scholarly journals Preparation and Identification of Some New Heterocyclic Derivatives from Suberoyl Chloride and Their Study as Anti-bacterial

2019 ◽  
Vol 24 (4) ◽  
Author(s):  
Nabeel Abed Abdul‐Reda ◽  
Miad Hassan jebur
Keyword(s):  
Thin Layer ◽  
Sodium Hydroxide ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Melting Points ◽  
Phenyl Hydrazine ◽  
Heterocyclic Derivatives ◽  
Ft Ir ◽  
New Compounds ◽  
Layer Chromatography

Some new derivatives ofsuberic chloride synthesized by reactionssuberoyl chloride with 4-amino acetophenoneto prepare N1,N8-bis(4-acetylcyclohex-2-en-1-yl)octanediamide,then react with 4-nitrobenzaldehydein the presence of sodium hydroxide,the product reacted with (urea,thiourea, phenyl hydrazine, 2-amino aniline,2-aminophenol, 2,4-dinitrophenyl hydrazine and 2-amino benzothiol) to prepare many hetrocyclicderivatives. This reaction was checked by thin‐layer chromatography (TLC) method. All new compounds were characterized by melting points, elemental analysis, FT‐IR,1H&13C-NMR. The antibacterial action of these derivatives was determined.

scholarly journals Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes

2019 ◽  
Vol 70 (11) ◽  
pp. 3769-3774
Author(s):  
Elena Valentina Rosca ◽  
Theodora Venera Apostol ◽  
Constantin Draghici ◽  
Octavian Tudorel Olaru ◽  
Laura Ileana Socea ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Acetic Anhydride ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Heterocyclic Compounds ◽  
Sodium Acetate ◽  
Artemia Salina ◽  
Ft Ir ◽  
New Compounds ◽  
Acetic Acids

This paper presents the synthesis of new heterocyclic compounds from oxazoles and triazinones classes. Some 2-(4-(4-X-phenylsulfonyl)benzamido)acetic acids were condensed with 4-iodobenzaldehyde in presence of acetic anhydride and sodium acetate, when the new corresponding unsaturated oxazol-5(4H)-one were obtained. Through the reaction of these oxazol-5(4H)-ones with phenylhydrazine, in presence of the acetic acid and sodium acetate, the new heterocyclic compounds from 1,2,4-triazin-6(5H)-ones class were obtained. The structures of synthesized compounds have been confirmed by spectral methods (FT-IR, 1H-NMR, 13C-NMR and MS) and elemental analysis. The cytotoxicity of the compounds was evaluated using the Daphnia magna and Artemia salina bioassays.

scholarly journals Synthesis and Characterization of Five, Sevene Heterocyclic Membered Rings

2013 ◽  
Vol 10 (3) ◽  
pp. 803-817
Author(s):  
Baghdad Science Journal
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
13C Nmr ◽  
Starting Material ◽  
Synthesis And Characterization ◽  
Melting Points ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
New Compounds

New compounds containing heterocyclic units have been synthesized. These compounds include 2-amino 5- phenyl-1,3,4-thiadiazole (1) as starting material to prepare the Schiff bases 2N[3-nitrobenzylidene -2 hydroxy benzylidene and 4-N,N-dimethyl aminobenzylidene] -5-phenyl-1,3,4-thiadiazole (2abc) , 2N[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl] 3-]2-amino-5-phenyl-1,3,4-thiadiazole]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dione] (3abc), 2N[3-nitrophenyl,2-hydroxyphenyl,4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-4,7-dione[(4abc), 2-N-[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2yl]-1,2,3-trihydro-benzo-[1,2-e][1,3] diazepine-4,7-dione (5abc) ,2N[2-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)]-4-oxo-1,3-thiazolidine-3-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (6abc), 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-tetrazolo-1-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (7abc) , 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dithione (8abc) , 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine -4,7-dithione -5-ene (9abc) and 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl] -1,2,3-trihydro-benzo-[1,2-e][1,3] diazepine -4,7-dithione - (10abc) . the structures of these compounds were characterized by FT-IR, 1H,13C-NMR,Uv/vis spectroscopy and the melting points were determined besides the evaluation of its biological activity.

scholarly journals Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes

2019 ◽  
Vol 70 (11) ◽  
pp. 3769-3774
Author(s):  
Elena Valentina Rosca ◽  
Theodora Venera Apostol ◽  
Constantin Draghici ◽  
Octavian Tudorel Olaru ◽  
Laura Ileana Socea ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Acetic Anhydride ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Heterocyclic Compounds ◽  
Sodium Acetate ◽  
Artemia Salina ◽  
Ft Ir ◽  
New Compounds ◽  
Acetic Acids

This paper presents the synthesis of new heterocyclic compounds from oxazoles and triazinones classes. Some 2-(4-(4-X-phenylsulfonyl)benzamido)acetic acids were condensed with 4-iodobenzaldehyde in presence of acetic anhydride and sodium acetate, when the new corresponding unsaturated oxazol-5(4H)-one were obtained. Through the reaction of these oxazol-5(4H)-ones with phenylhydrazine, in presence of the acetic acid and sodium acetate, the new heterocyclic compounds from 1,2,4-triazin-6(5H)-ones class were obtained. The structures of synthesized compounds have been confirmed by spectral methods (FT-IR, 1H-NMR, 13C-NMR and MS) and elemental analysis. The cytotoxicity of the compounds was evaluated using the Daphnia magna and Artemia salina bioassays.

scholarly journals Synthesis, Characterisation and Biological Screening of s-Triazine Based Chalcones and its Derivatization into Phenyl Pyrazolines, Isoxazoles

2015 ◽  
Vol 47 ◽  
pp. 109-119 ◽  
Author(s):  
Anjani Solankee ◽  
Riki Tailor
Keyword(s):  
Antimicrobial Activity ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Hydroxylamine Hydrochloride ◽  
Aromatic Aldehydes ◽  
Phenyl Hydrazine ◽  
Biological Screening ◽  
Gram Negative ◽  
E Coli ◽  
Heterocyclic Derivatives

Heterocyclic derivatives such as phenyl pyrazolines and isoxaxoles were prepared from s - triazine based chalcones. Chalcones (A1 - A5) are synthesised by the reaction of compound (V) with various aromatic aldehydes. Moreover, further reaction of chalcones with phenyl hydrazine hydrochloride and hydroxylamine hydrochloride in the presence of alkali gives phenyl pyrazolines (A6 - A10) and isoxazoles (A11 - A15) derivatives respectively. The structures of the newly synthesised compounds were confiremed by spectroscopic (IR, 1H NMR, 13C NMR) and elemental analysis. All the newly synthesised compounds have been screened for their antimicrobial activity against selected Gram - positive (S. aureus and S. pyogenus), Gram - negative (E. coli and P. aeruginosa) bacterial and fungal strains (C. albicans, A. niger and A. clavatus).

scholarly journals Synthesis of New Furothiazolo Pyrimido Quinazolinones from Visnagenone or Khellinone and Antimicrobial Activity

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2793 ◽  
Author(s):  
Ameen Abu-Hashem
Keyword(s):  
Antimicrobial Activity ◽  
Growth Inhibition ◽  
Spectral Data ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Heterocyclic Compounds ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Bacteria And Fungi ◽  
New Compounds

Substituted-6-methyl-1-thioxo-1,2-dihydro-3H-furo[3,2-g]pyrimido[1,6-a]quinazolin-3-ones (5a,b) were synthesized from condensation of visnagenone (2a) or khellinone (2b) with 6-amino-thiouracil (3) in dimethylformamide or refluxing of (4a) or (4b) in dimethylformamide. Hence, compounds (5a,b) were used as the starting materials for preparing many new heterocyclic compounds such as; furo[3,2-g]pyrimido[1,6-a]quinazoline (6a,b), furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazolinone (7a,b), substituted-benzylidene-furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazoline-3,5-dione (8a–f), 3-oxo-furo[3,2-g]pyrimido[1,6-a]quinazoline-pentane-2,4-dione (9a,b), 1-(pyrazole)-furo[3,2-g]pyrimido[1,6-a]quinazolinone (10a,b), 2-(oxo or thioxo)-pyrimidine-furo[3,2-g]pyrimido[1,6-a]quinazolinone (11a–d), 1-(methylthio)-furo[3,2-g]pyrimido[1,6-a]quinazolinone (12a,b), 1-(methyl-sulfonyl)-furo[3,2-g]pyrimido[1,6-a]quinazolinone (13a,b) and 6-methyl-1-((piperazine) or morpholino)-3H-furo[3,2-g]pyrimido[1,6-a]quinazolin-3-one (14a–d). The structures of the prepared compounds were elucidated on the basis of spectral data (IR, 1H-NMR, 13C-NMR, MS) and elemental analysis. Antimicrobial activity was evaluated for the synthesized compounds against Gram-positive, Gram-negative bacteria and fungi. The new compounds, furothiazolo pyrimido quinazolines 8a–f and 11a–d displayed results excellent for growth inhibition of bacteria and fungi.

scholarly journals Synthesis, Characterization and Biological Activity Study of New Compounds Tetrazole Derivatives Azo-Schiff Base

2019 ◽  
Vol 25 (103) ◽  
pp. 68-89
Author(s):  
Hiba Ibrahim Abdulla AL-Joubory ◽  
Khalid Mohamad Motny Al-janaby
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Pathogenic Bacteria ◽  
Diazonium Salt ◽  
Aldehyde Group ◽  
Spectroscopic Techniques ◽  
Phenyl Hydrazine ◽  
Ft Ir ◽  
New Compounds ◽  
Tetrazole Derivatives

This work included synthesis of azo dye (H1) by the reaction of diazonium salt to sulfacetamide with 4-hydroxy benzaldehyde at (0-5) oC  and synthesis of schiff base (H2-H6) through reaction substituted aromatic amine (aniline, 4-nitro aniline, 4-chloro aniline, 4-amino benzoic acid and phenyl hydrazine)  with aldehyde group in azo compound (H1) in ethanol compounds (H2-H6) and tetrazole derivatives prepared by reaction schiff base with sodium azide in ethanol compounds (H7-H11) and characterization by using spectroscopic techniques Uv/Vis, FT-IR, C.H.N. and H1-NMR of some the prepared compounds using DMSO-d6 a solvent, in addition melting point and determination a purity of TLC, and this work consists a study of biological activity for the some prepared compounds against four types of pathogenic bacteria and know to be resistant to anti biotic.

scholarly journals Synthesis and spectral characterization of novel 1,5-benzodiazepine oxime derivatives

2019 ◽  
Vol 84 (4) ◽  
pp. 343-353
Author(s):  
Lina Rekovic ◽  
Lidija Kosychova ◽  
Irina Bratkovskaja ◽  
Regina Vidziunaite
Keyword(s):  
Nitrogen Atom ◽  
Fluorescence Spectroscopy ◽  
Organic Solvent ◽  
Elemental Analysis ◽  
13C Nmr ◽  
1H And 13C Nmr ◽  
Methyl Group ◽  
Oxime Derivatives ◽  
New Compounds

Three new 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one oximes were synthesized and characterized by the methods of 1H- and 13C-NMR, IR and elemental analysis. Along with previously described compounds bearing one additional methyl group on the 5th nitrogen atom, the new compounds were characterized in bulk by UV?Vis and fluorescence spectroscopy in various solvents. The influence of the nature of the organic solvent on the spectra of the title compounds was investigated and is discussed.

scholarly journals Synthesis, Anticonvulsant and Neurotoxicity Screening of Some Novel 2, 5-Disubstituted - 1, 3, 4 � Oxadiazole Derivatives

2017 ◽  
Vol 9 (01) ◽  
Author(s):  
Y. Khatoon ◽  
M. Shaquiquzzaman ◽  
V. Singh ◽  
M. Sarafroz
Keyword(s):  
Sodium Hydroxide ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Neurological Deficit ◽  
Anticonvulsant Activity ◽  
Sodium Hydroxide Solution ◽  
Maximal Electroshock ◽  
Rota Rod Test ◽  
Oxadiazole Derivatives ◽  
Ft Ir

A series of 2, 5-disubstituted - 1, 3, 4 oxadiazoles (4a-o) were synthesized on refluxing hydrazine carbothioamides with iodine and potassium iodide in ethanolic sodium hydroxide solution starting from methyl-3-amino-4-hydroxy benzoate via synthesis of an intermediate methyl-2-substitutedaryl-1, 3-benzoxazole-5-carboxylates and 2-substitutedaryl-1, 3-benzoxazole-5-carbohydrazides. The newly synthesized compounds were characterized on the basis of spectral (FT-IR, 1H-NMR, MS) and elemental analysis. All these compounds were screened for anticonvulsant activity using Maximal Electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) method. Anticonvulsant activity was shown by majority of the synthesized compounds when given i.p. to mice. Among the tested compounds 4e, 4j and 4o were considered to have potent anticonvulsant activity comparable to that of standard drugs Phenytoin and Carbamazepine. Compounds 4e, 4g, 4h, 4i, 4k and 4m passed the rota rod test successfully without any sign of neurological deficit.

scholarly journals Alkaloid and Steroid from the Stem Bark of Jatropha curcas (Euphorbiaceae)

2012 ◽  
Vol 10 (1) ◽  
pp. 9-11
Author(s):  
Dipankar Das Gupta ◽  
Md Enamul Haque ◽  
Md Nahidul Islam ◽  
Shafiqur Rahman ◽  
AKM Mahbub Hasan ◽  
...  
Keyword(s):  
Thin Layer ◽  
13C Nmr ◽  
Jatropha Curcas ◽  
Spectroscopic Analysis ◽  
Ethyl Acetate Extract ◽  
Preparative Thin Layer Chromatography ◽  
Stem Bark ◽  
Published Data ◽  
Layer Chromatography ◽  
Different Parts

The plant Jatropha curcas grows well in different parts of Bangladesh and used in many medicinal purposes locally. The alkaloid atherospermidine and a steroid stigmasterol were isolated from the ethyl acetate extract of the stem bark of J. curcas by a combination of column and preparative thin-layer chromatography over silica gel. The structures of these compounds were determined by spectroscopic analysis (UV, IR, 1H NMR and 13C NMR) and by comparison with published data. This is the first report of isolation of the alkaloid atherospermidine from this plant. DOI: http://dx.doi.org/10.3329/dujps.v10i1.10009 DUJPS 2011; 10(1): 9-11

scholarly journals Separation of Berberine Hydrochloride and Tetrahydropalmatine and Their Quantitative Analysis with Thin Layer Chromatography Involved with Ionic Liquids

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Jing Lu ◽  
Hong-yan Ma ◽  
Wei Zhang ◽  
Zhi-guo Ma ◽  
Shun Yao
Keyword(s):  
Ionic Liquids ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Silica Gel ◽  
Simple Procedure ◽  
Berberine Hydrochloride ◽  
Chinese Patent ◽  
Ft Ir ◽  
First Time ◽  
Layer Chromatography

[BMIM]OH was used in mobile and stationary phase of thin layer chromatography (TLC) to analyze berberine hydrochloride and tetrahydropalmatine for the first time. Supported imidazole ionic liquid with hydroxide ion on silica gel (SiO2·Im+·OH−) was synthesized through simple procedure and characterized by Fourier transform infrared spectroscopy (FT-IR), elemental analysis, and scanning electron microscope (SEM). Moreover, on the plates prepared by SiO2·Im+·OH−, the contents of the above alkaloids in the Chinese patent medicine (CPM) of “Stomacheasy” capsule were successfully determined by TLC scanner. The key conditions and chromatographic behaviors were also investigated in detail. According to similar ways, ionic liquids (ILs) also can be used in other planar chromatographies in two modes. This study is expected to be helpful in expanding the application of IL and its bonded silica gel in TLC separation field.

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