scholarly journals Association of HDL Cholesterol with In-Hospital Outcome of Patients with Acute Coronary Syndrome

2018 ◽  
Vol 32 (2) ◽  
pp. 114-118
Author(s):  
Chowdhury Muhammad Omar Faruque ◽  
Abdul Wadud Chowdhury ◽  
Miftaul Jannath Chowdhury ◽  
Abu Thaher Mohammad Mahfuzul Hoque ◽  
Md Solaiman Mia ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cross Sectional ◽  
Hospital Outcome ◽  
Coronary Syndrome ◽  
Group I ◽  
Low Hdl ◽  
Biochemical Evaluation ◽  
Cardiac Emergency

Background:Acute coronary syndrome is a cardiac emergency. It is increasing dramatically and becoming a major burden in our health care system. Relation between serum lipid profile and acute coronary syndrome is well established. Our study tried to reveal association of high density lipoprotein cholesterol (HDL-C) with in-hospital outcome of patients with acute coronary syndrome.Methods: The study was a cross sectional comparative study. Clinical & biochemical evaluation was done in hospital settings. A total number of 271 patients were included in the study and divided into two groups. Patients with low HDL-C level were in group I and patients with normal HDL-C were in group II.Results: Group I populations had more complications & more in- hospital stay than group II (74.3% vs 28.9%, P<0.001 and 6.65±2.04 days vs 5.09±1.44 days, p<0.001 respectively).Conclusion: The study revealed significant association of HDL-C with outcome of acute coronary syndrome patients. Complications of acute coronary syndrome were more in patients with low HDLC level.Bangladesh Heart Journal 2017; 32(2) : 114-118

scholarly journals In-Hospital Outcome of Older and Younger Patients with Acute Coronary Syndrome

2015 ◽  
Vol 8 (1) ◽  
pp. 49-52
Author(s):  
SM Eftar Jahan Kabir ◽  
Abdul Wadud Chowdhury ◽  
Md Gaffar Amin ◽  
Mohammad Sarwar Alam ◽  
Khandker Md Nurus Sabah ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Older Patients ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hospital Outcome ◽  
Coronary Syndrome ◽  
Group I ◽  
Biochemical Evaluation ◽  
Cardiac Emergency

Background: Acute coronary syndrome is a cardiac emergency. It is increasingly common in younger peoples. Management of elderly peoples is difficult due to their associated comorbidity. This study tried to compare the in-hospital outcome of the younger and older patients with acute coronary syndrome.Methods: The study was a comparative cross sectional study. Clinical and biochemical evaluation was done in hospital settings. A total number of 120 patients were included in the study and divided into two groups according to distribution of age. In group I there were elderly groups of aged >60 yrs. and in group II there were patients within the age 40 to 60 yrs. All the data were collected systematically in a preformed data collection form.Results: Group I populations had more in hospital stay and more complications than group II.Conclusion: The study revealed significant association with age and outcome of Acute coronary syndrome patients. Complications of acute coronary syndrome increase as the age of the patients increases.Cardiovasc. j. 2015; 8(1): 49-52

High-Density Lipoprotein Cholesterol (HDL-C) Levels Independently Correlates With Cardiac Arrhythmias and Atrial Fibrillation

2018 ◽  
Vol 35 (5) ◽  
pp. 438-444 ◽  
Author(s):  
Farzin Brian Boudi ◽  
Nicholas Kalayeh ◽  
Mohammad Reza Movahed
Keyword(s):  
Acute Coronary Syndrome ◽  
High Density Lipoprotein ◽  
Medical Center ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
Cholesterol Levels ◽  
Low Hdl

Objective: Acute coronary syndrome is frequently complicated by rhythm disturbances, yet any association between high-density lipoprotein (HDL) cholesterol levels and arrhythmias in the setting of non-ST-segment elevation myocardial infarction (non-STEMI) is uncertain. The goal of this study was to evaluate any association between HDL-cholesterol levels and arrhythmias in the setting of non-STEMI. Methods: Retrospective data from Phoenix Veterans Affair Medical Center records were utilized for our study. A total of 6881 patients were found who presented during 2000 to 2003 with non-STEMI with available fasting lipid panels collected within the first 24 hours of admission. Patients were followed for the development of rhythm disturbances up to 6 years after initial presentation, with a mean follow up of 1269 days. Results: We found that high triglycerides/HDL and low-density lipid/HDL ratios were predictive of arrhythmias. However, low HDL levels had strongest association with highest odds ratio (OR) for development of arrhythmias (for HDL <31 mg/dL, OR = 3.72, 95% confidence interval [CI] = 2.55-5.44, P < .05) in patients with diabetes and (for HDL < 31 mg/dL, OR = 3.69, 95% CI = 2.85-4.71, P < .05) in patients without diabetes. Using multivariate analysis adjusting for comorbidities, low HDL level remained independently associated with arrhythmias. Conclusions: Patients with low HDL levels during hospitalization with non-STEMI have a greater risk of developing cardiac rhythm disturbances independent of other risk factors. These data suggest a possible protective role of HDL in preventing arrhythmias in the setting of acute coronary syndrome.

scholarly journals Frequency of low levels of High Density Lipoprotein cholesterol in patients with acute coronary syndrome.

2019 ◽  
Vol 26 (12) ◽  
pp. 2054-2057
Author(s):  
Muhammad Niaz Khan ◽  
Tahir Ullah Khan ◽  
Siraj Ud Din
Keyword(s):  
Acute Coronary Syndrome ◽  
Teaching Hospital ◽  
Sample Size Calculation ◽  
Density Lipoprotein ◽  
Female Gender ◽  
High Density ◽  
High Density Lipoproteins ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Low Hdl

To find out frequency of low HDL-C levels in patients suffering from acute coronary syndrome. Study Design: Descriptive cross sectional study. Setting: Department of cardiology Khyber Teaching Hospital (KTH) Peshawar. Period: 04/04/2016 to 04/10/2016. Material & Methods: By applying WHO formula for sample size calculation and 95% confidence interval, a total of 154 Patients admitted to coronary care unit (CCU) of Khyber Teaching Hospital with acute coronary syndrome were selected. Anticipated portion of low HDL in ACS was 73.3 % and absolute precision of about 7%. Results: In this study, mean age was 55.720 ± 8.901 years. About 38% patients were of female gender while 62% patients were male. About 20 % patients had UA, 9% patients had NSTEMI, and 71% patients had STEMI.  Patients with low high density lipoproteins constituted about 48% of the total patients admitted with ACS. Conclusion: Our study concluded that significant number (48%) of patients with ACS had low HDL levels.

scholarly journals Lipid Profile of the Patient with Acute Coronary Syndromes Undergoing Coronary Angiography (CAG) in Rural Costal Region of Maharashtra

2021 ◽  
Vol 28 (4) ◽  
pp. 397-400
Author(s):  
Deshpande Janhavi JAYWANT ◽  
◽  
Amit BHALERAO ◽  
Vikas RATNAPARKHI ◽  
Suryakant NISALE ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Angiography ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Low Density ◽  
Coronary Syndrome

Background: Coronary Heart Disease (CHD) is widely prevalent across the globe and significantly high level of Cholesterol in circulation is a single major risk factor associated with coronary heart disease. It is well established that cardiovascular disease is associated with hypertension and elevated blood levels of low-density lipoprotein (LDL), total cholesterol, and triglycerides. In disparity, a low level of high-density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Aim: The present study was conducted with the aim to assess the lipid profile in patients of Acute Coronary Syndrome (ACS) undergoing coronary angiography (CAG) in rural coastal population. Patients and Methods: The present study was done on 62 patients with Acute Coronary Syndrome (ACS) undergoing coronary angiography (CAG) Serum levels of total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides were examined in biochemical laboratory of the hospital. Coronary angiography was performed for the presence of lesions. Results: 43.5% of the patients (n=27) were elderly (age>60 years). Approximately 82% of the patients (n=51) aged more than 50 years. Males outnumbered females with a ratio of 2.4:1. 71% of the patients were males. Mean cholesterol levels were 177.86 mg/dl. Approx 3/4th of the patients (n=41) had cholesterol level <200 mg/Dl. Mean triglycerides levels in the patients were 158.29 mg/dl. Only 11 patients out of 62 CAD patients had abnormal triglycerides. Mean LDL level was 119.5 mg and Mean HDL level was 34.5 mg %. The high plasma concentration of low-density lipoprotein (LDL-C) in 30% and the low plasma concentration of high-density lipoprotein (HDL-C) n 33% of patients were important abnormal findings in our patients. Conclusion: Dyslipidemia as in form of very low levels of HDL cholesterol with comparatively high levels of LDL-c with near normal total Cholesterol and triglyceride levels associated with ACS in our rural costal region of Maharashtra.

scholarly journals Association of high density lipoprotein levels with advancing age in type 2 diabetes patients in Tertiary Hospital.

2019 ◽  
Vol 26 (09) ◽  
pp. 1471-1476
Author(s):  
Shahzad Alam Khan ◽  
Iqra Imtiaz
Keyword(s):  
Type 2 Diabetes ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
P Value ◽  
Diabetic Patients ◽  
Adverse Cardiovascular Event ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Low Hdl

Background: HDL particles have several biological functions. Low levels of HDL-cholesterol are responsible for atherosclerotic disease. Type 2 diabetes is a metabolic disease of chronic etiology and low HDL‐cholesterol is frequent finding in diabetics. Levels of HDL with advancing age are inconsistent, few study show decline in HDL with increasing age while others show vice versa results. Objectives: Objective of this study was to establish an association between low HDL levels with advancing age in type 2 diabetic patients. Study Design: Cross sectional descriptive study. Setting: Diabetes Outpatient Department Nishtar Hospital Multan. Period: 6 months extending from March 2018 to August 2018. Materials and Methods: 145 patients with newly or previously diagnosed type 2 diabetes mellitus, age >35 years were considered for the study. Those diabetics who had family history of dyslipidemias (to rule out familial hyperlipidemias) were excluded. Study was started after acquiring permission from ethical committee. All the patients were evaluated for the HDL levels by getting a fasting lipid assay. Results: Out of 145 cases 78 (53.6%) were males while remaining 67 (46.4%) were female. Mean age of the patients was 57.27 + 6.91 years. Mean HDL level was 37.82 + 8.42. It was seen that HDL is low in 116/145 (80%) patients. Those diabetic patients who were < 60 (91 cases), HDL was noticed to be low in 67/91(73.62%) patients. Among patients >60 years (54 cases), HDL was identified to be low in 49/54(90.7%) patients. P-value was found out to be 0.012 Conclusion: Due to falling levels of HDL with advancing age in diabetic patients, there is increase in cardiovascular events in elderly diabetic patients. So the measures which tend to increase HDL level will also give protection against adverse cardiovascular event in elderly diabetics.

scholarly journals Psychosocial job conditions and biomarkers of cardiovascular disease: A cross-sectional study in the Swedish CArdioPulmonary bioImage Study (SCAPIS)

2022 ◽  
pp. 140349482110640
Author(s):  
Mia Söderberg ◽  
Helena Eriksson ◽  
Kjell Torén ◽  
Göran Bergström ◽  
Eva Andersson ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Ldl Cholesterol ◽  
High Strain ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Diastolic Hypertension ◽  
Low Hdl ◽  
Job Conditions

Aims: The aim of this study was to investigate associations between psychosocial work exposure and the presence of biological and imaging biomarkers of cardiovascular disease. Methods: This cross-sectional study was conducted in a sub-cohort of the Swedish CArdioPulmonary bioImage Study (SCAPIS). Psychosocial exposure was evaluated with the job demand–control model, and analysed according to the standard categorization: high strain, active, passive and low strain (reference). Biomarkers (blood pressure, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, coronary artery calcification (CAC) and metabolic syndrome) were measured, or derived through measurements, from clinical examinations. Gender-specific prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated with regression models and adjusted for age, education, smoking, physical activity, general life stress and body mass index (BMI). Results: The analyses included 3882 participants (52.5% women). High strain (high demands–low control) was linked to increased PR for low HDL cholesterol in women, adjusted for all covariates (PR 1.76; 95% CI 1.25–2.48). High strain was also related to moderately increased PR for metabolic syndrome in men, after adjustments for all covariates except BMI (PR 1.25; 95% CI 1.02–1.52). In addition, passive work (low demands–low control) was associated with diastolic hypertension in women (fully adjusted: PR 1.29; 95% CI 1.05–1.59). All relationships between psychosocial factors and LDL cholesterol or CAC (both genders), or hypertension (men), were non-significant. Conclusions: Poor psychosocial job conditions was associated with the presence of low HDL cholesterol and diastolic hypertension in women, and metabolic syndrome in men. These findings contribute to the knowledge of potential pathways between stressful work and coronary heart disease.

scholarly journals Role of Diabetic Dyslipidemia on Coronary Atherosclerotic Severity in Acute Coronary Syndrome

2017 ◽  
Vol 31 (2) ◽  
pp. 65-69
Author(s):  
Golam Mahfuz Rabbani ◽  
Afzalur Rahman ◽  
Anisur Rahman Khan ◽  
Nur Hossain ◽  
Muhammad Badrul Alam ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Analytical Study ◽  
Cross Sectional ◽  
High Tc ◽  
Medical College ◽  
Coronary Syndrome ◽  
Low Hdl ◽  
Artery Disease ◽  
Age Range

Aims: To evaluate the association of coronary atherosclerotic severity in diabetic dyslipidemic patients of acute coronary syndrome.Methods: This was a cross sectional comparative analytical study, done in the Department of Cardiology, Sir Salimullah Medical College Mitford Hospital and Ibrahim Cardiac Hospital & Research Institute, Dhaka, during September 2009 to August 2010.Results: Most of the patients (57.5%) were in the age range of 40-70 years. Atherosclerotic severity in diabetic ACS patients was significantly higher with low HDL, high TC/HDL and high LDL/HDL ratio. Low HDL, high TC/HDL and high LDL/HDL ratio are indicators of the extent and severity of coronary artery disease. More frequent dyslipidemia in diabetic ACS patients were low HDL and it was about 54%.Conclusion: Atherosclerotic severity in diabetic acute coronary syndrome patients was significantly more in dyslipidemic group than non dyslipidemic group.Bangladesh Heart Journal 2016; 31(2) : 65-69

RELATIONSHIP BETWEEN THE ENVIRONMENTAL ENDOCRINE DISRUPTOR BISPHENOL A AND DYSLIPIDEMIA: A FIVE-YEAR PROSPECTIVE STUDY

2020 ◽  
Vol 26 (4) ◽  
pp. 399-406
Author(s):  
Ruolin Li ◽  
Shumin Yang ◽  
Rufei Gao ◽  
Yin Deng ◽  
Jiahuan Liu ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Odds Ratio ◽  
Regression Models ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Low Density ◽  
Cross Sectional ◽  
Low Hdl

Objective: To investigate whether serum bisphenol A (BPA) concentration is related to the occurrence of dyslipidemia. Methods: A total of 574 adults were enrolled at baseline and followed up for 5 years. Concentrations of serum BPA, triglycerides (TGs), low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol were measured. Dyslipidemia was defined as the existence of one or more of the following conditions: high-LDL-cholesterolemia (LDL ≥140 mg/dL), hypertriglyceridemia (TGs ≥150 mg/dL), or low-HDL-cholesterolemia (HDL <40 mg/dL). Participants were stratified into tertiles according to low, median, and high baseline serum BPA levels. Multivariable linear and logistic regression models were used. Data from baseline and follow-up were used for cross-sectional and longitudinal analyses, respectively. Results: In the cross-sectional analysis, compared to subjects in the low BPA tertile, those in the high BPA tertile showed a higher level of LDL cholesterol (108.1 ± 24.4 mg/dL versus 119.5 ± 26.9 mg/dL; P<.05) and a lower level of HDL cholesterol (46.2 ± 11.7 mg/dL versus 39.5 ± 7.5 mg/dL; P<.05). In multivariable linear regression models, Z-transformed BPA was positively associated with LDL cholesterol (β= 0.13, P = .002) and negatively associated with HDL cholesterol (β= −0.28; P<.001). After cross-sectionally adjusting for confounders, subjects in higher BPA exposure was associated with a higher prevalence of low-HDL-cholesterolemia. Longitudinally, in subjects without low-HDL-cholesterolemia at baseline, each SD increment in baseline BPA was associated with a higher incidence of low-HDL-cholesterolemia after adjustment for confounders (odds ratio [95% confidence interval; CI] 2.76, 95% CI 1.21, 6.29). Conclusion: Cross-sectionally, higher BPA exposure is associated with a higher prevalence of low-HDL-cholesterolemia. Longitudinally, baseline BPA is an independent predictor of the 5-year incidence of low-HDL-cholesterolemia. Abbreviations: BMI = body mass index; BPA = bisphenol A; CI = confidence interval; CVD = cardiovascular disease; EIMDS = environment, inflammation and metabolic diseases study; HDL = high density lipoprotein; LDL = low density lipoprotein; OR = odds ratio; PPAR = peroxisome proliferator-activated receptor; SBP = systolic blood pressure; TG = triglyceride; Z-BPA = Z-transformed bisphenol A

scholarly journals ACUTE CORONARY SYNDROME;

2017 ◽  
Vol 24 (12) ◽  
pp. 1818-1822
Author(s):  
Huma Muzaffar ◽  
Shakeel Ahmad ◽  
Naeem Asghar
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Study Population ◽  
Artery Disease ◽  
Medical Wards

Objectives: To determine the frequency of raised low density lipoprotein (LDL)cholesterol in patients with acute coronary syndrome. Study Design: Cross sectional study.Setting: Coronary care unit (CCU) and medical wards at Allied Hospital Faisalabad. Durationand Dates: Six months from 01-01-2010 to 30-06-2010. Methods: This was a cross sectionalstudy that included 215 patients fulfilling the criteria of acute coronary syndrome admittingin CCU and medical wards. The demographic details, history and clinical examination of thepatients were recorded and blood samples were collected for the estimation of LDL cholesterol.Statistical Test: Descriptive statistics like mean and standard deviation (S.D) was appliedon age and LDL cholesterol. Gender and type of coronary artery event will be presented aspercentages. Frequency of raised LDL cholesterol was calculated in patients with ACS. Results:In this study population, out 215 patients, 183 (85.1) were found to have raised LDL cholesterollevels. There were 117 (54.4) males and 98 (45.6) females. Mean age was 56.29+- 13.01. Thefrequency of raised level of LDL cholesterol was slightly high in among males. STEMI was mostcommon type of ACS followed by unstable angina and NSTEMI. Conclusions: Frequency ofraised LDL cholesterol was high among the patients with acute coronary syndrome. It supportsthe potential for preventive efforts in persons with high risk of coronary artery disease.

scholarly journals Association of Non HDL-Cholesterol and other lipid parameters in patients with Acute Coronary Syndrome.

2021 ◽  
Vol 29 (01) ◽  
pp. 82-87
Author(s):  
Syeda Sabahat Haider ◽  
Muhammad Shahid ◽  
Khalid Razaq ◽  
Shama Iqbal ◽  
Muhammad Tariq Ghafoor ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Total Cholesterol ◽  
Statistical Significance ◽  
Sampling Technique ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Control Group ◽  
P Value ◽  
Cross Sectional ◽  
Coronary Syndrome

Objective: To determine the frequency of hypercholesterolemia in patients who are diagnosed with acute coronary syndrome and to also document the association of Non HDL-C with Acute coronary syndrome in these patients. Study Design: Observational Cross Sectional study. Setting: Department of Cardiology and Pathology of Sheikh Zayed Hospital, Rahim Yar Khan. Period: September 2019 to February 2020. Material & Methods: One hundred and thirty five patients with Acute coronary syndrome were included using non probability purposive sampling technique and equal number of patient who visited the outpatient department or admitted in indoor with complaints other than ACS were taken as control (n=135). Frequency and percentages were calculated and odd ratio was determined to see the association. Statistical significance was set at P-value<0.05. Results: Patient’s mean age was 55.5±12.4 years and there were 98(73%) male and 37(27%) female. Higher Non HDL-C (>130mg/dl) was found in 120(88.9%) cases and in 38(28.1%) controls with odd ratio 20.4211 at 95 %CI and p value <0.001.Hypercholesterolemiawas seen in 49(36.3%) of the cases while in 21(15.6%) of control group (without ACS) with odd ratio of 3.3 and p-value <0.001. Odds ratio was maximum for Non HDL cholesterol, followed by LDL cholesterol, HDL cholesterol and Total cholesterol. Conclusion: Non-HDL cholesterol showed a good association in patients with ACS than with primary target LDL-C or total cholesterol.

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