ5/03715). Conclusions Serotonin level correlates with the severity of CD and decreases after anti-TNF-α therapy. It is associated with sleep fragmentation, which may be caused by diarrhea.

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Sleep quality and child abuse: the mediating role of alexithymia

Emotional and Behavioural Difficulties ◽

10.1080/13632752.2021.1958498 ◽

2021 ◽

pp. 1-10

Author(s):

Michael Bakhshesh-Boroujeni ◽

Sepideh Farajpour-Niri ◽

Ali karimi

Keyword(s):

Child Abuse ◽

Sleep Quality ◽

Mediating Role

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Poor sleep quality predicts decline in physical health functioning in patients with coronary heart disease and moderating role of social support

Behavioral Medicine ◽

10.1080/08964289.2021.1895050 ◽

2021 ◽

pp. 1-17

Author(s):

Biing-Jiun Shen ◽

Jonathan Jun Liang Tan ◽

Yue Xu ◽

Hung Yong Tay

Keyword(s):

Social Support ◽

Coronary Heart Disease ◽

Heart Disease ◽

Sleep Quality ◽

Physical Health ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Health Functioning ◽

Moderating Role

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Sex differences in mental disorder symptoms among Canadian police officers: the mediating role of social support, stress, and sleep quality

Cognitive Behaviour Therapy ◽

10.1080/16506073.2021.1877338 ◽

2021 ◽

pp. 1-18

Author(s):

Andréanne Angehrn ◽

Kelsey D. Vig ◽

Julia E. Mason ◽

Andrea M. Stelnicki ◽

Robyn E. Shields ◽

...

Keyword(s):

Social Support ◽

Sex Differences ◽

Sleep Quality ◽

Mental Disorder ◽

Police Officers ◽

Mediating Role

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The role of couple sleep concordance in sleep quality: Attachment as a moderator of associations

Journal of Sleep Research ◽

10.1111/jsr.12825 ◽

2019 ◽

Vol 28 (5) ◽

Author(s):

Taylor Elsey ◽

Peggy S. Keller ◽

Mona El‐Sheikh

Keyword(s):

Sleep Quality

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Perceptions of the Importance of Sleep in Common Cold—Two Online Questionnaire-Based Surveys

SN Comprehensive Clinical Medicine ◽

10.1007/s42399-020-00265-5 ◽

2020 ◽

Vol 2 (5) ◽

pp. 596-605

Author(s):

Gill Phillipson ◽

Sue Aspley ◽

Ingo Fietze

Keyword(s):

Immune System ◽

Sleep Quality ◽

Common Cold ◽

Western Europe ◽

Online Survey ◽

Symptom Relief ◽

Online Questionnaire ◽

The Common ◽

Waking Up

Abstract Sleep deprivation affects the immune system and can render subjects more susceptible to symptoms associated with the common cold. The aim of this research was to investigate cold sufferers’ and doctors’ perceptions of the role of sleep in recovery from cold/flu. An online survey of 4000 adults who had suffered from cold/flu in the previous 12 months was conducted in eight countries and an online survey of 150 doctors was conducted in Germany. Responses were collected to questions regarding aspects of life affected by, and concerns while suffering from, cold/flu symptoms including nighttime awakening and actions taken to aid recovery. Responses were also collected to questions regarding advice given to cold/flu patients and the importance of sleep. Ability to sleep well was widely reported as negatively impacted by cold/flu (mean 46.1% of respondents across eight countries), especially in Western Europe, and inability to sleep well was a frequently reported concern associated with suffering from cold/flu (21.8%). To sleep more than usual was a frequently reported action taken to feel better (40.5%). Ninety-four percent of respondents reported waking up at night because of symptoms, cough being the most frequently reported symptom to awaken respondents. There was evidence of a possible relationship between sleep quality and medication taken at night for symptom relief. Countries with the highest proportions of respondents who reported sleep to be the aspect of life most negatively affected by a cold (France, Germany and Italy) were also those with the lowest proportions of respondents who reported that taking medications at night was the most effective way of getting back to sleep after waking due to cold symptoms. The majority of doctors believed sleep helped cold/flu patients to recover faster and that a good night’s sleep was important. Sleep is widely considered to be important in promoting recovery from cold/flu. Hence, the relief of symptoms that disrupt sleep is also likely to be important for a faster recovery.

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