scholarly journals Systemic toxicity of metal ions release from specific types of implanted medical devices: Systemic review of clinical studies

2021 ◽  
Vol 12 (2) ◽  
pp. 401-415
Author(s):  
Henryk Matusiewicz ◽  
Magdalena Richter
Keyword(s):  
Metal Ions ◽  
Medical Devices ◽  
Metal Ion ◽  
Systemic Toxicity ◽  
Systemic Review ◽  
Medical Implants ◽  
Ion Release ◽  
Wear And Corrosion ◽  
Metal Ion Release ◽  
Implanted Medical Devices

There is public concern over the long term systemic health effects of metal released from implanted medical devices that use metal alloys. Systemic toxic side effects have been associated with excessive metal ion release from implants into human biological specimen's circulation, in which cobalt and chromium plays an important role. Cobalt intoxication has become more frequent due to the wide use of metallic medical implants. Despite the technological improvements in replacement metallic medical implants, wear and corrosion products associated with the metal compounds of these implants may result in systemic reactions and toxicities. The current review encompasses a literature of the systemic toxicity studies concerning the effect of metallic wear debris released from wear and corrosion of specific types of implanted medical devices, resulting in a postoperative increase in metal ion levels in bodily fluids and at different organ sites. Release of metallic debris is mainly in the form of particles and ions of different valences, and oxides composed of cobalt and chromium. Toxicological, clinically significant, data regarding "potential hazards" of circulating metals after systemic chronic exposure to the metal ions from metals have been included. This review further highlights some of the clinical features of cobalt toxicity.

Metal Ion Release after Hip and Knee Arthroplasty – Causes, Biological Effects and Diagnostics

2019 ◽  
Vol 158 (04) ◽  
pp. 369-382 ◽  
Author(s):  
Jörg Lützner ◽  
Klaus-Peter Günther ◽  
Anne Postler ◽  
Michael Morlock
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Biological Effects ◽  
Ion Concentration ◽  
Blood Levels ◽  
Ceramic Head ◽  
Ion Release ◽  
Imaging Results ◽  
Metal Ion Release ◽  
Metal Metal

AbstractAll metal implants in human bodies corrode which results in metal ions release. This is not necessarily a problem and represents for most patients no hazard. However, if a critical metal ion concentration is exceeded, local or rarely systemic problems can occur. This article summarizes the mechanisms of metal ion release and its clinical consequences. Several situations can result in increased metal ion release: metal-on-metal hip arthroplasties with increased wear, increased micromotion at taper interfaces, direct metal-metal contact (polyethylene wear, impingement), erroneously used metal heads after ceramic head fracture. Possible problems are in most cases located close to the concerned joint. Furthermore, there are reports about toxic damage to several organs. Most of these reports refer to erroneously used metal heads in revisions after a broken ceramic head. There is currently no evidence of carcinogenic or teratogenic effects of implants but data is not sufficient to exclude possible effects. Cobalt and chromium blood levels (favorably in whole blood) should be measured in patients with suspected elevated metal ions. According to current knowledge levels below 2 µg/l seem to be uncritical, levels between 2 and 7 µg/l are considered borderline with unknown biological consequences and levels above 7 µg/l indicate a local problem which should be further diagnosed. Metal ion levels always need to be interpreted together with clinical symptoms and imaging results.

scholarly journals Alkaline Phosphatase Immobilization on New Chitosan Membranes with Mg2+ for Biomedical Applications

Marine Drugs ◽  
2018 ◽  
Vol 16 (8) ◽  
pp. 287 ◽  
Author(s):  
Gratiela Tihan ◽  
Roxana Zgarian ◽  
Elena Berteanu ◽  
Daniela Ionita ◽  
Georgeta Totea ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Metal Ions ◽  
Inductively Coupled Plasma ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Morphological Characteristics ◽  
Ion Release ◽  
Microscopy Technique ◽  
Metal Ion Release ◽  
Chitosan Membranes

In this paper, we present the fabrication and characterization of new chitosan-based membranes while using a new biotechnology for immobilizing alkaline phosphatase (ALP). This technology involved metal ions incorporation to develop new biopolymeric supports. The chemical structure and morphological characteristics of proposed membranes were evaluated by infrared spectroscopy (FT-IR) and the scanning electron microscopy technique (SEM). The inductively coupled plasma mass spectrometry (ICP-MS) evidenced the metal ion release in time. Moreover, the effect of Mg2+ on the enzymatic activity and the antibacterial investigations while using Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria, hemolysis, and biocompatibility behavior were studied. Immobilizing ALP into the chitosan membranes composition followed by the incorporation of Mg2+ led to polymeric supports with enhanced cellular viability when comparing to chitosan-based membranes without Mg2+. The results obtained evidenced promising performance in biomedical applications for the new biopolymeric supports that are based on chitosan, ALP, and metal ions.

scholarly journals Metal ion release from silver soldering and laser welding caused by different types of mouthwash

2014 ◽  
Vol 85 (4) ◽  
pp. 665-672 ◽  
Author(s):  
Ayse Tuygun Erdogan ◽  
Didem Nalbantgil ◽  
Feyza Ulkur ◽  
Fikrettin Sahin
Keyword(s):  
Laser Welding ◽  
Metal Ions ◽  
Sodium Fluoride ◽  
Inductively Coupled Plasma ◽  
Metal Ion ◽  
Artificial Saliva ◽  
Ion Release ◽  
Sem Images ◽  
Metal Ion Release ◽  
Group Comparisons

ABSTRACT Objective:  To compare metal ion release from samples welded with silver soldering and laser welding when immersed into mouthwashes with different ingredients. Materials and Methods:  A total of 72 samples were prepared: 36 laser welded and 36 silver soldered. Four samples were chosen from each subgroup to study the morphologic changes on their surfaces via scanning electron microscopy (SEM). Each group was further divided into four groups where the samples were submerged into mouthwash containing sodium fluoride (NaF), mouthwash containing sodium fluoride + alcohol (NaF + alcohol), mouthwash containing chlorhexidine (CHX), or artificial saliva (AS) for 24 hours and removed thereafter. Subsequently, the metal ion release from the samples was measured with inductively coupled plasma mass spectrometry (ICP-MS). The metal ion release among the solutions and the welding methods were compared. The Kruskal-Wallis and analysis of variance (ANOVA) tests were used for the group comparisons, and post hoc Dunn multiple comparison test was utilized for the two group comparisons. Results:  The level of metal ion release from samples of silver soldering was higher than from samples of laser welding. Furthermore, greater amounts of nickel, chrome, and iron were released from silver soldering. With regard to the mouthwash solutions, the lowest amounts of metal ions were released in CHX, and the highest amounts of metal ions were released in NaF + alcohol. SEM images were in accord with these findings. Conclusions:  The laser welding should be preferred over silver soldering. CHX can be recommended for patients who have welded appliances for orthodontic reasons.

scholarly journals Effect of Carbamide Peroxide Treatments on the Metal-ion Release and Microstructure of Different Dental Amalgams

2007 ◽  
Vol 32 (5) ◽  
pp. 476-481 ◽  
Author(s):  
S. Gurgan ◽  
A. Kiremitci ◽  
F. Yalcin ◽  
T. Alpaslan ◽  
E. Yazici
Keyword(s):  
Metal Ions ◽  
Clinical Relevance ◽  
Metal Ion ◽  
Dental Amalgam ◽  
Carbamide Peroxide ◽  
Ion Release ◽  
Peroxide Bleaching ◽  
Metal Ion Release ◽  
Dental Amalgams

Clinical Relevance Carbamide peroxide bleaching releases metal-ions from dental amalgam.

Metal ion release from bearing wear and corrosion with 28 mm and large-diameter metal-on-metal bearing articulations

2010 ◽  
Vol 92-B (1) ◽  
pp. 12-19 ◽  
Author(s):  
P.-A. Vendittoli ◽  
A. Roy ◽  
S. Mottard ◽  
J. Girard ◽  
D. Lusignan ◽  
...  
Keyword(s):  
Metal Ion ◽  
Large Diameter ◽  
Ion Release ◽  
Wear And Corrosion ◽  
Metal On Metal ◽  
Metal Ion Release

scholarly journals The impact of nanosilver addition on element ions release form light-cured dental composite and compomer into 0.9% NaCl.

2014 ◽  
Vol 61 (2) ◽  
Author(s):  
Krzysztof Sokołowski ◽  
Małgorzata I Szynkowska ◽  
Aleksandra Pawlaczyk ◽  
Monika Łukomska-Szymańska ◽  
Jerzy Sokołowski
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Test Tube ◽  
Dental Composite ◽  
Nacl Solution ◽  
Ion Release ◽  
Dental Fillings ◽  
Metal Ion Release ◽  
Different Temperatures ◽  
The Impact

The aim of this paper was to identify and to assess in semi-quantified way the release of different ions from composite and compomer restorative materials subjected to 0.9% NaCl solution, which simulates the environment of the human body. In the present study, the number of ions (Al, Ag, Ba, Sr, Ti) released from dental fillings over time (one week, one month and 3 months), in different temperatures (23°C, 37°C) and depending on the materials applied (unmodified/modified with nanosilver) was investigated. The results suggest that nanosilver addition influences directly on the process of metal ion releasing into 0.9% NaCl solution. The increase in the number of counts of metal ions was observed in the solutions in which samples modified with nanosilver were kept. Higher amount of metal ion release was observed for composite samples rather than for compomer materials. The study revealed that in general the number of released metal ions increases with the time of storage (for metal ions: Ti, Ba, Sr) and at higher temperature (Ag, Ti, Ba). Reverse tendency observed for silver ion release versus incubation time may be caused by the process of silver adsorption, which takes place on the surface of analyzed material and test-tube walls, where samples were incubated.

scholarly journals Comparison of Metal Ion Release from Different Bracket Archwire Combinations: An in vitro Study

2012 ◽  
Vol 13 (3) ◽  
pp. 376-381 ◽  
Author(s):  
CM Manjith ◽  
Srinivas Kumar Karnam ◽  
A Naveen Reddy
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Artificial Saliva ◽  
In Vitro Study ◽  
Iron Ions ◽  
Orthodontic Appliance ◽  
Ion Release ◽  
Nickel Chromium ◽  
Metal Ion Release

ABSTRACT Aim The metal ion released from the orthodontic appliance may cause allergic reactions particularly nickel and chromium ions. Hence, this study was undertaken to determine the amount of nickel, chromium, copper, cobalt and iron ions released from simulated orthodontic appliance made of new archwires and brackets. Materials and methods Sixty sets of new archwire, band material, brackets and ligature wires were prepared simulating fixed orthodontic appliance. These sets were divided into four groups of fifteen samples each. Group 1: Stainless steel rectangular archwires. Group 2: Rectangular NiTi archwires. Group 3: Rectangular copper NiTi archwires. Group 4: Rectangular elgiloy archwires. These appliances were immersed in 50 ml of artificial saliva solution and stored in polypropylene bottles in the incubator to simulate oral conditions. After 90 days the solution were tested for nickel, chromium, copper, cobalt and iron ions using atomic absorption spectrophotometer. Results Results showed that high levels of nickel ions were released from all four groups, compared to all other ions, followed by release of iron ion levels. There is no significant difference in the levels of all metal ions released in the different groups. Conclusion The study confirms that the use of newer brackets and newer archwires confirms the negligible release of metal ions from the orthodontic appliance. Clinical significance The measurable amount of metals, released from orthodontic appliances in artificial saliva, was significantly below the average dietary intake and did not reach toxic concentrations. How to cite this article Karnam SK, Reddy AN, Manjith CM. Comparison of Metal Ion Release from Different Bracket Archwire Combinations: An in vitro Study. J Contemp Dent Pract 2012;13(3):376-381.

scholarly journals Metal Ion Release from Engineered Stone Dust in Artificial Lysosomal Fluid—Variation with Time and Stone Type

2021 ◽  
Vol 18 (12) ◽  
pp. 6391
Author(s):  
Preeti Maharjan ◽  
Joseph Crea ◽  
Michael Tkaczuk ◽  
Sharyn Gaskin ◽  
Dino Pisaniello
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Metal Release ◽  
Ion Release ◽  
Lung Macrophage ◽  
Stone Dust ◽  
Metal Ion Release ◽  
Stone Type ◽  
Iron And Manganese

Inhalational exposure to dust from engineered stone (ES), also known as artificial or composite stone, is associated with a specific disease profile, namely accelerated silicosis, and scleroderma. The pathogenic mechanisms are poorly understood, particularly the role of resin and metal ions. Metal ions are present in pigments and constituent minerals and may be considered potential contributors to toxicity. The aim of this preliminary study was to understand the solubility of ES-containing metals in artificial lysosomal fluid (ALF) simulating the acidic intracellular environment of the lung macrophage lysosome. Differences with respect to ES types and temporal release were explored. Ten ES products of variable colour and company origin were comminuted and assessed for four different metals, solubilized into ALF solutions at 1,2,4 and 8 weeks at 37 °C. There was significant variability in metal release, particularly with regard to iron and manganese, which could be correlated with the reflected brightness of the stone. A majority of the available Mn, Fe, Al and Ti was solubilized. Time trends for metal release varied with ES type but also with metal ion. The data suggest a high metal ion bioavailability once engulfed by lung macrophages. There is a need to investigate a wider range of ES dust and relate metal content to markers of ES toxicity.

scholarly journals Bioactive Plasma Coatings on Orthodontic Brackets: In Vitro Metal Ion Release and Cytotoxicity

Coatings ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 857
Author(s):  
Lasni Samalka Kumarasinghe ◽  
Neethu Ninan ◽  
Panthihage Ruvini Lakshika Dabare ◽  
Alex Cavallaro ◽  
Esma J. Doğramacı ◽  
...  
Keyword(s):  
Metal Ion ◽  
Prolonged Exposure ◽  
Orthodontic Brackets ◽  
Plasma Polymer ◽  
Functional Coatings ◽  
Key Factors ◽  
Ion Release ◽  
Metal Ion Release ◽  
Surface Functionalisation

The metal ion release characteristics and biocompatibility of meta-based materials are key factors that influence their use in orthodontics. Although stainless steel-based alloys have gained much interest and use due to their mechanical properties and cost, they are prone to localised attack after prolonged exposure to the hostile oral environment. Metal ions may induce cellular toxicity at high dosages. To circumvent these issues, orthodontic brackets were coated with a functional nano-thin layer of plasma polymer and further immobilised with enantiomers of tryptophan. Analysis of the physicochemical properties confirmed the presence of functional coatings on the surface of the brackets. The quantification of metal ion release using mass spectrometry proved that plasma functionalisation could minimise metal ion release from orthodontic brackets. Furthermore, the biocompatibility of the brackets has been improved after functionalisation. These findings demonstrate that plasma polymer facilitated surface functionalisation of orthodontic brackets is a promising approach to reducing metal toxicity without impacting their bulk properties.

Sign in / Sign up

Export Citation Format

Share Document