FIBROIDS IN PREGNANCY;

Objectives: The objective of this study was to determine the frequency ofcomplications in pregnant women with fibroids in 3rd trimester. Study design: Descriptive CaseSeries. Setting: Department of Obstetrics & Gynecology, Nishtar Hospital, Multan. Period: 15thDecember 2014 to 15th June 2015. Subjects & Methodology: Where sample size was calculatedusing WHO sample size calculator using expected proportion of intrauterine growth restrictionp= 4%.11 163 pregnant women of 20-40 year of age with uterine fibroid of ≥3cm on ultrasoundwere included in this study. Patients of endometriosis and hypertension were excluded. Anobstetrical ultrasonography was done to confirm singleton pregnancy, size of uterine fibroidand to confirm gestational age. Patients were monitored until delivery and complications wererecorded. Preterm labour was defined as dilation of the cervix <4cm with the presence ofuterine contractions of ≥ 4 per hour of 30 seconds duration with intensity to effect progressiveeffacement, assessed by vaginal examination. Malpresentation was defined as a presentationin which baby’s bottom or feet, instead of head, are in position relative to the maternal pelvis byultrasound and IUGR was defined as fetal weight below the 10th percentile and fetal abdominalcircumference below the 10th percentile on ultrasound. Results: Age range in this studywas from 20 to 40 years with mean age of 32.773±1.99 years, mean gestational age34.730±2.44 weeks, fibroid size 5.736±1.51cm, duration of complain 5.018±1.41 months,height 1.561±0.11 meters, mean weight 73.619±13.66 Kg and mean BMI was 28.607±3.106Kg/m2. Majority of the patients were from 31-40 year group (89%). Preterm labour was seenin 15.3% patients, malpresentation was 7.4% and IUGR was seen in 6.1% patients. Conclusion:Our study conclude that, most common complication of uterine fibroids during pregnancy waspreterm labour followed by malpresentation and IUGR.

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Maternal and perinatal outcomes of hyperthyroidsm in pregnancy at Dr. Cipto Mangunkusumo Hospital, Jakarta, period of January 2015 - December 2016

Majalah Obstetri & Ginekologi ◽

10.20473/mog.v29i12021.36-40 ◽

2021 ◽

Vol 29 (1) ◽

pp. 36

Author(s):

Fita Maulina ◽

M Adya F F Dilmy ◽

Ali Sungkar

Keyword(s):

Pregnant Women ◽

Preterm Delivery ◽

Intrauterine Growth Restriction ◽

Fetal Death ◽

Perinatal Outcomes ◽

Growth Restriction ◽

Intrauterine Fetal Death ◽

Adequate Treatment ◽

Intrauterine Growth ◽

In Pregnancy

Objectives: To report maternal and perinatal outcomes of hyperthyroidsm in pregnancy.Case Report: There were 3622 cases of delivering pregnant women during the period of the study. From this number, the prevalence of pregnant women with hyperthyroid was 0.2 %. We reported 9 cases of hyperthyroid in pregnancy. The number of pregnancy complication and outcome on pregnant women with hyperthyroidism were preterm labor (44%) and preeclampsia (22%), both were found in group of mother who did taking antihyperthyroid therapy. In those who did not take antihyperthyroid therapy 11% had spontaneous abortion and 11% had preterm delivery. Fetal complications were intrauterine growth restriction (11%) and intrauterine fetal death (23%), both of these complication were on the group who did not take antihyperthyroid. On the contrary, 44% babies were born with normal birthweight in group who took antihyperthyroid.Conclusion: There were differences noted between the group that took adequate treatment and the group that did not take antihyperthyroid. The incidence of intrauterine growth restriction and intrauterine fetal death were high in group that did not took antihyperthyroid therapy but the incidence of preterm delivery as the maternal complication was high in group that did take the antihyperthyroid therapy.

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Pregnancy Anemia as a Favorable Factor of Premature Birth

Revista de Chimie ◽

10.37358/rc.18.7.6437 ◽

2018 ◽

Vol 69 (7) ◽

pp. 1886-1888

Author(s):

Alexandru Oancea ◽

Casiana Stanescu ◽

Diana Maria Anastasiu Popov ◽

Radu Neamtu ◽

Doru Anastasiu ◽

...

Keyword(s):

Pregnant Women ◽

Growth Retardation ◽

Premature Birth ◽

Intrauterine Growth Retardation ◽

Preterm Births ◽

Premature Births ◽

Intrauterine Growth ◽

Economic Context ◽

Hb Concentration ◽

In Pregnancy

Hematological physiological changes during gestation are intended to compensate and support pregnancy-related changes in the woman�s body. In pregnancy there is a dilution of the known Hb concentration known as gestational hemodilution or physiological pregnancy anemia. On a group of 300 pregnant women with different forms of anemia, we followed its implications on the evolution of pregnancy, its role in the determinism of premature labor, and its role in the apparition of intrauterine growth retardation. In 46 cases (15.33%) we reported premature births, in 23 (7.66%) of the cases we considered that anemia was the main (unique) cause of premature birth, in other cases (84.67%) anemia associated with other etiologic factors of premature birth. Comparing the incidence of preterm birth with a group of 300 pregnant women without anemia revealed the incidence of premature birth is 3 times less and is represented by 12 cases (4%) and 2 times less for intrauterine growth retardation represented by 16 cases (5.33%). Pregnancy anemia can cause a frequent pathology with major consequences in pregnancy development during birth and fetal development involving 15.33% of preterm births and 12.35% of cases of intrauterine growth retardation. In the current social and economic context, it is necessary to prophylactically administer iron for pregnant women from 20 weeks of gestation, at least 30mg / day for prophylaxis of pathology due to iron deficiency.

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Association Between Pre-Term Labour and Inter Pregnancy Interval

10.53350/pjmhs2115103137 ◽

2021 ◽

Vol 15 (10) ◽

pp. 3137-3139

Author(s):

Mona Fatima ◽

Urooj Naz ◽

Aruna Kumari Hira ◽

Aneela Habib ◽

Prof Sarah Kazi ◽

...

Keyword(s):

Pregnant Women ◽

Premature Birth ◽

Preterm Labour ◽

Short Interval ◽

Tertiary Care ◽

Care Hospital ◽

Interpregnancy Interval ◽

Singleton Pregnancy ◽

Cross Sectional ◽

Detailed Medical History

Objectives: To determine the frequency of preterm labour in association with interpregnancy interval among pregnant women visiting tertiary care Hospital. Subject and Methods: This prospective cross-sectional study was performed at Unit-I, Obstetrics and Gynaecology Department, Civil Hospital Karachi; from June to November 2020. A total of 190 women with singleton pregnancy confirmed by ultrasound were included. After taking detailed medical history regarding previous fetal death and C-section was recorded either patient goes into preterm labour or not and confirmed by history for short and prolong interpregnancy interval (IPI). Data was collected by pre-designed study proforma. Results: The average age of study subjects was 26.27±4.07 years. The frequency of preterm labour among the pregnant women was 51.05%. The rate of preterm was significantly higher in those women who had with short inter interpregnancy interval (p=0.0005). Conclusion: Our findings clearly show that a short interval in inter-pregnancy is a cause of premature birth. Preterm birth can also be indicated by the antenatal care visits, inter-pregnancy complications, and having a birth defect. Premature birth minimization can enhance overall newborn's health and can lead to considerable minimization of neonatal death in the future. Keywords: Preterm labor, prolong pregnancy interval, neonatal health

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Indication and Complication of Induction of Labour by Misoprostol among Pregnant Women in a Clinical Trial in Dhaka City

Journal of Current and Advance Medical Research ◽

10.3329/jcamr.v7i2.49596 ◽

2020 ◽

Vol 7 (2) ◽

pp. 80-83

Author(s):

Shafeya Khanam ◽

Nasrin Akhter ◽

Muqsuda Ashraf Shuvro ◽

Trifa Obayed ◽

Habiba Shamim Sultana ◽

...

Keyword(s):

Clinical Trial ◽

Pregnant Women ◽

Private Hospital ◽

Induction Of Labour ◽

Dhaka City ◽

Singleton Pregnancy ◽

Intrauterine Growth ◽

Obstetrics And Gynaecology ◽

Study Population ◽

Selection Of

Background: Misoprostol is very useful for induction of labour among the pregnant women. Objective: The purpose of the present study was to see the indication and complication of induction of labour by misoprostol among pregnancy women. Methodology: This single center clinical trial was carried out in the Department of Obstetrics and Gynaecology at a private hospital in Dhaka city, Bangladesh from September 2005 to February 2006 for a period of six months. Primi or second gravida patients with the gestational age between 37 weeks to 42 weeks in singleton pregnancy with cephalic presentation and not in labour were selected as study population. After proper selection of the cases, induction of labour was done by applying tablet misoprostol 50mcg in the posterior vaginal fornix. Complication of induction were recorded. Result: A total number of 60 patients were recruited for this study. 24 patients were between 23 to 26 years and 12 patients were between 27 to 30 years. Pre-eclampsia, pregnancy induced hypertension and intrauterine growth retardation were the most common indication of induction. In this study 31(51.7%) patients needed only 1 dose of Misoprostol and 24 (40.0%) patients needed 2 doses and only 5(8.3%) patients needed 3 doses of Misoprostal. In this study 11.67% patients experienced Nausea & vomiting and 3.33% patients developed hyperstimulation. Conclusion: In the conclusion, the use of misoprostol results in a shorter induction to delivery time and miserable adverse effects on the method of delivery. Journal of Current and Advance Medical Research 2020;7(2): 80-83

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Association of Thyroid Dysfunction and Pregnancy Outcomes

10.53350/pjmhs2115123367 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3367-3369

Author(s):

Nagina Bibi ◽

Iram Inam ◽

Ghiasul Hassan

Keyword(s):

Pregnant Women ◽

Pregnancy Outcomes ◽

Thyroid Dysfunction ◽

Adverse Outcomes ◽

Common Finding ◽

P Value ◽

Binary Logistic Regression Analysis ◽

Thyroid Disorder ◽

Singleton Pregnancy ◽

In Pregnancy

Background: Hypothyroidism in pregnancy results in serious consequences for both mother and fetus. Pregnant women are prone to thyroid dysfunction due to physiological changes taking place in body. This study is undertaken to see the effect of thyroid dysfunction on pregnancy outcomes. Methodology: A prospective observational study was done. Study was conducted in a private gynecological and obstetric unit. A sample size of 200 women in selected institute with singleton pregnancy was recruited. Pregnant women with chronic disabilities and previously known thyroid disorders were excluded. Data was analyzed using SPSS version 23.0 and binary logistic regression analysis was done. Ethical rules were followed throughout the study and consent taken from all participants. Results: Out of 200, 23 participants were positive for thyroid disorder. Thyroid dysfunctions are responsible for causing multiple complications in pregnancy for mother and fetus. Findings suggest a signification association of thyroid dysfunction and feto-maternal consequences (p-value <0.005). Conclusion: Subclinical hypothyroidism is a common finding during pregnancy. It is compulsory to detect and treat thyroid dysfunction early in pregnancy so that adverse outcomes could be avoided. There is a need for timely screening of thyroid profile in suspected pregnancies. keywords: TSH, FT3, FT4, Pregnancy, Outcomes.

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Porphyromonas gingivalis in dental plaque and serum C-reactive protein levels in pregnancy

The Journal of Infection in Developing Countries ◽

10.3855/jidc.1031 ◽

2010 ◽

Vol 4 (06) ◽

pp. 362-366 ◽

Cited By ~ 1

Author(s):

Nada M. Souccar ◽

Marita Chakhtoura ◽

Joseph G. Ghafari ◽

Alexander Michael Abdelnoor

Keyword(s):

Pregnant Women ◽

Porphyromonas Gingivalis ◽

Preterm Labour ◽

Systemic Infection ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Vaginal Swabs ◽

Serum Crp ◽

In Pregnancy

Background: The periodontopathogen Porphyromonas gingivalis (Pg) has been reported as a risk factor for preterm labour. Its pathogenesis and role in pregnancy have not been investigated in Lebanon. Elevated C-reactive protein (CRP) levels in pregnant women with periodontitis also appear to mediate preterm labour. Methodology: The study included 20 pregnant women with periodontitis and 20 with normal periodontium. PCR was done for Pg detection in oral plaque and vaginal samples. Serum CRP levels were determined by ELISA. Results: Pg was detected in the oral plaque of 13 of 20 pregnant subjects with clinical periodontitis (patients) and 2 of 20 controls with a healthy periodontium. Vaginal swabs were all Pg-negative, ruling out systemic infection. Serum CRP levels were elevated in 12 of 20 patients and 8 of 20 controls. None of the participants experienced preterm labour. Conclusions: This is the first report that implicates Pg in Lebanese periodontitis patients. Preliminary results do not indicate a relationship among Pg, periodontitis, CRP levels and preterm labour.

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Assessing the Outcome of Management of Thyroid Dysfunction in Pregnancy With Second Affiliated Hospital of Chongqing Medical University Guideline.

10.21203/rs.3.rs-252844/v1 ◽

2021 ◽

Author(s):

Samuel Chigbo Obiegbusi ◽

Xiao Jing Dong ◽

Ming yu Deng ◽

Chidera Nneji Obiegbusi ◽

Yin Yang ◽

...

Keyword(s):

Pregnant Women ◽

Thyroid Disease ◽

Intrauterine Growth Restriction ◽

Thyroid Dysfunction ◽

Second Trimester ◽

Intrauterine Growth ◽

Chinese Medical Association ◽

Significant Difference ◽

Medical University ◽

In Pregnancy

Abstract Introduction – Pregnancy comes with hormonal changes which, when not properly managed, could lead to complications. Thyroid hormone is one of the hormones that are affected during pregnancy, and it plays a significant role in pregnancy, from conception to delivery. In a bid to identify intended pregnant women and pregnant women with thyroid dysfunction, the Endocrinology Branch of Chinese Medical Association and Perinatal medicine branch of Chinese Medical Association set guidelines for diagnosis and treatment of thyroid diseases in pregnancy and postpartum women. The guideline recommends screening for all women who desire getting pregnant soon and pregnant women, which Second Affiliated Hospital of Chongqing Medical University is implementing.Purpose - To Identify the common thyroid disease found among pregnant women in Chongqing. Evaluate the effectiveness of the management guideline toward improving pregnancy outcome among women diagnosed with thyroid disease during their pregestational and gestational period, and ascertain the need for additional measures to be taken towards thyroid disease management during pregnancy in certain areas with unfavourable outcome.Method – A retrospective cohort study of 774 pregnant women diagnosed with thyroid dysfunction in the Second Affiliated Hospital of Chongqing Medical University from 2016 -2018 was extracted from the hospital computer patient’s record. Only 724 patients that met the inclusive criteria were analysed. Participants were grouped into four, according to the time they were diagnosed and managed. The Multiple logistic regression and binary logistic regression statistical analysis were done with SPSS, and we adjusted for potential confounders, including maternal age, parity, and gravida.Result – There is an association between maternal age and abortion among pregnant women diagnosed with subclinical hypothyroidism, P-0.018(OR 1.459, 95%CI 1.067-1.997) and significant difference in pregnant women who developed intrauterine growth restriction after being diagnosed with hypothyroidism in the second trimester, P-0.048(OR-0.152, 95%CI 0.024-0.981). There was also a significant difference in gravida, P-0.032(OR 1.368, 95%CI 1.028 1.821) and normal delivery mode, P-0.010(OR 2.521, 95%CI 1.246-5.100).Conclusion – The study shows a promising result as less complication is observed. However, more attention is needed toward managing subclinical hypothyroidism in pregnancy to curb abortion/miscarriage incidence. Hypothyroidism in second trimester could lead to intrauterine growth restriction. Multigravida increases the risk of complication among pregnant women with thyroid dysfunction.

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СРАВНЕНИЕ ТОКОЛИЗА ГЕКСОПРЕНАЛИНОМ И АТОЗИБАНОМ

Medical Council ◽

10.21518/2079-701x-2017-2-57-61 ◽

2017 ◽

pp. 57-61

Author(s):

О. Р. Баев ◽

О. Н. Васильченко ◽

А. О. Карапетян ◽

Н. К. Тетруашвили ◽

З. С. Ходжаева

Keyword(s):

Pregnant Women ◽

Clinical Condition ◽

Preterm Labor ◽

Preterm Labour ◽

Premature Labour ◽

Loading Dose ◽

Efficacy And Safety ◽

Treatment Start ◽

Tocolytic Agents ◽

In Pregnancy

The aim of the study was to compare the efficacy and safety of tocolytic agents - atosiban and hexoprenaline.Patients and methods: The study included 119 pregnant women with threatening preterm labour between 28 to 34 weeks of gestation. Sixty two pregnant received 62 tocolysis by hexoprenaline and fifty seven - atosiban. There were no differences in the clinical condition of pregnant women and features of preterm labour among groups before start of the tocolysis.The degree of effectiveness is determined by the duration of the pregnancy prolongation (48 hours, 7 days, more than 14 days).Results: 9 women of 62 that received hexoprenaline tocolysis (22,6%), and 2 – atosiban (3.5%) failed to prolong the pregnancy for more than 48 hours (p < 0,05). Additionally, 5 women of the hexoprenaline group had premature labour within the first week from the treatment start and eight within 7-14 days. In the group of women with an effective atosiban tocolysis all births took place in a range of more than 7 days from the beginning of tocolysis. Four woman in hexoprenaline group received one repeated course of therapy with this drug (without a loading dose) for 24 hours. In atosiban group full repeated course was conducted in the two cases. Full-term gestation births occurred in 14 women (22.6%) after hexoprenaline tocolysis and in 19 (33.3%) – atosiban (p > 0,05%). On average, atosiban tocolysis allowed to prolong pregnancy by 6.5 days longer than hexoprenaline (p < 0,05).Conclusion: The results of study has shown that atosiban is more effective than hexoprenaline in pregnancy prolongation for more than 48 hours in threatening preterm labor.

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PRETERM LABOUR

The Professional Medical Journal ◽

10.29309/tpmj/2018.25.09.104 ◽

2018 ◽

Vol 25 (09) ◽

pp. 1342-1345

Author(s):

Saima Ashraf ◽

Shahida Parveen ◽

Shahzad Alam

Keyword(s):

Preterm Labour ◽

Serum Magnesium ◽

Venous Blood ◽

Cross Sectional Study ◽

Serum Magnesium Level ◽

Amniotic Fluid Index ◽

Singleton Pregnancy ◽

Cross Sectional ◽

History Of ◽

Age Range

Objectives: To determine the frequency of hypomagnesaemia in women withpreterm labour. Study Design: Cross sectional study. Settings: Department of obstetrics &gynaecology Nishtar Hospital Multan. Duration of Study: From 10th November 2016 to 10th May2017. Subject and Methods: A total of 219 pregnant women with singleton pregnancy, pretermlabour and parity 1 – 4 were included in the study. Women with history of diabetes, hypertensionsmoking and polyhhydramnious amniotic fluid index (AFI)>25 cm on ultrasound were excluded.Venous blood was drawn from entire subjects to evaluate the serum magnesium level and sentimmediately to laboratory for analysis venous blood samples were obtained by venepunctureand collected in lithium heparin specimen bottles. Data was collected for hypomagnesaemia.Results: Age range in this study was from 20 to 40 years with mean age of 30.356±3.60 years,mean parity 1.936± 0.96, mean gravida 2.936 ± 0.96, mean gestational age 32.000±2.25weeks and mean BMI was 27.337 ± 1.67 kg/m2. Majority of the patients were from 20 – 30 years(51.1%). History of preterm delivery was 17.4%. Majority of patients belong to middle economicstatus (66.2%). Hypomagnesaemia was seen in 37.9% patients. Conclusion: it is concludedthat low serum magnesium (hypomagnesaemia) is associated with preterm onset of labour.Maternal hypomagnesaemia may be used as a predictor of preterm labour.

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