scholarly journals Estimation of the Medico-Ecological Component of Life Quality at the Level of Risk of Morbidity with Mass Non-Infectious Diseases

2019 ◽  
Vol 4 (2) ◽  
pp. 44-50
Author(s):  
A. V. Prusakova ◽  
V. M. Prusakov
Keyword(s):  
Environmental Factors ◽  
Objective Assessment ◽  
Anthropogenic Load ◽  
Noncommunicable Diseases ◽  
Time Interval ◽  
Environmental Pressures ◽  
Atmospheric Air ◽  
Industrial Cities ◽  
The Impact

For an objective assessment of the quality of life (QOL) in areas with different environmental pressures and the development of recommendations for improving medical care, population studies of children are used. The purpose of this study is to assess the risk of a general incidence of mass noncommunicable diseases (МND) of the child population of industrial cities with various environmental pressures as an indicator of QOL. To assess the anthropogenic load in industrial cities, atmospheric air pollution with harmful substances was analyzed. The assessment of the influence of local factors of cities was determined by relative and attributable risks of morbidity using synchronous annual and corresponding to the studied time interval values of background and estimated morbidity, and the influence of common background factors by the value of initial background morbidity at the beginning of the long-term observation period. To assess and rank changes in QOL in areas with different environmental loads, we used the results of the analysis of the long-term risk dynamics of the minority disease of children’s population with long-term exposure to a complex of general and local environmental factors of industrial cities of the Irkutsk region. To do this, we used the criteria developed by the authors for assessing the degree of tension of the medico-ecological situation and the strength of the impact of environmental factors on them by the relative risk levels of the minimum level and the corresponding QOL levels for the specified component.QOL in terms of the minimum number of children’s diseases in the period under review decreases as a whole due to the increasing influence of general background (regional) factors throughout the region, and in the studied cities in addition from the influence of local adverse factors, including anthropogenic pollution of atmospheric air.A significant decrease in the local anthropogenic load is accompanied by a decrease in the associated additional МND and the severity of the additional to the background decrease in QOL in the industrial cities of the region, especially in Angarsk.

scholarly journals The diversity of the circumgalactic medium around z = 0 Milky Way-mass galaxies from the Auriga simulations

2019 ◽  
Vol 488 (1) ◽  
pp. 135-152 ◽  
Author(s):  
Maan H Hani ◽  
Sara L Ellison ◽  
Martin Sparre ◽  
Robert J J Grand ◽  
Rüediger Pakmor ◽  
...  
Keyword(s):  
Star Formation ◽  
Environmental Factors ◽  
Active Galactic Nucleus ◽  
Observational Studies ◽  
Milky Way ◽  
Narrow Range ◽  
Gas Reservoirs ◽  
Circumgalactic Medium ◽  
The Impact

ABSTRACT Galaxies are surrounded by massive gas reservoirs (i.e. the circumgalactic medium; CGM) which play a key role in their evolution. The properties of the CGM, which are dependent on a variety of internal and environmental factors, are often inferred from absorption line surveys which rely on a limited number of single lines-of-sight. In this work we present an analysis of 28 galaxy haloes selected from the Auriga project, a cosmological magneto-hydrodynamical zoom-in simulation suite of isolated Milky Way-mass galaxies, to understand the impact of CGM diversity on observational studies. Although the Auriga haloes are selected to populate a narrow range in halo mass, our work demonstrates that the CGM of L⋆ galaxies is extremely diverse: column densities of commonly observed species span ∼3 − 4 dex and their covering fractions range from ${\sim } 5$ to $90{{\ \rm per\ cent}}$. Despite this diversity, we identify the following correlations: 1) the covering fractions (CF) of hydrogen and metals of the Auriga haloes positively correlate with stellar mass, 2) the CF of H i, C iv, and Si ii anticorrelate with active galactic nucleus luminosity due to ionization effects, and 3) the CF of H i, C iv, and Si ii positively correlate with galaxy disc fraction due to outflows populating the CGM with cool and dense gas. The Auriga sample demonstrates striking diversity within the CGM of L⋆ galaxies, which poses a challenge for observations reconstructing CGM characteristics from limited samples, and also indicates that long-term merger assembly history and recent star formation are not the dominant sculptors of the CGM.

scholarly journals Clinical utility of complex assessment with evoked potentials in acute lymphoblastic leukemia survivors: comparison of various treatment protocols

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Slawomir Kroczka ◽  
Konrad Stepien ◽  
Izabela Witek-Motyl ◽  
Kinga Kwiecinska ◽  
Eryk Kapusta ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Evoked Potentials ◽  
Lymphoblastic Leukemia ◽  
Objective Assessment ◽  
Harmful Effect ◽  
Diagnostic Methods ◽  
Joint Analysis ◽  
Control Group ◽  
The Impact

Abstract Background One of the greatest success of pediatric hematology is a prominent improvement of survival in acute lymphoblastic leukemia (ALL). Therefore, special attention needs to be paid to long-term side effects of the treatment such as neurotoxicity. One of the few diagnostic methods that allow an objective assessment of sensory systems are evoked potentials (EP). Methods The analyzed group consisted of 167 ALL long-term survivors, aged 4.9–28.4 years, without auditory, visual and sensory deviations. Patients were treated with New York (NY, n = 35), previous modified Berlin-Frankfurt-Münster (pBFM, n = 47) and BFM95 (n = 85) protocols. In order to assess the impact of radiotherapy on recorded EP, a joint analysis of NY and pBFM groups was performed. The control group consisted of 35 patients, aged 6–17 years. The analyzed patients underwent a complex assessment with visual EP (VEP), somatosensory EP (SEP) and brainstem auditory EP (BAEP) in accordance with current standards. Results ALL treatment contributed to the shortening of wave I latency (1.59 vs 1.90, P = 0.003) and prolongation of I-III (2.23 vs 2.04, P = 0.004) and I-V (4.57 vs 4.24, P = 0.002) interwave latencies of BAEP. A significant effect was also noticed in P100 (106.32 vs 101.57, P < 0.001) and N135 (151.42 vs 138.22, P < 0.001) latencies of VEP and N18 amplitude (3.24 vs 4.70, P = 0.007) and P25 latency (21.32 vs 23.39, P < 0.001) of SEP. The distribution of abnormalities between protocols was similar in BAEP (NY - 68.6%, pBFM - 61.7%, BFM95–69.4%, P = 0.650), VEP (NY - 68.6%, pBFM - 42.5%, BFM95–58.3%, P = 0.053) and significantly different for SEP (NY - 62.9%, pBFM - 36.2%, BFM95–53.0%, P = 0.045). The harmful effect of radiotherapy was most clearly marked in numerous disturbances of SEP parameters. Conclusions The presented analysis indicates a high frequency of subclinical abnormalities in EP regardless of the analyzed protocol. To our knowledge current study is the largest and one of the most complex research examining the role of EP in ALL patients. The obtained results indicate the possibility of using a single, objective and non-invasive measurement of EP in ALL survivors in order to stratify the risk of developing sensory abnormalities in adulthood.

Immunological footprint: the development of a child's immune system in environments rich in microorganisms and parasites

Parasitology ◽  
2011 ◽  
Vol 138 (12) ◽  
pp. 1508-1518 ◽  
Author(s):  
YENNY DJUARDI ◽  
LINDA J. WAMMES ◽  
TANIAWATI SUPALI ◽  
ERLIYANI SARTONO ◽  
MARIA YAZDANBAKHSH
Keyword(s):  
Immune System ◽  
Environmental Factors ◽  
Later Life ◽  
Third Party ◽  
Middle Income ◽  
Middle Income Countries ◽  
Geographical Regions ◽  
Micro Organisms ◽  
The Impact

SUMMARYThe shaping of a child's immune system starts in utero, with possible long-term consequences in later life. This review highlights the studies conducted on the development of the immune system in early childhood up to school-age, discussing the impact that environmental factors may have. Emphasis has been put on studies conducted in geographical regions where exposure to micro-organisms and parasites are particularly high, and the effect that maternal exposures to these may have on an infant's immune responses to third-party antigens. In this respect we discuss the effect on responses to vaccines, co-infections and on the development of allergic disorders. In addition, studies of the impact that such environmental factors may have on slightly older (school) children are highlighted emphasizing the need for large studies in low to middle income countries, that are sufficiently powered and have longitudinal follow-up components to understand the immunological footprint of a child and the consequences throughout life.

Strategic Culture and Environmental Dimensions as Determinants of Anomie in Publicly-Traded and Privately-Held Firms

2011 ◽  
Vol 21 (3) ◽  
pp. 473-502 ◽  
Author(s):  
Jean L. Johnson ◽  
Kelly D. Martin ◽  
Amit Saini
Keyword(s):  
Environmental Factors ◽  
Organizational Factors ◽  
Strategic Flexibility ◽  
Publicly Traded ◽  
Technological Turbulence ◽  
Ethics Research ◽  
Strategic Aggressiveness ◽  
The Impact ◽  
Privately Held

ABSTRACT:Anomie is a condition in which normative guidelines for governing conduct are absent. Using survey data from a sample of U.S. manufacturing firms, we explore the impact of internal (cultural) and external (environmental) determinants of organizational anomie. We suggest that four internal organizational factors can generate or suppress organizational anomie, including strategic aggressiveness, long-term orientation, competitor orientation, and strategic flexibility. Similarly, we argue that external contextual factors, including competitive intensity and technological turbulence, can influence organizational anomie. We extend anomie and ethics research by considering the impact of these firm cultural and environmental factors according to whether firms are publicly-traded or privately-held. Findings demonstrate that a number of firm cultural and environmental factors can generate or reduce anomie in firms. Moreover, strategic aggressiveness, long-term orientation, and strategic flexibility influence organizational anomie differently depending on whether the firm is publicly-traded or privately-held. Theoretical and practical implications of our findings are discussed.

scholarly journals Evaluating the impacts of environmental factors on soil moisture temporal dynamics at different time scales

2020 ◽  
Author(s):  
Qi Chai ◽  
Tiejun Wang ◽  
Chongli Di
Keyword(s):  
Soil Moisture ◽  
Environmental Factors ◽  
Time Scales ◽  
Temporal Dynamics ◽  
Soil Moisture Dynamics ◽  
Temporal Variance ◽  
The Impact ◽  
Moisture Dynamics ◽  
Different Time Scales

Abstract Soil moisture displays complex spatiotemporal patterns across scales, making it important to disentangle the impacts of environmental factors on soil moisture temporal dynamics at different time scales. This study evaluated the factors affecting soil moisture dynamics at different time scales using long-term soil moisture data obtained from Nebraska and Utah. The empirical mode decomposition method was employed to decompose soil moisture time series into different temporal components with several intrinsic mode functions (IMFs) and one residual component. Results showed that the percent variance contribution (PVC) of IMFs to the total soil moisture temporal variance tended to increase for the IMFs with longer time periods. It indicated that the long-term soil moisture variations in study regions were mainly determined by low-temporal frequency signals related to seasonal climate and vegetation variations. Besides, the PVCs at short- and medium-temporal ranges were positively correlated with climate dryness, while negatively at longer temporal ranges. Moreover, the results suggested that the impact of climate on soil moisture dynamics at different time scales might vary across different climate zones, while soil effect was comparatively less in both regions. It provides additional insights into understanding soil moisture temporal dynamics in regions with contrasting climatic conditions.

scholarly journals Does delaying curative surgery for colorectal cancer influence long-term disease-free survival? A cohort study

2021 ◽  
Author(s):  
Stephanie Garcia-Botello ◽  
J. Martín-Arevalo ◽  
C. Cozar-Lozano ◽  
A. Benitez-Riesco ◽  
D. Moro-Valdezate ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Disease Free Survival ◽  
Time Interval ◽  
Wait List ◽  
Free Survival ◽  
Ajcc Stage ◽  
Definitive Surgery ◽  
The Impact ◽  
Disease Free

Abstract Background Surgical wait list time is a major problem in many health-care systems and its influence on survival is unclear. The aim of this study is to assess the impact of wait list time on long-term disease-free survival in patients scheduled for colorectal cancer resection. Materials and methods A prospective study was carried out in patients with colorectal cancer scheduled for surgery at a tertiary care center. Wait list time was defined as the time from completion of diagnostic workup to definitive surgery and divided into 2-week intervals from 0 to 6 weeks. The outcome variables were 2-year and 5-year disease-free survival. Results A total of 602 patients, 364 (60.5%) male, median age 73 years (range = 71) were defined. The median wait list time was 28 days (range = 99). Two and 5-year disease-free survival rates were 521 (86.5%) and 500 (83.1%) respectively. There were no differences in 2-year or 5-year disease-free survival for the whole cohort or by tumor stage between wait list time intervals except for AJCC stage II tumors which showed a higher 5-year disease-free survival for the 2–4 and 4–6-week wait list time interval (p = 0.021). Conclusions Time from diagnosis to definitive surgery up to 6 weeks is not associated with a decrease in 2-year or 5-year disease-free survival (DFS) in AJCC stage I through III colorectal cancer patients. These are important findings in the light of the COVID-19 pandemic and offer a window of opportunity for preoperative optimization and prehabilitation.

scholarly journals Product reliability and warranty period as a cost-forming factors

2016 ◽  
Vol 17 (4) ◽  
pp. 361-369
Author(s):  
Nataly Podolyakina
Keyword(s):  
High Tech ◽  
Time Interval ◽  
Competitive Advantages ◽  
Product Reliability ◽  
Complete Replacement ◽  
Warranty Period ◽  
Manufactured Products ◽  
Warranty Service ◽  
The Impact

The relevance of this study is determined by the fact that, in modern conditions, the manufacturers of high-tech products offer long-term warranty service for their products aiming at receiving the consumer. In turn, the frequency of warranty service depends on the probability of trouble-free operation of the product in a certain time interval. However, increasing the uptime of the products and increase the warranty period results in increased costs. Therefore, the purpose of this study is to develop a model that allows determining the impact of the following factors on the product cost: the reliability of the manufactured products and the term of their warranty. To achieve the goal of the research there has been determined the content of warranty service, has been introduced the integrated indicator of quality warranty services, and has been shown the level of products reliability as a dependence from the costs of their manufacturing and warranty service. The novelty of this study is estimation of the manufacturer’s cost depending on the way of providing the warranty service, either by repair, or by complete replacement of the failed product. The research results provide competitive advantages to manufacturers of high-tech products since it enables to find the efficient period and intensity of the warranty service.

scholarly journals Perioperative complications and oncological outcomes following radical cystectomy among different racial groups: A long-term, single-center study

2019 ◽  
Vol 14 (10) ◽  
Author(s):  
Alireza Ghoreifi ◽  
Anirban P. Mitra ◽  
Jie Cai ◽  
Gus Miranda ◽  
Siamak Daneshmand ◽  
...  
Keyword(s):  
Radical Cystectomy ◽  
Racial Differences ◽  
Perioperative Complications ◽  
Clinical Stage ◽  
Time Interval ◽  
Racial Groups ◽  
Curative Intent ◽  
Oncological Outcomes ◽  
The Impact

Introduction: Current literature on perioperative and oncological outcomes following radical cystectomy among different racial groups is limited, especially among Hispanics and Asians. The objective of this study was to assess the impact of racial differences on perioperative and oncological outcomes in a large cohort of bladder cancer patients who underwent radical cystectomy. Methods: We retrospectively reviewed the records of 3293 patients who underwent radical cystectomy with curative intent at our institution between 1971 and 2017. Based on race, patients were categorized as Hispanic (n=190), Asian (n=145), African Americans (n=67), and Caucasian (n=2891). Baseline characteristics, pericystectomy complications, and oncological outcomes, including recurrence-free and overall survival, were compared between the racial groups. Results: Mean patient age was 68±10.6 years. Median followup was 10.28 years. Body masss index and American Society of Anesthesiologists scores were significantly higher in Hispanic and African American population, and smoking incidence was lower in Asian patients. Hispanics presented with significantly higher clinical stage and longer time interval from diagnosis to treatment (mean 85.5 vs. 75.4 days in Caucasians, p<0.001). Overall 90-day complication and readmission rates were higher in Hispanics (41.06% and 18.95%, respectively). Oncological outcomes, however, were comparable between different race groups. In multivariate analysis, pathological nodal status and lymphovascular invasion were independent predictors of oncological outcomes, but race was not. Conclusions: In this very large, ethnically diverse patient cohort who underwent radical cystectomy with curative intent, pericystectomy complications were more common in Hispanics; however, race was not an independent predictor of long-term oncological outcome.

scholarly journals A 2-decade (1988–2009) record of diatom fluxes in the Mauritanian coastal upwelling: impact of low-frequency forcing and a two-step shift in the species composition

2021 ◽  
Vol 18 (5) ◽  
pp. 1873-1891
Author(s):  
Oscar E. Romero ◽  
Simon Ramondenc ◽  
Gerhard Fischer
Keyword(s):  
Coastal Waters ◽  
Temporal Dynamics ◽  
Southern Oscillation ◽  
Low Frequency ◽  
Meridional Overturning Circulation ◽  
Benthic Diatoms ◽  
Time Interval ◽  
Data Set ◽  
The Impact

Abstract. Eastern boundary upwelling ecosystems (EBUEs) are among the most productive marine regions in the world's oceans. Understanding the degree of interannual to decadal variability in the Mauritania upwelling system is crucial for the prediction of future changes of primary productivity and carbon sequestration in the Canary Current EBUE as well as in similar environments. A multiyear sediment trap experiment was conducted at the mooring site CBmeso (“Cape Blanc mesotrophic”, ca. 20∘ N, ca. 20∘40′ W) in the highly productive coastal waters off Mauritania. Here, we present results on fluxes of diatoms and the species-specific composition of the assemblage for the time interval between March 1988 and June 2009. The temporal dynamics of diatom populations allows the proposal of three main intervals: (i) early 1988–late 1996, (ii) 1997–1999, and (iii) early 2002–mid 2009. The Atlantic Multidecadal Oscillation (AMO) appears to be an important driver of the long-term dynamics of diatom population. The long-term AMO-driven trend is interrupted by the occurrence of the strong 1997 El Niño–Southern Oscillation (ENSO). The extraordinary shift in the relative abundance of benthic diatoms in May 2002 suggests the strengthening of offshore advective transport within the uppermost layer of filament waters and in the subsurface and in deeper and bottom-near layers. It is hypothesized that the dominance of benthic diatoms was the response of the diatom community to the intensification of the slope and shelf poleward undercurrents. This dominance followed the intensification of the warm phase of AMO and the associated changes of the Atlantic Meridional Overturning Circulation. Transported valves (siliceous remains) from shallow Mauritanian coastal waters into the bathypelagic should be considered for the calculation and model experiments of bathy- and pelagic nutrients budgets (especially Si), the burial of diatoms, and the paleoenvironmental signal preserved in downcore sediments. Additionally, our 1988–2009 data set contributes to the characterization of the impact of low-frequency climate forcings in the northeastern Atlantic and will be especially helpful for establishing the scientific basis for forecasting and modeling future states of the Canary Current EBUE and its decadal changes.

scholarly journals The analysis of the impact of environmental factors on turbine performance, develpoment of the models relating the periods between maintenances with selected maintenance factors

2021 ◽  
pp. 1-10
Author(s):  
Magdalena THIELMANN
Keyword(s):  
Environmental Factors ◽  
Gas Turbines ◽  
Time Model ◽  
Reliability Models ◽  
Average Value ◽  
Turbine Performance ◽  
Maintenance Factors ◽  
Maintenance And Inspection ◽  
The Impact

There are currently around 18,000 commissioned Gas Turbines in use worldwide, with almost 7,500 long-term service agreements[1]. At the same time, orders for new units increase year by year, and after a decrease in production in 2020 from 353 to 328 new units, from 2022 onwards, the level is planned to rise to the previous level of growth. Gas turbines operate worldwide and are exposed to variations in environmental conditions, such as changes in humidity, temperature, and salinity, which can significantly affect the efficiency and faster degradation of individual components. Based on the unit's maintenance report, there are more than 1,940 event alerts annually. A need exists to create a more dynamic analytical and numerical model that determines the impact of environmental variables on gas turbine stability. It is necessary to analyze and improve existing reliability models, which vary due to configurations and the impact of working conditions. The first step should be an analysis of the impact of environmental factors on turbine performance. This paper describes how the maintenance and inspection model developed from an average value over time model to a model tracking the actual degradation of gas turbines. It includes a comparison ofthree models used in the research, considering the developed methodology for selecting input parameters, their correlation, and their appropriateness for use in further analyses.

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