scholarly journals Predictors of mortality in neonatal sepsis in a resource-limited setting

2021 ◽  
Vol 4 (1) ◽  
pp. 057-061
Author(s):  
Nyenga Adonis Muganza ◽  
Mukuku Olivier ◽  
Mutombo André Kabamba ◽  
Mpoy Charles Wembonyama ◽  
Luboya Oscar Numbi ◽  
...  
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Democratic Republic Of Congo ◽  
University Hospitals ◽  
Predictors Of Mortality ◽  
Resource Limited

Introduction: Sepsis remains a major cause of death in neonatal period. Although significant advances in diagnosis, therapeutic and prevention strategies have been noted, sepsis remains a common concern in clinical practice especially in low-resource countries. The aim of this study was to determine the predictors of mortality in neonatal sepsis in Lubumbashi city (Democratic Republic of Congo). Methods: The records of newborns with sepsis managed in Neonatal Intensive Care Units in two University Hospitals between November 2019 and October 2020 were studied. Binary and multiple logistic regressions have been used to observe the association between independent variables and dependent variable. Results: A total of 162 cases of neonatal sepsis were reviewed. The mortality rate of neonatal sepsis was 21% of babies admitted. Very low birth weight (< 1500 grams) and primiparity were significantly associated with mortality in neonatal sepsis (AOR = 12.66; 95% CI 2.40 to 66.86; p = 0.003 and AOR = 3.35; 95% Cl 1.31 to 8.59; p = 0.012, respectively). Conclusion: The mortality rate of neonatal sepsis was 21%. Very low birth weight and primiparity were significantly associated with mortality in neonatal sepsis.

scholarly journals Intelligent Neonatal Sepsis Early Diagnosis System for Very Low Birth Weight Infants

2021 ◽  
Vol 11 (1) ◽  
pp. 404
Author(s):  
Fabio Tarricone ◽  
Antonio Brunetti ◽  
Domenico Buongiorno ◽  
Nicola Altini ◽  
Vitoantonio Bevilacqua ◽  
...  
Keyword(s):  
Intensive Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Clinical Signs ◽  
Therapeutic Interventions ◽  
Low Birth Weight Infants ◽  
Promising Tool

Neonatal sepsis is a critical pathology that particularly affects the neonates in intensive care, especially if they are preterm and low birth weight, with an incidence varying between 1and 40% according to the onset (early or late) of the disease. Prompt diagnostic and therapeutic interventions could reduce the high percentage of mortality that characterises this pathology, especially in the premature and low weight neonates. The HeRO score analyses the heart rate variability and represents the risk of contracting sepsis because of the hospitalization in the neonatal intensive care unit up to 24 h before the clinical signs. However, it has been demonstrated that the HeRO score can produce many false-positive cases, thus leading to the start of unnecessary antibiotic therapy. In this work, the authors propose an optimised artificial neural network model able to diagnose sepsis early based on the HeRO score along with a series of parameters strictly connected to the risk of neonatal sepsis. The proposed methodology shows promising results, outperforming the diagnostic accuracy of the only HeRO score and reducing the number of false positives, thus revealing itself to be a promising tool for supporting the clinicians in the daily clinical practice.

Device-associated pneumonia of very low birth weight infants in Polish Neonatal Intensive Care Units

2016 ◽  
Vol 61 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Jadwiga Wójkowska-Mach ◽  
T. Allen Merritt ◽  
Maria Borszewska-Kornacka ◽  
Joanna Domańska ◽  
Ewa Gulczyńska ◽  
...  
Keyword(s):  
Intensive Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Intensive Care Units ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Neonatal Intensive Care Units ◽  
Low Birth Weight Infants

Very Low Birth Weight Outcomes

PEDIATRICS ◽  
1992 ◽  
Vol 89 (2) ◽  
pp. 357-357
Author(s):  
HELEN HARRISON
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Meta Analysis ◽  
Low Birth Weight Infants ◽  
Randomized Controlled Clinical Trials ◽  
Weight Outcomes ◽  
Term Evaluation

To the Editor.— The authors of the National Institute of Child Health and Human Development report on neonatal care1 found "important" variations among neonatal intensive care units in philosophies of treatment, methods of treatment, and short-term outcomes. In a recent meta-analysis of follow-up studies,2 researchers document a similarly haphazard approach to the long-term evaluation of very low birth weight survivors. Until randomized controlled clinical trials validate the safety and efficacy of neonatal therapies, and until long-term outcomes are assessed accurately, the treatment of very low birth weight infants should be declared experimental.

scholarly journals Prevalence and Pathogen Distribution of Neonatal Sepsis Among Very-Low-Birth-Weight Infants

2012 ◽  
Vol 53 (4) ◽  
pp. 228-234 ◽  
Author(s):  
Wai Ho Lim ◽  
Reyin Lien ◽  
Yhu-Chering Huang ◽  
Ming-Chou Chiang ◽  
Ren-Huei Fu ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants

scholarly journals GROWTH OF VERY LOW BIRTH WEIGHT PRETERM UNTIL 12 MONTHS OF CORRECTED AGE

2015 ◽  
Vol 25 (3) ◽  
pp. 351 ◽  
Author(s):  
Milene De Moraes Sedrez Rover ◽  
Cláudia Silveira Viera ◽  
Beatriz Rosana G. de Oliveira Toso ◽  
Sabrina Grassiolli ◽  
Bruna Maria Bugs
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Progressive Increase ◽  
Z Score ◽  
Monitoring Methods ◽  
Male Birth ◽  
Growth Changes

Introduction: facing the progressive increase in the survival of premature ta infants, a concern for health professionals would be related to the possible consequences arising from prematurity, among them the growth changes. Objectives: to describe the anthropometric variables of newborns Premature Very Low Birth Weight in the follow-up monitoring. Methods: observational, longitudinal and retrospective study, involving 71 children who left Neonatal Intensive Care Unit (NICU), with a weight lower than 1500 g who were treated between 2006 and 2013. They should have at least three outpatient visits within twelve months of corrected age after NCAU discharge, in the following periods: period I up to 3 months of corrected age; period II between 4-6 months of corrected age and period III between 7-12 months of corrected age. Results: the mean Gestational Age (GA) was 29.4 weeks, 51% male, birth weight 1073.2 g, 70% with appropriate GA. The hospitalization stay was 68.73 days. Weight Z score at birth -0.95; at discharge -3.05; in period I -2.4; period II -1.8; period III -1.2. Height at birth -1.21, at discharge -2.23; -2.5; -1.8 and -1.1 for the periods I, II and III , respectively. Regarding the PT Z score at birth -0.71; at discharge -1.5; and monitoring -1.1; - 0.8 and -0.5 respectively in the periods I, II and III. Conclusions: despite of the great Z score reduction in NICU, there was a progressive improvement during follow-up in the Z score in the three anthropometric variables.

scholarly journals Clinical profile and outcome of early onset sepsis in high risk very low birth weight neonates

2018 ◽  
Vol 5 (2) ◽  
pp. 389 ◽  
Author(s):  
Omprakash S. Shukla ◽  
Aditi Rawat
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Blood Culture ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Very Low Birth Weight ◽  
Gram Negative ◽  
Early Onset Sepsis ◽  
Culture Positive

Background: Neonatal sepsis is one of the main causes of mortality and morbidity, especially in very low birth weight neonates (birth weight <1499 grams) despite the progress in hygiene, introduction of new and potent antimicrobial agents for treatment and advanced measures for diagnosis. The aim of the study was to find correlation of clinical features and risk factors of neonatal sepsis in culture positive cases.Methods: A cross- sectional study was carried out in one hundred neonates with risk factors of septicemia after obtaining informed consent. Blood culture was done using Bactec Peds Plus/F Culture as a gold standard to diagnose septicaemia. Correlation of  risk factors, clinical features with laboratory findings was obtained by using chi-square test. p-value of less than 0.05 was considered as significant.Results: Out of 100 neonates with suspected sepsis, BACTEC culture proven sepsis was seen in 40% cases. Gram negative sepsis was seen in 62.5% cases. The most common bacteria for early onset sepsis were Klebsiella, Pseudomonas and MRSA contributing 17% each to the bacteriological profile. The most common predisposing factor and clinical feature in culture positive cases were Premature rupture of membrane >24 hours (67%) and bleeding/petechia/pupura (72%) respectively. The major cause of mortality was pulmonary hemorrhage.Conclusions: Gram negative organism were more common and associated with higher mortality. Blood culture positivity increases with increase in number of risk factors in neonatal septicemia. A detailed history and thorough clinical examination is vital for early recognition of sepsis. 

scholarly journals Short- and long-term outcomes of very low birth weight infants in Korea: Korean Neonatal Network update in 2019

2020 ◽  
Vol 63 (8) ◽  
pp. 284-290 ◽  
Author(s):  
Jang Hoon Lee ◽  
YoungAh Youn ◽  
Yun Sil Chang ◽  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Annual Reports ◽  
Long Term Outcomes ◽  
Post Discharge ◽  
Low Birth Weight Infants ◽  
Korean Society

Korea currently has the world’s lowest birth rate but a rapidly inreasing number of preterm infants. The Korean Neonatal Network (KNN), launched by the Korean Society of Neonatology under the support of Korea Centers for Disease Control, has collected population-based data for very low birth weight infants (VLBWIs) born in Korea since 2013. In terms of the short-term outcomes of VLBWIs born from 2013 to 2016 registered in the KNN, the survival rate of all VLBWIs was 86%. Respiratory distress syndrome and bronchopulmonary dysplasia were observed in 78% and 30% of all VLBWIs, respectively. Necrotizing enterocolitis occurred in 7%, while 8% of the VLBWIs needed therapy for retinopathy of prematurity in the neonatal intensive care unit (NICU). Sepsis occurred in 21% during their NICU stay. Intraventricular hemorrhage (grade ≥III) was diagnosed in 10%. In terms of the long-term outcomes for VLBWIs born from 2013 to 2014 registered in the KNN, the post-discharge mortality rate was approximately 1.2%–1.5%, mainly owing to their underlying illness. Nearly half of the VLBWIs were readmitted to the hospital at least once in their first 1–2 years of life, mostly as a result of respiratory diseases. The overall prevalence of cerebral palsy was 6.2%–6.6% in Korea. Bilateral blindness was reported in 0.2%–0.3% of VLBWIs, while bilateral hearing loss was found in 0.8%–1.9%. Since its establishment, the KNN has published annual reports and papers that facilitate the improvement of VLBWI outcome and the formulation of essential healthcare policies in Korea.

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