scholarly journals Frequency of low levels of High Density Lipoprotein cholesterol in patients with acute coronary syndrome.

2019 ◽  
Vol 26 (12) ◽  
pp. 2054-2057
Author(s):  
Muhammad Niaz Khan ◽  
Tahir Ullah Khan ◽  
Siraj Ud Din
Keyword(s):  
Acute Coronary Syndrome ◽  
Teaching Hospital ◽  
Sample Size Calculation ◽  
Density Lipoprotein ◽  
Female Gender ◽  
High Density ◽  
High Density Lipoproteins ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Low Hdl

To find out frequency of low HDL-C levels in patients suffering from acute coronary syndrome. Study Design: Descriptive cross sectional study. Setting: Department of cardiology Khyber Teaching Hospital (KTH) Peshawar. Period: 04/04/2016 to 04/10/2016. Material & Methods: By applying WHO formula for sample size calculation and 95% confidence interval, a total of 154 Patients admitted to coronary care unit (CCU) of Khyber Teaching Hospital with acute coronary syndrome were selected. Anticipated portion of low HDL in ACS was 73.3 % and absolute precision of about 7%. Results: In this study, mean age was 55.720 ± 8.901 years. About 38% patients were of female gender while 62% patients were male. About 20 % patients had UA, 9% patients had NSTEMI, and 71% patients had STEMI.  Patients with low high density lipoproteins constituted about 48% of the total patients admitted with ACS. Conclusion: Our study concluded that significant number (48%) of patients with ACS had low HDL levels.

High-Density Lipoprotein Cholesterol (HDL-C) Levels Independently Correlates With Cardiac Arrhythmias and Atrial Fibrillation

2018 ◽  
Vol 35 (5) ◽  
pp. 438-444 ◽  
Author(s):  
Farzin Brian Boudi ◽  
Nicholas Kalayeh ◽  
Mohammad Reza Movahed
Keyword(s):  
Acute Coronary Syndrome ◽  
High Density Lipoprotein ◽  
Medical Center ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
Cholesterol Levels ◽  
Low Hdl

Objective: Acute coronary syndrome is frequently complicated by rhythm disturbances, yet any association between high-density lipoprotein (HDL) cholesterol levels and arrhythmias in the setting of non-ST-segment elevation myocardial infarction (non-STEMI) is uncertain. The goal of this study was to evaluate any association between HDL-cholesterol levels and arrhythmias in the setting of non-STEMI. Methods: Retrospective data from Phoenix Veterans Affair Medical Center records were utilized for our study. A total of 6881 patients were found who presented during 2000 to 2003 with non-STEMI with available fasting lipid panels collected within the first 24 hours of admission. Patients were followed for the development of rhythm disturbances up to 6 years after initial presentation, with a mean follow up of 1269 days. Results: We found that high triglycerides/HDL and low-density lipid/HDL ratios were predictive of arrhythmias. However, low HDL levels had strongest association with highest odds ratio (OR) for development of arrhythmias (for HDL <31 mg/dL, OR = 3.72, 95% confidence interval [CI] = 2.55-5.44, P < .05) in patients with diabetes and (for HDL < 31 mg/dL, OR = 3.69, 95% CI = 2.85-4.71, P < .05) in patients without diabetes. Using multivariate analysis adjusting for comorbidities, low HDL level remained independently associated with arrhythmias. Conclusions: Patients with low HDL levels during hospitalization with non-STEMI have a greater risk of developing cardiac rhythm disturbances independent of other risk factors. These data suggest a possible protective role of HDL in preventing arrhythmias in the setting of acute coronary syndrome.

scholarly journals Association of HDL Cholesterol with In-Hospital Outcome of Patients with Acute Coronary Syndrome

2018 ◽  
Vol 32 (2) ◽  
pp. 114-118
Author(s):  
Chowdhury Muhammad Omar Faruque ◽  
Abdul Wadud Chowdhury ◽  
Miftaul Jannath Chowdhury ◽  
Abu Thaher Mohammad Mahfuzul Hoque ◽  
Md Solaiman Mia ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cross Sectional ◽  
Hospital Outcome ◽  
Coronary Syndrome ◽  
Group I ◽  
Low Hdl ◽  
Biochemical Evaluation ◽  
Cardiac Emergency

Background:Acute coronary syndrome is a cardiac emergency. It is increasing dramatically and becoming a major burden in our health care system. Relation between serum lipid profile and acute coronary syndrome is well established. Our study tried to reveal association of high density lipoprotein cholesterol (HDL-C) with in-hospital outcome of patients with acute coronary syndrome.Methods: The study was a cross sectional comparative study. Clinical & biochemical evaluation was done in hospital settings. A total number of 271 patients were included in the study and divided into two groups. Patients with low HDL-C level were in group I and patients with normal HDL-C were in group II.Results: Group I populations had more complications & more in- hospital stay than group II (74.3% vs 28.9%, P<0.001 and 6.65±2.04 days vs 5.09±1.44 days, p<0.001 respectively).Conclusion: The study revealed significant association of HDL-C with outcome of acute coronary syndrome patients. Complications of acute coronary syndrome were more in patients with low HDLC level.Bangladesh Heart Journal 2017; 32(2) : 114-118

Blood Triglyceride and High-Density Lipoprotein Levels Are Associated with Plasma Amyloid-β Transport: A Population-Based Cross-Sectional Study

2021 ◽  
pp. 1-12
Author(s):  
Shan Wei, ◽  
Suhang Shang ◽  
Liangjun Dang ◽  
Fan Gao ◽  
Yao Gao ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Amyloid Β ◽  
Density Lipoprotein ◽  
Underlying Mechanism ◽  
Population Based ◽  
High Density ◽  
Soluble Form ◽  
Cross Sectional ◽  
Low Hdl ◽  
Positive Correlations

Background: Studies have found that blood lipids are associated with plasma amyloid-β (Aβ) levels, but the underlying mechanism is still unclear. Two Aβ transporters, soluble form of low-density lipoprotein receptor related protein-1 (sLRP1) and soluble receptor of advanced glycation end products (sRAGE), are crucial in peripheral Aβ transport. Objective: The aim was to investigate the effects of lipids on the relationships between plasma Aβ and transporter levels. Methods: This study included 1,436 adults aged 40 to 88 years old. Blood Aβ, sLRP1, sRAGE, and lipid levels were measured. Univariate and multivariate analyses were used to analyze the relationships between lipids and plasma Aβ, sLRP1, and sRAGE. Results: After adjusting for all possible covariates, high-density lipoprotein (HDL-c) was positively associated with plasma Aβ 42 and sRAGE (β= 6.158, p = 0.049; β= 121.156, p <  0.001, respectively), while triglyceride (TG) was negatively associated with plasma Aβ 40, Aβ 42, and sRAGE (β= –48.389, p = 0.017; β= –11.142, p = 0.020; β= –147.937, p = 0.003, respectively). Additionally, positive correlations were found between plasma Aβ and sRAGE in the normal TG (Aβ 40: β= 0.034, p = 0.005; Aβ 42: β= 0.010, p = 0.001) and HDL-c groups (Aβ 40: β= 0.023, p = 0.033; Aβ 42: β= 0.008, p = 0.002) but not in the high TG and low HDL-c groups. Conclusion: Abnormal levels of TG and HDL-c are associated with decreased Aβ and sRAGE levels. Positive correlations between plasma Aβ and sRAGE were only found in the normal TG and HDL-c groups but not in the high TG and low HDL-c groups. These results indicated that dyslipidemia contributing to plasma Aβ levels might also be involved in peripheral Aβ clearance.

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