<p class="abstract"><strong>Background:</strong> Infections of throat is a major health problem in developing countries. It can cause significant complications and morbidity if not addressed on time. The aim of the study was to study the drug sensitivity profile of patients with throat infections in lower Himalayan region.</p><p class="abstract"><strong>Methods:</strong> 100 patients with throat infections or sore throat were included in the study. Throat samples collected through a sterile culture sensitivity tube and sent to microbiological lab in the Regional Hospital Bilaspur (SRL diagnostics). </p><p class="abstract"><strong>Results:</strong> Gram positive organisms were resistant to benzyl penicillin or ampicillin, clindamycin, ciprofloxacin or levofloxacin, trimethoprim or sulphamethoxazole and sensitive to tetracycline, gentamicin and linezolid. Gram negative organisms were resistant to ampicillin, amoxyclav and sensitive to pipracillin or tazobactum, cefoperazone, amikacin, gentamicin, imipenem, cefepime, ciprofloxacin and trimethoprim or sulphamethoxazole.</p><p class="abstract"><strong>Conclusions:</strong> Throat infections along with emerging drug resistance are still a major health in developing countries.</p>