scholarly journals Role of zinc in acne: a study of 77 patients

2018 ◽  
Vol 4 (3) ◽  
pp. 301
Author(s):  
Jacob Thomas
Keyword(s):  
Acne Vulgaris ◽  
Treatment Options ◽  
Serum Zinc ◽  
Zinc Level ◽  
Chronic Inflammatory Disease ◽  
Acrodermatitis Enteropathica ◽  
Control Group ◽  
Serum Zinc Level ◽  
Pre Treatment ◽  
Average Serum

<p class="abstract"><strong>Background:</strong> Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit occurring in adolescent age group. Though not life threatening it can cause physical and psychological scars which can produce social problems in house, school and office. It is a multifactorial disease. Many treatment options are available, but not optimal. Zinc was found to be effective in pustular acne in a patient with acrodermatitis enteropathica. Hence a study on the level serum zinc in acne patients and the effect of zinc on acne is worthwhile. The aim was estimation of serum zinc level in acne patients and correlation of serum zinc level and improvement of acne.</p><p class="abstract"><strong>Methods:</strong> Pre-treatment serum zinc level was estimated in acne and non-acne patients. Acne patients were given oral zinc 220 mg two times a day and control group was given placebo. Post treatment serum zinc levels were estimated and the serum zinc level and improvement of acne was correlated.<strong></strong></p><p class="abstract"><strong>Results:</strong> Study subjects attained average serum zinc level of 5.829 µg/ml from 1.33 µg/ml. 59.5% patients on zinc therapy showed more than 50% improvement in acne severity. 10.6% showed &gt;75%, 48.9% showed 50-75%, 36.1% showed 25-50% and 4.25% patients showed less than 25% improvement.</p><p class="abstract"><strong>Conclusions:</strong> Statistically significant low levels of zinc were not observed in acne. Oral zinc sulphate 220 mg two times a day raised serum level to 5.82 µg/ml Exponential response in acne was noticed as serum zinc level was raised. Inflammatory lesions showed better response than comedo. Oral zinc has definite role in treatment of acne.</p>

scholarly journals EVALUATION OF SERUM ZINC LEVEL

2018 ◽  
Vol 25 (02) ◽  
pp. 307-312
Author(s):  
Thiga Mohammed Mohammed Osman Alhassan ◽  
Abdelmula Mohamed Abdalla ◽  
Eshtiag Mohammed Mohammed Osman Alhassan ◽  
Suhair Abdelrahman Ahmed
Keyword(s):  
Reference Group ◽  
Acne Vulgaris ◽  
Serum Zinc ◽  
Zinc Level ◽  
Chronic Inflammatory Disease ◽  
Acrodermatitis Enteropathica ◽  
Serum Zinc Level ◽  
Severe Acne ◽  
Zinc Levels ◽  
Serum Zinc Levels

Back ground: Acne vulgaris is a common chronic inflammatory disease ofthe skin. Zinc is a trace element, exists in high amounts within the skin and especially theepidermis. Its importance for human metabolism has been noted by the dramatic improvementof acrodermatitis enteropathica following zinc supplementation. Objectives: To evaluate theserum zinc level among patients with acne vulgaris, and to correlate age, grade and durationof acne vulgaris with serum zinc level. Study Design: Case- control hospital base study.Setting: Khartoum state at Khartoum Dermatology & Venerology Hospital. Period: February toSeptember 2017. Materials Methods: 100 samples were collected from patients attending toKhartoum Dermatology & Venerology hospital suffering from acne vulgaris. Acne severity wasclassified according to Global Acne Grading System (GAGS). In addition to other 100 samplescollected from healthy individuals (students and nurse) sex and age matched as control. Thelevels of serum zinc was measured in each group by atomic absorption spectroscopy. Results:The study showed significant decrease in the zinc concentrations in acne vulgaris patientswhen compared with the reference group (0.207±0.04 mg/l versus 0.788 ± 0.14 mg/l) (p=0.000). The study observed decreased serum zinc level with advancedgrade of acne; mild47 patients (47%) (0.247 ± 0.05), moderate 33 (33%) (0.1925 ± 0.04) and severe in 20 (20%)(0.180 ± 0.03), based on the anova test analysis mean serum zinc levels were significantlylower in patients with mild to moderate and to severe acne vulgaris when compared betweenacne vulgairs grades and with reference group(p ≤ 0.001, p ≤ 0.01, p ≤ 0.05 respectively).The present study showed no correlation between zinc level (mg/l) and age in patient with acnevulgaris (years) (r=0.032, P =0.827). On the other hand significant correlation was recordedbetween serum zinc level (mg/l) and duration of the acne vulgaris in the study group (r=-0.311,p = 0.028). Conclusion: Study revealed that serum zinc levels is significantly decreased inpatients with acne vulgaris, and prescribing zinc supplement treatments help increasing thesuccess rate of acne treatment.

scholarly journals Effects of Iron and Amloki (EmblicaOfficinalis) on Serum Zinc Level in Anaemia with Pregnancy

2021 ◽  
Vol 49 (1) ◽  
pp. 33-37
Author(s):  
Tahmina Akter ◽  
Qazi Shamima Akther ◽  
Saima Haque Lisa ◽  
Mst Ariza Sultana ◽  
Farhana Sultana ◽  
...  
Keyword(s):  
Side Effects ◽  
Iron Deficiency Anaemia ◽  
Iron Supplementation ◽  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Serum Zinc Level ◽  
Deficiency Anaemia ◽  
Medical College ◽  
And Control

Pregnancy is associated with several trace elements deficiency in developing countries. Supplementation of iron in iron deficiency anaemia (IDA) has several side effects including alterations of serum zinc level. Traditionally, amloki is used as a well known supplement in pregnancy, which is rich in trace elements.To determine the effects of iron and amloki on serum zinc level in IDA with pregnancy. The study was a non blind, non random sampling interventional type of clinical trial. This study was performed in the Department of Physiology, Dhaka Medical College, Dhaka on 43 pregnant women between 13th to 20th weeks of gestation with IDA from July 2016 to June 2017.  They were recruited from Outpatient Department of Obstetrics and Gynaecology of Dhaka Medical College Hospital. Anaemic pregnant women supplemented with oral iron and amloki were considered as study group (A) and control group (B) were with only iron supplementation for 45 days. Serum zinc level was estimated in the laboratory of the Department of Soil, Water and Environment, University of Dhaka, Bangladesh.  For statistical analysis, Paired Student’s‘t’ test and Unpaired Student’s‘t’ test were considered using SPSS 22.0 version. Significant decrease (p<0.001) of serum zinc level was observed after intervention of iron in both groups. In this study, there was no significant difference in serum zinc level in between study and control group. It can be concluded that oral iron supplementation causes decrease in serum zinc level in IDA with pregnancy. Amloki shows no significant role in preventing decrease of serum zinc level in this study.  Emblicaofficinalis (amloki) is traditionally used to treat iron deficiency anaemia. It can increase haemoglobin concentration and decrease side effects of iron supplementation. Bangladesh Med J. 2020 Jan; 49 (1): 33-37

scholarly journals Study on serum zinc and copper levels in pulmonary tuberculosis patients before starting Directly Observed Treatment, Short-course

Mediscope ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 122-127
Author(s):  
Prithwy Shankar Biswas ◽  
Abu Md Mayeenuddin Al Amin ◽  
Syed Didarul Haque
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Serum Copper ◽  
Copper Level ◽  
Control Group ◽  
Case Group ◽  
Serum Zinc Level ◽  
Mean Values ◽  
Short Course ◽  
Directly Observed Treatment

Background: Tuberculosis is a major public health concern throughout the world including Bangladesh. The prevalence of tuberculosis (TB) is increasing day by day. Around one-third of world population is infected with M. tuberculosis. Still pulmonary tuberculosis (PTB) remains one of the important causes of mortality throughout the world with economic burden. Objective: To evaluate levels of the serum zinc and serum copper in smear positive PTB patients before starting Directly Observed Treatment, Short-course (DOTs) therapy. Methods: This was a cross-sectional type of observational study. A total of 100 subjects were included in this study. Among them 50 were smear positive PTB patients denoted as case group and 50 were apparently healthy individuals denoted as control group. Biochemical tests were carried out in the department of biochemistry of Mymensingh Medical College, Mymensingh. All the statistical analyses were performed by using SPSS version 21. Results were evaluated by using Student’s t-test. Results: After careful evaluation there was significant decrease in serum zinc level along with significant increase in serum copper level among the case group when compared with the control group. The mean values of serum zinc level were 93.96±10.04 μg/dl and 72.84±7.73 μg/dl in control and case group respectively. Serum zinc level decreased significantly (p <0.001) in PTB patients. The mean values of serum copper were 111.81±21.26 μg/dl and 125.99±27.93 μg/dl in control and case group respectively. There was significant (p <0.001) rise of serum copper level in PTB patients. Mediscope 2021;8(2): 122-127

scholarly journals Nutritional Assessment and Serum Zinc Level in Children with Acute Lymphoblastic Leukaemia

2017 ◽  
Vol 40 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Akma Morshed ◽  
Ikram Soma ◽  
TR Choudhury ◽  
Shahnoor Islam ◽  
Md Salim ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Case Group ◽  
Z Score ◽  
Serum Zinc Level ◽  
The Mean ◽  
Height For Age

Background: Acute lymphoblastic leukaemia (ALL) is a common malignancy in children which may cause significant nutritional problem as well as micronutrient deficiency like zinc. These deficiencies ultimately affect the outcome of the patient.Objective: The present study was done to identify the relationship of height, weight and serum zinc with acute lymphocytic leukemia in pediatric patients.Methods: This observational study was carried out in the Department of Pediatric Haematology and Oncology, Dhaka Medical College Hospital, Dhaka over a period of one year from July 2013 to June 2014. All children ranging from 1-10 years with newly diagnosed acute lymphocytic leukaemia were enrolled as case. An equal number of healthy children of similar age and sex were also included as control. The outcome measures were weight for height (wasting) and height for age (stunting) in children 5 or below 5 years of age and BMI in children > 5 years of age. The serum zinc level was also studied as a measure of micronutrient status.Result: Majority (80%) of the cases and 60% of the controls were 5 or < 5 years old. The mean ages of the children of cases and controls were almost similar (4.2 ± 2.3 vs. 4.8 ± 1.8 years, p >0.05). The groups were significantly different in terms of sex with male children being more prone to develop leukaemia than the females (p <0.05). Anaemia was invariably present. Majority (83.3%) of the children in the case group was wasted (weight for height Z-score lie below -2SD) as opposed 22.2% in the control group (p < 0.001). About 37% the children in the case group were stunted (height for age Z-score lies -2SD) as opposed to 16.7% in the control group (p< 0.05). The mean BMI was significantly lower in the case group than that in the control group (8.8 ± 2.7 vs. 17.1 ± 1.8, p < 0.001). Serum zinc level was also significantly lower in the former group than that in the latter group (0.7 ± 0.1 vs. 1.5 ± 0.5 mg/dl, p< 0.05).Conclusion: A good number leukaemia patients present with wasting and stunting and low BMI. Serum zinc level is significantly reduced which, in turn, may hamper various enzymatic functions in the body thereby reducing growth.Bangladesh J Child Health 2016; VOL 40 (1) :12-16

CARBONIC ANHYDRASE ACTIVITY AND ZINC DEFICIENCY

1997 ◽  
Vol 07 (01n02) ◽  
pp. 49-52
Author(s):  
TOSHIRO KUMAKAWA ◽  
TAKAHITO KONDO
Keyword(s):  
Zinc Deficiency ◽  
Specific Activity ◽  
Laboratory Data ◽  
Serum Zinc ◽  
Carbonic Anhydrase Activity ◽  
Zinc Level ◽  
Sweat Glands ◽  
Acrodermatitis Enteropathica ◽  
Normal Range ◽  
Serum Zinc Level

A 60-year-old female was hospitalized because of anemia, edema, and diarrhea. She was diagnosed as having short bowel syndrome. The patient developed acrodermatitis enteropathica and taste impairment. Laboratory data showed that the serum zinc level was 21 μ g/dl and erythrocyte CAI specific activity was 0 units/mg isozyme (normal range 0.37 ± 0.08 units/mg isozyme) and CAII specific activity was 2.99 units/mg isozyme (normal range 3.02 ± 0.05 units/mg isozyme). The patient was diagnosed as being in a zinc deficient status. Zinc supplementation resulted in the disappearance of these complications. The serum zinc level reached 50 μ g/dl and erythrocyte CAI specific activity was recovered to 0.26 units/mg isozyme and CAII specific activity was 1.60 units/mg isozyme. CAI is found in gastrointestinal epithelial cells, in vascular epithelium, corneal, lens, ciliary body epithelium, and in sweat glands. CAII is found in virtually all tissues and is especially abundant in secretory and absorbing epithelia. The tissue distribution of CAI corresponds to clinical and physiologic indicators of zinc deficiency. Thus, the erythrocyte CAI specific activity may reflect the actual tissue zinc deficiency status.

scholarly journals Comparison of birth weights of neonates of mothers receiving vs. not receiving zinc supplement at pregnancy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hassan Boskabadi ◽  
Gholamali Maamouri ◽  
Javad Akhondian ◽  
Farah Ashrafzadeh ◽  
Abbas Boskabadi ◽  
...  
Keyword(s):  
Birth Weight ◽  
Essential Element ◽  
Serum Zinc ◽  
Zinc Level ◽  
Maternal Serum ◽  
Control Group ◽  
Serum Zinc Level ◽  
Zinc Supplement ◽  
Neonatal Birth Weight ◽  
Zinc Supplements

Abstract Background Zinc is an essential element for normal embryogenesis and embryonic and neonatal development. Therefore, we compared the birth weights of neonates born to mothers who consumed zinc supplement during pregnancy with that of neonates born to mothers who did not. Methods In a cross-sectional study, we divided 200 pregnant mothers into two groups: case group (mothers receiving zinc supplement during pregnancy) and control group (mothers not receiving zinc supplement during pregnancy) Then, the neonate’s cord zinc level and mother’s serum level were measured and neonate’s growth charts (weight, height and head circumference)were completed. Results In this study, both groups of mothers were observed to have zinc deficiency; 35% of the mothers who consumed zinc supplements and 81% of the mothers who did not consume zinc supplements (P < 0.001). Based on the results, maternal serum of zinc (P < 0.001), neonatal birth weight (P = 0.008), maternal age (P < 0.001) and parity (P < 0.01) in zinc-supplemented group were higher. Neonatal birth weight was associated moderately with mother’s zinc serum levels and poorly with neonatal serum zinc levels. Conclusion Zinc consumption during pregnancy increases serum zinc level of mother and neonatal weight. Neonatal weight has a higher correlation to maternal serum zinc level.

scholarly journals Association of Serum Zinc Level with Febrile Seizures in Children

2021 ◽  
pp. 200-203
Author(s):  
Maryum Naveed ◽  
Rimsha Mohsin ◽  
Palwasha Khan
Keyword(s):  
Febrile Seizure ◽  
Serum Zinc ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Control Group ◽  
Case Group ◽  
Serum Zinc Level ◽  
Cross Sectional

Introduction: Febrile seizure (FS), previously known as febrile convulsion, is the most common seizure in children. FS usually occurs between six months and five years of age. Aims and objectives: The main objective of the study is to find the association of serum zinc level with febrile seizures in children of Pakistan. Material and methods: This cross sectional study was conducted at Mayo Hospital, Lahore during June 2020 to January 2021. The data was collected from 164 patients of both genders. Results: The data was collected from 164 patients. In the case group, 46 children were male (53.3%), and 36 children (46.7%) were female. In the control group 44 children were male (43.3%) and 38 children were female (56.7%). The age of all participants was between one months and six years. Conclusion: It is concluded that low serum zinc levels are fairly un-sufficient to support the hypothesis that Zinc deficiency could not be a potential risk factor for febrile seizure in children.

scholarly journals ROLE OF SERUM ZINC LEVEL IN CHILDREN WITH FEBRILE CONVULSIONS

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Dr. Laxminarayan Nagal ◽  
Dr Jagdish Dabi ◽  
Dr. Harish Kumar Mourya
Keyword(s):  
Febrile Seizure ◽  
Tertiary Care ◽  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Serum Zinc Level ◽  
Tertiary Care Centre ◽  
Febrile Convulsions ◽  
Zinc Levels ◽  
And Control

Background: The aim of the present study was to determine whether there were any changes in serum zinc level in children with febrile seizure in comparison with febrile children without seizure. Methods: A prospective observational study was done on 100 children, admitted in a tertiary care centre. Of these 50 children were diagnosed to have febrile convulsions. The other 50 were febrile children without seizures. Serum zinc levels were measured in all 100 subjects using calorimetric methods. Data was analyzed using SPSS version 22. Results: In present study, we studied 50 children (36 males, 14 females) with febrile seizure and a control group of 50 patients (37 male, 13 female). The mean ages of patients in the febrile seizure and control group were 25.01±14.07 months and 26.07±13.6 months, respectively. Mean zinc level was 69.78±13.13mcg/dl and 80.72±10.21 mcg/dl in study and control groups respectively and this difference was found statistically highly significant (p<0.001). Conclusion: Our findings revealed that serum zinc level was significantly lower in children with febrile seizure in comparison with children without seizure. Keywords: febrile seizure, children, epilepsy.

scholarly journals Low Serum Zinc Level May be Related to Higher Doses of EPO in Hemodialysis Patients

2015 ◽  
Vol 12 (1) ◽  
pp. 40-44
Author(s):  
Itir Yegenaga ◽  
Zeki Aydin
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Inadequate Response ◽  
Recombinant Erythropoietin ◽  
Serum Zinc Level ◽  
Human Recombinant Erythropoietin ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

AbstractIntroduction.Anemia is a complication of chronic renal failure observed in patients on hemodialysis (HD) affecting morbidity and mortality of these patients. It is associated with erythropoietin (EPO) deficiency and can be treated by human recombinant erythropoietin (hrEPO). Iron deficiency has been reported as the first line cause for inadequate response to this treatment. Zinc deficiency in hemodialysis (HD) patients was previously reported and the relationship between iron and zinc deficiencies has been known for years. The aim of this study was to find out the relationship between serum zinc level, anemia and rhEPO consuming in HD patients.Methods.A total of 69 HD patients and 34 healthy individuals were included in the study. Serum zinc levels, clinical, hematologic, biochemical parameters and rhEPO doses were evaluated.Results.Serum zinc levels were found to be lower in HD patients in comparison to those in the control group (29.92±12.94, 44.82±27.69μg/dL, respectively) (p<0.001). There was a positive correlation between serum zinc and hemoglobin (Hb) in the control group (R2=0.06). In HD patients who needed less then 8000U/week rhEPO, Hb levels (p<0.05) and serum zinc levels were higher. Serum zinc and Hb levels were found to be higher in patients who were under HD treatment for more than 12 months (10.05±1.06 vs 10.69±1.29; p=0.022 and 26.96±13.29 vs 30.88±12.61; p=0.178).Conclusions.HD patients who needed lower dose of EPO had higher serum zinc levels. Although the difference was not statistically significant, these results provide evidence that serum zinc level should be taken into consideration especially in HD patients resistant to EPO therapy.

A Case of Acrodermatitis Enteropathica with Normal Serum Zinc Level in a Breastfed Preterm Infant

2011 ◽  
Vol 18 (2) ◽  
pp. 383
Author(s):  
Jung Hyun Baek ◽  
Chul Park ◽  
Kyu Hee Park ◽  
Jung Hwa Lee ◽  
Young Sook Hong ◽  
...  
Keyword(s):  
Preterm Infant ◽  
Serum Zinc ◽  
Zinc Level ◽  
Normal Serum ◽  
Acrodermatitis Enteropathica ◽  
Serum Zinc Level
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